AAPS PHARMSCITECH
·
2018
·Vol. 19
·期 5
·2288-2300
·
IF 2.666
Hu Beibei,Sun Wei,Yang Baixue,Li Heran,Zhou Liuchenzi,Li Sanming
Solvents, accounting the majority of the organogel system, have a tremendous impact on the characteristics of gels. To date, there is a large variety of organogel systems; relatively few have been investigated in the field of structure-solvent correlation. Here, a series of solvent parameters were applied to explore the role of solvent effect on network forming and gel property, intending to build the connection between the precise solvent parameter and gel property. Among the solvent parameters, Kamlet–Taft Parameters and Hansen solubility parameters can distinguish specific types of intermolecular interactions, which could correlate solvent parameter with the gel property. From an analysis of the morphologies obtained from POM and SEM, the gelator structure has an impact on its self-assembly. For possible conformations, the gelators were investigated through XRD. The investigation of solvent-property relationship will provide a theoretical basis for controllable drug delivery implants.
研究领域:
材料科学
·
药物递送
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Mengdan Ma,Anning Zhou,Tao Hong,Xinyu Jia,Moxuan Liu
Metal-organic frameworks (MOFs) are promising materials for CO 2 adsorption and capture. The unique crystal structure and the open porous structure of MOFs are key factors affecting their CO 2 adsorption performance, but the precise tuning of MOF structures remains a challenge. Herein, we applied the Kamlet-Taft method to investigate the effect of solvent proton-supplying/accepting capaity (β/α parameters) on the structure and CO 2 adsorption performance of Mg-MOF-74 by tuning the reaction solvent polarity. It was found that the ratio of the nucleation rate/growth rate of Mg-MOF-74 could be effectively controlled by adjusting the β/α value of the solvent, realizing the regulation of the crystal structure and morphology of Mg-MOF-74. In addition, the size of solvent molecules played a crucial role in the pore size of Mg-MOF-74. Interestingly, the solvent molecules were competitively coordinated with ligands and participate in the growth of Mg-MOF-74 upon decreasing the β/α value. The crystal structure, morphology and pore size of Mg-MOF-74 could be precisely regulated by the β/α value and molecular size of the reaction solvent, and the highest performing Mg-MOF-74 exhibited a CO 2 adsorption capacity of 7.38 mmol/g.
研究领域:
材料科学
·
环境化学
·
多孔材料
·
气体吸附
·
晶体工程
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Zhuo Liu,Cheng Li,Rongxin Zhang,Rude Lin,Zhaowen Dong,Bo Peng,Fan Zhang
Poly(bisphenol A carbonate) (PC) is a widely used engineering plastic that is often disposed of by landfilling or incineration, resulting in severe environmental concerns. Alcohol-aminolysis with ethanolamine can convert PC waste back into its monomer bisphenol A (BPA) and the valuable product 2-oxazolidinone. However, the use of hazardous solvents complicates both the recovery of PC and the synthesis and separation of 2-oxazolidinone. Herein, we developed a sustainable alcohol-aminolysis strategy utilizing the eco-friendly solvent ethanol (EtOH), achieving yields of 93% BPA and 88% 2-oxazolidinone from compact discs in 4 h at 80 °C. Multilinear regression revealed that elevated Kamlet–Taft parameters (β, π*) correlate strongly with enhanced PC alcohol-aminolysis efficiency for most solvents. Conversely, in monohydric alcohols, reactivity exhibits minimal dependence on β- and π*-values but is primarily governed by their steric hindrance. Mechanistic investigation reveals that EtOH enhances the nucleophilicity of ethanolamine, enabling nucleophilic attack on the activated carbonyl group of PC while facilitating cyclization of the intermediate. In gram-scale experiments, we recovered 8.64 g of BPA and 2.96 g of 2-oxazolidinone from 10.16 g of PC using simple filtration and evaporation. Economic assessments show that our innovative process presents a sustainable and economically viable method for upcycling waste polymers into valuable products, eliminating the need for hazardous solvents, harsh conditions, and complex purifications, thereby highlighting its potential for industrial applications.
研究领域:
高分子化学
·
绿色化学
·
废弃物管理
·
有机合成
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Weimeng Cai,Haojie Du,Erju Wang,Yuting Qiang,Kunhong Hu,Jianhua Guo
The synthesis of value-added chemicals from renewable biomass is becoming increasingly important in the transition to a sustainable and low-carbon energy system. Herein, we demonstrate a solvent-polarity modulation strategy to engineer biomass-derived Cu-MOF using 2,5-furandicarboxylic acid (FDCA) as a renewable ligand, where tailored β/α ratios via Kamlet-Taft parameters balance nucleation-growth kinetics to optimize textural properties. Pyrolyzed Cu-MOF at 500 °C under a nitrogen atmosphere yield the Cu/C catalysts, which were subsequently employed in the selective hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL). Among the various solvents used, the Cu-MOF precursor synthesized in a mixed solvent of methanol and N, N-dimethylformamide (DMF) demonstrated the highest catalytic performance, outperforming those synthesized in other solvents. This highlights the significant impact of solvent selection on the structure of Cu-MOF, which in turn affects their hydrogenation activity. Advanced characterization confirming that the uniform Cu dispersion (confirmed by HRTEM mapping) and Cu⁰/Cu⁺ electronic synergy (via Cu Auger analysis) enhanced hydrogenation performance. Additionally, the biomass-derived catalysts exhibited excellent durability. Overall, this research provides a promising approach to develop highly efficient catalysts using renewable ligands and demonstrates the potential of regulating catalyst properties through the strategic selection of solvents, as informed by Kamlet-Taft parameters.
研究领域:
催化化学
·
绿色化学
·
材料科学
·
可再生能源
·
化学合成
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2019
·
IF 2.29
Yameng Wan,Rui Zhao,Pengshuai Zhang,Haixia He,Jiao Sha,Tao Li,Baozeng Ren
Solubility of ( R )-(-)-phenylephrine hydrochloride ( R -PEHC) in ten pure solvents including methanol (MtOH), ethanol (EtOH), n -propanol (NPrOH), iso-propanol (IPrOH), 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, 2-butoxyethanol, N-methyl pyrrolidone (NMP) and N,N-dimethylformamide (DMF) was determined by using a laser monitoring technique in the range of 278.15 K to 323.15 K under 0.1 MPa. Solubility of R -PEHC increases with the increment of temperature. The solvent effect on R -PEHC solubility was investigated by the linear solvation energy relationships concept (Kamlet-Taft parameters). The interaction energy ( E inter ) between R -PEHC and selected solvents was calculated by molecular simulation to explain the solubility behavior. Experimental solubility was correlated by five activity coefficient models including the Two-Suffix Margules model, Wilson model, NRTL model, NRTL-SAC model and uniquac model. Five models can fit experimental solubility values well. Furthermore, thermodynamic properties of solutions of R -PEHC in selected solvents were investigated by the van’t Hoff equation.
研究领域:
物理化学
·
热力学
·
药学
·
分子模拟
✓ 已验证
DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2019
·
IF 2.514
Yameng Wan,Haixia He,Pengshuai Zhang,Rui Zhao,Jiao Sha,Tao Li,Baozeng Ren
Mole-fraction solubility of 5-norbornene-2,3-dicarboximide (NODI) in eleven solvents including methanol (MtOH), ethanol (EtOH), 2-ethoxyethanol, methyl acetate (MAC), ethyl acetate (EAC), n-propyl acetate (NPAC), isopropyl acetate (IPAC), n-butyl acetate (NBAC), acetone (DMK), N,N-dimethylformamide (DMF) at (278.15–323.15) K and 1,4-dioxane at (288.15–323.15) K was experimentally measured by laser monitoring technique under 0.1 MPa. Solubility of NODI increased with the increasing temperature. Hansen Solubility Parameter was employed to explain the solubility behavior. The Kamlet-Taft parameters were calculated to investigate the solvent effect based on linear solvation energy relationships concept. Thermodynamic modeling including the Two-Suffix Margules model, Wilson model, NRTL model, NRTL-SAC model and UNIQUAC model were employed to correlate the experimental solubility. Wilson model and NRTL-SAC model were more suitable in correlation with solubility data. Furthermore, thermodynamic properties of mixing process (Δ mix G , Δ mix H , Δ mix S , ln γ 1 ∞ , H 1 E,∞ , ζ TS and ζ H ) were discussed based on Wilson equation.
研究领域:
化学工程
·
物理化学
·
热力学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）