INORGANIC CHEMISTRY
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2024
·
IF 4.3
Yufei Wang,Shuang Liu,Junyao Pan,Haoyang Zhang,Binyu Wang,Wenfu Yan
MER zeolite, a low-silica zeolite with an 8-membered ring aluminosilicate framework, has been recognized as a promising material in sorption, separation, and ion-exchange applications. Herein, we developed a cost-effective and rapid method to convert parent zeolite H-STI, which was derived from natural stellerite, into MER zeolite through interzeolite conversion with a crystallization time of 8 h. This MER zeolite exhibits high efficiency in removing Pb2+ and Cd2+ from simulated heavy metal wastewater over a pH range of 3–8. It also shows excellent selectivity in the presence of competitive cations, including Na+, K+, Ca2+, Mg2+, Zn2+, Cu2+, and Co2+. At 25 °C, with a MER-S dosage of 1/3000 g·mL–1 for Pb2+ and 1/500 g·mL–1 for Cd2+, the removal efficiencies were 99.7 and 99.9%, respectively. The distribution coefficients were 1097 L·g–1 for Pb2+ and 550 L·g–1 for Cd2+, and the sorption capacities reached 513 mg·g–1 for Pb2+ and 171 mg·g–1 for Cd2+, indicating that the product MER zeolite is one of the highest sorbents for Pb2+ and Cd2+ reported for zeolitic materials. The sorption for Pb2+ and Cd2+ both follows the chemisorption-dominated mechanism, driven by the ion-exchange process between the K+ in the channels MER-S and the Pb2+ or Cd2+ in solution. This work highlights the potential of rapidly synthesized MER zeolite for the effective removal of heavy metal cations, emphasizing its performance and practical applicability.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
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2017
·Vol. 25
·期 1
·215-220
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IF 1.624
Chen Wu,Guo Qingyue,Yang Chunpeng,Hou Jin
Merlinoite(MER) zeolite membranes were synthesized on the outer surface of porous α-alumina tubular support by in-situ hydrothermal synthesis method without organic template. The synthetic MER zeolite membranes (sample 1, sample 2 and sample 3) were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX). The thickness of sample 2 without cracks is about 15 μm. The synthetic MER membrane which is mainly composed of Si, Al, O and K is typical merlinoite structure. The performance of sample 2 for potassium extraction in simulated seawater was researched by the membrane tube reactor. The continual ion-exchange reaction was carried out for 108 h at room temperature. The average exchange rate for K + ion was 32.8% and the average rejection rates for Na + , Ca 2+ and Mg 2+ ions were 93.4, 98.4 and 98.2% respectively. So the MER zeolite membrane (sample 2) has preference selectivity for K + ion and can be used as a potential inorganic membrane for potassium extraction from seawater.
研究领域:
材料科学
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膜分离技术
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资源回收利用
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无机非金属材料
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环境工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR RECOGNITION
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2018
·Vol. 31
·期 8
·e2714
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IF 1.868
Juxin Yin,Jianjian Zhuang,Shaowu Lv,Ying Mu
Excessive reactive oxygen species (ROS) levels are harmful to the body. The peroxidase, GPx, and the superoxide dismutase, SOD, are important antioxidant enzymes for preventing ROS-induced damage. Se-CuZn-65P is an enzyme mimetic with dual GPx and SOD antioxidant function. However, currently, its production is mainly based on the cysteine auxotrophic expression technique, which is inefficient, expensive, and time consuming. In this study, we combined protein engineering and the chemical mutation method to synthesize Se-CuZn-65P. The DNA sequence encoding the 65 amino acid peptide with the desired sequence transformations to incorporate the SOD and the GPx catalytic sites was cloned and expressed in a soluble protein expression vector. The protein yield increased up to 152 mg/L, which is 10 times higher than in previous studies. The SOD and GPx activity of Se-CuZn-65P was high (1181 U/mg and 753 U/μmol, respectively). The binding constant of glutathione was 5.6 × 10 4 L·mol −1 , which shows that Se-CuZn-65P efficiently catalyzed hydrogen peroxide reduction by glutathione. Mitochondrial damage experiments confirmed the double protective role of the Se-CuZn-65P peptide and demonstrated functional synergy between the SOD and the GPx domains, which indicates its potential to be used in the treatment of ROS-related diseases. Our research may give a new thought to increase the yield of mimic.
研究领域:
生物化学
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分子生物学
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药理学
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生物技术
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产品关联
DOI
PubMed
高影响因子
RSC Advances
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2017
·Vol. 7
·期 24
·14438-14447
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IF 3.108
Lin Zhou,Yujie Wu,Youfei Cheng,Jie Wang,Jun Lu,Jinyan Gao,Juanli Yuan,Hongbing Chen
Celiac disease (CD) is a T cell-mediated enteropathy of the small intestine and caused by the ingestion of wheat gluten and related prolamins in barley and rye. However, there is no effective therapy to alleviate symptoms of celiac disease except for a life-long gluten-free diet. Recent studies showed that modification by microbial transglutaminase (mTG) could reduce the gliadin-specific immune response. In the present study, different acyl-acceptor substrates in combination with mTG were used to modify the model 33-mer peptide (LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF), which is a particular celiac toxic α-gliadin peptide. RP-HPLC and LC-ESI-MS were performed to test the extent of the modifications. R5 ELISA and G12 ELISA were used to analyze the antigenicity of the modified peptide. The shifts of retention time and molecular weight showed great modification of 33-mer peptide after 2 h of incubation with mTG. When acyl-acceptor substrates were crosslinked with 33-mer peptide, the antigenicity of modified peptide forms was decreased compared to its initial level. In summary, it is demonstrated that mTG is active on a variety of chemically acyl-acceptor substrates. Transamidation by mTG with an appropriate amine donor can be used to block the antigenicity of gliadin peptide related to celiac disease. These findings highlight a potential strategy to prevent cereal toxicity in celiac disease.
研究领域:
免疫学
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食品科学
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胃肠病学
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分子生物学
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DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2024
·
IF 9.7
Dingxi Zhang,Bowei Chu,Qingqing Yang,Xiaoyan Zhang,Yingying Fang,Guangliang Liu,Lina Liang,Yingying Guo,Yongguang Yin,Yong Cai,Guibin Jiang
Mercury (Hg), particularly organic mercury, poses a global concern due to its pronounced toxicity and bioaccumulation. Bioremediation of organic mercury in high-salt wastewater faces challenges due to the growth limitations imposed by elevated Cl − and Na + concentrations on microorganisms. In this study, an isolated marine bacterium Alteromonas macleodii KD01 was demonstrated to degrade methylmercury (MeHg) efficiently in seawater and then was applied to degrade organic mercury (MeHg, ethylmercury, and thimerosal) in simulated high-salt wastewater. Results showed that A. macleodii KD01 can rapidly degrade organic mercury (within 20 min) even at high concentrations (>10 ng/mL), volatilizing a portion of Hg from the wastewater. Further analysis revealed an increased transcription of organomercury lyase ( merB ) with rising organic mercury concentrations during the exposure process, suggesting the involvement of mer operon ( merA and merB ). These findings highlight A. macleodii KD01 as a promising candidate for addressing organic mercury pollution in high-salt wastewater.
研究领域:
环境微生物学
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生物修复
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海洋生物学
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毒理学
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产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Xiaojun Deng,Ping Zhou,Xiayan Yan,Renjin Xiong,Huaqin Kou,Wenhua Luo
To spare the use of OSDA and fluorides, for the sake of reducing cost and environmental conservation, a green and efficient synthesis recipe of low-silica CHA zeolites has been demonstrated, without using seeds or any other zeolites. The main factors that determine the formation of CHA zeolites have been investgated systemmatically, and several rules are obtained. (i) just considering simple memallic cations acting as the SDA , K + is indispensable for the formation of CHA framework, with noting that K + can also direct to MER topology. (ii) working as catalyst or minerization agent, OH − and F − function almost identically, but when the concentration of F − has reached a really high level or even only F − was used, CHA framework can not form because the intermediate fluoride complexes are inclined to produce small melecules of fluoride salts with morderate solubility over to enter the zeolite framework. (iii) at conditions of this work, the second stirring after the RT aging should be adopted since the contrastive tests have showed the benifits of the second stirring in making fewer or smaller impurity grains. (iv) when the concentration of K + is too high in reactive gels, with the other same conditions, MER over CHA framework is preferentially to form. (v) it is reasonable to consider the as-synthesized K-CHA materials can be used to research the novel “trapdoor” effect later. The authors considered the discussions and conclusions would offer some beneficial references to the green synthesis of zeolites and further understanding of the mechanism of hydrothermal treatment .
研究领域:
材料科学
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环境化学
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无机化学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jian Gao,Yuqi Shi,Minglu Tang,Yuancai Chen
Chromate bioreduction is a promising bioremediation strategy, but its application in wastewater treatment is limited by the Cr(VI) biotoxicity, particularly due to the generation of Cr(VI)-induced reactive oxygen species (ROS). To mitigate these adverse effect, this study synthesized bio-Pd 0 in Citrobacter freundii to modulate distinct Cr(VI) aerobic/anaerobic reduction pathways. With the incorporation of bio-Pd 0 , aerobic and anaerobic Cr(VI) specific removal rate increased by 18.1–21.2 and 51.5–87.9 times, respectively. The genomics, RT-qPCR, respiratory inhibition experiments, ROS levels and antioxidant enzyme activity assays demonstrated that bio-Pd 0 enhanced intracellular Cr(VI) aerobic bioreduction mainly via upregulating the chromate multi-electron reductase (Cr-MER) (related with YieF, NfsA and NemA), together with the energy-dependent resistance system (antioxidant enzyme superoxide dismutase and catalase, efflux pump Emr, DNA repair protein RecG). Cr-MER and resistance system effectively reduced the generation and accumulation of ROS, respectively. For anaerobic conditions, bio-Pd 0 facilitated hydrogenase-mediated short respiratory chain (S-chain) to reduce Cr(VI) extracellularly (related with HypE, RutF and OmcG), avoiding ROS generation and the energy consumption of the intracellular detoxification system, and maximized the energy utilization for Cr(VI) extracellular reduction. This study provides a new strategy for Cr(VI) bioreduction and elucidates the underlying mechanism.
研究领域:
环境生物技术
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微生物学
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生物修复
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生物化学
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基因组学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yanpeng Chen,Rongshu Zhu,Guanyu Chen,Minghu Zhao,Min Ju,Rongming Cai,Jinqiang Gao,Mei Hong,Shihe Yang
Synthesis of small-pore chabazite (CHA) zeolites in the absence of organic structure-directing agents (OSDA) has been proven difficult. A judicious mixed cation approach recently reported could expand the design space of CHA formation. In a seemingly opposite direction, we herein report an anion tuning approach for controlling the zeolite polymorphism in an OSDA-free system that effectively promotes hierarchical CHA formation in a competitive growth with MER. Phenoxide media, utilizing mild in-situ nucleophilic etching in cooperation with zeolite framework growth, allow beneficial kinetic control to facilitate CHA nucleation. Operando analyses reveal the crucial role of stabilized dimeric aluminate species as a key intermediate for CHA phase selection. The phenol-mediated CHA zeolites exhibit almost perfect 9 molecules per unit cell CO 2 uptake capacity and no CH 4 adsorption. This work offers an anion tuning strategy for controlling zeolite polymorphism as a supplement to the current phase-selection toolbox that utilizes mixed inorganic cations.
研究领域:
材料科学
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化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yanyan Wang,Hai Gao,Xinya Huang,Zhaoan Chen,Pengyu Kang,Yunyi Zhou,Danhua Qin,Wenli Zhang,Jianping Liu
A promising therapy for atherosclerosis treatment was designed by targeting LXR receptor (LXR) on atherosclerotic macrophage, where LXR activation could regulate cholesterol efflux and efferocytosis . Herein, a sequential-targeting nanoplatform (HT-rHDL) was constructed to deliver LXR agonist into macrophage, which was composed of discoidal reconstituted high-density lipoprotein (d-rHDL) core for agonist encapsulation and external modifications: (i) the outermost hyaluronan , targeting injured endothelium; (ii) modified β-cyclodextrin of d-rHDL, accelerating cholesterol efflux of foam cells ; (iii) conjugated apolipoprotein A-I of d-rHDL, targeting macrophage. This design underlines that the nanoplatform could increase its plaque accumulation, accomplish cholesterol efflux-remodeling-drug delivery behavior and specifically activate LXR in macrophage. After a 3-month treatment with HT-rHDL, 31.47% plaque area reduction, 56.0% lipid accumulation decrease, obvious inflammation resolution and enhanced plaque stability were observed. Furthermore, the atherosclerosis intervention was demonstrated to benefit from the upregulations of ABC transporters and Mer tyrosine kinase . Collectively, HT-rHDL provides new strategies to regress atherosclerosis.
研究领域:
心血管疾病
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药学
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分子生物学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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