MBene nanozyme-driven dopamine flexible sensors: From technological development to mechanistic exploration of stress-related disorders
The measurement of fluctuations in the kinetic levels of the dopamine signal is important for the detection of the body's endocrine response to stressful stimuli. However, traditional dopamine measurements are prone to damage, while the stability of existing wearable sensors needs to be improved. To address this, a non-invasive, self-cleaning, and stretchable and flexible electrochemical sensor patch (i.e., sCMZ sensor) has been presented for a non-invasive, rapid, simple, and highly sensitive long-term and stable monitoring of dopamine levels in biofluids. Subsequently, an innovative “zipper” synthesis strategy was employed to successfully prepare a new generation of highly selective and environmentally friendly MBene-based heterojunction-like nanozymes (MBAzy), they thereby enabled a highly sensitive in situ detection in the detection range of 512 pM – 125 mM (LOD = 4.44 pM). Innovative combination of bionic snake-shaped flexible electrodes and self-cleaning antibacterial electrodes for long-term monitoring of the human body's condition. Unlike previous studies, this study reveals the circadian rhythm of dopamine in human urine and its changes under different stress states, clarifies the significant difference between long-term and short-term stress on neurotransmitter levels, and explores the weak correlation between stress and fatigue, which provides new perspectives for the study of psychophysiology and related diseases.
危险品化学品经营许可证（带存储）