Journal of Materials Chemistry C
·
2025
·
IF 5.1
Andrei S. Toikka,Ramazan Kenesbay,Maria Baeva,Dmitry M. Mitin,Maria Sandzhieva,Aleksandr Goltaev,Vladimir Fedorov,Alexander Pavlov,Dmitry Gets,Ivan Mukhin,Sergei Makarov
As alternatives to conventional perovskite light-emitting diodes, perovskite light-emitting electrochemical cells (PeLECs) are in great demand in modern science and technology due to their simplified structure and attainable higher luminance. Here, for the first time, we present the implementation and characterization of red CsPbIBr2-based PeLECs/LEDs. To improve perovskite material phase stability, we applied the following strategies for mitigating the mixed anion lead halide perovskite phase segregation: Pb2+ partial substitution by Mn2+, boundary passivation by poly(ethylene oxide) with polyvinylidene fluoride, and two-step thermal treatment with vacuuming and annealing. The complex measurements of photoluminescence, optical density, energy-dispersive X-ray spectroscopy, and X-ray diffraction confirm the minor phase segregation in the optimized perovskite layers. The performed ab-initio calculations predicted the band gaps of perovskite materials with a mixed anion composition, corresponding well to the results of optical measurements. Finally, current and electroluminescence time tracking proved the formation of a dynamic p–i–n structure in the studied PeLEC devices. The developed PeLECs/LEDs exhibited relatively high, for red PeLECs, electroluminescence up to 96 cd m−2 with a peak position at 667–672 nm.
研究领域:
材料科学
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光电技术
·
半导体物理
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 6
·1546-1556
·
IF 6.331
Junmei Tang,Sihao Liu,Yuemei Han,Rui Wang,Jiayi Xia,Hao Chen,Quankui Lin
Posterior capsular opacification (PCO) is an emerging complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from the adhesion, proliferation, and trans-differentiation of the post-surgery residual lens epithelial cells (LECs). Previous investigations have shown that an anti-proliferative drug eluting coating on the IOL surface provides an effective way to inhibit PCO. However, due to the undesirable elution of the anti-proliferative drug, the safety of such modification is one of the important issues to be solved. In this investigation, photodynamic coating was introduced into IOL surface modification. The photosensitizer chlorin e6 grafted α-cyclodextrin (α-CD-Ce6) was synthesized and self-assembled onto the poly(poly(ethylene glycol) methacrylate) (PPEGMA) brush established IOL surface via the supramolecular interaction between α-CD and poly(ethylene glycol) chains. The results of investigation into its optical properties, including transmittance, refractive index, and surface morphology, showed no obvious alterations after photodynamic coating modification on the IOL surface. The in vitro LEC behaviour investigation optimized the photodynamic therapy parameters when light illumination was used for the cell elimination on the photodynamic coating modified IOL. The results have also shown that this functional coating modification effectively eliminates the cells on the surface of the IOL material when treated with light illumination, whereas it keeps excellent cytocompatibility in the absence of light illumination. The investigation of the cell elimination mechanism shows that this kind of functional coating eliminates the adherent cells by ROS induced apoptosis. The in vivo implantation result confirms the excellent PCO inhibition effect, as well as their safety and biocompatibility to the surrounding tissues. As a result, the proposed photodynamic coating provides a safer and effective alternative of IOL modification for preventing PCO.
研究领域:
眼科学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2022
·
IF 9.273
Yanjuan Huang,Tao Zhang,Qin Wei,Zishan Zeng,Yujun Gong,Xiaoyu Xu,Meixu Chen,Chunshun Zhao
Posterior capsular opacification (PCO) is the leading cause of vision loss after cataract, mainly caused by the adhesion, proliferation and trans-differentiation of post-operative residual lens epithelial cells (LECs). Effective PCO prevention remains a huge challenge to ophthalmologists and researches for decades. Herein, we developed a “NIR-triggered ROS storage” intraocular implant (CTR-Py-PpIX) based on capsular tension ring (CTR), which is concurrently linked with photosensitizer protophorphyrin IX (PpIX) and energy storage 2-pyridone derivative (Py), to guarantee instantaneous and sustainable ROS generation for LECs killing, aiming to achieve more efficient and safer photodynamic therapy (PDT) to effectively prevent PCO. The silylated PpIX-Si and Py-Si were covalently conjugated to the plasma activated CTR surface to obtain CTR-Py-PpIX. Results demonstrated that CTR-Py-PpIX had dual functions of PDT and battery, in which PpIX could generate ROS extracellularly under irradiation, with one part directly inhibiting LECs by lipid peroxidation (LPO) induction of cell membranes. Meanwhile, the excess ROS stored in Py could be continuously released to amplify LPO levels after the irradiation was removed. Ultimately, the proliferation of LECs in capsular bag was completely inhibited under mild irradiation conditions, achieving a sustainable and controlled PDT effect for effective PCO prevention with good biocompatibility. This NIR-triggered ROS storage intraocular implant would provide a more efficient and safer approach for long-term PCO prevention.
研究领域:
眼科学
·
光动力疗法
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生物医学工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
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