JOURNAL OF APPLIED POLYMER SCIENCE
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2014
·Vol. 132
·期 9
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IF 1.64
Yan-Yan Hu,Jing Zhang,Qi-Chen Fang,Dong-Mei Jiang,Chu-Cheng Lin,Yi Zeng,Ji-Sen Jiang
A novel semi-interpenetrating poly(2-hydroxyethyl methacrylate) (pHEMA) based polyelectrolyte hydrogel [p(HEMA- co -METAC)/PEG] was prepared by copolymerizing HEMA with the cationic monomer 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) in the presence of polyethylene glycol (PEG) with different content and molecular weight (MW 4000 and 400). The chemical structure of the gels was confirmed by FT-IR spectroscopy, morphology study was performed by scanning electron microscope (SEM), thermal stability was revealed by thermogravimetric analysis (TGA), and the mechanical properties were determined by electronic universal testing machine. Swelling studies showed introduction of cationic monomer METAC led to high water content, and the obvious salt and pH sensitive properties were observed which proved the smart behavior of the semi-interpenetrating polymer networks (IPNs) gels. In addition, the effect of temperature and some important biological solution on swelling behavior were reported. Cytotoxicity test demonstrated that synthesized gels owned satisfactory cytocompatibility and were convenient for the application as biomaterials. Finally, the weak bovine serum albumin (BSA) adsorption on semi-IPNs by introducing METAC and controlling the content of PEG in gels demonstrated that they were of good protein resistance effect in biomedical applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41537.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2024
·
IF 10.7
Pengyu He,Dawei Wang,Ruizhu Zheng,Hao Wang,Lina Fu,Guoliang Tang,Zhijun Shi,Yiping Wu,Guang Yang
Infection-associated complications and repair failures and antibiotic resistance have emerged as a formidable challenge in hernia repair surgery. Consequently, the development of antibiotic-free antibacterial patches for hernia repair has become an exigent clinical necessity. Herein, a GBC/Gel/LL37 biological patch (biopatch) with exceptional antibacterial properties is fabricated by grafting 2-Methacryloyloxyethyl trimethylammonium chloride (METAC), a unique quaternary ammonium salt with vinyl, onto bacterial cellulose (GBC), followed by compounding with gelatin (Gel) and LL37. The GBC/Gel/LL37 biopatch exhibits stable swelling capacity, remarkable mechanical properties, flexibility, and favorable biocompatibility. The synergistic effect of METAC and LL37 confers upon the GBC/Gel/LL37 biopatch excellent antibacterial efficacy against Staphylococcus aureus and Escherichia coli , effectively eliminating invading bacteria without the aid of exogenous antibiotics in vivo while significantly reducing local acute inflammation caused by infection. Furthermore, the practical efficacy of the GBC/Gel/LL37 biopatch is evaluated in an infected ventral hernia model, revealing that the GBC/Gel/LL37 biopatch can prevent the formation of visceral adhesions, facilitate the repair of infected ventral hernia, and effectively mitigate chronic inflammation. The prepared antibacterial GBC/Gel/LL37 biopatch is very effective in dealing with the risk of infection in hernia repair surgery and offers potential clinical opportunities for other soft injuries, exhibiting considerable clinical application prospects.
研究领域:
生物医学工程
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材料科学
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外科研究
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组织工程
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抗菌技术
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Mingjun Zou,Yikun Ji,Bin Liu,Shujuan Liu,Qian Ye,Feng Zhou
Hydrogels exhibit great potential in marine antifouling applications due to their ability to form a surface hydration layer that resists microbial adhesion. However, their practical application is often hindered by poor mechanical properties and limited antifouling performance. To address these challenges, nanomaterials have been employed to enhance hydrogel performance. Herein, we functionalized MXene nanosheets by grafting methacryloxyethyltrimethyl ammonium chloride (METAC) microgels, followed by electrostatic adsorption of sodium lignosulfonate (SLS), resulting in functionalized MXene nanosheets with enhanced antibacterial and antifouling properties. These nanosheets were then embedded within hydrogel matrix to form nanocomposite hydrogels. The reinforced internal crosslinking network significantly improved the mechanical performance, increasing tensile stress from 55 KPa to 167 KPa and tensile strain from 636 % to 971 %. The MXene-METAC-SLS/Gel also exhibited excellent antifouling performance, achieving antibacterial rates of 91.0 % and 93.1 % against Staphylococcus aureus and Escherichia coli , along with algal removal rates of 83.5 % and 85.1 % for Dunaliella and P orphyridium , respectively. The incorporation of functionalized nanosheets not only enhanced antimicrobial capability but also strengthened the surface hydration layer, further resisting microbial adhesion. This study expands the potential applications of nanocomposite hydrogels in marine antifouling coatings.
研究领域:
材料科学
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纳米技术
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高分子科学
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表面工程
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海洋技术
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生物医学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Haiyan Liu,Yang Hu,Yongjun Zhu,Xiuping Wu,Xin Zhou,Haobo Pan,Shu Chen,Pengfei Tian
Bacterial cellulose (BC) is a biosynthesized carbohydrate polymer with excellent biocompatibility and water holding capability. However, it lacks an inherent antibacterial activity that has limited its in-depth biomedical applications. This study investigated a novel strategy of adopting a simultaneous process to chemically anchor a quaternary ammonium salt (R-N(CH 3 ) + ) with a special vinyl group (2-methacryloyloxyethyl trimethylammonium chloride, METAC) onto the BC, and meanwhile, enhance the density of (R-N(CH 3 ) + ) via free radical vinyl polymerization. The results have confirmed the transition of BC surface from a negatively-charged surface to a polycationic surface via such a simultaneous reaction. As compared to chitin film (a representative of R-NH 3 + ), the resulting METAC-grafted BC (a representative of high-density R- N(CH 3 ) + ) acquired excellent water absorbability (40 times of dry weight of the BC), 99% antibacterial activity against Escherichia coli and Staphylococcus aureus , a satisfactory in - vitro biocompatibility, and a better in - vivo wound healing outcome with an excellent in - vivo antibacterial efficacy. This study has exhibited potential in utilizing a facile method to prepare a bio-safe, adaptive antibacterial surface for various biomedical applications.
研究领域:
材料科学
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生物医学工程
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化学工程
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微生物学
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DOI
PubMed
高影响因子
DESIGNED MONOMERS AND POLYMERS
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2022
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IF 3.718
Xiang Li,Ye Ju,Yongkang Jia,Fenggang Liu,Guangpu Liu,Shuo Wang,Haoyi Wang,Shihua Mao,Jintao Yang,Guangyan Du
Development of polymer-based flooding technology to improve oil recovery efficiency, water dispersion copolymerization of acrylamide, cationic monomer methacryloxyethyltrimethyl ammonium chloride (METAC), and anionic monomer acrylic acid (AA) were carried out in aqueous ammonium sulfate solution with polyvinyl pyrrolidone (PVP) as the stabilizer. The copolymers were characterized by 1H-NMR, FT-IR, TG, and SEM to confirm that they were prepared successfully and exhibited excellent salt-resistant property. Moreover, the effect of the aqueous solution of ammonium sulfate (AS) concentration, stabilizer concentration, and initiator concentration on the viscosity and size were systematically investigated. To further improve the thermal endurance properties of copolymer, hydrophobic monomers with different alkyl chain lengths were added to the above system. The acrylamide-based quadripolymer possessed prominent thermal and salt endurance properties by utilizing the advantages of zwitterionic structure and hydrophobic monomer. With the temperature rising, the viscosity retention could reach 70.2% in the water and 63.8% in the saline. This work had expected to provide a new strategy to design polymers with excellent salinity tolerance and thermal-resistance performances.
研究领域:
高分子科学
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石油工程
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材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）