MOLECULES
·
2019
·Vol. 24
·期 17
·3041
·
IF 3.06
Yanqing Liu,Gengxin Hu,Hongwu Wang,Su Yao,Yinjian Ye
A hybrid nanocomposite consisting of hydroxylated multi-walled carbon nanotubes (MWCNTs−OH) and cube mesoporous carbon (CMK−8) was applied in this study to construct an MWCNT−OH/CMK−8/gold electrode (GE) electrochemical sensor and simultaneously perform the electro-reduction of olaquindox (OLA) and carbadox (CBX). The respective peak currents of CBX and OLA on the modified electrode increased by 720- and 595-fold relative to the peak current of GE. The performances of the modified electrode were investigated with electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry. Then, the modified electrodes were used for the individual and simultaneous determination of OLA and CBX. The fabricated sensor demonstrated a linear response at 0.2–500 nmol/L in optimum experimental conditions, and the detection limits were 104.1 and 62.9 pmol/L for the simultaneous determination of OLA and CBX, respectively. As for individual determination, wide linear relationships were obtained for the detected OLA with levels of 0.05–500 nmol/L with LOD of 20.7 pmol/L and the detected CBX with levels of 0.10–500 nmol/L with LOD of 50.2 pmol/L. The fabricated sensor was successfully used in the independent and simultaneous determination of OLA and CBX in spiked pork samples.Keywords:CMK−8;MWCNTs−OH;electrochemical sensor;differential pulse voltammetry;simultaneous determination;carbadox;olaquindox
研究领域:
分析化学
·
环境科学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Guoliang Zhang,Yaolong Zhang,Yu Zhang,Changshun Wang,Jin Tan,Ruxangul Jamal,Tursun Abdiryim,Ahmat Ali
Hydroxyl-functionalized MWCNs and PEDOT are better suited for loading MIP. • The sensor detects pefloxacin at the picomolar level. • Synthesis of ultra-thin tubular PEDOT-OH@Au/MWCNs-OH nanocomposites. • The excellent thin-layered structure offers an efficient electron transport pathway. To safeguard public health and prevent the increase of bacterial resistance, the creation of practical and accurate detection methods for the quantitative analysis of fluoroquinolone antibiotics is essential. In this study, a tubular PEDOT-OH@Au/MWCNTs-OH substrate material was prepared using a one-step in situ oxidation method, with chloroauric acid as the oxidant. Pyrrole (Py) was used as the functional monomer, and pefloxacin (PFX) as the template molecule, to ingeniously design a molecularly imprinted electrochemical sensor (MIP/PEDOT-OH@Au/MWCNT-OH) with sensitive sensing capabilities. As expected, the unique structure and properties of PEDOT-OH@Au/MWCNTs-OH provided the sensor more surface area and enhanced electrochemical activity, increasing the number of distinct recognition sites. Based on experimental results, the MIP/PEDOT-OH@Au/MWCNT-OH sensor showed good anti-interference and stability, a low detection limit of 0.149 nM, S/N = 3, and a broad linear range of 0.002–30 μM. Additionally, the sensor achieved a recovery rate of 97%–103% in detecting PFX in pefloxacin mesylate ointment. This sensor shows promise as a highly selective and sensitive portable detection method for the quantitative analysis of PFX in the environmental monitoring. Download: Download high-res image (239KB) Download: Download full-size image
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高影响因子
MOLECULES
·
2023
·Vol. 28
·期 16
·6103
·
IF 4.6
Lanlan Wei,Yanan Chen,Dongliang Shao,Jingjun Li
In this work, a sensitive analytical method based on packed-nanofiber solid-phase extraction (PFSPE), after derivatization with trichloroacetic acid and high-performance liquid chromatography with a fluorescence detector (HPLC-FLD), has been established for the determination of aflatoxins (AFs) in milk. Polystyrene polymeric multi-walled carbon nanotube (PS-MWCNT/OH) composite nanofibers were fabricated by electrospinning and used to prepare homemade extraction columns. The extraction efficiency of the HPLC-FLD analysis method was sufficiently investigated and validated. After the implementation of optimal conditions, all of the analytes were separated efficiently and the components of the milk matrix did not disturb the determination. The obtained linear ranges of the calibration curves were 0.2–20 ng/mL for AFTB1 and AFTG2, 0.1–10 ng/mL for AFTB2, and 0.4–40 ng/mL for AFTG1. The recoveries ranged between 80.22% and 96.21%. The relative standard deviations (RSDs) for the intra-day and inter-day results ranged from 2.81–6.43% to 3.42–7.75%, respectively. Generally, 11 mg of sorbent and 200 μL of elution solvent were used to directly extract all of the AFs from the milk matrix. Reported herein is the first utilization of PS-MWCNT/OH-PFSPE HPLC-FLD to simultaneously analyze the occurrence of aflatoxins in milk.Keywords:aflatoxins;packed-nanofiber solid-phase extraction (PFSPE);sample preparation;polystyrene polymeric multi-walled carbon nanotube (PS-MWCNT/OH);milk
研究领域:
食品科学
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分析化学
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DOI
PubMed
高影响因子
Small Methods
·
2026
·
IF 8.7
Rimsha Abbas,Muhammad Umair,Zhao Fu,Jingjing Luo,Suzhu Yu,Jun Wei
Omnidirectional strain sensors capable of detecting large and complex deformations are highly promising for wearable motion monitoring; however, achieving both multidirectional strain perception and enhanced electrical sensitivity remains challenging. Herein, a peelable circular piezoresistive strain sensor based on KH570-modified hydroxylated multi-walled carbon nanotubes (m-MWCNT-OH)/Ecoflex is developed through a screen-printing strategy and further functionalized with a copper (II) 2,3,6,7,10,11-hexahydroxytriphenylene (Cu 3 (HHTP) 2 ) conductive metal-organic framework (c-MOF)/poly(3,4-ethylenedioxythiophene) nanofiber (PEDOT-NFs) nanolaminate. The circular sensing architecture facilitates uniform strain distribution and orientation-independent strain transfer, while the c-MOF/PEDOT-NFs coating constructs additional conductive pathways, enhancing strain-induced resistance variation. The sensor is fabricated using a sequential process involving screen printing of the m-MWCNT-OH/Ecoflex sensing layer, peel transfer, and spray deposition of the functional coating. The resulting sensor demonstrates a wide strain detection range of 0%–300%, a gauge factor (GF) of 8, a fast response time of 33 ms, a recovery time of 420 ms, and stable performance over 10 000 loading-unloading cycles. Compared with unmodified sensor, c-MOF/PEDOT-NFs functionalization significantly improves electrical sensitivity while maintaining the intrinsic omnidirectional sensing capability. Finite element analysis (FEA) confirms similar strain-transfer characteristics under different loading directions. The sensor enables accurate monitoring of multidirectional human motions, highlighting its potential for wearable electronics, soft robotics, and human-machine interfaces.
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高影响因子
Environmental Chemistry and Ecotoxicology
·
2025
·
IF 8.2
Huizi Zheng,Zhipeng Zhang,Guanlan Wu,Haoming Sun,Xiaolin Zhu,Jiao Qu,How Yong Ng
Nanoplastics and bisphenols (including bisphenol A and its alternatives) are emerging co-contaminants in aquatic ecosystems, yet their combined toxicological effects remain poorly understood. To address this gap, we developed a novel electrochemical biosensor using HepG2 cells and a nanocomposite of hydroxylated multi-walled carbon nanotubes, poly(diallyldimethylammonium chloride), and boron-doped graphene quantum dots (MWCNT-OH/PDDA/B-GQDs). This unique composite design, verified by density functional theory (DFT) calculations, revealed strong adsorption energies for cellular electroactive substances (xanthine: −1.12 eV; guanine: −1.56 eV), confirming the sensor's superior detection capability. The biosensor was used to assess the cytotoxicity of polystyrene nanoplastics (PS 25 nm ) and five bisphenols individually; their mixture exhibited an additive combined effect. Beyond rapid toxicity screening, we further conducted comprehensive mechanistic investigations through oxidative stress analysis, apoptosis assessment, and transcriptome sequencing. Results indicated that exposure to PS 25 nm and bisphenols, either individually or in combination, induced oxidative stress, as evidenced by decreased glutathione (GSH) levels and reduced superoxide dismutase (SOD) activity. Transcriptome analysis revealed substantial enrichment of differentially expressed genes in the pathways related to protein synthesis, oxidative stress response, and liver disease. This study not only establishes a rapid and sensitive approach for evaluating the toxicity of nanoplastics and bisphenols in aquatic environments but also provides a comprehensive understanding of the underlying mechanisms through integrated multi-level analysis, thereby providing essential mechanistic data to support their comprehensive biosafety assessment and regulatory management.
研究领域:
环境毒理学
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分析化学
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纳米材料
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环境科学
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生物电化学
·
分子生物学
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DOI
高影响因子
危险品化学品经营许可证（带存储）