ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zhao Chen,Yaowen Xu,Ruheng Jiang,Haipeng Zhu,Qiangfeng Zhang,Li Ma,Chunxiao Zhang,Liangjun Zhou,Weifeng Wei
Aqueous zinc-ion batteries (AZIBs) are promising for grid-scale energy storage but suffer from Zn anode instability caused by dendrite growth, hydrogen evolution, and corrosion. In this work, L-carnosine (L-C), a natural dipeptide, is introduced as an electrolyte additive to address these challenges, due to its dual ion-chelating and Zn-adsorbing capabilities. It is demonstrated that L-C can regulate Zn 2+ solvation structures by displacing water molecules via strong coordination bonds. Simultaneously, L-C can preferentially adsorb on Zn surfaces, guiding uniform Zn deposition along the (101) plane and forming a dynamic protective layer that dynamically repairs interfacial defects. This self-healing capability enables short-circuited Zn anodes to recover stable cycling for over 2000 h, while pre-scratched surfaces are fully restored during cycling. These synergistic mechanisms enable Zn||Zn symmetric cells to achieve exceptional cycling stability (>5400 h at 1 mA cm −2 , 1 mAh cm −2 ) and high-rate durability (>1100 h at 5 mA cm −2 , 5 mAh cm −2 ). Full cells, paired with NH 4 V 4 O 10 (NHVO) cathodes, retain 82.26% capacity after 2000 cycles at 5 A g −1 , highlighting practical viability. The bioinspired solvation-interfacial dual-regulation strategy provides a universal approach for designing eco-friendly, high-performance AZIBs.
研究领域:
储能
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电化学
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材料科学
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电池技术
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表面工程
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纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Tian Tian,Duo Wei,Lingling Ge,Zhifeng Wang,Chong Chen,Rong Guo
Hypothesis: Taking advantage of photoinduced electron transfer , one dimensional organic nanomaterials with tunable donor-acceptor (D-A) interface provide a promising avenue to get high optoelectric properties. However, strong charge transfer interaction between D and A segments impedes the formation of long-range ordered structure, which limits the charge transport through efficient π electronic delocalization. Incorporation of chiral peptide offering various hydrogen bonding (H-bonding) along with asymmetric molecular structure enables substantially controllable D-A interface and tunable organization of the π -conjugates. Experiments: A new amphiphilic perylene diimide (CUPDI) with PDI as an acceptor is designed and synthesized. A polar chiral dipeptide composed of β -alanine and l -histidine with the imidazole ring as the donor i.e. , l -carnosine, is incorporated at one of imides . Transition of various supramolecular assemblies of CUPDI is realized by changing CUPDI concentration and solvents. The photoelectronic properties of the assemblies are investigated as well as their association with the microstructure of the nanomaterials. Findings: Delicately tuned hydrogen bonds between the peptides and π - π interaction between PDI cores in different solvents enable the formation of assemblies with multifarious microstructures such as small spherical aggregates, nanowires with uniform diameter, nanobelts , and irregular aggregates. The maximum amount of photocurrent enhancement is up to 1.08 µA observed for the nanobelt, four times higher than that of irregular aggregates. However, the nanowires show the best performance of 7.1-fold in response to ammonia. Thus, the photoelectric performances are strongly dependent on the the molecular arrangement within the nanomaterials.
研究领域:
有机化学
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材料科学
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纳米技术
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光电学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Peng Yang,Guixia Zhong,Juanchun Yang,Linyu Zhao,Ding Sun,Yaqin Tian,Ruren Li,Liangyan Rong
Understanding the interrelationships between the differentially abundant microorganisms and metabolites of traditional “Fuet” fermented sausages (FSs) and inoculated fermented sausages (IFSs) can help us identify key species that are missing from commercial starter cultures to reproduce the flavor compounds and nutrients of traditional Fuet FSs. IFSs, inoculated with P. pentosaceus , P. acidilactici , S. xylosus , S. carnosus (SBM-52) or P. pentosaceus , and S. xylosus (THM-17), were deficient in reproducing the volatilome profile (in particular esters, methyl aldehydes, and methyl ketones) of traditional Fuet FSs because of the lack of diverse Staphylococci ( S. carnosus , S. xylosus , S. equorum , and S. saprophyticus ). Moreover, the combination of Pediococcus and Staphylococcus were positively associated with amino acid, fatty acid, l -anserine, and l -carnosine levels. Pyridoxal and indolelactic acid levels were significantly increased in IFSs with the addition of P. acidilactici and S. carnosus , which were positively associated with vitamin B 6 and tryptophan metabolic pathways.
研究领域:
食品科学
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微生物学
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代谢组学
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营养学
✓ 已验证
DOI
PubMed
高影响因子
Matter
·
2025
·
IF 17.5
Shang Chi,Yaping Li,Tingting Ye,Jiawei Kang,Zhihui Xiang,Xiaoqing Kuang,Chenggang Yi,Yiying Qi,Wei Wang
This work developed a de novo sonosensitizer based on carnosine_zinc piezoelectric metal-organic frameworks (PMOFs) that possesses a prominent reactive oxygen species (ROS)-generating function, biocompatibility, and degradability. Further, the PMOF was modified by a carbon monoxide (CO) donor through a metal complexation reaction to result in a multifunctional CO-PMOF to launch CO/ROS-mediated antimicrobial under ultrasound (US). However, the heat generated during sonodynamic therapy (SDT) may harm wounds. To minimize the waste energy and promote wound self-closure rate, a strong adhesive, and rapid thermal-responsive contraction (52.4%, 4 min), injectable hydrogel was designed to load CO-PMOF. The resulting ultrasonic triple-responsive hydrogel (UTGel) exhibits an effective biofilm destruction capability based on a CO/ROS-mediated antimicrobial therapy. After administration in an infected diabetic skin wound model in mice, UTGel can efficiently harvest the thermal energy by the CO-PMOF under US to trigger a centripetal shrinkage of the hydrogel and guide rapid wound self-closure.
研究领域:
生物医学工程
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药剂学
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组织工程
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Peptide Research and Therapeutics
·
2026
·Vol. 32
·期 5
·80
·
IF 2.5
Jiang Xinyi,Li Junxiang,Lu Yi,Ni Fangyuan,Li Sen
Purpose Advanced glycation end products (AGEs) and their downstream inflammatory consequences contribute to skin dysfunction and aging-related deterioration. EQ-9 has been identified as a novel functional peptide with anti-aging and skin repair potential. In this study, we investigated the effects of EQ-9 and its two derivatives (EL-6 and ac EL-6) on Methylglyoxal (MGO)-induced glycation and inflammatory damage. Methods We exposed HaCaT cells to MGO to simulate hyperglycemic conditions. The protective effects of these peptides were assessed through measurements of cell viability, migration, CML levels, inflammatory cytokine secretion, RAGE expression, and NF-κB pathway activation. Additionally, TNF-α/IFN-γ were used to induce inflammatory injury and evaluate the anti-inflammatory effectiveness of the peptides. A murine excision wound model was also established to examine the effects of ac EL-6 on skin inflammation, collagen deposition, angiogenesis, and wound healing. Results All three peptides significantly reduced MGO-induced CML generation, downregulated RAGE, inhibited NF-κB activation, attenuated proinflammatory cytokine secretion, alleviated cell damage, and promoted migration. They also mitigated TNF-α/IFN-γ-evoked inflammatory responses via NF-κB suppression. Topical application of ac EL-6 decreased cytokine levels, increased VEGF expression and collagen deposition, and consequently accelerated wound healing in mice. Conclusion Together, these findings identify ac EL-6 as a stabilized lead candidate derived from EQ-9, which exhibits anti-glycation activity and modulates NF-κB-mediated inflammatory signaling in keratinocytes, and demonstrates initial skin-repair potential in vivo. The data support further development of ac EL-6 for skin-directed applications. Graphical
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产品关联
DOI
高影响因子
Translational Psychiatry
·
2026
·
IF 7.5
Liu Yiran,Liu Xiao,Yin Xueyong,Li Yunluo,Yu Xiaohui,Nan Xinyu,Xue Jiping,Lu Hengtai,Li Bingyu,Zhou Fei,Liu Xiaoyu,Zhang Xiangyu,He Xiangjun,Yu Xi,Yan Shu,Li Yating,Wang Shuang,Gao Yuan,Liu Yifan,Kang Ying,Zhang Jingwen,Zhao Ye,Shi Haishui
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for metabolic diseases, their role in aggressive behavior remains unclear. Here, we employed behavioral assays, chemogenetics, immunofluorescence, pharmacological manipulations, and metabolomics to investigate the regulatory effects of GLP-1RA on defensive aggression in mice. Acute intracerebroventricular administration of GLP-1RA significantly suppressed defensive aggression without affecting locomotor activity or time spent in the center of the open field. c-Fos immunofluorescence indicated that this effect was associated with reduced neuronal activity in the dorsomedial periaqueductal gray (DMPAG). Chemogenetic activation of DMPAG neurons reversed the suppressive effect of GLP-1RA on defensive aggression, supporting a key regulatory role of this region. In a social isolation (SI) induced pathological aggression model, GLP-1RA alleviated excessive defensive aggression and modulated the metabolic state of the DMPAG. Notably, GLP-1RA restored levels of L-carnosine, a dipeptide with neuroprotective and anti-excitotoxic properties whose levels were reduced in SI mice. Carnosine infusion into the DMPAG suppressed defensive aggression in SI mice, whereas administration of the carnosine degrading enzyme CNDP2 attenuated the suppressive effect of GLP-1RA, supporting carnosine signaling as a functionally relevant downstream component. These findings identify a carnosine-associated pathway by which GLP-1RA regulates defensive aggression and highlight its therapeutic potential beyond metabolic regulation.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Siyu Wu,Xiaojuan Niu,Jiali Chen,Wangni Meng,Han Tao,Jianli Zhou,Yuangen Wu
Kanamycin (KAN) can generate a serious threat to human health due to its tendency to accumulate in food. Current colorimetric strategy for KAN detection still faces some challenges, and nanozyme-based colorimetry is an ideal alternative approach. Herein, a non‑copper-based multivalent laccase mimic named Mn-Car is first synthesized through a self-assembly of manganese ions and the endogenous biomolecule carnosine, which is further used to develop a novel colorimetric method for ultrasensitive and selective detection of KAN. The laccase-like catalytic center is formed through the multidentate chelation bonds between manganese ions and imidazolium groups of histidine as well as carboxyl groups of β-alanine in carnosine. The multivalent oxidation states of manganese dynamically regulate electron transfer pathways through synergistic coordination. The unique Mn-Car architecture drives the efficient generation of superoxide radicals (O 2 · − ) and semiquinone radicals (SQ· − ). Leveraging the excellent laccase-like activity of Mn-Car , a highly sensitive colorimetric method for KAN detection is developed. Mn-Car forms polydentate chelation with the amino and hydroxyl groups in KAN, which can trigger multi-step cascade oxidation reactions that disrupt the structural core of Mn-Car and lead to reduced colorimetric signals. The colorimetric method achieves a limit of detection (LOD) of 0.102 μM and is successfully applied for on-site detection of KAN in water samples and honey, providing a novel platform for antibiotic residue analysis.
研究领域:
分析化学
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纳米技术
·
生物传感
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2021
·
IF 3.171
Junyang Xu,Yanjun Jiang,Liya Zhou,Li Ma,Zhihong Huang,Jiafu Shi,Jing Gao,Ying He
Immobilization is an effective method to promote the application of enzyme industry for improving the stability and realizing recovery of enzyme. To some extent, the performance of immobilized enzyme depends on the choice of carrier material. Therefore, the development of new carrier materials has been one of the key issues concerned by enzyme immobilization researchers. In this work, a novel organic–inorganic hybrid material, nickel-carnosine complex (NiCar), was synthesized for the first time by solvothermal method. The obtained NiCar exhibits spherical morphology, hierarchical porosity and abundant unsaturated coordination nickel ions , which provide excellent anchoring sites for the immobilization of proteins. His-tagged organophosphate-degrading enzyme (OpdA) and ω-transaminase (ω-TA) were used as model enzymes to evaluate the performance of NiCar as a carrier. By a simple adsorption process , the enzyme molecules can be fixed on the particles of NiCar, and the stability and reusability are significantly improved. The analysis of protein adsorption on NiCar verified that the affinity adsorption between the imidazole functional group on the protein and the unsaturated coordination nickel ions on NiCar was the main force in the immobilization process, which provided an idea way for the development of new enzyme immobilization carriers.
研究领域:
生物化学
·
材料科学
·
酶工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 102
·期 11
·6517-6528
·
IF 3.094
Liu Pei,Yan Xu,Jiaqiang Liu,Junbiao Wu,Yide Han,Xia Zhang
Morphology modulation of photocatalyst has been demonstrated to be a crucial strategy for improving the catalytic performance in solar energy conversion system. Here we systematically investigated the influence of the solvent-dependent morphology evolution of Zn 2 GeO 4 phase on the photocatalytic efficiency of the as-prepared g-C 3 N 4 /Zn 2 GeO 4 composites. The morphologies of Zn 2 GeO 4 were rationally tuned from flower-like nanosheets to length-controllable nanorods, and microclusters assembled from microrods through regulating the solution polarity of different organic solvents. Accordingly, the Zn 2 GeO 4 sample prepared in ethylene glycol (EG) with long rod-like morphology and integrated with g-C 3 N 4 , abbreviated as g-C 3 N 4 /Zn 2 GeO 4 (1:1)-EG, exhibited the best visible-light absorption ability and the highest efficiency. The synergetic effect of the long rod-like Zn 2 GeO 4 phase with many exposed (110) crystalline facets and g-C 3 N 4 accelerates the separation and interface transportation of photoexcited charge carriers, as confirmed by photocurrent measurements. The MB degradation mechanism was also proposed to clarify the charge-transfer process and the improved photodegradation activity. This study offers an experimental basis for understanding the significance of morphology control on rational design of photocatalysts with improved performance.
研究领域:
材料科学
·
光催化
✓ 已验证
产品关联
DOI
高影响因子
ELECTROPHORESIS
·
2016
·Vol. 37
·期 14
·2106-2111
·
IF 2.482
Wei Wang,Lihong Ma,Ping Lin,Kaixuan Xu
In this work, CE-LIF was employed to investigate the amino acid metabolites produced by Escherichia coli ( E. coli ) in microbial fuel cell (MFC). Two peptides, l -carnosine and l -alanyl-glycine, together with six amino acids, cystine, alanine, lysine, methionine, tyrosine, arginine were separated and detected in advance by a CE-LIF system coupled with a homemade spontaneous injection device. The injection device was devised to alleviate the effect of electrical discrimination for analytes during sample injection. All analytes could be completely separated within 8 min with detection limits of 20–300 nmol/L. Then this method was applied to analyze the substrate solution containing amino acid metabolites produced by E. coli . l -carnosine, l -alanyl-glycine, and cystine were used as the carbon, nitrogen, and sulfur source for the E. coli culture in the MFC to investigate the amino acid metabolites during metabolism. Two MFCs were used to compare the activity of metabolism of the bacteria. In the sample collected at the running time 200 h of MFC, the amino acid methionine was discovered as the metabolite with the concentrations 23.3 μg/L.
研究领域:
生物化学
·
环境微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROCESS BIOCHEMISTRY
·
2016
·
IF 2.529
Ru Song,Kai-qiang Zhang,Rong-bian Wei
Squid viscera, one of the major by-products in squid processing, were hydrolyzed to generate bioactive autolysates using their endogenous proteases. In vitro antioxidative activities of squid viscera autolysates (SVAs) were evaluated. The SVAs demonstrated strong activity on scavenging 1,1-diphenyl-2-picryl-hydrazil (DPPH) and hydroxyl radicals, as well as reducing power ability. The SVAs were purified using size exclusion chromatography and RP-HPLC. Nineteen peptides were identified in the active fraction SVAs3 by liquid chromatography-electrospray ionization/multi-stage mass spectrometry (LC-ESI-Q-TOF-MS/MS). Among these identified peptides, six peptides with relatively small molecular weights (700–800 Da), LLAPPER, FPGLADR, WVAPLK, FFNPVH, FNVVLK and LELPLK, were synthesized for assaying antioxidative activity in vitro. Peptide WVAPLK demonstrated strong scavenging effects on free radicals, with the IC 50 values of 0.82 ± 0.08 mg/mL (or 1.14 ± 0.11 mM) for DPPH radical and 1.85 ± 0.04 mg/mL (or 2.60 ± 0.06 mM) for hydroxyl radical, respectively. The low molecular weight and hydrophobic residue W at the N-terminus and basic residue K at the C-terminus as well as specific residues P and L within sequence should play a key role for the high antioxidative activity of WVAPLK. The results suggested that the SVAs could be used as a source of antioxidants and peptides.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Lu Wang,Limei Xiao,Shoujing Zheng,Jie Pang,Jiebo Chen
A better understanding of amino acids (AA) characteristics is beneficial for breeding, processing and storage of sugarcane. The differences and classification in AA of 10 different sugarcane varieties (S1-S10) were investigated in this study. Varieties affected components and concentrations of free AA ( p ＜ 0.05) significantly. The total AA of sugarcanes ranged from 51.44 to 781.61 mg/L, while the content of essential amino acids (EAA) was in the range of 0.72–60.98 mg/L. Glu (glutamic acid) was the most abundant free amino acids in all varieties of sugarcane except S4. Even though S6 had the highest concentration of medicinal AA (781.61 mg/L), the highest proportion of medicinal AA in total AA was found in S5 (81.76%). S6 got the highest comprehensive score in amino acids based on the results of Principal Component Analysis (PCA). The cluster analysis roughly divided the sugarcanes into 2 groups. Group Ⅰ including S1, S6, S2 and S5 got positive scores in PCA might had great edible and medicinal development and utilization value.
研究领域:
食品科学
·
植物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）