MICROPOROUS AND MESOPOROUS MATERIALS
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2022
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IF 5.876
Xiuxuan Fang,Yingzhi Zhu,Haotian Dong,Na Ma,Wei Dai
In view of unstable Cu-BTC could be destroyed by water molecules, causing a significantly performance decrease of adsorptive desulfurization, a (MOF-818)-on-(Cu-BTC) composite was innovatively designed and synthesized to achieve win-win for enhancing abilities of water-stability and desulfurization in this work. We approved that the novel (MOF-818)-on-(Cu-BTC) desulfurizer was achieved through nitrogen adsorption-desorption, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS), etc. Thiophene (Th), benzothiophene (BT), and dibenzothiophene (DBT) capture performances from different simulated fuels in presence of moisture were systematic evaluated by means of batch tests. Further investigations demonstrated that the (MOF-818)-on-(Cu-BTC) exhibited remarkably sulfur capture ability, attributing to associative effects of specific surface area, nanopores , and acid-base interaction. Importantly, this (MOF-818)-on-(Cu-BTC) impressively retained sulfur capacity and its structural integrity even soaked in water for 7 days. Water-resistant ability was accordance with the order: (MOF-818)-on-(Cu-BTC)＞MOF-818＞Cu-BTC. This novel work would provide a new idea for adsorptive desulfurization by MOF-on-MOF in the presence of water environment.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Analytical Methods
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2025
·
IF 2.6
Wei Li,Xin Hu,Anyi Chen,Rongxin Wu,Chaorui Li
Metal–organic framework (MOF-818) and nanocomposite (Fe3O4@PB-Au) dual nanozymes for enhanced cascade signal amplification were designed. MOF-818 has excellent catechol oxidase mimetic activity and catalyzes the production of color and in situ generation of hydrogen peroxide from the substrate 3,5-di-tert-butylcatechol (3,5-DTBC). Subsequently, Fe3O4@PB-Au with peroxidase-like activity catalyzes the generation of reactive oxygen species from hydrogen peroxide, which oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) to generate the oxidized state of oxTMB, resulting in a signal-enhancing effect. The prepared dual nanozymes can be combined with aptamers with specific recognition ability, thus developing a colorimetric aptamer sensor with high sensitivity and selectivity for detecting Golgi protein 73, which provides a feasible assay for clinical detection of GP73 protein. Detection of GP73 was accomplished by measuring the UV absorption peak at 415 nm. Under the optimal conditions, the concentration of GP73 was linearly correlated with the absorbance in the range of 10.0–100.0 ng mL−1 with a detection limit of 1.83 ng mL−1. The proposed colorimetric biosensor was successfully applied to the determination of GP73 in spiked human serum samples with recoveries of 96.15–100.95% and RSDs of 1.52–6.85%, which demonstrated the great potential of the highly sensitive GP73 assay in clinical detection.
研究领域:
生物化学
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医学检测
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纳米技术
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2024
·
IF 4.9
Xu Liu,Peide An,Yide Han,Hao Meng,Xia Zhang
Cu-based nanozyme shows good oxidase-like activities due to the changeable states of Cu(II) and Cu(I), which are proven to be effective in the electron transfer in the redox process. Herein, the self-made MOF-818 with more Cu(II) loading was synthesized through a modified two-steps hydrothermal routes, which was then used as a sacrificial precursor to construct copper/zirconium composite oxides nanozymes (CN-MOF-818). The pyrolysis temperature was varied to obtain the best enzyme-like activities of the resulting CN-MOF-818. The laccase-like and catecholase-like activities were evaluated by using the oxidation of the mixture of 4-aminoantipyrine (4-AAP) and 2,4-dichlorophenol (2,4-DP), and 3,5-Di- tert -butylcatechol (3,5-DTBC) respectively. The enzyme-like activities were optimized through altering the catalytic conditions, and the corresponding enzyme catalytic kinetics including K m and V max were also determined. The enzyme-like mechanism of the CN-MOF-818 were also discussed based on EPR technique and the in-situ FT-IR analyses. In comparison with the pristine MOF-818 and the other reported Cu-based mimics, the as-prepared CN-MOF-818 exhibits the higher oxidase mimetic activities. These CN-MOF-818 can also be employed to detect the epinephrine with a low detection limit of 1.63 μM.
研究领域:
纳米技术
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催化
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分析化学
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生物化学
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DOI
高影响因子
Food Bioscience
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2025
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IF 5.9
Hai Chi,Yue Xiao,Xuefei Wen,Houqi Ning,Xingzhong Zhang,Hongrui Chen,Jie Tang
This study developed an electrochemical sensor incorporating a dual recognition strategy that integrates molecularly imprinted polymer (MIP) and aptamers for the ultra-sensitive detection of zearalenone (ZEN) in grains. Exploiting the high specific surface area of the Cu-Zr bimetallic metal-organic framework-818 (MOF-818), aptamers were covalently immobilized on the olefin-functionalized MOF-818 surface via thioenol reaction. Employing 3-thiopheneacetic acid functionalized gold nanoparticles (3-TAA@AuNPs) as functional monomers, nanoscale molecularly imprinted cavities were electro-polymerized onto the modified electrode surface in the presence of the ZEN template. This synergistic recognition system integrates the aptamer's specific binding capability with the spatial complementarity of MIP, displaying an excellent linear response over a concentration range of 10 −13 to 10 −5 g/L and a detection limit as low as 2.8 × 10 −14 g/L. Analysis of real samples exhibited ZEN recoveries ranging from 96.5 % to 105.0 % (RSD <5.2 %) in corn and wheat matrices, confirming its practical applicability for rapid screening of fungal toxins in agricultural commodities.
研究领域:
分析化学
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生物传感器
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食品安全
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纳米技术
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电化学
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材料科学
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产品关联
DOI
高影响因子
TALANTA
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2025
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IF 6.1
Shuojiang Liu,Gongke Li,Yuling Hu
The integration of surface-enhanced Raman scattering (SERS) and nanozymes has proven to be a highly effective strategy in bioanalytical applications, owing to its superior capabilities in signal transduction and amplification. Nevertheless, clinical applications still face obstacles, particularly in achieving sufficient selectivity. In this work, we have presented a SERS strategy for the selective detection of dopamine in human urine with MOF-818 which exhibits selective catechol oxidase-like activities. AgNPs@MOF-818 catalyze the oxidation of o -phenylenediamine (OPD) to diaminobenzazine (DAP) molecules, when dopamine (DA) is present, the oxidation of OPD is inhibited while DA is catalyzed into o -quinones, thereby suppressing the SERS signal intensity. An indirect SERS detection strategy of dopamine with high sensitivity and selectivity was established. The catechol oxidase-like activity of MOF-818 provides ideal selectivity to dopamine, while the OPD-dopamine catalytic system induces significant changes in SERS intensity. The detection protocol was subsequently optimized to achieve high sensitivity for dopamine, yielding a linear response range of 0.1–30 μmol/L and a low limit of detection (LOD) of 0.04 μmol/L. The method was successfully applied to the quantitative analysis of dopamine in human urine samples, demonstrating excellent recovery rates and minimal relative error in comparison with results obtained by commercial dopamine ELISA kit. This strategy presents a cost-effective, efficient, and accurate approach for dopamine detection while delivering insights into the integration of selective multifunctional nanozymes with sensitive SERS technique.
研究领域:
生物分析化学
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纳米医学
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临床检验
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分子诊断
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转化医学
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
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2025
·Vol. 192
·期 11
·1-13
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IF 5.3
Wu Chaoqian,Wang Yanlin,Li Nana,Zhang Haoqing,Ge Tida,Yu Shaoning
Bacillus subtilis (BS) effectively suppresses soilborne pathogens and enhances crop resistance through various mechanisms. However, its efficacy is significantly influenced by effective inter-root colonization rates, among other factors, necessitating precise quantitative monitoring for optimal application. Conventional detection methods are often time-consuming and technically demanding, limiting their application in the field. To address this challenge, we developed a dual-recognition biosensing platform. Specifically, tridentate-functionalized aptamer was utilized for rapid BS enrichment and secondary recognition achieved using fragment crystallizable mannose-binding lectin (FcMBL)-modified nanozyme (MOF-818). The rigid scaffold of MOF-818 ensured superior catechol oxidase activity and environmental stability, facilitating sensitive and robust online quantification of BS in complex soil matrices. The linear detection range of the platform was 10 2 –10 7 CFU/mL, and the detection limit was 12 CFU/mL. This work provides a reliable tool for real-time monitoring of BS in agricultural systems, facilitating its efficient use in biocontrol and soil health management. Graphical
A dual-recognition specific colorimetric sensing platform for detecting BS in soil
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Haonan Zhang,Huili Zhao,Yingying Liu,Tuo Ji,Yuzhi Gao,Guohua Chen,Yuwei Bian,Zhiwen Zhao,Kun Yu,Xinwei Li,Xuzhu Gao
The treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) remains a major clinical challenge due to its complex pathogenesis, which involves dysregulated lipid metabolism and severe oxidative stress. To address this issue, we produced a novel and multifunctional nanozyme, MOF-818@UDPG/ASGR1, designed for synergistic therapy via dual-channel lipid regulation and potent reactive oxygen species (ROS) scavenging. The nanozyme was synthesized by functionalizing a trinuclear copper-based MOF-818 core, possessing intrinsic superoxide dismutase (SOD) and catalase (CAT) activities, with uridine diphosphate glucose (UDPG) and an asialoglycoprotein receptor 1 (ASGR1) antibody. The surface-conjugated ASGR1 antibody not only facilitated specific hepatocyte targeting but also triggered intracellular signaling pathways, activated liver X receptor α (LXRα), and promoted cholesterol and lipid efflux. Concurrently, the encapsulated UDPG was delivered intracellularly to the Golgi apparatus, where it could bind to and induce the degradation of site-1 protease (S1P), effectively blocking the proteolytic activation of the key lipogenic transcription factor SREBP1c and suppressing de novo lipogenesis. In both cellular and diet-induced murine models of MASLD, MOF-818@UDPG/ASGR1 showed superior efficacy in alleviating hepatic steatosis, reducing oxidative damage, improving serum lipid profile, restoring liver function (ALT/AST), and protecting against hepatocyte apoptosis. Transcriptomic (RNA-seq) and molecular analyses also validated the coordinated activation of LXRα and suppression of SREBP1c, confirming the proposed synergistic mechanism. This study presents a powerful and rationally designed nano-therapeutic strategy that addresses multiple pathological axes in MASLD, offering a promising and integrated treatment approach.
研究领域:
纳米医学
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肝脏病学
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代谢性疾病
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活性氧生物学
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药物递送
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分子治疗
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2021
·
IF 4.821
Jing Jiang,Yuanyuan Wang,Xianwen Kan
Herein, a label-free and ultra-sensitive sensing strategy was proposed for the colorimetric detection of thrombin. A catechol oxidase-mimicking nanozyme, MOF-818, was in-situ uniformly synthesized on carbon cloth (CC) fibers surface by hydrothermal method, which did not aggregate during the colorimetric sensing and showed high catalytic activity to the oxidation of faint yellow colored substrate 3,5-Di- tert -butylcatechol (3,5-DTBC) to luminous yellow colored 3,5-di- tert -butyl- o benzoquinone (3,5-DTBQ). After the conjugation of aptamer on MOF-818/CC, the nanozyme composite can effectively recognize and bind thrombin, resulting in the lighter color of substrate solution and the decrease of absorbance at 414 nm. Thus, the inhibition of the nanozyme activity by the bound thrombin was employed to detect thrombin in a wide linear range and a low limit of detection of 1.4 × 10 −10 M − 1.4 × 10 −5 M and 6.4 pM, respectively, which was superior to the most of reported methods including fluorescence and electrochemical sensing, Raman spectroscopy. Meanwhile, the nanozyme composite can be easily separated from the substrate solution by a tweezers instead of the conventional centrifugation, which greatly simplified the operation process and facilitated the on-site detection. The nanozyme composite has been successfully applied for the determination of thrombin in real samples with satisfactory results. Consequently, this work is not only important for a better understanding of the unique properties of MOF-818, but also has great potential for medical diagnosis and treatment of human health.
研究领域:
分析化学
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生物传感器
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纳米技术
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医学诊断
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DOI
高影响因子
Current Research in Food Science
·
2025
·
IF 7
Hai Chi,Yue Xiao,Houqi Ning,Xingzhong Zhang,Hongrui Chen,Jie Tang,Xuefei Wen
This study established a unified electrochemical sensing platform for the ultra-sensitive and rapid detection of foodborne pathogens. Targeting three representative pathogenic bacteria— Staphylococcus aureus , Escherichia coli , and Salmonella typhimurium —a composite sensing interface was fabricated by integrating MWCNT-COOH with MOF-818. Highly specific aptamers were directionally immobilized onto the MWCNT-COOH/MOF-818 composite surface through thiol-ene click chemistry, yielding an electrochemical biosensor with superior performance. Experimental results revealed detection limits of 3, 6, and 4 CFU mL −1 for the three target bacteria, respectively. Moreover, the sensor displayed strong detection capabilities in authentic food samples (pork paste). This detection strategy by integrating sample recognition and signal transduction within a single interface can be generalized to multiple pathogens via aptamer substitution, offering a novel technical approach for on-site rapid screening in food safety. This platform holds considerable potential for the prevention and control of foodborne diseases.
研究领域:
生物传感器
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食品安全
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纳米技术
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分析化学
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微生物学
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电化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Jing Tang,Guangping Qin,Qiuhui Wen,Wenhao Li,Liuci Huang,Jian Liang,Zhijiao Tang,Zhengyi Chen,Yumin Wang
The development of a simple-yet-practical and accurate sensing strategy for rapid detection of Alzheimer's disease (AD)-related miRNA in biofluids holds great promise for early diagnosis and monitoring of AD. Herein, a colorimetric/portable Raman dual-mode nanoprobe was proposed for quantification of AD-related miRNA-574-5p in biological fluids. The MOF-818@Au NPs@ssDNA nanoprobe was prepared by step-by-step loading of gold nanoparticles (Au NPs) and ssDNA onto the surface of MOF-818. Strikingly, the adsorbed ssDNA was capable of greatly improving the intrinsic peroxidase-like activity of MOF-818@Au NPs. In the presence of miRNA-574-5p, the ssDNA onto MOF-818@Au NPs will specifically hybridized with miRNA-574-5p, resulting in the desorption of ssDNA from MOF-818@Au NPs and the decrease of nanoenzyme activity for H 2 O 2 -mediated TMB oxidation. Based on this feature, visualization and quantitative analysis of miRNA-574-5p can be successfully realized by observing and measuring changes in output colorimetric/Raman signal from blue TMB oxide (oxTMB) with portable Raman spectrometer. Experimental results demonstrated that the colorimetric/portable Raman dual-mode nanoprobe can be utilized for fast, sensitive and accurate detection of AD-related miRNA-574-5p in complex human serum samples, providing a universal, valuable and practical tool for AD biomarkers detection and AD early diagnosis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
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IF 11.2
Meng Yu,Yi Guo,Shaowen Zhou,Yanhuai Li,Zexing Deng,Xin Zhao,Yong Han
Treating severe burn wounds poses significant challenges, including considerable cell loss, excessive inflammation, and a high susceptibility to bacterial infections. Ideal burn dressings should exhibit excellent antibacterial properties, anti-inflammatory effects, and promote cell proliferation. Additionally, they need facilitate painless dressing changes and be user-friendly. Herein, we synthesized a thermosensitive hydrogel by crosslinking poly (N-isopropylacrylamide-co-allyloxybenzaldehyde) (PNA) and amino-terminated Pluronic F127 (APF) through a Schiff base reaction. It exhibited reversible gel-sol transition and spreadability. By incorporating piezoelectric gold nanoparticle-modified barium titanate (Au@BaTiO 3 ) and cascade antioxidant MOF-818, a nanocomposite hydrogel dressing with diverse bioactive functionalities was developed. Results demonstrated that the nanocomposite hydrogel possessed gel-sol transition properties, maintained a stable gel state within a broad temperature range, and desirable self-healing property. Au@BaTiO 3 exhibited good piezoelectric properties and ROS generation upon ultrasound stimulation, while MOF-818 displayed highly efficient cascade nanozyme activity. The combination of Au@BaTiO 3 and MOF-818 promoted fibroblast proliferation and migration, reduced intracellular ROS levels, and induced anti-inflammatory polarization of macrophages under ultrasound stimulation. In vitro and in vivo antibacterial results disclosed that the nanocomposite hydrogel had excellent antibacterial activity under high-intensity ultrasound stimulation. When applied to infected burn wounds, the nanocomposite hydrogel can rapidly sterilize the wound upon initial high-intensity ultrasound, and then reduce inflammation and promote M2 macrophage polarization by the following low-intensity ultrasound stimulation, and thus accelerating the healing by improving granulation tissue formation, angiogenesis, and collagen deposition.
研究领域:
材料科学
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生物医学工程
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纳米技术
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伤口愈合
·
药剂学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）