ADVANCED FUNCTIONAL MATERIALS
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2024
·Vol. 34
·期 19
·2313146
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IF 18.5
Fengchun Li,Xin Gu,Akang Cui,Yang Li,Sijin Dong,Shuang Wu,Zhenjie Cheng,Qian Yao,Jian Yang,Mingbo Wu
Manganese-based layered oxide cathodes, particularly K x MnO 2 (KMO), have shown great potential in potassium-ion batteries (PIBs) due to their low cost, high theoretical capacities, and excellent thermal stability. However, Jahn-Teller distortion, manganese dissolution, and interface instability of electrode/electrolyte lead to structural instability and performance decay. Here, lithium difluoro(oxalate) borate (LiDFOB) is introduced as an electrolyte additive to improve the electrochemical performance of P3-type KMO. LiDFOB creates a uniform, thin, and robust cathode-electrolyte interphase layer on the cathode surface, enhancing reaction kinetics, preventing manganese dissolution, and stabilizing the structure. The P3-KMO cathode with LiDFOB in the basic electrolyte exhibits significantly improved electrochemical performance, such as a remarkable Coulombic efficiency of ≈99.5% and high capacity retention of 78.6% after 300 cycles at 100 mA g −1 . Moreover, the full cell of P3-KMO||soft carbon demonstrates satisfactory specific capacity and energy density. This study emphasizes the importance of interface chemistry for PIBs.
研究领域:
电化学
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储能
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材料科学
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电池技术
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2025
·
IF 8
Yuxin Lin,Luyao Wang,Sining Meng,Jianjia Liu,Xinyu Li,Wenjuan Wang,Miaoyang Hu,Xi Wang,Weixia Duan,Shangcheng Xu,Jun Wang,Rong Gao
Bisphenol F (BPF), one of the major substitutes for bisphenol A (BPA), is increasingly used in pharmaceuticals, food packaging, and chemical manufacturing. Emerging evidence suggests its potential neuropsychiatric risks. However, the underlying mechanisms remain poorly characterized. Thus, the present study was performed to investigate the roles of the kynurenine (KYN) pathway in BPF induced anxiety- and depression-like behaviors, especially the keys roles of the toxic metabolite 3-hydroxykynurenine (3−HK). The mice were administrated with BPF (10, 40, 160 μg/kg/day) for 30 consecutive days, and the behaviors as well as the changes of the KYN pathway were examined. Noteworthily, even low-dose of BPF exposure (40 μg/kg/day) elicited pronounced anxiety- and depression-like behaviors, molecularly shown as the synaptic marker proteins (PSD95, SYN) and dendritic spine proteins (Drebrin) loss in the prefrontal cortex and hippocampus, along with impaired synaptic connection. The UHPLC-MS/MS metabolomic profiling revealed the aberrant metabolism of the KYN pathway, as shown by the elevated neurotoxic metabolite 3-HK and decreased neuroprotective metabolite kynurenic acid (KynA). Mechanistic analyses demonstrated that the 3-HK rate-limiting enzyme KMO was upregulated while the KynA rate-limiting enzyme KAT2 was downregulated in mouse brain. Notably, pharmalogical inhibition of KMO (GSK180) or blockage kynurenine generation with the TDO2 inhibitor (680C91) substantially ameliorated the BPF induced anxiety- and depression-like behaviors and synaptic impairments. Collectively, the present study unravels a previously unrecognized the BPF induced anxiety- and depression-like behaviors in mice via KMO and 3-HK increase. Therefore, targeting the KMO may provide novel interventive strategy for BPF induced neurobehavioral disorders.
研究领域:
神经科学
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毒理学
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药理学
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分子生物学
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行为科学
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代谢组学
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环境卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Yue Yu,Kejian Tian,Pengfei Hao,Yibing Wang,Menghan Chang,Dandan Zhou,Jinming Gu,Fenglin Zhang,Hongliang Huo
Annual global plastic waste exceeds 287 million tonnes, devastating ecosystems and health. As a promising solution, yellow mealworm larvae have shown the ability to degrade plastics. In this study, we explored the regional characteristics of the yellow mealworm and isolated a novel enteric bacterium, S . maltophilia ZSL2493, from the intestinal tract of yellow mealworm larvae, which achieved a biodegradation efficiency of 14.7% of polystyrene (PS) within 30 days. The two most promising candidate enzymes, kynurenine 3-monooxygenase (Kmo) and 4-hydroxyphenylpyruvate dioxygenase (Hpd), were identified by transcriptome mining and molecular docking simulations. Their depolymerisation ability was also confirmed by heterologous expression experiments. Recombinant Kmo and Hpd reduced the mass of PS by 6.14% and 3.96%, respectively, within 30 days. Quantitative analysis by liquid chromatography showed that the yield of styrene monomer was 1.37 μg/mL (Kmo-treated group) and 0.95 μg/mL (Hpd-treated group), respectively, after 30 days of incubation, which is a direct evidence of the enzyme's cleavage of polymer chains. This study elucidates the key enzymatic drivers in the biodegradation of PS and promotes the development of enzymatic recycling strategies for difficult-to-degrade plastics.
研究领域:
环境生物技术
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微生物学
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酶学
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高分子科学
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生物降解
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废弃物管理
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生物信息学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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