OPTICAL MATERIALS
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2025
·
IF 4.2
Wanqiu Chen,Min Fang,Weiju Zhu,Cun Li
In this paper, a sensitive Gd 3+ aggregation-induced emission (AIE) fluorescent quantum dots probe for tetracycline detection was designed based on mercaptopropionic acid (MPA)-capped CdTe quantum dots (MPA-CdTe QDs). Gd 3+ can coordinate with the carboxyl groups on the surface of MPA-CdTe QDs, which triggers the aggregation-induced enhancement fluorescence emission effect. Notably, the fluorescence of Gd 3+ -modified MPA-CdTe QDs (Gd 3+ @MPA-CdTe QDs) is quenched by tetracycline (TC). This fluorescent probe exhibits excellent selectivity and sensitivity, achieving the limit of detection of 4.26 nM. Consequently, the MPA-CdTe QDs show an “on-off” fluorescence response. Tetracycline molecule coordinates with Gd 3+ in Gd 3+ @MPA-CdTe QDs, promoting further aggregation of the quantum dots and forming a network structure. Additionally, the inner filter effect (IFE) contributes to fluorescence quenching. The Gd 3+ @MPA-CdTe QDs probe can be applied for detecting TC in milk and tap water, demonstrating significant application potential. Furthermore, Gd 3+ @MPA-CdTe QDs can be utilized for TC detection in living cells.
研究领域:
分析化学
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生物医学工程
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DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yuting Wang,Jia Liu,Bin Yang,Fengming Zhang,Xin Liu,Shiyue Niu,Shuyun Bi
Based on the fluorescence sensor of 3-Mercaptopropionic acid (MPA) capped CdTe quantum dots (QDs), two novel detection methods for aklomide and nitromide were developed. The MPA-CdTe QDs were synthesized and characterized by transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), ultraviolet visible (UV–vis) and fluorescence (FL). The quenchings were all static. The binding constants ( K a ) at different temperatures were obtained. Electrostatic forces were the main forces for the two bindings. For the detection of aklomide and nitromide, under the optimal conditions, the effects of some metal ions, glucose, bovine serum albumin (BSA) and congeneric drug on the determination were explored. The standard equations were established and the limits of detection (LOD) were 0.0215 and 0.0388 μg mL −1 (3 S 0 / S ), repectively. The methods were applied to analyse the samples of chicken and duck, the recoveries were 99.41 % – 101.24 % with RSDs of 0.29 % – 1.19 % ( n = 5).
研究领域:
分析化学
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食品科学
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DOI
PubMed
高影响因子
CHEMICAL PHYSICS LETTERS
·
2019
·
IF 1.901
Li Liu,Maomin Peng,Hong Xia,Nan Li
3-mercaptopropionic acid (MPA) capped ZnSe:Mn semiconductor nanocrystals (ZnSe:Mn@MPA NCs) were prepared in aqueous solution. It was found that the NCs appear as macroscopic precipitates after stored for 10 d. The change law of the NCs in three distinguished stages was studied. The results displayed that the optical stability of as-prepared NCs capped with MPA stabilizer is correlated with the depletion of MPA, which leads to the decomposition of ZnSe:Mn NCs under the existence of photo-induced holes. ZnS protective layer was formed on the surface of ZnSe:Mn@MPA NCs by epitaxial growth method to inhibit the photodegradation of MPA.
研究领域:
材料科学
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纳米技术
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DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2024
·
IF 4.1
Yu-Jie Xi,Zi-Rong Zhou,Haris Niamat,Jianmin Chen,Feng Wang
In this study, a novel CdSe@PEI-PVP luminescent hydrogel was constructed by using MPA-CdSe quantum dots (QDs) as a single emitter and hydrogen bond cross-linking network between highly branched polyethyleneimine (PEI) and polyvinylpyrrolidone (PVP) as a hydrogel skeleton, in which PEI also works as a passivation ligand for MPA-CdSe quantum dots. Utilizing the dual emission of MPA-CdSe quantum dots and adjusting the surface state of MPA-CdSe with PEI and Cd 2+ , CdSe@PEI-PVP hydrogel can emit bright white light as a whole. Furthermore, CdSe@PEI-PVP shows specific recognition for Cu 2+ , luminescent color changes from bright white to orange when Cu 2+ is added, which enables CdSe@PEI-PVP hydrogel to serve as a fluorescent probe for ion detection. The luminescent hydrogel has great self-healing ability and reversible morphological thermal responsiveness, existing as a white luminescent hydrogel at room temperatures and transforming into a pale green luminescent solution at high temperatures.
研究领域:
材料科学
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分析化学
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环境科学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yan Qiao,Menglin Wang,Erling Guo,Ke Wang,Ling Ma,Kaoqi Lian
This study aimed to design and synthesize a novel adsorbent Fe 3 O 4 @SiO 2 @MPA-TAPA-COF material for the first time and used as an adsorbent of MSPE. It had significant potential for the pretreatment of trace analytes. The MSPE was coupled with ultra performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) for the rapid extraction and detection of 12 sulfonamides (SAs) from water and milk samples for the first time. Several experimental parameters were optimized, including adsorbent dosage and the effects of pH, ionic strength, adsorption time, and desorption conditions. Under the optimized pretreatment and instrumental conditions, good linearity of 0.1–100 μg·L −1 with a correlation coefficient 0.9994–0.9999, low limits of detection (0.004–0.044 μg·L −1 ) and limits of quantitation (0.013–0.136 μg·L −1 ) were obtained. Moreover, the recoveries of sulfonamides in water and milk samples were in the range of 60.88 %-102.94 %, and the relative standard deviations not exceeding 9.62 %. Finally, the magnetic Fe 3 O 4 @SiO 2 @MPA-TAPA-COF material possessed the magnetic separation and high adsorption affinity for extracting SAs from real samples. This study holds great significance in enhancing the monitoring of SAs drug residues in water and milk.
研究领域:
分析化学
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环境科学
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食品科学
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DOI
高影响因子
PANCREAS
·
2010
·Vol. 39
·期 8
·1231
·
IF 2.733
Chen SuYu,Shi Hong,Zou Xiaoping,Luo Hesheng
Objectives: The role of prophylactic ulinastatin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is debated. A meta-analysis of all published randomized clinical trials was performed to evaluate the efficacy of ulinastatin on post-ERCP pancreatitis. Methods: Searches were conducted in multiple databases composed of PubMed, EMBASE, the Cochrane Library, the Science Citation Index Expanded, and the China National Knowledge Infrastructure series full-text database. Primary outcome was post-ERCP pancreatitis, with or without hyperamylasemia. Results: Seven randomized clinical trials fulfilling the inclusion criteria were selected for meta-analysis, 5 comparing ulinastatin with placebo and 2 for ulinastatin versus gabexate. The incidence of post-ERCP pancreatitis was reduced by ulinastatin (odds ratio, 0.53; 95% confidence interval, 0.31-0.89; P = 0.02; test for heterogeneity: I 2 = 0%; P = 0.51), so was the event of hyperamylasemia (odds ratio, 0.42; 95% confidence interval, 0.30-0.59; P < 0.00001; test for heterogeneity: I 2 = 13%; P = 0.33). Subsequent sensitivity and subgroup analyses produced conflicting results. Conclusions: Ulinastatin shows to be of value on preventing post-ERCP pancreatitis and hyperamylasemia for patients in average risk, when given intravenously at a dose of not less than 150,000 U, just before ERCP. More high-quality trials are needed for further confirmation.
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DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 10
·4120
·
IF 4.6
Lei Xing,Hongyang Song,Jinjian Wei,Xue Wang,Yaozhen Yang,Pengbo Zhe,Mingming Luan,Jing Xu
Thin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces the biocompatibility between the implant and the bone tissue, resulting in reduced osseointegration. In the present study, Ti specimens were surface-negatively ionized using a hot alkali activation method, after which polylysine and polydopamine layers were deposited on them using a layer-by-layer self-assembly method, then a quaternary ammonium salt (QAS) (EPTAC, DEQAS, MPA-N+) was grafted onto the surface of the coating. In all, 17 such composite coatings were prepared. AgainstEscherichia coliandStaphylococcus aureus, the bacteriostatic rates of the coated specimens were 97.6 ± 2.0% and 98.4 ± 1.0%, respectively. Thus, this composite coating has the potential to increase the osseointegration and antibacterial performance of implantable Ti devices.Keywords:Ti;polylysine;self-assembly technology;EPTAC;DEQAS;MPA-N+;cell viability;antibacterial properties
研究领域:
生物材料学
·
医学工程
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DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Hao-Hua Deng,Fei-Fei Wang,Xiao-Qiong Shi,Hua-Ping Peng,Ai-Lin Liu,Xing-Hua Xia,Wei Chen
This paper reports a new and facile method for the synthesis of water-soluble thiolate-protected AuNCs via protein-ligand interaction. Using 3-mercaptopropionic acid (MPA) as a model ligand and bovine serum albumin (BSA) as a model protein, water-soluble AuNCs (BSA/MPA-AuNCs) with intense orange-yellow fluorescent emission (quantum yield=16%) are obtained. Results show that AuNCs produced with this method have hydrophobic interactions with BSA. The synthetic strategy is then successfully extended to produce water-soluble AuNCs protected by other thiolates. Moreover, a sensitive and eco-friendly sensing system is established for detection of the activity of inorganic pyrophosphatase (PPase), which relies on the selective coordination of Fe 3+ with BSA/MPA-AuNCs, the higher affinity between pyrophosphate (PPi) and Fe 3+ , and the hydrolysis of PPi by PPase . A good linearity between the fluorescence intensity and PPase activity within the range from 0.1 to 3 U/L is found, with a detection limit down to 0.07 U/L. Additionally, the fluorescent assay developed here is utilized to assay the PPase activity in real biological samples and as well as to evaluate PPase inhibitor, illustrating the great potential for biological analysis.
研究领域:
生物化学
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纳米生物学
·
分析化学
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DOI
高影响因子
Soft Matter
·
2017
·Vol. 14
·期 4
·499-507
·
IF 3.889
Zhaolan Zhai,Xinyan Yan,Zhanqian Song,Shibin Shang,Xiaoping Rao
A novel bio-based anionic surfactant containing a large rigid group and a flexible alkyl chain, namely, sodium N-dodecyl-maleimidepimaric carboxylate (C12-MPA-Na), was synthesized from rosin. The molecular structure of C12-MPA-Na was identified using 1H NMR, FT-IR spectroscopy and MS. Despite containing 36 carbon atoms, C12-MPA-Na showed good water solubility at room temperature. Large spherical aggregates with diameters of 100–200 nm were formed by C12-MPA-Na when its concentration was above 0.1 mM, which was slightly higher than the critical micelle concentration (0.078 mM). Annular wormlike micelles were discovered with increasing C12-MPA-Na concentration, and began to change into extremely long threadlike wormlike micelles when the C12-MPA-Na concentration reached approximately 58 mM. The viscoelastic properties of the wormlike micelle solutions were investigated using steady state and oscillatory shear sweep rheological measurements. The zero-shear viscosity (η0) strongly depended on the concentration of C12-MPA-Na, and the scaling exponent was 34.1. Cryo-TEM confirmed the formation of large spherical aggregates and wormlike micelles. 1H–1H 2D nuclear Overhauser effect spectroscopy (NOESY) was used to detect the molecular interactions of C12-MPA-Na. The results indicated that the alkyl chain of C12-MPA-Na was partially overlapped with its non-planar rigid structure in aqueous solution, and the possible aggregation process for C12-MPA-Na was proposed.
研究领域:
化学
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材料科学
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生物学
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DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2020
·Vol. 15
·期 14
·2153-2159
·
IF 4.056
Zhihong Zhuang,Yicheng Zhang,Liang Hu,Hangjun Ying,Weiqiang Han
Graphical A thiol-assisted one-pot method by using 3-mercaptopropionic acid (MPA) to synthesize carbon-supported metal nanoparticles catalysts for efficient electrocatalytic reduction of carbon dioxide (CO 2 RR) has been reported. The synthesized Au−MPA/C catalyst achieves a FE CO of 96.2% with a CO current density of −11.4 mA/cm 2 , which is much higher than that over Au foil or MPA-free Au/C. The typical preparation route of carbon-supported metallic catalyst is complex and uneconomical. Herein, we reported a thiol-assisted one-pot method by using 3-mercaptopropionic acid (MPA) to synthesize carbon-supported metal nanoparticles catalysts for efficient electrocatalytic reduction of carbon dioxide (CO 2 RR). We found that the synthesized Au−MPA/C catalyst achieves a maximum CO faradaic efficiency (FE) of 96.2% with its partial current density of −11.4 mA/cm 2 , which is much higher than that over Au foil or MPA-free carbon-supported Au (Au/C). The performance improvement in CO 2 RR over the catalyst is probably derived from the good dispersion of Au nanoparticles and the surface modification of the catalyst caused by the specific interaction between Au nanoparticles and MPA. This thiol-assisted method can be also extended to synthesize Ag−MPA/C with enhanced CO 2 RR performance.
研究领域:
材料科学
·
电化学
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环境科学
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DOI
PubMed
高影响因子
Advanced Intelligent Systems
·
2023
·Vol. 5
·期 12
·2300296
·
IF 7.4
Shaoyu Liu,Daohui Zhang,Xin Fu,Liyan Mo,Qile Miao,Rong Huang,Xin Huang,Wei Guo,Yangyang Li,Qingyang Zheng,Ganguang Yang,Kun Bai,Bin Xie,Zhoupin Yin,Hao Wu
Deep-sea exploration remains a challenging task as the extreme hydrostatic pressure environment, darkness, and suspended sediment launch severely hinder the capability of deep-sea vehicles. As a complement to underwater camera, tactile perception becomes especially important in situations where machine vision is limited. However, tactile sensors utilized in deep sea, which should be able to detect pressure changes of only hundreds of pascals under high hydrostatic pressure, are still lacking. To tackle the challenge imposed by hydrostatic pressure, a simulated deep-sea environment flexible sensor (SDEFS) is proposed, consisting of a force sensor array and a bending sensor based on hydrogels for tactile sensing in 50 MPa hydrostatic pressure environments. The force sensor is unaffected by the hydrostatic pressure and achieves high sensitivity of 82.62 N −1 under 100 MPa hydrostatic pressure. The SDEFS is utilized to classify objects based on the difference in hardness. It can accurately classify seven objects on the ground, and three objects in an underwater environment with hydrostatic pressure of 50 MPa, with total recognition accuracies of 98.3% and 96%, respectively. With high force measurement sensitivity and accurate recognition ability under water, the SDEFS is expected to provide very valuable haptic sensing and feedback in deep-sea exploration.
研究领域:
生物医学工程
·
柔性电子
·
水下机器人
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触觉传感
·
深海技术
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DOI
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 6
·929-936
·
IF 1.9
Fan Zhang,Miaomiao Chen,Haiqing Zhang,Huayu Xiong,Wei Wen,Xiuhua Zhang,Shengfu Wang
A sensitive, convenient and rapid fluorescent sensor for effectively and directly detecting propranolol was proposed based on the fluorescence suppression of 3-mercaptopropionic acid stabilized CdTe quantum dots. The fluorescence suppression mechanism between CdTe QDs and propranolol was studied by time-resolved fluorescence spectroscopy, UV-Vis spectroscopy and fluorescence spectroscopy, and it was attributed to the simultaneous action of the inner filter effect (IFE) and dynamic quenching effect (DQE). The effects of the concentration of quantum dots, pH value of buffer solution and incubation time on the fluorescence signal of the propranolol/CdTe quantum dot system were also investigated. The results indicated that, when the experiment was conducted under optimal experimental conditions, the linear range of this assay was 0.1 μM to 2 μM and 5 μM to 200 μM, with a corresponding detection limit of 0.055 μM. Moreover, some common drug excipients and analogues of propranolol and stimulants had no apparent effect on the determination of propranolol. The proposed fluorescent sensor could be readily used for effectively and directly detecting propranolol in biological samples.
研究领域:
分析化学
·
生物医学
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DOI
高影响因子
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