查找使用阿拉丁产品的科研文献

Fiber-Optic SPR pH Sensor Based on MMF–NCF–MMF Structure and Self-Assembled Nanofilm

Like Li,Ya-Nan Zhang

High-Sensitivity MMF–TCF–MMF Sensor Based on the Synergistic Effect of Au Film and AgNPs

Fangzheng Wang,Yunhao Ma,Liyin Hu,Xingjun Yue,Xin Yan

In this work, a high-performance sensor based on a multimode fiber-thin core fiber-multimode fiber (MMF–TCF–MMF) structure is demonstrated. By using a continuous Au film and covalently anchored AgNPs on the TCF surface, the synergistic coupling between exciting surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) is realized. Following a systematic optimization guided by COMSOL simulations and experimental validation, the refractive index (RI) sensitivity reached 2525.06 nm/RIU with a figure of merit (FOM) of 9.494 RIU−1, and the temperature sensitivity reached −1.07 nm/°C. The system demonstrated excellent linearity, repeatability, and stability. The proposed sensor effectively merges cost-efficiency with robust precision, showing significant potential for biochemical, environmental, and industrial sensing applications.

An MMF–HCF Reflective SPR Sensor for Simultaneous Measurement of Temperature and Relative Humidity

Chuanxin Teng,Yang Liu,Rui Min,Xuehao Hu,Zujun Qin,Hongchang Deng,Libo Yuan

In this article, a reflective surface plasmon resonance (SPR) sensor based on multimode fiber (MMF)–hollow core fiber (HCF) structure is proposed for simultaneous measurement of temperature and humidity. Along the HCF, two different films, i.e., polyvinyl alcohol (PVA) film and polydimethylsiloxane (PDMS) film are coated on the outer surface to generate two SPR resonances at different wavelengths and achieve the simultaneous measurement function. In order to get a better sensing performance, the length ratio of PVA film and PDMS film, and the PVA coating times are optimized. The experimental results show that the humidity sensitivity of the sensor is 0.6351 nm/% relative humidity (RH) in the RH range of 48%–84% RH, and the temperature sensitivity of the sensor is 1.791 nm/°C in the temperature measurement range of 25 °C–80 °C. The sensor has great potential applications in monitoring the environmental temperature and humidity changes.

The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion

Yanjia Che,Yuanyang Chen,Zhiwei Wang,Sihao Zheng,Kai Xing,Shun Yuan,Xiaohan Zhong

Despite being the gold-standard treatment for end-stage heart disease, heart transplantation is associated with acute cardiac rejection within 1 year of transplantation. The continuous application of immunosuppressants may cause side effects such as hepatic and renal toxicity, infection, and malignancy. Developing new pharmaceutical strategies to alleviate acute rejection after heart transplantation effectively and safely is of critical importance. In this study, we performed a murine model of MHC-full mismatch cardiac transplantation and showed that the combination of Rhodosin (Rho) and mycophenolate mofetil (MMF) could prevent acute rejection and oxidative stress injury and prolong the survival time of murine heart transplants. The use of Rho plus MMF in allografts improved the balance of Tregs/Teff cells, which had a protective effect on allotransplantation. We also isolated bone marrow-derived dendritic cells (BMDCs) and determined that Rho inhibited DC maturation by promoting mitochondrial fusion mainly through the mitochondrial fusion-related protein MFN1. Herein, we demonstrated that Rho, an active ingredient isolated from the plant Rhodiola rosea with antioxidant and anti-inflammatory activities, could efficiently alleviate acute rejection and significantly prolong murine heart allograft survival when used with a low dose of MMF. More importantly, we found that Rho restrained DC maturation by promoting mitochondrial fusion and decreasing reactive oxygen species (ROS) levels, which then alleviated acute rejection in murine cardiac transplantation. Interestingly, as a novel immunosuppressant, Rho has almost no side effects compared with other traditional immunosuppressants. Taken together, these results suggest that Rho has good clinical auxiliary applications as an effective immunosuppressant and antioxidant, and this study provides an efficient strategy to overcome the side effects of immunosuppressive agents that are currently used in organ transplantation.

Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation

Tianliang Fang,Baoqi Li,Meng Li,Yuli Zhang,Zhangyan Jing,Yuan Li,Tianyuan Xue,Zhirang Zhang,Wenli Fang,Zhongda Lin,Fanqiang Meng,Liyan Li,Yang Yang,Xingding Zhang,Xin Liang,Shu-Na Chen,Jun Chen,Xudong Zhang

Immune intervention of B cell activation to blockade the production of autoantibodies provokes intense interest in the field of systemic lupus erythematosus (SLE) therapy development. Although the survival rate for SLE is improved, many patients die untimely. Engineered cell membrane vesicles manifest remarkable capacity of targeted drug delivery and immunomodulation of immune cells such as B cells. Herein, this work engineered cellular nanovesicles (NVs) presenting CD40 (CD40 NVs) that can blunt B cells and thus alleviate SLE. CD40 NVs disrupt the CD40/CD40 ligand (CD40L) costimulatory signal axis through the blockade of CD40L on CD4 + T cells. Therefore, the CD40 NVs restrain the generation of the germinal center structure and production of antibodies from B cells. Furthermore, immunosuppressive drug mycophenolate mofetil (MMF) is also encapsulated in the vesicles (MMF-CD40 NVs), which is employed to deplete immunocytes including B cells, T cells, and dendritic cells. Together, CD40 NVs are promising formulations for relieving autoimmunity and lupus nephritis in MRL/lpr mice.

Furan Carboxylic Acids Production with High Productivity by Cofactor-engineered Whole-cell Biocatalysts

Xue-Ying Zhang,Xin Wang,Nan-Wei Li,Ze-Wang Guo,Min-Hua Zong,Ning Li

Graphical Whole-cell biocatalysis : Cofactor-engineered E. coli cells proved to be versatile catalysts to produce furan carboxylic acids from toxic biobased furans with high productivities. The introduction of NADH oxidase (NOX) into E. coli harboring aldehyde dehydrogenases (ALDHs) significantly promoted intracellular NAD + regeneration, thus enhancing ALDH-catalyzed aldehyde oxidation. A group of aromatic aldehydes was efficiently oxidized to target carboxylic acids. More importantly, these engineered whole-cell biocatalysts displayed high substrate tolerance toward toxic furans. Furan carboxylic acids are useful chemicals in various industries. In this work, biocatalytic production of furan carboxylic acids was reported with high productivities by cofactor-engineered Escherichia coli cells. NADH oxidase (NOX) was introduced into E. coli harboring aldehyde dehydrogenases (ALDHs) to promote intracellular NAD + regeneration, thus significantly enhancing ALDH-catalyzed oxidation. These engineered biocatalysts were capable of efficient aerobic oxidation of a variety of aromatic aldehydes. More importantly, they exhibited high substrate tolerance toward toxic furans. E. coli co-expressing vanillin dehydrogenase and NOX ( E. coli_ CtVDH1_NOX) enabled efficient oxidation of 250 mM of 5-hydroxymethylfurfural (HMF) to 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), providing a productivity of 3.7 g/L h. With E. coli_ CtVDH2_NOX as catalyst, up to 240 mM of furfural and 5-methoxymethylfurfural (MMF) could be smoothly oxidized. 2-Furoic acid (FCA, 227 mM) and 5-methoxymethyl-2-furancarboxylic acid (MMFCA, 287 mM) were produced in fed-batch synthesis, providing the productivities of 2.0 and 5.6 g/L h, respectively.

Simple building blocks from forestry residues via convergent catalytic pathways

Zhe-Hui Zhang,Meng-Ying Liu,Zhuohua Sun,Katalin Barta,Tong-Qi Yuan

Funneling complex lignocellulose into simple and valuable building blocks has garnered significant interest in the field of biorefinery as a competitor to the petrochemical industry. Reductive Catalytic Fractionation (RCF) of lignocellulose, an innovative biorefinery technology, provides a promising strategy for complete valorization of lignocellulose into various valuable chemicals. In this study, integrated processes utilizing RCF strategies were developed to achieve complete conversion of lignocellulose into various simple and valuable platform chemicals. The core of this system is the flexible use of commercial Ni catalysts including Raney Ni and Ni/SiO 2 -Al 2 O 3 which brings great benefits for future upscale and industrial applications. Surprisingly, both monomers derived from lignin and high molecular weight fractions could be converted to 4-ethylcyclohexanol while carbohydrate pulp was converted to furfural and 5-methoxymethylfurfural (MMF) in one-pot. MMF could be further upgraded to 2,5-Furandicarboxylicacid (FDCA) via catalytic oxidation by Ru/C catalysts. This work could inspire the development of more sustainable and economically viable biorefinery processes.