One-pot synthesis of Mn3O4 nanorods is reported for the first time by the oxidation of manganese metal resulting from reducing Mn2+ by NaBH4 at room temperature. The resultant Mn3O4 nanorods were 10–70 nm in width and up to hundreds of nanometers in length, and were very stable in aqueous solution. The Mn3O4 nanorods can oxidize H2O2 under acidic conditions quickly accompanying their decomposition. Using 3,3′,5,5′-tetramethylbenzidine (TMB) as a competitive chromogenic substance, colorimetric methods were developed for the sensitive detection of H2O2 and glucose. The methods exhibited a linear range of 2–100 μM with a limit of detection (LOD) of 1.7 μM for detecting H2O2, and a linear range of 5–200 μM with a LOD of 4.4 μM for detecting glucose. The application in analyzing glucose in human serum samples demonstrates its practicability.
Implant-associated infections (IAIs) caused by drug-resistant bacteria remain a critical factor in the failure of implant procedures. Therefore, it is urgent to develop an effective anti-infection coating for implant surface modification to prevent IAIs. Herein, an antibacterial and anti-adhesive coating (CMP-Ti) constructed on the surface of titanium implants is reported, formed by the nanomaterial CeO 2 @Mn 3 O 4 NRs (CM NRs) with antibacterial activity and the superhydrophilic polymer polyethylene glycol (PEG). The nanocatalyst CM NRs on the surface of CMP-Ti induce ferroptosis-like death of bacteria by catalyzing the production of hydroxyl radical (•OH) and singlet oxygen ( 1 O 2 ) and the consumption of glutathione (GSH). The superhydrophilic coating of CMP-Ti can effectively prevent adherence of drug-resistant bacteria and avoid biofilm formation. By combining the “active offense” antibacterial mechanism with the “passive defense” anti-adhesion mechanism, CMP-Ti can kill bacteria and inhibit biofilm formation. The results of in vivo studies showed that CMP-Ti effectively prevented implant-associated infections caused by Methicillin-resistant Staphylococcus aureus (MRSA), thus promoting tissue repair and osseointegration. Therefore, this multifunctional coating combining “active offense” and “passive defense” provides a promising way to prevent IAIs caused by drug-resistant bacteria and to promote tissue repair in the future.
危险品化学品经营许可证（带存储）