Nano-Micro Letters
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2023
·Vol. 15
·期 1
·1-19
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IF 26.6
Li Luolin,Yu Zheng,Liu Jianfeng,Yang Manyi,Shi Gongpu,Feng Ziqi,Luo Wei,Ma Huiru,Guan Jianguo,Mou Fangzhi
Micro/nanorobots can propel and navigate in many hard-to-reach biological environments, and thus may bring revolutionary changes to biomedical research and applications. However, current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments. Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment. The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe 3 O 4 nanoparticles encapsulated in a responsive hydrogel shell, and show multiple integrated functions, including energetic magnetically-driven swarming motions, bright stimuli-responsive structural colors, and photothermal conversion. Thus, they can actively navigate in complex environments utilizing their controllable swarming motions, then visualize unknown targets (e.g., tumor lesion) by collectively mapping out local abnormal physicochemical conditions (e.g., pH, temperature, or glucose concentration) via their responsive structural colors, and further guide external light irradiation to initiate localized photothermal treatment. This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflammatory diseases.
研究领域:
生物医学工程
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纳米医学
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智能材料
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 29
·e52649
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IF 3.057
Chen Gao,Junbo Jiang,Juan Wang,Yutong Wang,Yangyang Zhang,Caihua Rao,Yue Cheng,Zhongrong Chen,Runhuai Yang,Gang Zhao
Mineralization of hydroxyapatite mineralized by acidic metal oxides has attracted substantial research interest in the research and development of orthopedic substitutes. In this study, Polycaprolactone (PCL) nanofibers with nano-tantalum oxide (Ta 2 O 5 ) were successfully fabricated through electrospinning. The scaffold simulates the mineralization process of hydroxyapatite in simulated body fluid. However, in the process of mineralization, there is a chemical reaction between hydrophobic scaffolds and acid oxides, which is believed to have a significant impact on the biological effects of the scaffolds. The results of SEM, EDS, XRD, Mapping, FTIR, GPC, 13 CNMR, and 1 HNMR explain the principle of hydroxyapatite mineralization by Ta 2 O 5 and the reason why the composite scaffold is blurred, that is, the carbonyl carbon of PCL attacked by the surface hydroxyl groups of Ta 2 O 5 to catalyze its ring-opening polymerization to synthesize PCL/Ta 2 O 5 nanocomposites in one step. In order to accurately explore the effect of this reaction on the metabolism of biological macromolecules in the future, we provide a detailed route of Ag Nanoparticles -Dimercaptosuccinic acid@Transcription activator (AgNPs-DMSA@TAT) probe synthesis. The results provide a reference for the sedimentation of hydroxyapatite induced by acid oxides and its effect on traditional electrospun fiber scaffolds.
研究领域:
材料科学
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生物材料
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骨科
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生物医学工程
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DOI
高影响因子
ACS Applied Electronic Materials
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2025
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IF 4.7
Huanjing Yang,Shicheng Zeng,Yan Hu,Zengxing Zhang,Zhengzong Sun
Two-dimensional materials have been widely considered as a solution for the further scaling of transistors. The polarity and charge distribution of these materials are critical factors that influence the electrical properties of two-dimensional devices. Current testing methods are limited to postdevice fabrication, preventing the observation of surface charge distribution during device operation. By applying a back gated bias during Kelvin probe force microscopy (KPFM) testing, we successfully obtained the electronic distribution of the channel region in field-effect transistors (FETs) composed of various transition metal dichalcogenides (TMDs), such as MoS2, WSe2, and MoTe2. This method allows for in situ characterization of the intrinsic properties of MoS2 in FETs, independent of the contact influences. Moreover, this approach is applicable to the characterization of N-type, P-type, and ambipolar semiconductor materials, enabling accurate determination of surface potential distribution changes within different FET induced fabrication processes. Our method enables the direct mapping of the electronic distribution and variation trend of the TMD FET materials under biased conditions, providing valuable insight for optimization of the high-performance electronic devices.
研究领域:
纳米电子学
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材料科学
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凝聚态物理
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半导体器件
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二维材料
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纳米尺度表征
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高影响因子
Advanced Sensor and Energy Materials
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2022
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IF 0
Jia Gao,Rui-Yang Zhao,Yi-Guang Wang,Ruo-Chen Xie,Wei Wang
We present a fluorescent microscopic method using an ultra-pH-sensitive polymeric probe to rapidly map within subsecond the pH distribution resulting from oxygen reduction reaction electrocatalysed by an array of platinum nanoparticles. Upon voltammetry of the surface-supported Pt catalysts, fluorescent quenching waves are observed to depend on the electrode potential. The spatiotemporal fluorescent evolution is then confirmed under a constant potential control to be due to the local pH change as a function of diffusing time by an estimation of the proton diffusion coefficient ( L α t 1 / 2 ) . On these bases, the fluorescent measurements at short reaction times can provide quantitative information regarding the one and two dimensional pH distributions, which are shown to exhibit the expected shape of a typical diffusion-driven concentration gradient. Such imaging of proton/pH profiles may find important applications such as efficient screening of different micro/nanoscale electrocatalysts.
研究领域:
分析化学
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电化学
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材料科学
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生物传感器
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DOI
Journal of Advanced Research
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2025
·
IF 13
Baojie Zhu,Jing Zhao,Shaoping Li
Introduction As a key technique in saccharide mapping, polysaccharides analysis using carbohydrate gel electrophoresis (PACE) analysis platform has always been self-assembled and built in various laboratories independently, but there is no unified commercial analysis instrument platform so far. Objective This research aimed to establish an integrated commercially viable PACE analysis platform to standardize the application of PACE in the field of saccharides analysis and the quality control of polysaccharides. Methods We established an online detection platform of saccharide-mapping apparatus (SMA) and took advantage of it to characterize the oligosaccharides for quality control of polysaccharides in herbal medicine. The polysaccharides from Gastrodia elata Bl. were finally selected to verify the potential of SMA including precision, repeatability, stability, and sensitivity. Results The online detection platform of SMA was more integrated and commercially viable, which can investigate oligosaccharides from polysaccharides after hydrolysis more quickly and accurately for quality control. Consequently, it could enable real-time monitoring of oligosaccharide migration, facilitate the determination of the optimal endpoint of polyacrylamide gel electrophoresis (PAGE), and improve the sensitivity of PACE. In addition, the refrigeration device configured in SMA can solve the problem of temperature fluctuation caused by joule heat during gel electrophoresis, which greatly enhances the separation resolution. Finally, the proposed platform was applied to real samples of polysaccharides from Gastrodia elata Bl., and the results successfully distinguished the polysaccharides from Gastrodia elata Bl. with different cultivars. Conclusion The developed online detection platform of SMA offers a rapid and convenient approach for quality control of polysaccharides in Chinese medicines and can be applied for future advancements toward commercialization.
研究领域:
分析化学
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碳水化合物生物化学
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药物分析
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中药质量控制
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高影响因子
Nature Communications
·
2026
·
IF 15.7
Xu Qingyang,Luo Kangwei,Wang Yipu,Wu Jiajie,Lu Hongwei,Chen Manyu,Xiong Zuping,Sun Jing Zhi,Zhang Jianyu,Huang Feihe,Tang Ben Zhong,Zhang Haoke
Multi-axis atropisomers are ubiquitous in nature, and their intricate stereoconformations not only deepen stereochemical understanding but also elucidate fundamental principles of molecular atropisomeric dynamics. Nevertheless, insights into multi-axis atropisomerism remain limited. This work presents a systematic investigation of three classes of LaPlente-type biaxial atropisomers based on naphthalene rotors and phenyl linkers. Thermodynamically and kinetically controlled interconversion of molecular conformations is achieved in 22-NB, 11-NB, and 11-NB-8DMe. Concurrently, a direct correlation between molecular dynamics and electronic through-space conjugation (TSC) is elucidated. Furthermore, absolute separation of syn and anti conformers is accomplished in 11-NB-2DMe, whose distinct TSC-induced fluorescence enables direct visualization of dynamic conformer populations and kinetics during temporally sequential crystallization. This work provides fundamental mechanistic insights into multi-axis atropisomer stereochemistry and establishes a fluorescence-based approach as an in-situ platform for real-time analysis of molecular dynamics across life and materials sciences.
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高影响因子
Nano Research
·
2018
·Vol. 11
·期 4
·1967-1976
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IF 7.994
Wang Xiandi,Ling Rui,Zhang Yufei,Que Miaoling,Peng Yiyao,Pan Caofeng
Mechanoluminescent materials that convert mechanical stimuli to light emission have attracted extensive attention for potential applications in human-machine interactions. Here, we report a simple and available novel approach for the oxygen-assisted preparation of ZnS:Mn particles by solid-state reaction at atmospheric pressure without the formation of the corresponding oxides. The existence of O 2 has a positive impact on the formation of S vacancies in wurtzite-phase ZnS, leading to the introduction of Mn 2+ ion luminescent centers and shallow donor levels, which can improve the electron-hole recombination rate. The O 2 ratio and Mn 2+ ion doping concentration have significant effects on the luminous efficiency, which is optimal at 1%–20% and 1 at.%–2 at.% respectively. In addition, a device based on the piezo-photonic effect with excellent pressure sensitivity of 0.032 MPa −1 was fabricated, which can map the two-dimensional pressure distribution ranging from 2.2 to 40.6 MPa in situ . This device can be applied to real-time pressure mapping, smart sensor networks, high-level security systems, human-machine interfaces, and artificial skins.
研究领域:
材料科学
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光电子学
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传感器技术
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人机交互
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智能材料
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DOI
高影响因子
Cell Reports Methods
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2026
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IF 5.8
Yi-Jun Zhu,Ya-Qian Wang,Hua-Tai Xu
Mapping neuronal connectivity is essential for understanding the structure and function of neural circuits. While high-throughput, cost-effective methods using barcoded rabies viruses provide valuable cellular-level insights, they are limited by the spatial resolution of barcode sequencing. To provide a fluorescent in situ hybridization (FISH)-compatible alternative for spatial barcode readout, we developed the CASS (combination of artificial short sequences) barcode, an error-robust and in situ -hybridization-detectable tool. By combining CASS barcoding with rabies virus monosynaptic tracing, we enable in situ connectome mapping through FISH-based barcode decoding. Using this approach, we identified 1,532 synaptic pairs connected to neurons in the primary visual cortex with spatial precision across three mice, demonstrating its efficiency and scalability. This method provides a FISH-based approach for identifying neuronal connectivity with spatial context and may facilitate future integration of connectivity mapping with molecular profiling, thereby advancing our understanding of neural circuits.
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高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xingchun Zhai,Junjie Li,Weiwei Cheng,Xiaolu Li,Yongheng Zhang,Bingxue Cao,Junjie Wen,Ninghui Zhu,Da Wu,Tao Wang,Fuzhen Xuan,Guoyue Shi,Min Zhang
This study introduces a radial-hierarchical, diffusion-enhanced spatiotemporal sensing paradigm for volatile organic compound (VOC) analysis via an integrated microchamber paper-based chromatomimetic e-nose. The proposed system synergizes interlayer spatiotemporal dynamics with planar spatial variance by employing a radially symmetric electrode array and a hierarchical porous chemoresistive ink (CuP@G). This design leverages molecular diffusion gradients across the sensing plane, enabling precise discrimination of complex VOC mixtures through multidimensional “spatiotemporal fingerprints”. A physics-informed framework integrates molecular transport principles with multitask learning convolutional neural network (MTL-CNN) analytics, achieving unprecedented resolution in real-sample classification. Systematic validation demonstrates superior performance in discriminating diverse VOCs, binary mixtures, and authentic tobacco samples (origin and level classification accuracy: 92–99%). This work establishes a scalable blueprint for high-fidelity VOC analytics, bridging gas diffusion physics with intelligent signal processing to advance e-nose technology toward precision-driven design.
研究领域:
化学传感
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人工智能
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微流控技术
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环境监测
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传感器技术
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分析化学
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纳米技术
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DOI
PubMed
高影响因子
Nature Communications
·
2017
·Vol. 8
·期 1
·1-10
·
IF 12.124
Meng Xianghe,Zhang Hao,Song Jianmin,Fan Xinjian,Sun Lining,Xie Hui
Stiffness matching between the probe and deformed portion of the sample in piezo-drive peak force modulation atomic force microscopy (AFM) limits the modulus measurement range of single probes. Here we develop a magnetic drive peak force modulation AFM to broaden the dynamic range of the probe with direct cantilever excitation. This approach not only successfully drives the softest commercial probe (6 pN nm −1 ) for mapping extremely soft samples in liquid but also provides an indentation force of hundreds of nanonewtons for stiff samples with a soft probe. Features of direct measurements of the indentation force and depth can unify the elastic modulus range up to four orders of magnitude, from 1 kPa to 10 MPa (in liquid) and 1 MPa to 20 GPa (in air or liquid) using a single probe. This approach can be particularly useful for analysing heterogeneous samples with large elastic modulus variations in multi-environments.
研究领域:
材料科学
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纳米技术
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生物物理学
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DOI
高影响因子
ACS Omega
·
2026
·
IF 5.2
Ying Liu,Xiyuan Huang,Xinyi Qu,Dong Xie,Li Ji,Jianhua Zhou
Dental caries is among the most prevalent infectious chronic diseases worldwide, yet localized acidogenic activity associated with cariogenic processes often remains difficult to visualize at the whole-dentition level. This highlights the urgent need for analytical tools that enable imaging of localized acidity-related changes. However, current methods, such as salivary test strips and hand-held pH meters, remain limited to single-point or averaged measurements, lacking the spatial resolution required to visualize the distribution of acidic microenvironments. Herein, we present a conceptual approach that moves from single-point sensing to spatially resolved imaging through an AI-enhanced optical imaging platform for visualizing tooth-surface acidity patterns. The method integrates an imprint-based colorimetric assay using a food-derived pH indicator, with an AI-assisted image analysis workflow guided by dentist-labeled annotations, and explores the feasibility of supervised, annotation-guided image analysis under pilot conditions. By mapping localized acidogenic activity as an indicator associated with cariogenic bacteria, the method provides interpretable spatial readouts of acidic microenvironments. The method allows visual detection of lactic acid at concentrations as low as 5 mM under the tested conditions, and provides multisite results within 5 min, showing qualitative spatial correspondence with clinical findings within this pilot cohort. This approach demonstrates the initial feasibility of treating the dentition as an analytically accessible surface, and explores an AI-assisted analytical concept for relating spatial pH patterns to clinician-identified caries-associated regions on biological surfaces. By combining accessible materials with intelligent data interpretation, this study presents a proof-of-concept pathway toward low-cost visualization of microenvironments for at-home and low-resource settings, offering particular value for children, the elderly, and individuals in remote areas.
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高影响因子
ACS Applied Materials & Interfaces
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2020
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IF 8.758
Simin Peng,Zhen Luo,Shaojie Wang,Jiajie Liang,Chao Yuan,Zhikang Yuan,Jun Hu,Jinliang He,Qi Li
Heterogeneous dielectric materials such as dielectric polymer nanocomposites have attracted extensive attention because of their exceptional insulating and dielectric performance, which originates from the unique space charge dynamics associated with the various interfacial regions. However, the space charge distribution and transport in polymer nanocomposites remain elusive due to the lack of analytical methods that can precisely probe the charge profile at the nanoscale resolution. Although a few studies have explored the possibility of using scanning probe techniques for characterizing the local charge distribution, the interference from induced electrical polarization of the material has been unfortunately ignored, leading to inaccurate results. In this contribution, we report an open-loop Kelvin probe force microscopy (KPFM) method with nanoscale resolution for the direct detection of the space charge profile in dielectric polymer nanocomposites. Unlike the conventional studies where a vertical direct current (DC) voltage is applied on the sample through the probe to evoke the charge injection and transport in dielectric polymer nanocomposites, the present method is established based on a delicate electrode configuration where a lateral electric field is allowed to be applied on the sample during the KPFM test. This special testing configuration enables real-time charge injection and transport without inducing the electrical polarization of material along the vertical direction, which gives rise to clean mapping of space charges and reveals the interfacial charge trapping in polymer nanocomposites. This work provides a robust and reliable method for studying the sophisticated charge transport properties associated with the various interfacial regions in heterogeneous dielectric materials.
研究领域:
材料科学
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电气工程
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纳米技术
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DOI
PubMed
高影响因子
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