Current Research in Food Science
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2022
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IF 6.269
Jinxin Che,Keqin Chen,Jaorao Song,Ying Tu,Okwong Oketch Reymick,Xiumei Chen,Nengguo Tao
Cinnamaldehyde (CA) is a promising antimicrobial agent for the preservation of fruits and vegetables due to its excellent antibacterial activity. The application is however, limited by its unstable and volatile properties. A biocompatible carbon dots hybrid γ-cyclodextrin-based metal organic framework (CD/MOF) was developed by the seed-mediated method to improve the encapsulation and sustained continuous release of CA. CD/MOF-0.5 exhibited a CA loading efficiency of 28.42% and a sustained release duration time of more than 15 days at 8 o C. The release kinetics results showed that the release behavior of CD/MOF-0.5 fitted well with the Korsmeyer–Peppas release kinetics model, indicating that its sustained release is mainly controlled by diffusion. Both the Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses revealed that CD/MOF-0.5 and CA molecules were linked by hydrogen bonds. Due to the high sustained release performance, CA-loaded CD/MOF-0.5 considerably inhibited the growth of Escherichia coli , hence preventing the spoilage of fresh-cut cantaloupes. CD/MOF-0.5/CA treatment also maintained the qualities of the fresh-cut cantaloupes, prolonging their edibility to five days. This work provides a promising strategy for the prevention of spoilage in food industry.
研究领域:
食品科学
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材料科学
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生物技术
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化学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Showkat Ali Ganie,Rayees Ahmad Naik,Ovas Ahmad Dar,Luqman Jameel Rather,Mohammed A. Assiri,Qing Li
We developed a facile method for the fabrication of a biodegradable delivery system composed of two blocks: curdlan and curcumin. This was achieved by chemical functionalization of curdlan through tosylation, amination followed by complexation with curcumin. A comprehensive evaluation of structural characterization and component stability showed that cur-cum complex exhibited better anticancer properties with enhanced thermal properties. The cur-cum complex shows pH sensitive sustained release behaviour with higher release at acidic pH and kinetic data of drug release follows the Korsmeyer-Peppas model. The cur-cum complex has ability to block the proliferation of the MCF-7 cell line as revealed by MTT assay which showed increased toxicity of cur-cum complex against these cell lines. The results obtained from western blot analysis demonstrated that the co-administration of cur and cum effectively induced apoptosis in MCF-7 cells. This effect was observed by a considerable upregulation of the Bcl-2/Bax ratio, a decline in mRNA expression of LDHA, level of lactate and LDH activity. The results clearly depict the role of functionalized curdlan as efficient carrier for curcumin delivery with prolonged, sustained release and enhanced bioavailability, thereby improving the overall anticancer activity.
研究领域:
药学
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生物医学工程
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癌症研究
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2024
·
IF 4.4
Siyuan Yu,Xian Shao,Tong Wu,Zheng Liu,Pei Yu,Jinfeng Xing
In order to achieve long-term and controllable release of anti-tumor drugs at specific sites, temperature/pH responsive nanoparticles encapsulating 5-fluorouracil and methotrexate in situ are prepared through dispersion photopolymerization under green LED irradiation. The physicochemical properties of nanoparticles are characterized by scanning electron microscopy, Fourier transform infrared, dynamic light scattering, thermogravimetric/differential scanning calorimetry, and X-ray diffraction. In vitro drug release at different temperatures and pH values is examined to ascertain the release pattern of two drugs, which can be well described by Korsmeyer–Peppas kinetic model. The cytotoxicity evaluation illustrates that the tumor cells could be more effectively killed by the drug-loaded nanoparticles, and the improved therapeutic effect is attributed to the controllable and sustainable drug release as well as the enhanced cellular uptake. The blood safety and good biocompatibility of nanoparticles are further confirmed by hemolysis assay, indicating the prepared nanoparticles are potential candidates for effective tumor treatment.
研究领域:
纳米技术
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药学
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材料科学
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生物医学工程
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Xinyue Chen,Xiao Wang,Tongtong Pan,Lili Mao,Haizeng Wang
Designing a green flexible alginate hydrogel as a biomedical material is essential. Here, on the theoretical basis of the weak cross-linking ability of magnesium ions (Mg2+) and the mechanical supporting role provided by calcium ions (Ca2+), we successfully prepared uniform and dense magnesium–calcium sodium alginate (MgmCan-SA) flexible hydrogel using soft spray. Results of mechanical test showed that Mg2+ and Ca2+ exhibit mechanical synergy, and the elongation and toughness of Mg3Ca7-12-SA were 140.11% and 0.809 MJ/m3, which were increased by 37% and 47% compared with Mg0Ca10-12-SA, respectively. The swelling and drug release behaviors of MgmCan-SA hydrogel depicted good sensitivity at different physiological pH. Within 1 h of the initiation phase, the lowest release fractions in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) were 11% and 28%, respectively. In addition, the dense structure formed at high Mg2+ content (Mg9Ca1) gave the hydrogel a highly flexible property, a higher encapsulation efficiency (EE), and a slower drug release. The release of ibuprofen from MgmCan-SA was controlled by Fickian diffusion based on the Korsmeyer-Peppas model and the one-order kinetic model. Therefore, the prepared alginate flexible hydrogels have potential for applications in green and soft material regions for the future development of conventional and digital biomedicine.
研究领域:
生物医学材料
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药学
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材料科学
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生物技术
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药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chunwang Hu,Hongliang Wei,Hongli Chen,Bing Zhang,Wenjing Zhang,Gang Wang,Tao Guo
A temperature/pH dual sensitive hydrogel with a semi-interpenetrating network (semi-IPN) structure was synthesized through an aqueous amino-succinimide reaction between water-soluble polysuccinimide and polyethyleneimine in the presence of thermosensitive cellulose derivatives. Single-factor experiments were carried out to optimize the preparation conditions of the semi-IPN hydrogel. The swelling behavior and cytotoxicity assay of the hydrogel were tested. Finally, taking 5- fluorouracil (5-Fu) as a model drug, the release performance of the 5-Fu-loaded hydrogel was investigated. The results indicated that the swelling ratio (SR) first decreased and then increased when the pH of the solutions ascended from 2 to 10. The SR decreased with the increase in temperature. In addition, the swelling behavior of the hydrogel was reversible and reproducible under different pH values and temperatures. The prepared hydrogels had good cytocompatibility. The release behavior of 5-Fu was most consistent with the Korsmeyer-Peppas model and followed the case II diffusion. The acidic environment was beneficial for the release of 5-Fu. The preparation process of the semi-IPN hydrogel is simple and the reaction can proceed quickly in water. The strategy introduced here has great potential for application in the preparation of drug carriers.
研究领域:
材料科学
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高分子化学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Yingying Liu,Qing Fan,Ying Huo,Chao Liu,Bin Li,Youming Li
The development of intelligent and multifunctional hydrogels having photothermal properties, good mechanical properties, sustained drug release abilities with low burst release, antibacterial properties, and biocompatibility is highly desirable in the biomaterial field. Herein, mesoporous polydopamine (MPDA) nanoparticles wrapped with graphene oxide (GO) were physically cross-linked in cellulose nanofibril (CNF) hydrogel to obtain a novel MPDA@GO/CNF composite hydrogel for controllable drug release. MPDA nanoparticles exhibited a high drug loading ratio (up to 35 wt %) for tetracycline hydrochloride (TH). GO was used to encapsulate MPDA nanoparticles for extending the drug release time and reinforcing the physical strength of the obtained hydrogel. The mechanical strength of the as-fabricated MPDA@GO/CNF composite hydrogel was five times greater compared to that of the pure CNF hydrogel. Drug release experiments demonstrated that burst release behavior was significantly reduced by adding MPDA@GO. The drug release time of the MPDA@GO/CNF composite hydrogel was 3 times and 7.2 times longer than that of the polydopamine/CNF hydrogel and pure CNF hydrogel, respectively. The sustained and controlled drug release behaviors of the composite hydrogel were highly dependent on the proportion of MPDA and GO. Moreover, the rate of drug release could be accelerated by near-infrared (NIR) light irradiation and pH value change. The drug release kinetics of the as-prepared composite hydrogel was well described by the Korsmeyer–Peppas model, and the drug release mechanism of TH from the composite hydrogel was anomalous transport. Importantly, this carefully designed MPDA@GO/CNF composite hydrogel showed good biocompatibility through an in vitro cytotoxicity test. In particular, the toxicity of GO was well shielded by the CNF hydrogel. Therefore, this novel MPDA@GO/CNF composite hydrogel with an encapsulation structure for controllable drug release and toxicity shielding of GO could be used as a very promising controlled drug delivery carrier, which may have potential applications for chemical and physical therapies.
研究领域:
生物材料
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药物递送系统
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纳米技术
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Lei Chen,Xiuying Lin,Min Wei,Bo Zhang,Yani Sun,Xi Chen,Shitong Zhang,Hao Zhang,Jieyu Zhang,Xiaojiao Yu,Binghua Yao,Kang Zhao,Yufei Tang,Quanchang Tan,Zixiang Wu
Antibiotic-loaded calcium phosphate cement (CPC) has emerged as a promising biomaterial for drug delivery in orthopedics. However, there are problems such as the burst release of antibiotics, low cumulative release ratio, inappropriate release cycle, inferior mechanical strength, and poor anti-collapse properties. In this research, montmorillonite-gentamicin (MMT-GS) was fabricated by solution intercalation method and served as the drug release pathways in CPC to avoid burst release of GS, achieving promoted cumulative release ratios and a release cycle matched the time of inflammatory response. The results indicated that the highest cumulative release ratio and release concentration of GS in CPC/MMT-GS was 94.1 ± 2.8 % and 1183.05 μg/mL, and the release cycle was up to 504 h. In addition, the hierarchical GS delivery system was divided into three stages, and the kinetics followed the Korsmeyer-Peppas model, the zero-order model, and the diffusion-dissolution model, respectively. Meanwhile, the compressive strength of CPC/MMT-GS was up to 51.33 ± 3.62 MPa. Antibacterial results demonstrated that CPC/MMT-GS exhibited excellent in vitro long-lasting antibacterial properties to E. coli and S. aureus . Furthermore, CPC/MMT-GS promoted osteoblast proliferation and exhibited excellent in vivo histocompatibility. Therefore, CPC/MMT-GS has favorable application prospects in the treatment of bone defects with bacterial infections and inflammatory reactions.
研究领域:
生物材料
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药剂学
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骨科手术
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药物递送系统
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Ruijuan Wang,Chunliu Ma,Haitao Yan,Hailiang Zhao,Pu Wang,Shoubing Zhang,Jianwei Ju,Shuyan Yu,Zhigang Yin
Co-encapsulated hydrophilic vitamin C (Vc) and hydrophobic xanthoxylin (GX-50) liposomes (L-Vc-GX-50) were prepared using ethanol injection and ultrasonic methods and characterized by dynamical light scattering, ζ-potential, cryogenic transmission electron microscopy, UV–vis spectroscopy, Fourier transform infrared spectroscopy, antioxidant capacity, tyrosinase activity, and in vitro permeation measurements. L-Vc-GX-50 are formed by the assembly of egg yolk lecithin, cholesterol, and tween 80, with Vc and GX-50 encapsulated in their hydrophilic and hydrophobic cavities, respectively. By considering the hydrodynamic radius (Rh), ζ-potential, and encapsulation efficiency (EE) of L-Vc-GX-50, the optimum formulation was determined to be egg yolk lecithin/cholesterol/tween 80/GX-50 or Vc (15:3:3:1, w/w) with phosphate buffer (pH 6.8, 0.01 M). The as-prepared L-Vc-GX-50 have an average Rh of 114 nm, a negative ζ-potential (−23.63 mV), a high EE of Vc (73.3%) and GX-50 (87.4%), and a unilamellar vesicle structure. Compared co-encapsulated L-Vc-GX-50 with single encapsulated Vc or GX-50 liposomes (L-Vc or L-GX-50), the EE of Vc in L-Vc-GX-50 is obviously higher than that of L-Vc, while the EE of GX-50 in L-Vc-GX-50 is similar to that in L-GX-50; the antioxidant capacity and tyrosinase inhibition activity of L-Vc-GX-50 are higher than those of L-GX-50 or L-Vc. The in vitro permeation data indicate that the final cumulative permeation amount of Vc and GX-50 in L-Vc-GX-50 can reach around 2.1 and 1.3 mg/cm2, respectively. The release kinetics fitting data show that the release kinetics of L-Vc-GX-50 follows the Korsmeyer–Peppas model and that the release of active ingredients is mainly dominated by the synergistic effect of diffusion release and rupture release. Moreover, L-Vc-GX-50 has good low-temperature storage stability, and the storage stability of GX-50 in L-Vc-GX-50 is significantly improved compared to L-GX-50. The main objective of this study is to improve the instability of Vc and the insolubility of GX-50 in cosmetics.
研究领域:
药剂学
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纳米技术
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化妆品
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药物递送系统
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分析化学
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生物物理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）