INDUSTRIAL CROPS AND PRODUCTS
·
2019
·
IF 4.191
Wenqian Luo,Zhiyun Du,Yating Zheng,Xiaoxin Liang,Guomeng Huang,Qianhua Zhang,Zexuan Liu,Kun Zhang,Xi Zheng,Li Lin,Lanyue Zhang
Essential oils isolated from the Lamiaceae species are attracting increasing interest because of their applications in natural food preservation and pharmaceutics. The aim of this study was to systematically investigate the composition and biological effects of six Lamiaceae essential oils. Approximately 106 components were identified by gas chromatography-mass spectrometry (GC–MS), and the predominant compounds were linalool (0.05–46.55%), α-pinene (0.12–45.35%), o- cymene (0.91–41.20%), patchouli alcohol (28.27%), dl -menthol (21.12%), isobornyl acetate (22.52%), d -limonene (0.01–18.42%), α-terpineol (0.07–4.88%), and β-pinene (0.08–2.03%). Most of these essential oils were found to have effective antioxidant activities (IC 50 ; 1.07–18.77%), as estimated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assays. The essential oils not only had antibacterial activities (6.5–12.3 mm diameter inhibition zones), but also had antifungal activities (6.5–19.0 mm diameter inhibition zones). The essential oils exhibited strong anti-inflammatory activities and markedly decreased the production of tumor necrosis factor (TNF-α), nuclear factor-kappa B (NF-κB), interleukin 6 (IL-6), and cyclooxygenase 2 (COX-2). The most abundant compounds in the essential oils isolated from the six Lamiaceae species have potential applications in the scavenging of free radicals, inhibition of bacterial and fungal growth, and relief from inflammation.
研究领域:
植物化学
·
药理学
·
食品科学
✓ 已验证
DOI
高影响因子
Frontiers in Plant Science
·
2022
·
IF 6.627
Sun Jiahui,Sun Peipei,Kang Chuanzhi,Zhang Lanyue,Guo Lanping,Kou Yaping
Essential oils have attracted wide attention in recent years due to their extensive applications in natural functional ingredients, pharmaceutical preparations, biomedical products, and the cosmetics industry. In this study, the chemical compositions and biological activities of essential oils extracted from six Lamiaceae herbs, including Pogostemon cablin (Blanco) Benth. (PCEO), Perilla frutescens (L.) Britton (PFEO), Salvia japonica Thunb. (SJEO), Rosmarinus officinalis L. (ROEO), Lavandula angustifolia Mill. (LAEO), and Agastache rugosa (Fisch. & C. A. Mey.) Kuntze (AREO), were determined and analyzed. A total of 167 components were identified from the six essential oils by GC-MS analysis, with 35, 24, 47, 46, 54, and 37 components in PCEO, PFEO, SJEO, ROEO, LAEO, and AREO, respectively. Hierarchical cluster analysis of chemical compositions showed that the composition of the six essential oils was significantly different in content, and they were clearly divided into six classes. However, all of these six essential oils exhibited promising anti-inflammatory activity by inhibiting the expression of interleukin-1, interleukin-6, tumor necrosis factor-α, and cyclooxygenase-2 in rats with adjuvant arthritis, among which PFEO had the best performance. In addition, the six essential oils displayed significant cytotoxicity on B16 (IC50 = 86.91–228.91 μg/mL) and LNCaP cell lines (IC50 = 116.4–189.63 μg/mL). Meanwhile, all of them presented satisfactory antioxidant activity (IC50 = 4.88–13.89 μg/mL) compared with Trolox C (IC50 = 13.83 μg/mL), and SJEO (IC50 = 7.93 μg/mL) served as an optimal candidate natural antioxidant by DPPH assay. Taken together, these results indicate that the six Lamiaceae essential oils manifest excellent and diverse biological activities, enabling them to be used as perfect natural functional ingredients in antioxidant, antitumor, or anti-arthritic drugs. This study provides more references for pharmaphylogeny research and drug discovery from folk medicinal plants.
研究领域:
药理学
·
植物化学
·
天然产物研究
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）