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Longibrachiamide A, a 20-Residue Peptaibol Isolated from Trichoderma longibrachiatum Rifai DMG-3-1-1

Shu-Hua Zhang,Xian-Lin Yue,Xue Zhao,Jing Tang,Yu Yang,Rui Xu,Hao Ma,Shuai-Ming Zhu,Fu-Yao Luo,Qin Zhang,Guo-Gang Zhang,Chang-Wei Li

Longibrachiamide A ( 1 ), a new 20-residue peptaibol, along with three known ones ( 2 – 4 ), were isolated from the fungus Trichoderma longibrachiatum Rifai DMG-3-1-1, isolated from a mushroom Clitocybe nebularis (Batsch) P. Kumm, which was collected from coniferous forest of northeast China in our previous work. The structure of longibrachiamide A ( 1 ) was determined by its NMR and ESI-MS/MS data, the absolute configuration of 1 was further determined by Marfey's analyses. And the complete NMR data of 2 – 4 were also reported for the first time. The similar CD spectra of 1 – 4 showed that they all had mixed 3 10 -/α-helical conformations. Compounds 1 – 4 showed strong cytotoxicities against BV2, A549 and MCF-7 cells, and also showed moderate inhibitory effects against the tested Gram-positive bacteria, including MRSA T144 and VRE-10. Graphical