PLoS One
·
2021
·Vol. 16
·期 4
·e0249915
·
IF 3.24
Jing Han,Ze-Tian Qin,Jing Zhang,Wen-Qiang Wang,Jing-Ya Wu,Yong-Ze Lu,Li-Wei Sun
Ultraviolet (UV) filters are used in cosmetics, personal care products and packaging materials to provide sun protection for human skin and other substances. Little is known about these substances, but they continue to be released into the environment. The acute toxicity of 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC to Chlorella vulgaris and Daphnia magna were analyzed in this study. The 96 h-EC 50 values of 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC on C . vulgaris were 183.60, 3.50 and 0.16874 mg/L, respectively. The 48 h-LC 50 of 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC on D . magna were 12.50, 3.74 and 0.54445 mg/L, respectively. The toxicity of a mixture of 4,4’-dihydroxybenzophenone and 4-MBC showed addictive effect on C . vulgaris , while the toxicity of mixtures of 4,4’-dihydroxybenzophenone and 2,4,4’-trihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC as well as 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC all showed antagonistic effect on C . vulgaris . The induced no-effect concentrations of 4,4’-dihydroxybenzophenone, 2,4,4’-trihydroxybenzophenone and 4-MBC by the assessment factor (AF) method were 0.0125, 0.00350 and 0.000169 mg/L, respectively.
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Ren Suyu,Jin Xiaojie,Bekele Tadiyose Girma,Lv Min,Ding Jing,Tan Feng,Chen Lingxin
4-Methylbenzylidene camphor (4-MBC), a typical organic UV filter (OUVF) in personal care products, is considered to be a potential endocrine disruptor due to its estrogenic activity and bioaccumulation. Although 4-MBC residues have been extensively identified in aquatic waters, little is known about their occurrence, levels, and potential risk in coastal waters. This study developed a reliable sampling approach, based on diffusive gradients in thin films (DGT) with XAD-2 as the binding agent, for monitoring 4-MBC in coastal waters. The diffusion coefficients of 4-MBC in freshwater and artificial seawater were 3.65 × 10 −6 cm 2 /s and 3.83 × 10 −6 cm 2 /s, respectively. XAD-2 binding gel showed rapid adsorption to 4-MBC. The accumulated masses of 4-MBC in XAD-2 DGT increased linearly with deployed time for 7 days in freshwater and seawater, which agreed well with theoretical predictions. The sampling performance was independent of ionic strength (0.0001–0.5 M), pH (4.0–8.5), and dissolved organic matter (0–20 mg/L). Field deployment in the river estuary and bathing beach showed that DGT-measured 4-MBC concentrations were consistent in comparison with grab sampling. Environmental risk assessment showed that 4-MBC may pose a medium risk to aquatic organisms based on computed risk quotient (RQ) values. Sewage discharge is the main source of 4-MBC risk, while the residue in recreation beaches contributes more significantly in summer. The established DGT sampling is suitable for seasonal monitoring, source identification, and risk assessment of 4-MBC in coastal waters. Graphical abstract
研究领域:
环境科学
·
分析化学
·
水质
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BLOOD COAGULATION & FIBRINOLYSIS
·
2026
·
IF 1
Shen Yemei,Gao Xuemei,Huan Xuanrong,He Cui,Liu Yu,Li Yuan
Plain Language Summary This study aimed to systematically evaluate the antiplatelet activity of dihydromyricetin (DHM) and comprehensively investigate its effects on coagulation function within its therapeutically relevant concentration range. Using in-vitro experiments, we employed a panel of standard assays to assess the effects of DHM on platelet activation and aggregation induced by various agonists [adenosine diphosphate (ADP), arachidonic acid (AA), and collagen (COL)], as well as on agonist-independent adhesion and aggregation. Simultaneously, multidimensional techniques, including conventional coagulation tests, thromboelastography (TEG), and whole-blood dynamic coagulation analysis, were used to systematically evaluate the impact of DHM on the coagulation cascade and overall hemostatic dynamics. The results showed that DHM significantly inhibited platelet activation and aggregation in a concentration-dependent manner and effectively prevented their spontaneous adhesion and aggregation. Crucially, within the concentration range that exerted effective antiplatelet effects, DHM did not significantly affect any of the tested coagulation parameters, and no cytotoxicity was observed. These in-vitro findings suggest that DHM is a platelet-specific inhibitor, exerting potent antiplatelet effects while not interfering with normal physiological coagulation processes. Therefore, DHM shows potential as an antithrombotic candidate pending in-vivo studies with a potentially low risk of bleeding, providing crucial experimental evidence and a new direction for the development of safer antithrombotic strategies. Plain Language Summary This study explored the antiplatelet effects of dihydromyricetin (DHM) and its impact on blood clotting. Using lab tests, researchers found that DHM effectively reduced platelet activation and aggregation without affecting normal blood clotting or causing cell damage. DHM worked against various platelet activators like ADP, AA, and collagen, and also prevented spontaneous platelet adhesion and aggregation. Importantly, DHM did not alter coagulation parameters, suggesting it targets platelets specifically. These findings indicate DHM could be a promising antithrombotic agent with a low risk of bleeding, paving the way for safer blood clot prevention strategies in future studies. Text is machine generated and may contain inaccuracies. FAQ
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 20
·2107650
·
IF 15.153
Yin Xia,Lingyi Zong,Yu Pan,Xinyu Chen,Lihui Zhou,Yiwen Song,Ling Tong,Xiaojiao Guo,Jingyi Ma,Saifei Gou,Zihan Xu,Sheng Dai,David Wei Zhang,Peng Zhou,Yu Ye,Wenzhong Bao
Two-dimentional semiconductors have shown potential applications in multi-bridge channel field-effect transistors (MBC-FETs) and complementary field-effect transistors (C-FETs) due to their atomic thickness, stackability, and excellent electrical properties. However, the exploration of MBC-FET and C-FET based on large-scale 2D semiconductors is still lacking. Here, based on a reliable vertical stacking of wafer-scale 2D semiconductors, large-scale MBC-FETs and C-FETs using n-type MoS 2 and p-type MoTe 2 are successfully fabricated. The drive current of an MBC-FET with two layers of MoS 2 channel (20 µm/10 µm) is up to 60 µA under 1 V bias. Compared with the single-gate MoS 2 FET, the carrier mobility of MBC-FET is 2.3 times higher and the sub-threshold swing is 70% smaller. Furthermore, NAND and NOR logic circuits are also constructed based on two vertically stacked MoS 2 channels. Then, C-FET arrays are fabricated by 3D integrating n-type MoS 2 FET and p-type MoTe 2 FET, which exhibit a voltage gain of 7 V/V when V DD = 4 V. In addition, this C-FET device can directly convert light signals to an electrical digital signal within a single device. The demonstration of MBC-FET and C-FET based on large-scale 2D semiconductors will promote the application of 2D semiconductors in next-generation circuits.
研究领域:
电子器件
·
材料科学
✓ 已验证
DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2012
·Vol. 18
·期 5
·315-319
·
IF 0
Feng Yakai,Chen Chengbin,Zhang Li,Tian Hong,Yuan Wenjie
A series of novel copolymers were successfully synthesized by ring-opening polymerization (ROP) of 3(S)-methyl-morpholine-2,5-dione (MMD) and 5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one (MBC) using stannous octoate as catalyst. The copolymers were characterized by means of 1H-NMR and FT-IR spectroscopy. Gel permeation chromatography (GPC) test shows that the average-number relative molecular mass and average-weight relative molecular mass slightly increase with the increase of MBC content in feed. The results of differential scanning calorimetry (DSC) demonstrate that the glass transition temperature of copolymers increases with the increase of MBC content in copolymers. The copolymers of MMD and MBC are amorphous copolymers, as indicated by DSC results, while the homopolymer of MMD is semicrystalline.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
MATERIALS CHEMISTRY AND PHYSICS
·
2021
·
IF 4.094
Ruyi Zou,Lin Zhu,Lijun Yan,Bo Shao,Hui Cheng,Wei Sun
In this paper kelp was used as the carbon precursor to prepare a biomass carbon with meshy microstructure, and Co 3 O 4 nanoparticles were further modified on the meshy biomass carbon (MBC) by using solvothermal and pyrolysis methods. The prepared Co 3 O 4 @MBC composite combined the special structure of MBC with uniformly distributed Co 3 O 4 nanoparticles, which provided large specific surface and good conductivity. Different methods including scanning electron microscopy, transmission electron microscopy , X-ray powder diffraction, Raman spectroscopy , X-ray photoelectron spectroscopy and nitrogen adsorption-desorption were used to characterize the structure and performances of composite. Co 3 O 4 @MBC composite was used to construct an electrode for supercapacitor , which had better electrochemical performance than that of pristine Co 3 O 4 nanoparticles and MBC electrodes. The highest specific capacitance (1212.4 F g −1 at 0.5 A g −1 ) could be obtained with excellent cycle stability and the capacity retention was 99.5% at 2 A g −1 after 2000 cycles, which could be attributed to synergistic effects of both pseudocapacitance and electric double layer capacitance under optimized carbon-cobalt ratio. Furthermore, an asymmetric supercapacitor system was constructed utilizing Co 3 O 4 @MBC as positive electrode with MBC as negative electrode. This two-electrode system provided a good performance with energy density of 59.82 Wh·kg −1 at a power density of 700 W kg −1 , highlighting the potential application in efficient energy storage device.
研究领域:
材料科学
·
能源存储
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Hanye Ju,Yankun Zhang,Yongqiang Qin,Jin Liu,Yihou Tang,Inna M. Sokolova,Xiaoping Diao
UV filters, such as 4-Methylbenzylidene camphor (4-MBC), are emerging environmental contaminants that threaten marine life and ecosystem integrity. This study investigated metabolic disruptions in the liver of clown anemonefish ( Amphiprion ocellaris ) after exposure to 4-MBC (0, 10, 50 µg/L) for 7 or 14 days. Exposure led to 4-MBC accumulation and significant liver metabolic disturbances and endocrine disruption in the fish. Random forest analysis identified vitellogenin and testosterone levels as key factors distinguishing treatment groups. Molecular docking showed high binding affinity of 4-MBC to 17β-hydroxysteroid dehydrogenase and vitellogenin in the liver. Additionally, 4-MBC exposure reduced thyroid hormone levels and disrupted glucose and lipid metabolism, with more severe effects at 7 days compared to 14 days. Transcriptome analysis revealed that 4-MBC interfered with hepatic insulin sensitivity by disrupting pathways involving Insulin Receptor (INSR), Phosphoinositide 3-Kinase (PI3K), Insulin Receptor Substrate (IRS), and others. It also impacted genes related to lipid accumulation, gluconeogenesis, and lipid utilization. Furthermore, 4-MBC disrupted the endoplasmic reticulum (ER)’s protein degradation system, causing ER stress and activating lipogenic pathways, which enhanced lipid accumulation. The reduction in thyroid hormones and metabolic dysfunctions may impair the reproductive health and population stability of clown anemonefish. These findings underscore the potential ecotoxicity of 4-MBC and its adverse effects on coral reef fish populations, raising concerns about its environmental impact.
研究领域:
生态毒理学
·
海洋生物学
·
内分泌学
·
分子生物学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 27
·275707
·
IF 3.874
Songfa Qiu,Fan Gao,Zhijun Liang,Ximing Zhong,Li Hao,Huayao Chen,Xinhua Zhou,Hongjun Zhou
Tea tree oil, a natural antibacterial compound, cannot be used effectively because of its volatile nature. In this work, a biocompatible carrier was prepared and loaded with tea tree essential oil. The carrier was prepared via the electrostatic or chemical action of aminated mesoporous silica and sodium rosin for achieving a low volatilization rate of tea tree essential oil. A synergistic antibacterial effect was observed between sodium rosin and tea tree essential oil. This method utilized the positive charge of the amino group and the condensation reaction with the carboxyl group to achieve physical and chemical interactions with sodium rosin. Fourier Transform Infrared, Brunauer–Emmet–Teller, Zeta potential, SEM, TEM, and TG were performed to characterize the structure and properties of the samples. Compared to the electrostatic effect, the chemically modified system exhibited a longer sustained release, and the sustained release curve followed the Korsmeyer–Peppas release model. Also, the antibacterial properties of the chemically modified system exhibited better minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) respectively, the MIC and MBC for E. coli were 0.3 mg ml−1 and 0.6 mg ml−1 respectively, for S. aureus were 0.15 mg ml−1 and 0.3 mg ml−1 respectively. More strikingly, the sample also demonstrated long-term antibacterial performance. Therefore, this work provides a new way for the delivery of volatile antibacterial drugs to achieve sustained-release and long-lasting antibacterial effects.
研究领域:
药学
·
材料科学
·
生物技术
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD MICROBIOLOGY
·
2021
·
IF 5.516
Qiuxia Fan,Yahong Yuan,Ting Zhang,Wei Song,Qinglin Sheng,Tianli Yue
Vibrio parahaemolyticus is the primary pathogenic bacteria associated with seafood-borne illnesses . Lactobionic acid (LBA) is an organic acid with multiple biological activities that has recently been a focus of interest as an antibacterial agent. The aim of this study was to investigate the inhibitory effects of LBA on Vibrio parahaemolyticus planktonic cells and biofilms. The minimum inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of LBA against Vibrio parahaemolyticus were both identified as 4 mg/mL. LBA exerted antimicrobial effects against planktonic Vibrio parahaemolyticus cells by damaging their membranes, as revealed by reduced intracellular ATP concentrations, increased protein leakage, abnormal cell morphology and diminished membrane integrity after treatment. At 1/16 × MIC and 1/8 × MIC, LBA inhibited biofilm formation and downregulated the expression of some biofilm-related genes, which was confirmed by crystal violet staining, field-emission scanning electron microscopy (FESEM) observations, and real-time quantitative PCR analysis. Moreover, LBA inactivated Vibrio parahaemolyticus cells within biofilms (on polystyrene and stainless steel surfaces), destroyed biofilm structures on stainless steel surfaces, and also reduced the levels of polysaccharides and proteins in the biofilms. Therefore, LBA is a potential low-cost agent that can be used to control planktonic Vibrio parahaemolyticus and its biofilms.
研究领域:
微生物学
·
食品科学
·
海洋生物学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Lin Wang,Meihua Xin,Mingchun Li,Wenfeng Liu,Yangfan Mao
N -(4- N′, N′, N′ -trimethylphosphonium chloride) benzoyl chitosan (TMPCS), N -(4- N′, N′, N′ -triphenylphosphonium chloride) benzoyl chitosan (TPPCS), and N- (4- N′, N′, N′ -trimethylmethanaminium chloride) benzoyl chitosan (TMACS) were synthesized. The structures of the products were characterized by Fourier transform infrared spectroscopy, Nuclear magnetic resonance spectroscopy and ultraviolet-visible spectroscopy. Their antibacterial activities against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were investigated in vitro using the antibacterial rate, minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the antibiofilm activity was investigated by crystal violet assay. The antibacterial assessment revealed that the chitosan quaternary phosphonium salts of similar structure had superior antibacterial activity than chitosan quaternary ammonium salt. The antibacterial rate of CS, TMPCS, TPPCS and TMACS against E. coli at 0.5 mg/mL was 10.4 %, 42.0 %, 58.5 % and 21.6 % respectively. At the same concentration, the antibacterial rate of TMPCS, TPPCS and TMACS against S.aureus was all up to 100 %. The biofilm inhibition rate of CS, TMPCS, TPPCS and TMACS at a half of MIC against E.coli was 28.4 %, 33.9 %, 56.6 % and 57.6 % respectively, and against S.aureus was 30.8 %, 53.8 %, 62.2 % and 58.5 % respectively. The biofilm removal rate of CS, TMPCS, TPPCS, TMACS against E.coli at 2.5 mg/mL was 20.6 %, 46.4 %, 48.9 % and 41.6 % respectively, and against S.aureus at 2.5 mg/mL was 41.5 %, 60.4 %, 69.9 % and 59.01 % respectively.
研究领域:
材料科学
·
生物技术
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2022
·
IF 2.712
Zao Cheng,Junfei Gao,Qianqian Liu,Qun Gu
This work describes the relationship between the antibacterial activity and the ester chain length (C1-C8) of (R)-3-Hydroxybutyric ((R)-3-HB) alkyl esters that synthesized from (R)-3-HB acid ((R)-3-HBA) by esterification reaction. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) decrease as the length of the (R)-3-HB alkyl ester chain increases from 1 to 6, but (R)-3-HB-C7 and (R)-3-HB-C8 have their own rules for different microorganisms. Among them, the (R)-3HB-C6 has the relatively best antibacterial and antifungal properties, which MIC were 1.95 mg mL−1 against E. coli and S. aureus; 0.98 mg mL−1 against C. albicans and B. subtilis; 0.49 mg mL−1 against A. niger. Finally, the antimicrobial mechanisms of the (R)-3HB-C6 are revealed, and these include disruption of biofilm and the bacterial wall/membrane, leakage of the intracellular content, and change in the transmembrane potential. These results imply the potential application of (R)-3-HB alkyl ester as new antimicrobial agents; future research can use this as an antibacterial element to synthesize new polymer materials or agents with high-efficiency antibacterial activity.
研究领域:
药物化学
·
微生物学
·
有机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
·
2021
·
IF 5.277
Houqi Ning,Yu Cong,Hong Lin,Jingxue Wang
Cationic peptide chimeric lysins, Lysqdvp001-5aa, Lysqdvp001-10aa and Lysqdvp001-15aa, were designed based on lysin Lysqdvp001 from Vibrio parahaemolyticus ( V. parahaemolyticus ) phage qdvp001. These chimeric lysins showed equivalent peptidoglycan hydrolysis activities with Lysqdvp001 and could lyse the bacteria from the outside. The antibacterial activity as well as outer and inner membrane permeabilization of Lysqdvp001 and chimeric lysins against V. parahaemolyticus were Lysqdvp001-15aa>Lysqdvp001-10aa>Lysqdvp001-5aa>Lysqdvp001. Lysqdvp001-15aa exhibited an excellent antibacterial activity with minimum inhibition and bactericidal concentrations (MIC and MBC) of 0.2 and 0.4 mg/mL, respectively, and its antibacterial spectrum was much broader than phage qdvp001. Membrane hyperpolarization and membrane phospholipid exposure of V. parahaemolyticus were observed after Lysqdvp001-15aa treatments. Transmission electron microscope (TEM) showed Lysqdvp001-15aa destroyed structure integrity of V. parahaemolyticus . Besides, MIC and MBC of Lysqdvp001-15aa decreased V. parahaemolyticus counts in oyster by 3.20 and 4.03 log 10 CFU/g. Lysqdvp001-15aa at MBC eradicated about 50% of V. parahaemolyticus biofilms and inhibited over 90% of the formation of the bacterial biofilms.
研究领域:
微生物学
·
细菌学
·
食品安全
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）