JOURNAL OF POLYMER ENGINEERING
·
2024
·
IF 1.7
Yan Ren,Yonggang Lin,Yabei Ding,Ruimin Tang,Minglong Yuan,Hongli Li,Yongming Chuan
Poly( l -lactide- co -caprolactone) (PLCL) is the polymeric material with good biodegradability and biocompatible properties, but it is insufficient in strength properties that the pure PLCL is performed as orthopedic bandage. The PLCL has been blended with the laponite which is modified by cetyltrimethylammonium bromide (CTAB) to prepare composited bandage splines. The organic-modified laponite (OM-laponite) results of Fourier transform infrared (FTIR) and thermogravimetry analysis (TG) indicate that the laponite was successfully grafted with CTAB and the thermal stability was improved with increasing CTAB. The mechanical properties reveal that elongation at break strengthen with the increasing OM-laponite. When the content of OM-laponite is 2.0 %, the elongation at break and tensile strength of composited spline are superior to the medical orthopedic bandage. The results of thermal stability show that it was helpful to improve the crystallization properties of PLCL with the addition of OM-laponite. The water contact angle results demonstrate that the hydrophilicity is enhanced and is beneficial to cell adhesion. The results of cell experiment illustrate that the composite materials have a certain effect on cell proliferation when the content of OM-laponite is less than 2 %. Compared with the medical orthopedic bandage, it is satisfied with the application requirements.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2013
·
IF 2.108
Huili Wang,Wenxia Liu,Xiaofan Zhou,Haidong Li,Kaifeng Qian
Alkenyl succinic anhydride (ASA) is an oily paper sizing agent that is generally introduced into the paper manufacturing system as an ASA-in-water emulsion. In this paper, ASA-in-water emulsions are prepared by homogenizing the mixture of ASA and aqueous dispersion of Laponite modified with alanine . The modification of Laponite with alanine reduces the emulsion droplet size, and enhances the emulsion stability against coalescence due to lowering the interfacial tension between ASA and water containing Laponite and improving the affinity of Laponite particles toward ASA. Infrared spectrum analysis indicates that the adsorption of alanine on the Laponite particles retards the hydrolysis of ASA when the alanine-modified particles are employed to stabilize ASA emulsions. Meanwhile, the sizing efficiency of the as-prepared ASA emulsion is also improved by the modification of Laponite with alanine, and more dependent on emulsion droplet size than on the hydrolysis of ASA.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2020
·Vol. 16
·期 36
·8394-8399
·
IF 3.14
Xinyu Liu,Xiaofeng Niu,Zhinan Fu,Liqun Liu,Shengyu Bai,Jie Wang,Li Li,Yiming Wang,Xuhong Guo
LAPONITE® sheets have been widely used for the preparation of tough nanocomposite hydrogels for enticing applications; however, their inferior dispersion in aqueous media resulting from electrostatic interactions between the nanosheets remarkably limits further improvements in the mechanical performances of the nanocomposite hydrogels. Here, we show a simple approach to dramatically accelerate the dispersion of LAPONITE® sheets in water, and in turn further improve the mechanical performances of the resulting nanocomposite hydrogels. Upon addition of poly(acrylic acid) (PAA), the electrostatic interactions between the LAPONITE® sheets were effectively reduced due to the adsorption of PAA onto the positively charged edges of the LAPONITE® sheets, thereby accelerating the dispersion of the LAPONITE® sheets in water. On this basis, a series of polyacrylamide (PAAm) hydrogels with a high content of LAPONITE® sheets was prepared, showing excellent tensile strength, stretchability, and anti-fatigue properties. This study will be beneficial for the preparation of LAPONITE®-based nanocomposite hydrogels bearing excellent mechanical properties for new applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2022
·
IF 5.395
Jinwei Luo,Zewei Ma,Fengjuan Yang,Tianhua Wu,Shengwu Wen,Jingxian Zhang,Langhuan Huang,Suiping Deng,Shaozao Tan
Natural polymer gels with sensitivity to near-infrared (NIR) light have attracted the attention of scientists working on intelligent drug delivery systems. Compared to ultraviolet or visible light, NIR light has the advantages of strong trigger levels, deep penetration through affected tissues, and fewer side effects. Herein, we present a topical photothermal hydrogel for NIR-controlled drug delivery. The proposed DexIEM-GM-Laponite hydrogel was prepared through free radical polymerization of vinyl-functionalized dextran (DexIEM), vinyl-modified graphene oxide (GM), and Laponite; thereafter, the hydrogel was loaded with ciprofloxacin (CIP, an antibacterial drug) as a model drug. With the Laponite content increased, the density of crosslinking in the hydrogel increased, and its mechanical properties improved noticeably. Under NIR irradiation, the DexIEM-GM-Laponite hydrogel exhibited a photothermal property, where the surface temperature increased from 26.8 to 55.5 °C. The simulation of subcutaneous drug delivery experiments ex vivo showed that under the specified pork tissue thickness (2, 4, and 6 mm), the CIP release remained NIR-controllable. Additionally, the results of the antibacterial performance tests indicated the excellent antibacterial effect of the hydrogel, and the blood hemolysis ratio of the hydrogel was less than 5%, signifying good blood compatibility. This work will provide an avenue for the application of NIR light-responsive materials in antimicrobial therapy.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
He Zhang,Hua Liu,Jianing Xu,Chao Zhou
This study utilized ionic liquids (ILs) to exfoliate Laponite nanosheets(XLP), altering the interlayer spacing of XLP, thus significantly improving its dispersibility and stability. More importantly, ILs can also benefit the dispersibility of graphene (GN) as well. The synergistic effects of sodium carboxymethyl cellulose (CMC), acrylamide, acrylic acid, SMA, and XLP significantly enhanced the mechanical properties of the hydrogel. At the same time, evenly dispersed GN enhanced the conductivity and sensing ability of the hydrogel dramatically. The hydrogel's multi-network structure, including physical cross-linking, chemical cross-linking, hydrophobic associations, and hydrogen bonding interactions, exhibited excellent mechanical performance and flexibility. The hydrogel sensors demonstrated excellent strain sensing capabilities, effectively responding under various strain conditions with high sensitivity and stability over a wide range of strains. Notably, the hydrogel sensors showed good responsiveness and repeatability in detecting human joint movements (wrist, elbow, knee), allowing for the differentiation of different joint motions. In summary, the P(AM-co-AA)/SMA/CMC/XLP/GN hydrogel, with its excellent dispersibility, mechanical properties, and sensing capabilities, exhibits great potential for applications in flexible sensors and wearable devices. This multi-mechanism enhancement strategy provides an effective method and theoretical foundation for designing high-performance hydrogel materials. Future research can further optimize the material's properties and expand its applications in other fields.
研究领域:
生物医学工程
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材料科学
·
纳米技术
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柔性电子器件
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传感器技术
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2021
·
IF 4.889
Ziyan Wang,Jingyao Li,Yanbin Sun,Jiangtao Peng,Jian Wang,Yizhan Hao,Wenqing Li,Peiping Zhang,Weikun Ning,Shiding Miao
The fluorescence resonance energy transfer (FRET) between donor-acceptor molecules of fluorescein (FL) and rhodamine B (RhB) was enhanced by clay sheets of laponite. This enhancement was implemented by the Langmuir-Blodgett (LB) technique. Hybrid films were prepared by incorporating elementary clay sheets into dye molecules (FL and RhB for different molar ratios) at the air/water interface. The spectroscopic measurements (UV–Vis absorption and photoluminescence) of these mixture systems (FL, RhB and clay mineral) were analyzed both in colloidal dispersion and LB films . A high efficiency (92%) of FRET from FL to RhB was achieved with presence of laponite. Characterizations such as surface pressure versus area (π-A) isotherms, atomic force microscopy (AFM) and contact angle measurements were used to confirm the successful incorporation of clay sheets in hybrid films with loaded dye molecules. The clay incorporation were indicated to shorten the distance between donor and acceptor chromophores (Förster radius), which was realized by the tightly bounded dye molecules on clay sheets and self-assembly of dye molecule pairs.
研究领域:
材料科学
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 37
·6182-6188
·
IF 3.117
Xueshuai Chen,Rongli Jiang,Huilin Hou,Zihan Zhou,Xingwen Wang
ZSM-5/SAPO-34 zeolite composites were successfully synthesized by adding ZSM-5 into SAPO-34 synthetic gel under hydrothermal synthesis conditions, and SAPO-34 as a part of the composite zeolite was synthesized from LAPONITE® as the Si source. The presence of ZSM-5 in the synthetic gel affects the nucleation and crystal growth rate, and core–shell structured zeolite composites can be formed by adding an appropriate amount of ZSM-5. LAPONITE® itself contains Li and Mg atoms which were subsequently introduced into the framework of the SAPO-34 part in the composites via depolymerization–reorganization during the process of crystallization. Furthermore, the depolymerized LAPONITE® can be converted in situ into zeolitic precursors and act as crystalline seeds under hydrothermal conditions. Compared with the ZSM-5/SAPO-34 zeolite composites synthesized from tetraethylorthosilicate (TEOS) instead of LAPONITE® as the Si source, the ZSM-5/SAPO-34 composites synthesized from LAPONITE® exhibited higher selectivity to light olefins and longer lifetime in the MTO reaction. This work provides a convenient route to the synthesis of ZSM-5/SAPO-34 zeolite composites with excellent MTO performance.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 30
·5011-5020
·
IF 4.776
Jinyu Li,Yue Yang,Yibin Yu,Qi Li,Guoxin Tan,Yuanyuan Wang,Wei Liu,Weisan Pan
The synthetic clay material, LAPONITE® (LAP), having a nanodisk structure together with a negatively charged surface, has been used for effective drug encapsulation by virtue of its interlayer space. In this research effort, the LAP nanodisk was used for the first time to encapsulate the antifolic methotrexate (MTX); the MTX-loaded LAP nanodisks (LAP/MTX) demonstrated a high drug loading efficiency of 80.39%. An efficient and reliable tumor-targeting device that rests on the synthesized oligomeric hyaluronic acid-L-histidine (oHA–His) was then encapsulated in the MTX-loaded LAP disks (forming LAP/MTX/oHA–His nanohybrids). The drug released from the LAP/MTX/oHA–His nanohybrids was pH-dependent and matched the first-order kinetics that describes the diffusion mechanism. In vitro biological evaluation manifested that the MTX-loaded LAP nanocarriers, particularly the LAP/MTX/oHA–His nanohybrids that have targetability and lysosomal antineoplastic activity, can be effectively internalized by the MCF-7 cell line, and can exhibit a more prominent anticancer cytotoxicity than free MTX. In vivo studies with mice indicated that the LAP/MTX/oHA–His nanohybrids demonstrated much higher antitumor efficiency compared to the LAP/MTX nanohybrids and pure MTX. Taken together, the LAP/oHA–His, CD44 receptor targeting and pH-sensitive multifunctional nanohybrids conferred the MTX with excellent cytocompatibility, dispersion stability, sustained pH-responsive release properties, and improved anticancer activity, and may be further developed as a potential active nanoplatform for various anticancer drugs.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 4
·1952-1959
·
IF 3.361
Yi Zhao,Fangfang Peng,Yangchuan Ke
The application of nanotechnology in the oil and gas industry has attracted widespread attention in recent years. This study aims to develop a nanoemulsion (NE) for use in enhanced oil recovery (EOR). The NE stabilized by anion amphiphilic copolymer, nonionic surfactant (Brij30) and modified LAPONITE® RD was prepared by the phase inversion composition (PIC) method. The appearance of the emulsion is translucent and the average particle size is less than 60 nm. The micromorphology and interfacial tension (IFT) are examined using transmission electron microscopy (TEM) and a spinning drop IFT meter, respectively. The NE possesses good stability evaluated by conductivity and particle size tests. The absolute value of the zeta potential of NE increases when modified LAPONITE® RD is added. In a core flooding experiment with an artificial sandstone core, the NE flooding increased oil recovery by 23.53% compared to water flooding.
研究领域:
石油工程
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纳米技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 9
·1733-1739
·
IF 4.872
Jingli Yang,Shuang Liu,Ying Xiao,Guorong Gao,Yuanna Sun,Qingzhong Guo,Jiangyu Wu,Jun Fu
Multi-responsive hydrogels with high strength have great significance for potential applications in smart soft devices. However, it remains a challenge to incorporate multiple responsive moieties with energy dissipation mechanisms. Herein, multi-responsive nanocomposite hydrogels with high compressive strength and toughness were synthesized via in situ copolymerization of N-isopropylacrylamide (NIPAM) and acryloyloxyethyltrimethyl ammonium chloride (DAC) in an aqueous dispersion of exfoliated LAPONITE® RDS with a minute amount of N,N′-methylenebisacrylamide (MBAA) as a crosslinker. The combined use of clay and MBAA is demonstrated to be favorable for the high strength and toughness, and helped in avoiding precipitation of clay nanosheets, which otherwise occurred upon addition of cationic DAC. The effect of the NIPAM/DAC molar ratio, MBAA and clay contents on the properties of the hydrogels has been systematically investigated. Compression tests showed a compressive strength up to 6.2 MPa, with fracture strain higher than 90%. The presence of ionic DAC moieties in the hydrogels rendered a very high swelling ratio up to 40 (g g−1). These hydrogels were responsive to temperature changes due to the presence of NIPAM units, with the transition temperature (Ttrans) dependent on the molar ratio of NIPAM and DAC monomers. The internal electrostatic repulsion of the NIPAM/DAC copolymer network changed upon exposure to solutions with different pH and/or ion strength. Cyclic swelling–shrinking was demonstrated by shuttling the gels between pure water and 0.1 mol L−1 NaCl solution.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2022
·Vol. 22
·期 4
·2100491
·
IF 5.859
Manshan Xie,Zhiwen Zheng,Shiheng Pu,Yong-Guang Jia,Lin Wang,Yunhua Chen
Developing nanocomposite hydrogel with multi-functions including adjustable mechanical property, tissue-adhesion, and blood coagulation property to accelerate wound healing is highly desirable in surgical application. Here a macroporous adhesive nano-enabled hydrogel constructed from gelatin methacryloyl stabilized air-in-water emulsions incorporated with dopamine-grafted-gelatin (GelDA) and Laponite nanoclay is reported. The hydrogel exhibits interconnected macroporous structure. The physical/chemical cross-linked network formed among the various components contributes to the good mechanical strength of hydrogel, which could be further regulated by adjusting the concentration of Laponite nanoclay. Furthermore, the nanocomposite macroporous hydrogel is endowed with self-healing properties and tissue adhesion by the intermolecular hydrogen bonds, ionic interactions among Laponite nanoclay and polymers, as well as the catechol functional groups. The in vitro studies demonstrate that the macroporous hydrogel has good biocompatibility and could significantly reduce blood clotting time, which is expected to be applied for the rapid sealing and hemostasis of bleeding wounds.
研究领域:
生物材料
·
医学工程
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS RESEARCH INNOVATIONS
·
2015
·
IF 0.83
D. Shi,T. Mei,Q. Chen,F. Duan,M. Chen
Laponite–cyclodextrin complex was synthesised by amidation of carboxylated cyclodextrin and amine-modified laponite, which were first modified by amine-terminated silane coupling agents with different chain lengths and functional groups. The structures of the laponite before and after modification were characterised by Fourier transform infrared and proton nuclear magnetic resonance. The effect of the silane coupling agents on the loading amounts of cyclodextrin onto laponite was investigated by thermogravimetric analyser. The results showed that the loading amounts of cyclodextrin and silane coupling agents increased with the increasing chain lengths and the decreasing alkoxyl groups of silane coupling agents. The laponite–cyclodextrin complexes gathered the advantages of adsorbing aromatic organic compounds by cyclodextrin via host–guest inclusion interaction and adsorbing metal ions by laponite via ion exchange. The laponite–cyclodextrin complex presents great applications in the aspect of wastewater treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）