PROGRESS IN ORGANIC COATINGS
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2021
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IF 5.161
Jinhe Dou,Jing Wang,Yupeng Lu,Chuanzhong Chen,Huijun Yu,Robin Lok-Wang Ma
MAO/CS composite coatings were generated on Mg-1.75Zn-0.56Ca alloy surface for protection and improving biocompatibility of Mg -Zn- Ca alloy in the physiological environment. The microstructure, surface analysis and corrosion resistance of samples were evaluated by scanning electronic microcopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) in SBF solution. In addition, in vitro cell cytotoxicity test was performed by MTT tests. The findings of this work indicated that MAO/CS composite coatings were smooth and defect-free. The MAO/CS coatings retained a low degradation rate and the solution pH value at a moderate level (≤7.5) during immersion test. The corrosion resistance and cell proliferation were greatly enhanced by the composite coating. Furthermore, the different cell cytotoxicity on Mg alloy, MAO and MAO/CS coating was discussed.
研究领域:
生物材料
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医学工程
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腐蚀科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Chunting Guo,Yang Li,Caixia Qi,Huilai Sun,Dejian Zhang,Yong Wan
This study evaluated the effect of solvent acids on the structure and corrosion resistance performance of chitosan (CS) film on MAO-treated AZ31B magnesium (Mg) alloy. Initially, CS solutions were prepared in four solvent acids: acetic acid (HAc), lactic acid (LA), hydrochloric acid (HCl), and citric acid (CA). The CS films were subsequently deposited on MAO-treated AZ31B Mg alloy via a dip-coating technique. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FT-IR), contact angle measurement, and atomic force microscopy (AFM) were employed to characterize the surface and cross-sectional morphology as well as chemical composition. Furthermore, the samples were subjected to potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) tests to assess their resistance against corrosion in simulated body fluid (SBF). These results indicated that the CS film prepared with LA exhibited the lowest surface roughness (R a = 31.2 nm), the largest contact angle (CA = 98.50°), and the thickest coating (36 μm). Additionally, it demonstrated superior corrosion protection performance, with the lowest corrosion current density ( I corr = 3.343 × 10 −7 A/cm 2 ), highest corrosion potential ( E corr = −1.49 V ), and highest polarization resistance ( R p = 5.914 × 10 4 Ω·cm 2 ) in SBF. These results indicated that solvent acid types significantly influenced their interactions with CS. Thus, the structure and corrosion protection performance of CS films can be optimized by selecting an appropriate solvent acid.
研究领域:
材料科学
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腐蚀与防护
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
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2022
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IF 5.307
Chuansheng Yao,Xiaoying Jiang,Rui Zhao,Zhichao Zhong,Jiamin Ge,Junlong Zhu,Xiang-Yang Ye,Yuanyuan Xie,Zhen Liu,Tian Xie,Renren Bai
A series of N -propargylamine-hydroxamic acid/ o -aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine were designed and synthesized as HDAC1/MAO-B dual inhibitors for the treatment of Alzheimer’s disease. Most of the hybrids displayed moderate to good MAO-B inhibitory activities. Among them, Hybrid If exhibited the most potent activity against MAO-B and HDAC1 (MAO-B, IC 50 = 99.0 nM; HDAC1, IC 50 = 21.4 nM) and excellent MAO selectively (MAO-A, IC 50 = 9923.0 nM; SI = 100.2). Moreover, compound If significantly reversed Aβ1-42-induced PC12 cell damage and decreased the production of intracellular ROS, exhibiting favorable antioxidant activity. More importantly, hybrid If instantly penetrated the BBB and accumulated in brain tissue as well as markedly ameliorated cognitive dysfunction in a Morris water maze ICR mice model. In summary, HDAC1/MAO-B dual inhibitor If is a promising potential agent for the therapy of Alzheimer’s disease.
研究领域:
神经生物学
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药物化学
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医学
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
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2024
·
IF 6.3
Siyuan Jin,Zhou Jie,Ruizhi Wu,Xiaochun Ma,Zhe Yu,Wang Guixiang,Jinghuai Zhang,Boris Krit,Sergey Betsofen,Neshchimenko Vitalii,Buzikov Ruslan,Min Qiu,Yurong Yang,Jiaming Chen
An in-situ grown LDH/ZIF-8 hybrid film on the surface of MAO film based on the LA93 alloy was successfully fabricated by the one-step method. The composite film, called as MLZ, demonstrates exceptional corrosion resistance. The corrosion current density is reduced by two orders of magnitude compared to the MAO film. Furthermore, it possesses significant long-term protective capabilities. Experimental measurement and density functional theory (DFT) calculations were conducted to investigate the formation mechanism of MLZ composite film. During the hydrothermal, Zn ions from the in-situ generated LDH on the MAO surface serves as active nucleation sites, facilitating the nucleation and growth of ZIF-8 crystals. The formation of ZIF-8 effectively compensates for the intergranular defects in LDH, enhancing the integrity of the film. LDH/ZIF-8 film effectively seals defects in the MAO film and constructs a robust physical barrier, significantly enhancing the protective capacity of the film.
研究领域:
材料科学
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腐蚀与防护
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Lu Fan,Yulong Jin,Aiguo Zhang,Youzhen Feng,Kai Wang
In this study, A fluorescent/photoacoustic dual-modal probe HD-MAO for hemicyanine derivatives was successfully designed and synthesized, achieving high-sensitivity and high-specificity detection of monoamine oxidase A (MAO-A). Through the ingenious combination of the specific MAO-A recognition group and the hemipanocyanine fluorophore, the probe produced a significant enhancement of the intramolecular charge transfer (ICT) effect after enzymatic digestion, showing the synergistic activation characteristics of fluorescence (∼730 nm) and photoacoustic (∼700 nm) signals, with a detection limit of 0.806 mg/L. In the diet-induced obese mouse model, HD-MAO successfully revealed a significant increase in liver MAO-A activity, which was highly consistent with the serum test results, providing molecular imaging evidence for the early diagnosis of metabolic diseases. The probe behaves stably under physiological conditions and shows no cross-reaction to common interferents. Serum detection experiments further confirm its clinical applicability. This study not only provides an innovative tool for the research on MAO-A-related mechanisms, but also opens up a new approach for the early diagnosis and treatment monitoring of metabolic diseases.
研究领域:
生物成像
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分子诊断
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酶检测
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代谢疾病
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生物医学光学
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探针开发
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DOI
PubMed
高影响因子
OTOLOGY & NEUROTOLOGY
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2024
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IF 1.9
Li Yingying,Xu Hui,Shi Jinping,Li Cong,Li Mengxin,Zhang Xiaoling,Xue Qing,Qiu Jingjing,Cui Limei,Sun Yan,Song Xicheng,Chen Liang
Background Gentamicin is a commonly used aminoglycoside antibiotic, with ototoxicity as a significant side effect. Ferroptosis, an iron-dependent form of cell death, has been implicated in a variety of disorders. Whether ferroptosis impacts gentamicin ototoxicity is not yet known. The current work used an in-vitro model to examine the influence of gentamicin-induced ferroptosis on cochlear hair cell damage and probable molecular biological pathways. Methods House Ear Institute-Organ of Corti 1 (HEI-OC1) cells were treated with different concentrations of gentamicin for 24 hours, with or without ferrostatin-1 pretreatment, to observe gentamicin-induced ferroptosis. The role of p53/solute carrier family 7 member 11 (SLC7A11)/glutathione peroxidase 4 (GPX4) signaling in gentamicin-induced ferroptosis was explored by pretreating cells with the p53 inhibitor pifithrin-α (PFT-α). We investigated the effect of gentamicin on cells by assessing cell viability. Cellular proteins were isolated and Western blots were performed to detect changes in the expression of p53, SLC7A11, and GPX4. Fluorescence staining was used to assess levels of reactive oxygen species. An enzymatic detection kit was used to detect glutathione, Fe, and malondialdehyde markers. Results Gentamicin reduced cell viability, glutathione content, and SLC7A11 and GPX4 protein levels, and increased levels of p53 protein, reactive oxygen species, malondialdehyde, and Fe. These effects were largely blocked by pretreatment with ferrostatin-1. Pretreatment with the p53 inhibitor PFT-α prevented the gentamicin-induced reduction in SLC7A11 and GPX4, which alleviated several features of ferroptosis including glutathione depletion, iron overload, and lipid peroxidation build-up. Conclusion Gentamicin induces ferroptosis in the HEI-OC1 cell line, and the mechanism may be related to the p53/SLC7A11/GPX4 signaling pathway.
研究领域:
耳科学
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细胞生物学
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分子生物学
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DOI
高影响因子
OTOLOGY & NEUROTOLOGY
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2023
·Vol. 45
·期 1
·e49
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IF 2.1
Li Cong,Chen Liang,Li Yingying,Li Mengxin,Zhang Xiaoling,Cui Limei,Sun Yan,Song Xicheng
Hypothesis The stress hormone cortisol affects aminoglycoside-induced ototoxicity. Background The widespread use of aminoglycosides is a prevalent cause of sensorineural hearing loss. Patients receiving aminoglycosides usually have elevated levels of circulating stress hormones due to disease or physiological stress; however, whether the stress hormone cortisol impacts aminoglycoside-mediated injury of cochlear hair cells has not been fully investigated. Methods House Ear Institute-Organ of Corti 1 (HEI-OC1) cells with or without cortisol pretreatment were exposed to gentamicin, we investigated the effect of cortisol pretreatment on gentamicin ototoxicity by assessing cell viability. Molecular pathogenesis was explored by detecting apoptosis and oxidative stress. Meanwhile, by inhibiting glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), the potential roles of receptor types in cortisol-mediated sensitization were evaluated. Results Cortisol concentrations below 75 μmol/l did not affect cell viability. However, pretreatment with 50 μmol/l cortisol for 24 hours sensitized hair cells to gentamicin-induced apoptosis. Further mechanistic studies revealed that cortisol significantly increased hair cell apoptosis and oxidative stress, and altered apoptosis-related protein expressions induced by gentamicin. In addition, blockade of either GR or MR attenuated cortisol-induced hair cell sensitization to gentamicin toxicity. Conclusion Cortisol pretreatment increased mammalian hair cell susceptibility to gentamicin toxicity. Sensitization was related to the activation of the intrinsic apoptotic pathway and excessive generation of reactive oxygen species. Cortisol may exacerbate aminoglycoside ototoxicity.
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产品关联
DOI
PubMed
高影响因子
ORGANOMETALLICS
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2016
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IF 4.186
Wenlong Luo,Antai Li,Shaofeng Liu,Hongqi Ye,Zhibo Li
A series of chromium(III) complexes, LCrCl3 (Cr1–Cr4: L = 2-(N-R2-benzimidazol-2-yl)-6-(3,5-R1-pyrazol-1-yl)pyridine; Cr1: R1 = H, R2 = H; Cr2: R1 = Me, R2 = H; Cr3: R1 = Me, R2 = Me; Cr4: R1 = Me, R2 = Bn), were synthesized and characterized by IR spectroscopy and elemental analysis. The studies of the solid state of Cr2 and Cr3 revealed distorted octahedral geometries around the chromium centers by X-ray diffractions. In the presence of MAO, Cr1–Cr4 exhibited high activities toward ethylene oligomerization (up to 2.17 × 106 g·mol–1(Cr)·h–1) and ethylene polymerization (up to 6.78 × 105 g·mol–1(Cr)·h–1). The oligomers were produced with high selectivity for α-olefins (>99%), confirmed by FT-IR and 13C NMR, and the distributions followed the Schulz–Flory equation. Various reaction parameters including the amount of cocatalyst, reaction temperature, and time were evaluated in detail, and it was evident that the title complexes had good thermal stability and the substituents on imidazole-N of the ligands dramatically impacted the catalytic activities as well as the distribution of the products.
研究领域:
化学
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材料科学
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DOI
高影响因子
INORGANICA CHIMICA ACTA
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2016
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IF 1.918
Cuiqin Li,Fengfeng Wang,Zhiyu Lin,Na Zhang,Jun Wang
Two novel nickel complexes with hyperbranched structure were synthesized with 1.0 generation hyperbranched polyamine molecules (1.0G), salicylaldehyde and anhydrous nickel chloride as materials via the Schiff’s base and the complexation reactions. The structures of the novel hyperbranched ligands and their nickel complexes were characterized by FT-IR, 1 H NMR, UV, ESI-MS and elemental analysis. The hyperbranched nickel complexes were evaluated as catalyst precursors for ethylene oligomerization after being activated with methylaluminoxane (MAO), diethylaluminum chloride (Et 2 AlCl) and ethylaluminum sesquichloride (EASC). The influence of Al/Ni ratio, temperature and ethylene pressure on ethylene oligomerization was also investigated using the novel hyperbranched nickel complexes as pre-catalysts and MAO as co-catalyst. The catalytic activities of the two hyperbranched nickel complexes with dodecyl and octadecyl as cores (R 12 -complex and R 18 -complex) were 2.33 × 10 5 g/(mol Ni·h) and 1.23 × 10 5 g/(mol Ni·h), respectively, and the selectivities for C 8+ oligomers of R 12 -complex and R 18 -complex were 56.16% and 88.64% respectively, when the Al/Ni molar ratio was 500:1, the temperature was 25 °C, the pressure of ethylene was 0.5 MPa and the co-catalyst was MAO. The catalytic activities and product distribution were largely dependent on the nature of the co-catalysts and the structures of nickel complexes. The catalytic activities decreased with increasing of the length of alkyl chain of the hyperbranched nickel complexes.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
SURFACE ENGINEERING
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2020
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IF 2.433
Jun Xing,Yingjie Chen,Chen-yun Yu,Ming-an Chen
For micro-arc oxidation (MAO) coating on aluminium alloys, the corrosion medium can permeate through the microvoids and cracks in it to decrease its corrosion resistance. In this study, a method of two-steps hydrothermal synthesis has been developed to prepare a composite coating by the synthesis of zeolite film on MAO-coated Al alloy substrate. The zeolite crystals are well intergrown into a continuous film and the micro defects in the MAO coating are sealed. This kind of composite coating can provide excellent long-term corrosion protection to Al alloy substrate. The effect of the first-step hydrothermal synthesis on the microstructure of the MAO coating and zeolite film has been studied.
研究领域:
材料科学
·
腐蚀与防护
✓ 已验证
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2026
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IF 5.2
Yuan Zhong,Minqi Wu,Binjing Huang,Yuxiang Chen,Liangliang Liu,Xiaokai An,Mahmood Hussain,Xiaowei Wang,Yaoyao Liu,Yanfei Zhao,Suihan Cui,Ricky K.Y. Fu,Paul K. Chu,Zhongzhen Wu
With power electronic devices advancing toward higher voltages, there is a growing demand for insulating coatings with high dielectric breakdown strength. Micro-arc oxidation (MAO) can form ceramic coatings on aluminum alloys, but its porous structure limits performance. Here, an alternating aluminum (Al) deposition/MAO multilayer strategy is proposed to achieve cumulative enhancement. Namely, a dense Al layer is deposited via continuous high-power magnetron sputtering (C-HPMS) to seal pores and regulate subsequent MAO discharge, enabling stable repeated oxidation. The influence of Al interlayer thickness on surface morphology, discharge behavior, and breakdown strength was studied. Thin Al layers cannot effectively seal the pores, causing local field distortion and unstable arc discharge, resulting in limited improvement. When the Al layer reaches a critical thickness of ∼35 μm, pore bridging and surface planarization are achieved, forming an equipotential interface that suppresses field concentration. This enables uniform micro-spark discharge and produces coatings comparable to the initial MAO layer. The breakdown voltage reaches 998 ± 23 V (∼17.21 kV/mm) for a bilayer and 1400 ± 100 V (∼16.09 kV/mm) for a trilayer. This strategy offers an effective route to overcome the breakdown limitation of MAO coatings and develop reliable insulating ceramics.
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DOI
高影响因子
INORGANICA CHIMICA ACTA
·
2025
·
IF 3.2
Na Zhang,Xiaoyue Wang,Sen Shen,Guohui Qi,Liduo Chen,Cuiqin Li,Jun Wang
A novel salicylaldiminato phthalocyanine nickel catalyst was prepared and characterized by FT-IR, UV–Vis, 1 H NMR, ICP-MS, TG-DSC and elemental analysis. The catalytic performance of ethylene oligomerization catalyzed by salicylaldiminato phthalocyanine nickel catalyst was investigated. The catalytic activity could reach up to 1.25 × 10 6 g (mol Ni·h) −1 , and the products were mainly butene, hexene as well as a small amount of octene when the cyclohexane was used as solvent, the MAO was used as co-catalyst. In addition, the kinetics of ethylene oligomerization was also investigated. The kinetic parameters such as the reaction order to the nickel molar concentration ( n ) and oligomerization pressure ( m ), the apparent activation energy ( E a) and the pre-exponential factor (A) were determined. The result indicated that the reaction order to the nickel molar concentration was 1.18, the reaction order to oligomerization pressure was 1.12, and the apparent activation energy was 54.78 kJ/mol when the nickel concentration was 5 μmol/L, the oligomerization pressure was 1.0 MPa, and the oligomerization temperature was 5–35 °C.
研究领域:
化学工程
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催化科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）