Toxicology Research
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2025
·Vol. 14
·期 1
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IF 2.1
Zhang Yan,Zhou Jin,Zhao Jianxin,Cheng Xiurong,Xing Caihong
In this study, we aimed to investigate the effects of chronic benzene exposure on the self-renewal capacity of C57BL/6 bone marrow HSPCs. Twenty-four male C57BL/6 mice were randomly divided into two groups: the control group and the benzene-exposed group. Mice in the benzene-exposed group inhaled 1,000 mg/m3 (308 ppm; conversion factor: 20 °C, 101 kPa, 1 ppm = 3.25 mg/m3) benzene for 32 weeks and the control group mice inhaled clean air. The peripheral blood hematological alterations were monitored every two weeks. Competitive bone marrow transplantation was performed to assess the self-renewal capacity of bone marrow HSPCs and the donor cell chimerism was quantified through flow cytometry. By the fourth week of benzene exposure, significant reductions in leukocytes, erythrocytes, and hemoglobin levels (P < 0.05) were observed, suggesting the development of benzene poisoning in mice. In the B6.SJL recipient mice, the chimerism ratio of bone marrow cells from C57BL/6 donors exposed to benzene for 20 weeks significantly decreased after transplantation (16 weeks post-transplant: 52.58% ± 17.38% in controls vs. 3.89% ± 1.96% in the benzene group, P < 0.05). Furthermore, the chimerism ratio in recipients of 32-week benzene-exposed donors approached zero by week 84 post-transplant, suggesting a loss of self-renewal capacity in bone marrow HSPCs due to benzene exposure. The study concludes that bone marrow suppression and the diminished self-renewal ability of C57BL/6 bone marrow HSPCs may lead to bone marrow failure in mice, contributing to the potential occurrence of MDS.
研究领域:
毒理学
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血液学
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实验医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Delian Yang,Shengli Yuan,Yuqi Chen,Ying Huang,Litao Ma,Deyong He,Ming Duan,Qianhui Ou,Yong Tang,Shenwen Fang,Yan Xiong
In this work, the interaction performance of zwitterionic surfactant [dodecyl dimethyl sulfopropyl betaine (DSB-12) and hexadecyl dimethyl sulfopropyl betaine (DSB-16)] at the n-octadecane oil surface is investigated from experimental and simulation insights. For a macroscopic experiment, interfacial interferometry technology was developed for real-time monitor interaction performances and to obtain the quantitative interfacial thickness and mass results. The Langmuir model was characterized by thermodynamic analysis, deducing the aggregation spontaneity of DSB-16 > DSB-12 with ΔGagg(DSB-16) = −5.94 kJ mol–1 < ΔGagg(DSB-12) = 24.08 kJ mol–1. A three-step dynamic model (adsorption, arrangement, and aggregation) was characterized by kinetic analysis, indicating arrangement process as slow-limiting step with k2(arr) < k1(ads), k3(agg). For microscopic simulation, and molecular dynamic (MD) method was utilized to theoretically investigate interaction performances and obtain the interfacial configuration and energy results. The interaction stability and interaction strength were indicated to be DSB-16 > DSB-12 with differences of final energy ΔEfin = 48–88 kcal mol–1. The interaction mechanism was explained by proposing the model of “response enhancement” and “deposition activity” for DSB-16 interactions, and “response decrease” and “elution activity” for DSB-12 interactions. The different performances can be attributed to the different interaction forms and forces of surfactants. This work provided a platform for performance and mechanism investigation between the surfactant molecule and oil surface, which is of great significance in reservoir exploitation and enhanced oil recovery (EOR).
研究领域:
化学工程
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石油工程
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界面科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Yanqi Gu,Shayu Li,Yuehong Xu,Jiaguang Han,Miao Gu,Zhipeng Cai,Yan lv,Guoxin Xie,Tianbao Ma,Jianbin Luo
The influence of an external magnetic field on the picosecond network dynamics of the salt (KCl) solution is investigated by terahertz time-domain spectroscopy. Because hydration changes the motions of water molecules clusters, we test hydration by measuring the change of dielectric loss caused by the slow relaxation of water molecules clusters. We find experimentally that the magnetic field enhances the number of water molecules involved in hydration and the radius of dynamic hydration layer in salt solutions. However, with the increasing concentration, there is a downward in the hydration enhancement per equivalent. Meanwhile, the simulated results show the number of water molecules in hydration layers increases which is consistent with our experimental results. Besides, the simulation reveals that external magnetic field mainly affects the second hydration layer and the stability of water molecules network in hydration layer is enhanced with external magnetic field .
研究领域:
物理化学
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生物物理
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分子生物学
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光谱学
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溶液化学
✓ 已验证
DOI
高影响因子
POWDER TECHNOLOGY
·
2024
·
IF 4.5
Zhihao Shen,Qicheng Feng,Shuming Wen,Han Wang,Jing Cao,Zhengyong Song
The separation of polymetallic sulfide ores by flotation is a difficult task in the mineral processing industry. In this investigation, a small-molecule organic compound, mercaptosuccinic acid (MSA), was used as a new depressant for inhibiting galena in chalcopyrite flotation. Micro-flotation and surface wettability tests indicated that MSA pronouncedly weakened the floatability of galena but not chalcopyrite, resulting in marked differences in their flotation recovery. Findings of Fourier transform infra-red (FT-IR) spectroscopy measurements and reagent adsorption trials showed that MSA was strongly adsorbed on galena, resulting in the inability of the collector to effectively interact with galena. Atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS) analyses further corroborated that MSA showed a greater affinity for galena than chalcopyrite, this behavior markedly altered the superficial chemical environment of galena. Molecular dynamic simulations (MDS) showed that MSA increased the concentrations of H 2 O molecules on galena, which enhanced the surface hydrophilicity of galena.
研究领域:
矿物加工工程
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yuzhao Hou,Binyan Yang,Simon Sani Ocholi,Fengchao Wang,Zhifei Fu,Liming Wang,Lifeng Han,Pengli Du,Jia Zhao,Ping He,Zixin Zhang,Erwei Liu
Estrogen compounds in food exhibit bioaccumulation and endocrine-disrupting effects, posing serious risks to ecosystems and human health. Here, a novel core–shell magnetic covalent organic framework (COFs @ Fe 3 O 4 @C NPs) was developed for efficient enrichment and sensitive detection of estrogens in meat samples. The adsorption feasibility and mechanism of TAPB-DVA-COF were investigated using density functional theory (DFT) and molecular dynamics simulation (MDS). DFT calculations confirmed that hydrogen bonding and π–π stacking drive spontaneous adsorption, with adsorption energies ranging from −21.26 to −11.59 kcal mol −1 . MDS further revealed the formation of stable estrogen-COF complexes through close interfacial contact and persistent hydrogen bonding, confirming the existence of low-energy conformations. Based on these insights, COFs were anchored onto polydopamine-modified carbon-coated Fe 3 O 4 nanoparticles at room temperature to fabricate a magnetic adsorbent, which was then employed as a magnetic solid-phase extraction (MSPE) material. The adsorbent exhibited high surface area, strong magnetic responsiveness, and excellent stability. Coupled with high-performance liquid chromatography (HPLC), the established MSPE–HPLC method achieved a wide linear range ( R ≥ 0.9996) and low detection limits (0.21–12.79 μg L −1 ). In pork and chicken samples, recoveries ranged from 91.7 % to 113.5 % with relative standard deviations of 1.0–6.1 %. This study demonstrates the superior performance of COFs @ Fe 3 O 4 @C NPs for estrogen detection and highlights MDS as an efficient and economical tool for predicting adsorption behavior, offering valuable guidance for material design.
研究领域:
分析化学
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食品安全
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纳米材料
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计算化学
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环境毒理学
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药物代谢
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分离科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）