Advanced Healthcare Materials
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2025
·
IF 9.6
Zeyu Shou,Dong Yang,Yewen Liu,Jiawei Yu,Jiali Shou,Ming Cai,Lianxin Li,Shuohui Yuan,Xiufeng Wang
To address the clinical challenges of bacterial infection, inflammation, oxidative stress, ischemia-hypoxia, and excessive bone resorption during infected bone therapy, a multifunctional nanoparticle (Cur/Sr@CAMEL0 NPs) is engineered by integrating a self-assembled curcumin-strontium metal-phenolic network core (Cur/Sr NPs) with a hexameric lysine-conjugated antimicrobial peptide (K6-CAMEL0) via surface modification. The resultant nanoparticle exhibits distinctive morphological and structural characteristics, along with favorable cellular compatibility. Functionally, it is demonstrated to exhibit broad-spectrum antibacterial activity, along with inflammation and reactive oxygen species (ROS) scavenging capabilities, pro-angiogenic effects, and significant promotion of necrotic bone resorption and normal bone regeneration. In an infected bone defect animal model, the composite nanoparticle effectively eradicated Staphylococcus aureus （ S. aureus ） colonization and facilitated the bone regeneration process through single-dose administration. These findings collectively highlight the therapeutic potential of Cur/Sr@CAMEL0 as a multifunctional platform for managing bone infections, offering a promising strategy to address complex challenges in infected bone diseases.
研究领域:
生物材料学
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骨科学
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纳米医学
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感染性疾病
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炎症生物学
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组织工程
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药剂学
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转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2022
·
IF 3.571
Dongyuan Lu,Zhipeng Wang,Shouhong Gao,Yuehao Han,Hongsen Wang,Hanglin Li,Hongxia Yan,Bosu Meng,Yuhui Mu,Yi Jiang,Xia Tao,Wansheng Chen
Depression is a mental health disorder characterized by chronic negative mood, and depression has become a major threat to human health and quality of life. Anyupeibo capsule , a fifth-class new Chinese medicine, was prepared with extracts of Piper laetispicum C.DC. (Piperaceae), and the alkaloid K6 (5′-methoxy-3′,4′-methyl-enedioxycinnamic-acidisob-utylamide-isobutylamide) was found to be the main active component. Using high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (LC-MS/MS), we developed a method to quantify the concentration of K6 in serum samples from patients with depression. Pretreatment of samples was completed based on solid-phase extraction, and the mobile phase for subsequent LC analysis consisted of aqueous ammonium acetate (0.1 mmol/L, phase A) and acetonitrile (phase B) with isocratic elution at 60% B. Chromatographic separation of K6 was achieved within 3 min with an Agilent ZORBAX SB-C 18 column (2.1 × 150 mm, 3.5 µm) at a flow rate of 0.3 mL/min. A linear regression equation for K6 yielded correlation coefficients of r 2 > 0.99 within a linear range 0.0503–100.5000 ng/mL. Extraction recovery ranged from 85.33% to 101.18%, and the matrix effect ranged from 87.15% to 100.28%. The inter-day and intra-day precision values—expressed as relative standard deviation—were less than 15%, and the corresponding accuracy values were within ±15%. All validation results for stability, specificity, and carry-over met the requirements of Pharmacopoeia. The LC-MS/MS method was applied to determine the K6 concentration in serum samples from patients with depression in a phase III clinical trial of Anyupeibo capsule.
研究领域:
药理学
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分析化学
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临床试验
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心理健康
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 7
·3226-3235
·
IF 3.069
Shuai-yong Dou,Rui Wang
Herein, three polyoxometalates, namely K3PW12O40·10H2O, K6[α-P2W18O62]·14H2O, and K8H[P2W15V3O62]·9H2O, were successfully prepared and used in the air/n-octanaloxidative desulfurization (ODS) system. Among the compounds, the Dawson-type polyoxometalate K6[α-P2W18O62]·14H2O exhibited the best performance, with a 99.63% desulfurization ratio. Then, K6[α-P2W18O62]·14H2O was supported on graphene oxide (GO) to obtain K6P2W18O62/GO. The prepared catalysts were characterized by Fourier transform infrared spectroscopy (FTIR), 31P nuclear magnetic resonance (31P NMR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, transmission electron microscopy (TEM), and Boehm titration. Using K6P2W18O62/GO as a catalyst, a final sulfur removal ratio of 96.10% was achieved without extraction post-treatment due to the inherent adsorption capacity of the catalyst. In addition, the factors influencing the desulfurization process were investigated. The recovery experiment showed that the supported catalyst could be reused 5 times with slight catalyst deactivation. Finally, the reaction mechanism was proposed with the aid of gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS) and contrast tests.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Jun Sun,Tushagu Abudouwufu,Congcong Jin,Zhiyong Guo,Min Zhang
A new alkali-metal iodate, K6(IO6H4)(HI2O6)(HIO3)2(IO3)4·2H2O (KIOH), was successfully grown at room temperature by a slow evaporation method. To our knowledge, the title compound is the first alkali-metal iodate containing isolated [I5+O3] and [I7+O6] units in one structure. Both the bond valence sum and X-ray photoelectron spectroscopy confirmed this phenomenon, which is consistent with the single-crystal data. Also, the theoretical calculation results showed that the title compound is a potential birefringent material. What is more, the low-cost growth of centimeter-sized crystals for the title compound greatly enriches the structural chemistry of the iodate system.
研究领域:
无机化学
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晶体学
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材料科学
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光学材料
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固态化学
✓ 已验证
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 33
·期 6
·e4924
·
IF 3.259
Shuai-Yong Dou,Rui Wang
Eight Dawson-type polyoxometalates were successfully prepared and used in an octanal/air oxidative desulfurization (ODS) system for model oil. Among which, the classical 2:18 polyoxometalate K 6 [α-P 2 W 18 O 62 ]·14H 2 O exhibited the best catalytic performance with a sulfur removal ratio of 99.63%. Then, K 6 [α-P 2 W 18 O 62 ]·14H 2 O was supported on graphene oxide (GO) to afford K 6 P 2 W 18 O 62 /GO using the hydrothermal method. Due to the in situ adsorption of the supported catalysts in the ODS process, the sulfur removal ratio was 96.10% without extraction treatment. Compared with the octanal/air ODS system using pure GO as an adsorbent for the oxidation products, the sulfur removal ratio increased from 89.21 to 96.10%, and the n -octanal/S molar ratio decreased from 24 to 4. To facilitate the recycling of the catalyst and avoid catalyst loss, K 6 [α-P 2 W 18 O 62 ]·14H 2 O was supported on magnetic graphene oxide (mGO) to afford K 6 P 2 W 18 O 62 /mGO. The results showed that the supported catalyst could be easily recovered with the aid of an external magnetic field, while maintaining high catalytic activity during five cycles of reuse with little catalyst loss. Furthermore, all the prepared materials were analyzed by a series of characterizations, and the reaction mechanism of the studied system was proposed through contrast tests and GC-MS characterization analysis.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）