Scientific Reports
·
2018
·Vol. 8
·期 1
·1-11
·
IF 4.122
Zhuang Xueheng,Zhang Ying,Cai Chang,Zhang Jing,Zhu Yuejin
Magnetic microencapsulated phase change materials (magnetic MicroPCMs) are hotly researched for their dual-functions with phase change and magnetic properties, which provided the new applications in fields of maneuverable phase change materials and infrared electromagnetic dual shield. A series of magnetic MicroPCMs samples are synthesized by polymerization and coprecipitation method and the chemical composition contained poly(MMA-MAA) @ n-octadecane modified by Fe 3 O 4 . In addition, the characterizations exhibit the excellent magnetic and phase change properties. The magnetic MicroPCMs samples present 20 emu·g −1 saturation magnetization with still high enthalpy of 132 J·g −1 , which fully illustrates that the magnetic MicroPCMs fulfill both application on thermal energy storage and magnetic control.
研究领域:
材料科学
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能源工程
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DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 298
·期 6
·629-636
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IF 1.536
Yang Xu,Li Wenbo,Sun Zhaojie,Yang Chunhui,Tang Dongyan
In this work, pH/temperature dual-sensitive polymers of P(NVCL-co-MAA) with the increased low critical solution temperature (LCST) values of about 37 °C that differed from that of ~ 32 °C of pure poly(N-vinyl caprolactam) (PNVCL) were synthesized via radical polymerization. Then the nanofibers of P(NVCL-co-MAA) and its cospinned nanofibers with nifedipine (NIF) as drug model were fabricated by electrospinning method. Structures and the interactions within the components were detected by FT-IR, NMR, and XPS methods. The dual-responsive properties and the controlling release of the drug were investigated by water contact angle tests and in vitro drug release tested by UV-vis spectrophotometer. SEM was conducted to demonstrate the morphology of the nanofibers and the obvious improved stabilized morphology of the modified system within the aqueous media. The maintained morphology within the media and the obvious elongated releasing period of over 150 min at 37 °C and with pH of 1.99 both proved the promising prospects of the fabricated nanofibers as excellent carrier in drug delivery system.
Graphical abstract
研究领域:
材料科学
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药学
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生物医学工程
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yongli Shi,Zhaomin Liu,Yaxing Yang,Xiaojie Xu,Yan Li,Tong Li
To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA- co -MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH 1.2, 6.8, and 7.4 buffers. The final MLX-NPs@hydrogel preparation was obtained by immersing the hydrogels in the MLX-NPs suspensions (pH 7.4) for 48 h. The thermodynamic properties and cytotoxicity of the MLX-NPs@hydrogel preparation were also studied. TEM images illustrated that mPEG-b-PCL NPs had a uniform size distribution. The poly(mPEGMA- co -MAA) hydrogels showed an excellent pH-sensibility. Thermal gravity analysis (TGA) data suggested that the protection of hydrogels improved the stability of mPEG-b-PCL NPs. The release studies revealed that MLX-NPs@hydrogel could deliver the MLX-NPs into alkalescent environment ( e.g. intestinal tract). Then, the medicated NPs released MLX at a sustained release profile. Such preparation could overcome the drawbacks of oral MLX, and enhance its therapeutic effects. Therefore, the NPs@hydrogel was a promising sustained-controlled release matrix.
研究领域:
药剂学
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生物材料学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 13
·6176-6185
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IF 3.3
Fengjie Bu,Qianrui Xu,Wenjie Jiang,Yingying Wei,Zhifei Wang,Yong Jiang
Magnetic polymer microspheres have received a lot of attention owing to their high biocompatibility, superparamagnetism, and widespread use in protein purification, cell separation, medical diagnosis, targeted drug delivery, and environmental wastewater treatment. In this study, a facile method for preparing magnetic polymer microspheres was presented. First, hollow poly(divinylbenzene-co-methacrylic acid) (P(DVB-co-MAA)) microspheres were synthesized by one-step reflux-precipitation polymerization. Second, Fe3O4 magnetic nanoparticles were precipitated in situ within the microsphere cavities. Magnetic Fe3O4@P(DVB-co-MAA) microspheres have a uniform particle size, good suspension stability, superparamagnetism, and abundant surface functional groups. The particle size of the microspheres as well as the modification of the surface functional groups can be controlled to meet the requirements for practical applications. Furthermore, the magnetic Fe3O4@P(DVB-co-MAA) microspheres show good protein separation capacity. Therefore, this method will have potential in the application of protein separation and purification.
研究领域:
材料科学
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生物技术
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化学工程
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生物材料
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2017
·
IF 1.9
Qing Shang,Sijin Huang,Aixin Zhang,Jia Feng,Song Yang
To improve the bioavailability of ibuprofen (IBU), we developed a novel binary complex of poly(PEGMA-co-MAA) hydrogel and IBU-loaded PLGA nanoparticles (IBU-PLGA NPs@hydrogels) as an oral intestinal targeting drug delivery system (OIDDS). The IBU-loaded PLGA NPs and pH-sensitive hydrogels were obtained via the solvent evaporation method and radical polymerization, respectively. The final OIDDS was obtained by immersing the hydrogel chips in the IBU-loaded PLGA NPs solutions (pH 7.4) for 3 d. The size distribution and morphology of cargo-free NPs were studied by laser granularity analyzer and transmission electron microscope (TEM). The inner structures of the pH-sensitive hydrogel chips were observed with an S-4800 scanning electron microscope (SEM). The distribution states of IBU in the OIDDS were also studied with X-ray diffraction (XRD) and differential scanning calorimetry (DSC). TEM photographs illustrated that the PLGA NPs had a round shape with an average diameter about 100 nm. Fourier transform infrared spectrum (FTIR) confirmed the synthesis of poly(PEGMA-co-MAA) hydrogel. The SEM picture showed that the final hydrogel had 3D net-work structures. Moreover, the poly(PEGMA-co-MAA) hydrogel showed an excellent pH-sensitivity. The XRD and DSC curves suggested that IBU distributed in the OIDDS with an amorphous state. The cumulated release profiles indicated that the final OIDDS could release IBU in alkaline environment (e.g. intestinal tract) at a sustained manner. Therefore, the novel OIDDS could improve the oral bioavailability of IBU, and had a potential application in drug delivery.
研究领域:
药剂学
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药物递送系统
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材料科学
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高分子化学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
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2015
·
IF 5.75
Zhao Wang,Ting Luo,Ruilong Sheng,Hui Li,Jingjing Sun,Amin Cao
In this work, a series of diblock terpolymer poly(6-O-methacryloyl-d-galactopyranose)-b-poly(methacrylic acid-co-6-cholesteryloxy hexyl methacrylate) amphiphiles bearing attached galactose and cholesterol grafts denoted as the PMAgala-b-P(MAA-co-MAChol)s were designed and prepared, and these terpolymer amphiphiles were further exploited as a platform for intracellular doxorubicin (DOX) delivery. First, employing a sequential RAFT strategy with preliminarily synthesized poly(6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-d-galactopyranose) (PMAIpGP) macro-RAFT initiator and a successive trifluoroacetic acid (TFA)-mediated deprotection, a series of amphiphilic diblock terpolymer PMAgala-b-P(MAA-co-MAChol)s were prepared, and were further characterized by NMR, Fourier transform infrared spectrometer (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and a dynamic contact angle testing instrument (DCAT). In aqueous media, spontaneous micellization of the synthesized diblock terpolymer amphiphiles were continuously examined by critical micellization concentration assay, dynamic light scattering (DLS), and transmission electron microscopy (TEM), and the efficacies of DOX loading by these copolymer micelles were investigated along with the complexed nanoparticle stability. Furthermore, in vitro DOX release of the drug-loaded terpolymer micelles were studied at 37 °C in buffer under various pH conditions, and cell toxicities of as-synthesized diblock amphiphiles were examined by MTT assay. Finally, with H1299 cells, intracellular DOX delivery and localization by the block amphiphile vectors were investigated by invert fluorescence microscopy. As a result, it was revealed that the random copolymerization of MAA and MAChol comonomers in the second block limited the formation of cholesterol liquid-crystal phase and enhanced DOX loading efficiency and complex nanoparticle stability, that ionic interactions between the DOX and MAA comonomer could be exploited to trigger efficient DOX release under acidic condition, and that the diblock terpolymer micellular vector could alter the DOX trafficking in cells. Hence, these suggest the pH-sensitive PMAgala-b-P(MAA-co-MAChol)s might be further exploited as a smart nanoplatform toward efficient antitumor drug delivery.
研究领域:
聚合物化学
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纳米医学
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药物递送系统
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癌症治疗
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2015
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IF 2.752
Sha Jin,Dian Li,Peng Yang,Jia Guo,Jennifer Q. Lu,Changchun Wang
Stimuli responsive drug delivery systems have attracted considerable attention due to their ability to deliver drugs on demand to special tissues and cells (e.g. cancer cells). In this paper, we fabricated a new kind of redox/pH dual stimuli-responsive biodegradable poly(methacrylic acid) (MAA) nanohydrogels crosslinked by N , N -bis(acryloyl)cystamine (BACy) through a facile reflux-precipitation polymerization. Subsequently polyethylene glycol (PEG) was grafted onto the surface of nanohydrogels to improve their long circulation time. This kind of PEGylated nanohydrogels could be degraded into short linear polymer chains in the solution of 10 mM glutathione (GSH) due to the sensitive disulfide bonds in the cross-linked networks. Interestingly, we found that the hydrophilic PEGylated nanohydrogels could be simultaneously loaded with hydrophilic drug doxorubicin (DOX) and hydrophobic drug paclitaxel (PTX) with high drug loading efficiency because of its regional hydrophobic nature in the nanohydrogels. The cumulative release profile showed that either lower pH (5.0) or reducing environment (GSH) or a combination could significantly accelerate the drug release from the drug-loaded nanohydrogels. In addition, the experimental results on living cells indicated that the multi-drug-loaded system had synergistic effect on cancer therapy.
研究领域:
药剂学
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生物材料
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肿瘤学
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DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2019
·Vol. 28
·期 11
·957-967
·
IF 1.707
Yang Xiaoli,Wang Kunyan,Yan Lei,Yu QiNing,Xia Hongxia,Liu Yanbo,Yan Chengjun
Multi-stimuli-responsive hydrogels are being increasingly studied due to their sensitive response to small stimuli and wide applications in biosensors and drug delivery. In this study, a multi-stimuli-responsive hydrogel, poly(hydroxyethyl methacrylate- co - N -vinyl pyrrolidone- co -methacrylic acid- co - N -isopropylacryl amide) [poly(HEMA- co -NVP- co -MAA- co -NIPA)], was synthesized by radical polymerization and characterized by Fourier transform infrared (FTIR) and 13 C NMR spectroscopy techniques. With the aids of scanning electron microscopy (SEM) characterization, it was confirmed that the sensitive stimuli-responsive behavior of the hydrogel stemmed from its microstructure variation with those external stimulus. Rheological study showed that the hydrogel had rheological feature of typical elastomer. Compression tests revealed that the poly(hydroxyethyl methacrylate- co - N -vinyl pyrrolidone) [poly(HEMA- co -NVP)] played an important role in enhancing the compressive modulus of such hydrogel. More interestingly, the equilibrium swelling ratio (ESR) studies further confirmed that the composite hydrogel displayed response sensitively to the stimulus of temperature, pH, and ionic strength. Herein, theophylline as a drug model was adopted due to the multi-stimulus properties of hydrogels, which were a potential candidate for drug loading and delivering. Releasing drug continuously in a given period was dependent on the characteristics of solution and loading time. The mechanisms for drug release from the hydrogels were studied by Ritger–Peppas model.
研究领域:
材料科学
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生物医学工程
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药剂学
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产品关联
DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2019
·
IF 2.066
Amin Khan,Haojie Yu,Yang Wang,Li Wang,Raja Summe Ullah,Fazal Haq,Tarig Elshaarani,Muhammad Usman,Ahsan Nazir,Kaleem-ur-Rehman Naveed
Different copolymers (poly(2-(methacryloyloxy) ethyl ferrocene carboxylate- co -methacrylo-4-aminoazobenzene- co -methacrylic acid)s) (P(FHEMA- co -MAZO- co -MAA)s) were synthesized and their different properties were analyzed in this work. Methacrylic acid was introduced as a side group to possibly affect the photostability. The synthesized copolymers were characterized by nuclear magnetic resonance ( 1 H NMR) spectroscopy and gel permeation chromatography (GPC). Thermal studies were performed by thermogravimetric (TG), differential thermogravimetric (DTG) and differential scanning calorimetry (DSC) analysis, which showed that the copolymers were thermally stable under the operating conditions of the information storage devices. Redox studies and photoresponsive studies were performed by CV technique and UV/vis spectroscopy which showed that these copolymers contained good redox and photoresponsive properties. The obtained results paved the way towards the four states information storage of the materials.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2013
·
IF 3.498
Junling Zhang,Gang Chen,Miaomiao Tian,Ruigang Li,Xinjun Quan,Qiong Jia
γ-Alumina nanoparticles (γ-Al 2 O 3 ) were introduced to the conventional poly(methacrylic acid- co -ethylene glycol dimethacrylate) (MAA- co -EGDMA) monolith to prepare a novel organic-inorganic hybrid monolith, poly(MAA- co -EGDMA)-Al 2 O 3 monolith. The polymerization was induced in-situ with UV irradiation in an ultraviolet transparent polymethyl methacrylate (PMMA) microfluidic chip. The monolith-based solid phase microextraction system was used for the on-line determination of 2-amino-4-chlorophenol (ACP) in chlorzoxazone tablets coupled with an optical fiber spectrophotometer. Several parameters affecting the adsorption/desorption, including sample pH value, sample flow rate , sampling time, eluent flow rate, and eluting time, were investigated in detail. Under the optimized conditions, limit of detection (LOD) and limit of quantification (LOQ) of the method were calculated to be 2.8 and 9.1 µg L −1 , respectively, with the relative standard deviation (RSD) of 3.1%.
研究领域:
分析化学
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药物分析
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 17
·期 1
·89
·
IF 4.7
Haozhe Wang,Yusong Gao,Zhiying Yin,Jianbin Qin,Yongsheng Zhao,Guangcheng Zhang
Bead-foaming technology effectively addresses production cycles, polymerization control, and cellular structure defects in conventional bulk foaming, especially in high-performance PMI foams. In this work, highly expandable PMI beads were synthesized based on the aqueous suspension polymerization of methacrylic acid-methacrylonitrile-tert-butyl methacrylate (MAA-MAN-tBMA) copolymers. The suspension polymerization was stabilized by reducing the solubility of MAA by the salting-out effect and replacing formamide (a common PMI foaming agent) with tBMA. The polymerization process was optimized by varying salting-out agents, dispersants, water-to-oil ratio (WOR), and stirring speed to achieve uniform bead sizes (0.2–0.4 mm) and high bead yields (>70%). The expansion ratio of the beads can be easily tuned by adjusting tBMA content and foaming time and temperature. Beads with 10%tBMA can reach up to 64 times under a free-forming process at 240 °C, which serves as an excellent precursor toward high-performance in-mold foaming PMI. The beads exhibit excellent in-mold foaming capabilities, thermal stability (Td = 392 °C), and mechanical properties. This work provides a technical foundation for the bead-foaming technology of PMI foams, reducing the cost of PMI foam production and providing the possibility to expand the application of PMI foam in civilian use.
研究领域:
材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xinyu Chen,Yingrui Nie,Wenqian Fan,Zhimin Zhao,Zhifei Wang,Yong Jiang
In this study, yolk-shell magnetic hydrogel microspheres loaded with silver nanoparticles (Fe 3 O 4 @P(DVB-co-MAA)@Ag) were innovatively constructed for efficient catalytic reduction of nitroaromatic compounds. First, hollow P(DVB-co-MAA) microspheres were prepared as shell. Fe 3 O 4 magnetic nanoparticles were successfully deposited into the microspheres as yolk through the decomposition of metal-organic precursor salts in high-temperature organic solvents. The EM images shows that Fe 3 O 4 @P(DVB-co-MAA) microspheres consist of a magnetic core, an intermediate void layer, and a hydrophilic hydrogel shell, demonstrating a unique multilayered structural feature. Then, highly active silver nanoparticles were uniformly loaded onto the hydrogel shell surface using the thermal co-reduction method. Catalytic results demonstrated that the yolk-shell material showed significantly enhanced activity toward the reduction of 4-nitrophenol (4-NP) and 2-nitroaniline (2-NA), compared to the core-shell structured composite microspheres. The catalytic parameters were 65.44 s⁻¹ g⁻¹ and 46.44 s⁻¹ g⁻¹ , respectively. Remarkably, the composite retained over 85 % catalytic efficiency after five cycles of use and achieved rapid magnetic separation within 20 s under an external magnetic field.
研究领域:
材料科学
·
化学工程
·
纳米技术
·
催化
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）