International Journal of Pharmaceutics-X
·
2025
·
IF 6.4
Junxia Gao,Wenhui Zhang,Qiang Wang,Jingdan Cao,Ying Zhu,Guifang Liu,Youbiao Jia,Fengbo Yu
To mitigate the adverse effects of doxorubicin (DOX) during the treatment of liver cancer, this study aimed to develop a novel DOX-encapsulated active-targeted nanodelivery system. The auxiliary materials hydroxyapatite (HAP), polysuccinimide (PSI), galactose-modified polyethylene glycol (Gal-PEG), PSI covalently linked with three different mole ratios of polyethylene glycol (PEG-PSIs), and galactose covalently linked with PEG-PSIs (Gal-PSIs) were synthesized and structurally characterized. The Box-Behnken and Three-Level Factorial Design response surface methodologies were employed to optimize the formulations and synthesis protocols for DOX@HAP/PSI (DOX@DC, where DC denotes the drug carrier), DOX@PEG-DCs, and DOX@Gal-DCs. The in vitro drug release and in vivo tissue distribution of each formulation were examined. Furthermore, in vitro studies were conducted to examine the effects of these formulations on the proliferation, apoptosis, and migration of Huh-7 liver cancer cells. The formulations and synthesis protocols for different DOX-based preparations were optimized. All nanoparticles gradually released DOX at pH levels >5, with the release rate increasing with the pH value. Among the tested formulations, DOX@Gal-DC20 (mole ratio of Gal-PEG to PSI = 1:20) showed the best hepatic targeting in mice in vivo. Furthermore, in vitro pharmacodynamic experiments indicated that Gal-DC20 had low cytotoxicity, could be taken up by cancer cells, and could significantly inhibit the proliferation of Huh-7 cells. Hemolysis experiments confirmed that none of the prepared formulations induced hemolysis. The novel nanodelivery system established in the study (DOX@Gal-DC) is simple to prepare and shows significant hepatic targeting.
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高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Chenyan Lu,Dajie Zou,Yanyan Jia,Yongchang Lu,Huan Wang,Yanfeng He
In this study, a novel nitrogen-chlorine-codoped carbon quantum dots (NCl-CQDs) with low toxicity, thermal stability, good fluorescence properties, biocompatibility and high sensitivity was successfully prepared by hydrothermal carbonization. Based on the above advantages of NCl-CQDs, the NCl-CQDs was used to construct fluorescence sensing system for fluorescence probes. The maximum fluorescence emission wavelength was obtained at 470 nm when the excitation wavelength was 390 nm. The fluorescence signal was in the state of “ON”. The introduction of 2,6-Dichloroindophenol Sodium (DCIP) resulted in the quenching of fluorescence intensity due to photoinduced electron transfer between DCIP and NCl-CQDs. At this point, the color of the solution changed from brownish-yellow to light blue, indicating that the fluorescence signal was in an “OFF” state. Upon addition of ascorbic acid (AA) to the NCl-CQDs/DCIP system, the corresponding fluorescence signal was restored due to the special interaction between AA and DCIP. The color of the corresponding solution changed from light blue to colorless. The fluorescence signal was in the “on” state. Therefore, an “ON-OFF-ON” sensing system and colorimetric sensing system for AA was constructed using the NCl-CQD fluorescence probe. Under the optimized experimental conditions, the proposed methods exhibited satisfactory linear ranges. Specifically, the linear range for AA detection by the fluorescence sensor spanned from 1.2 μM to 180.33 μM, while that by the colorimetric sensor ranged from 1.32 μM to 166.55 μM. The corresponding detection limits were determined to be 0.68 μM and 0.55 μM, respectively. In summary, this sensing system could effectively enhance selectivity, sensitivity, and accuracy by preventing false positive detection results caused by environmental and system errors.
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LUMINESCENCE
·
2026
·Vol. 41
·期 2
·e70439
·
IF 2.8
Yuxun Zhao,Qiuhua Wu,Lu Bai,Chenghuan Wang,Guolin Zhang,Wenxiao Yang
Blue fluorescent carbon dots (CDs) were synthesized in this study from poly (butylene adipate co -terephthalate) (PBAT) and poly (ethylene terephthalate) (PET) waste through a sequential carbonization and hydrothermal treatment. The nanoparticles exhibited a spherical morphology with a narrow size distribution of 1.3–2.5 nm, abundant hydrophilic surface groups, and excellent dispersibility in aqueous solution. The CDs exhibited strong blue fluorescence with a quantum yield (QY) of 7.4% and remarkable stability. The fluorescence was selectively quenched by gefitinib primarily via a Förster resonance energy transfer (FRET) mechanism. The developed sensor showed a linear detection range of 0–30 μM, a low detection limit of 0.8433 μM, and outstanding anti-interference capability against common biomolecules and structurally similar drugs. The spiked recovery rates in real samples ranged from 96.7% to 103.0%, with the relative standard deviations (RSDs) less than 3.0%, demonstrating the probe's capability for detecting gefitinib in complex practical matrices. The proposed sensor shows great potential for applications in therapeutic drug monitoring and clinical diagnostics, offering a promising solution for both environmental sustainability and analytical science.
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CARBON
·
2026
·
IF 11.6
Qian Chen,Yuankui Huang,Huifei Wang,Yaoping Hu
Afterglow materials displaying time-dependent phosphorescence colors (TDPCs) are pivotal for advanced optical encryption, yet their rational design remains challenging. Herein, we report a controllable synthesis of carbon dots (CDs) embedded within a zirconia matrix (CDs@ZrO 2 ) that demonstrate remarkable TDPCs via facile calcination of a Zr-based metal–organic framework. The composites feature dual emissive centers, producing short-lived blue phosphorescence from the carbon core and long-lived yellow-green phosphorescence from surface states. The calcination temperature precisely tailors the graphitization degree and surface chemistry, enabling programmable control over the emission profile and dynamic color evolution. The ZrO 2 matrix provides multi-confinement of CDs via structural rigidity and covalent/hydrogen bonding, effectively stabilizing triplet excitons and endowing exceptional environmental robustness. The unique TDPC characteristic is successfully leveraged for high-level dynamic information encryption with temporal resolution. Furthermore, the distinct thermal quenching behaviors of the blue and yellow-green phosphorescence components in CDs@ZrO 2 facilitate the development of a ratiometric optical thermometer, exhibiting excellent linear response from 298 to 473 K for quantitative detection and visual semi-quantification of temperature in the range of 298–398 K. This work establishes a novel paradigm for creating intelligent afterglow materials with significant potential in photonic security and sensing technologies.
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Journal of Food Measurement and Characterization
·
2026
·
IF 3.3
Yang Fan,Ruan Ya,Yang Yaling
For the first time, copper-doped amino acid carbon dots (Cu/Asp-CDs) are reported as a green peroxidase-like nanozyme. Using Cu 2+ as the metal dopant and L-aspartic acid (Asp) as the ligand, Cu/Asp-CDs exhibit high catalytic activity and stability. They efficiently catalyze the oxidation of butylated hydroxyanisole (BHA) in the presence of 4-aminoantipyrine (4-AP) and H 2 O 2 , producing a visible color change for rapid and specific BHA detection. Based on this, a portable, cost-effective colorimetric sensor was developed, showing high sensitivity, selectivity, and linearity from 0.67 to 66.67 μM, with a detection limit of 0.27 μM. To extract BHA from edible oils, a deep eutectic solvent of choline chloride and thymol (1:2 molar ratio) was used in liquid–liquid microextraction, achieving recoveries of 89.0–109.0%. Combined with the nanozyme, this method enables a practical, rapid (within 20 min) assessment of synthetic antioxidants, offering a reliable tool for food quality monitoring.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 32
·25542-25553
·
IF 6.7
Bi Yongzhao,Pei Lizhen,Sun Xingming,Luo Jin,Liu Xialei,Huang Yan,Sun Baoguo,Liang Li,Zhang Yuyu
Bitter peptides (BPs) have a wide
range of applications in the
food and pharmaceutical industries. This study identified four food-derived
BPs (TPLVDR, VLY, LEEL, and FYL) as novel agonists of the human bitter
taste receptor hTAS2R4, using a rapid cell-based screening approach.
Activation of hTAS2R4 by these peptides inhibited downstream cAMP
signaling, with effective concentration values of 191.99, 222.96,
297.17, and 63.96 μM, respectively. Molecular docking and sequence
alignment across 25 bitter taste receptors highlighted eight potential
binding sites. Subsequent site-directed mutagenesis validated F62 2.57 , F69 2.64 , V85 3.29 , S184 5.461 , Y250 6.56 , and L266 7.38 as key binding sites
for hTAS2R4 activation by BPs. These findings provided crucial evidence
for the molecular mechanism of peptide recognition and signal transduction
by hTAS2R4 activation.
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INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 31
·18314-18324
·
IF 4.6
Zhu Lingfeng,Chen Hao,Liu Xinyue,Shen Quanyi,Yang Suyu,Pu ZeRui,Liu Lizhong,Wu Huifang
Stable
fluorescent sulfur quantum dots (SQDs) were generated directly
through a one-step process via S 2– -mediated regulation
(SMR) of residual polysulfides present in analytical-grade sodium
thiosulfate, eliminating the need for the conventional acid-induced
formation of elemental sulfur from sodium thiosulfate. During this
process, S 2– not only hydrolyzes to produce OH – , which promotes the cleavage of sulfur chains in the
residual polysulfides, but also rapidly captures the generated elemental
sulfur and converts it into abundant polysulfides. These polysulfide
intermediates subsequently undergo nucleation and structural reorganization,
ultimately yielding highly stable SQDs enriched with surface negative
charges. Steady-state and transient fluorescence spectroscopy reveals
that the SQDs produced via SMR (denoted as S 2– -SQDs)
exhibit a quantum yield of 11.13% and a fluorescence lifetime of 9.24
ns, together with significantly enhanced long-term photostability
compared with SQDs prepared under alkaline regulation alone. Furthermore,
the S 2– -SQDs enable rapid and selective fluorescence
sensing of bilirubin, with a detection limit as low as 0.23 μM.
This work provides new mechanistic insights into the fabrication of
stable sulfur-based quantum emitters. More importantly, it highlights
the often-overlooked role of residual sulfur species in commercial
reagents and underscores their substantial contribution to the formation
and luminescence behavior of SQDs.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yixuan Jiang,Yanlin Zhao,Fan Zhao,Xiaowei Cao,Dingding Jing,Haifeng Huang,Qinglei Hang
Chiral D Au NCs capillary SERS for label-free non-invasive saliva D-Glc assay. • Sensor achieves 0.30 nM LOD, covering clinical saliva glucose ranges. • Assay finishes in 10 min with 50 μL sample, high accuracy and anti-interference. • Assay shows correlation with GOD-POD gold std. (R 2 = 0.9313) and 0.947 AUC. • It offers a promising tool for early diabetes screening and clinical translation. Early, non-invasive screening and risk prediction of diabetes are crucial for effective prevention and control, as well as for delaying the onset and progression of complications. In this study, we developed a capillary surface-enhanced Raman scattering (SERS) sensor based on chiral gold nanocubes (D Au NCs) for the non-invasive, label-free, and rapid detection of d -glucose (D-Glc) in saliva. By leveraging the chiral recognition capability and strong SERS activity of D Au NCs, the sensor specifically identifies D-Glc and significantly amplifies its characteristic Raman signals, enabling quantitative analysis in complex saliva matrices without labeling. The sensor demonstrates outstanding analytical performance, covering the clinically relevant range of salivary glucose concentrations with a detection limit as low as 0.30 nM. Based on a capillary detection platform, the assay is simple and rapid, completed within 10 min using only a 50 μL micro-sample, while demonstrating strong anti-interference capability and high detection accuracy. Clinical saliva testing showed strong correlation with the glucose oxidase-peroxidase (GOD-POD) gold standard (R 2 = 0.9313), enabling reliable discrimination between healthy individuals and diabetic patients. Receiver operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.947, confirming its high efficacy in diabetes risk screening and strong diagnostic performance. Consequently, the D Au NCs-based capillary SERS sensor provides a promising strategy for early, non-invasive diabetes screening and prevention, possessing broad potential for clinical translation and application.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jingtian Wang,Zhehao Sun,Chen Hu,Kangning Wang,Kunkun Nie,Binjie Li,Ziyi Wang,Xiaorong Hao,Zongyou Yin,Zhengqing Liu
Entropy engineering stabilizes V O frameworks via multi-cation co-doping. • DFT results show reduced Zn 2+ diffusion barriers through electronic tuning. • HE-VO cathodes achieve an ultra-low decay rate of 0.0034% per cycle. • High-mass-loading pouch cells demonstrate the practical scalability of HE-VO. Aqueous zinc-ion batteries (AZIBs) have emerged as promising candidates for safe and cost-effective energy storage. However, their practical deployment is constrained by sluggish Zn 2+ diffusion and structural degradation of cathode materials during cycling. Here, report an entropy-driven lattice reprogramming strategy that regulates layered vanadium oxide through multi-ion incorporation, enabling the construction of a high-entropy vanadium oxide (HE-VO) cathode. Beyond simple compositional modification, the introduced configurational entropy regulates the local coordination environment, simultaneously enhancing structural stability and Zn 2+ transport kinetics. As a result, HE-VO exhibits highly reversible Zn 2+ storage and outstanding electrochemical durability, delivering 300 mAh g −1 at 1 A g −1 and an ultralow capacity decay rate of only 0.0034% per cycle over 5000 cycles at 10 A g −1 . Moreover, a Zn||HE-VO pouch cell with a high-mass loading (∼8 mg cm −2 ) attains a specific capacity of 162 mAh g −1 at 2 A g −1 , highlighting the practical scalability of this strategy. This work provides a viable pathway toward the development of durable and high-rate electrode materials for advanced AZIBs. A HE-VO nanoribbon was synthesized through an entropy engineering strategy, which reprograms the V O lattice to enhance electronic structure, stabilize coordination, and facilitate ion diffusion via entropy-driven lattice expansion and charge redistribution. The tailored cathode consequently delivers exceptional electrochemical performance, while a high-loading pouch cell further demonstrates its practical viability, establishing entropy engineering as an effective strategy for achieving concurrently stable and fast-kinetic AZIBs. Download: Download high-res image (154KB) Download: Download full-size image
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Nature Communications
·
2026
·
IF 18.1
Wang Xu,Li Shuangyu,Shi Wenzhuang,Xue Beiru,Wang Xu,Liu Miao,Lu Binjuan,Xu Zhouye,Gao Ye,Liu Jiachang,Ji Xingyue,Li Jia-Tang,Wang Yipeng
Antimicrobial peptides (AMPs) are essential components of the innate immune system in animals, playing crucial roles in defending against microbial infections. Hydrogen sulfide (H 2 S), a vital gasotransmitter, is involved in regulating a wide array of physiological functions. However, the role of H₂S in the anti-infective actions of AMPs remains poorly understood. Here, we demonstrate the crucial role of H 2 S in mediating the anti-infective functions of AMPs across diverse animal species. LL-37/CRAMP, the human cathelicidin family AMP and its mouse homolog, induce H 2 S production predominantly through 3-mercaptopyruvate sulfurtransferase (3MST) in Escherichia coli and Clostridium perfringens . The generated H₂S further participates in reactive oxygen species (ROS) accumulation, leading to bacterial death by oxidative damage. Additionally, LL-37 activates the Akt signaling pathway, upregulating cystathionine γ-lyase (CSE) expression to generate H 2 S in macrophages. This process plays a potential role in facilitating the immunomodulatory activity of LL-37/CRAMP and we confirmed that H 2 S is involved in their in vivo anti-infective activity of LL-37. Moreover, besides LL-37/CRAMP, we reveal that AMPs from various animal species also induce H 2 S production in bacteria and macrophages. Overall, our findings highlight a previously unrecognized role of H 2 S in AMP anti-infective function, which is ubiquitous across AMPs from different animals.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Lingya Fei,Xiaoting Ye,Jingyu Yu,Baoliang Chen,Xiaoying Zhu
Metal–organic frameworks (MOFs), with ultrahigh surface areas and tunable pore architectures, are promising for advanced separation membranes; however, despite advances in defect engineering for catalysis and adsorption, its potential in membrane separations remains largely unexplored. Here, we introduce a defect engineering strategy for the Zr-MOF MIP-202(Zr) through precise regulation of defect density. The defective MIP-202(Zr) was integrated with graphene oxide (GO) nanosheets via vacuum-assisted self-assembly to form hierarchical composite membranes. Notably, the defective composite membrane exhibited a two-fold increase in water permeability (up to 36.74 L m −2 h −1 bar −1 ) compared to the defect-free counterpart, while maintaining high rejection (>95%) for multiple model dyes, overcoming the conventional permeability–selectivity trade-off. The introduced defects created open sites and enhanced mass transport, collectively improving membrane hydrophilicity and water permeability. This work demonstrates defect engineering as a transformative strategy for designing high-efficiency MOF-based membranes, with significant implications for sustainable wastewater treatment and resource recovery.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Fengbo Yu,Ying Zhu,Xingjun Fan,Chonghuan Lin,Guifang Liu,Jingdan Cao,Qiang Wang
A pH-responsive core–shell nanogel gave fourfold enhanced skin retention of esculetin. • It matched steroid efficacy and restored barrier proteins, a dual-action therapy. • A safe, scalable platform for natural compounds as topical anti-inflammatory agents. To address the need for topical therapies with enhanced skin penetration and retention for infantile atopic dermatitis (AD), we screened esculetin (Esc), an active monomer from traditional Chinese medicine, in a cellular AD model. Esc demonstrated pronounced anti-inflammatory activity. Subsequently, a self-assembled nanogel delivery system, Esc@(HAP/PSI)-gel, was engineered using hydroxyapatite (HAP) and polysuccinimide (PSI) for sustained release. The optimized nanoparticles were spherical (Average diameter: 156 nm, zeta potential: −15.7 mV) with pH-responsive drug release. Compared with Esc-gel, Esc@(HAP/PSI)-gel significantly enhanced skin permeation and drug retention without inducing irritation. In AD mice, Esc@(HAP/PSI)-gel alleviated skin lesions, reduced ear swelling, lowered the spleen index, attenuated epidermal/dermal thickening, suppressed inflammatory cell infiltration, and modulated key cytokines (IL-6, TNF-α, IgE) more effectively than Esc-gel. Hence, the HAP/PSI-based nanogel delivery system enables the efficient and sustained delivery of Esc, enhances transdermal absorption, and demonstrates considerable therapeutic potential for AD. Download: Download high-res image (259KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）