Wenhua Zhan,Xiaoxia Cai,Hairui Li,Getao Du,Hao Hu,Yayan Wu,Lin Wang
Multidrug resistance (MDR) is a huge challenge for gastric cancer chemotherapy. Therefore, MDR accurate monitoring is of great significance for the treatment of gastric cancer. GMBP1, an extracellular internalization peptide, can target MDR gastric cancer cells through specific binding to GRP78, which is an MDR-related protein that is overexpressed in gastric cancer cells. Herein, we constructed GMBP1 conjugated Mn3O4 nanoplates (Mn3O4@PEG-GMBP1 NPs) for in vivo monitoring of MDR gastric cancer through magnetic resonance imaging (MRI). The generated Mn3O4@PEG-GMBP1 NPs had a size of about 11 nm and exhibited a good colloidal stability in PBS and in 10% FBS medium. Serial in vivo MRI studies in mice demonstrated that the magnetic resonance signal intensity, at the tumor site, reached a peak at 3 h after tail vein injection of Mn3O4@PEG-GMBP1 NPs. The specific targeting ability of MDR gastric cancer cells (SGC7901/ADR) by Mn3O4@PEG-GMBP1 NPs was authenticated in vitro, in vivo and by immunofluorescence analysis experiments. The systematic safety evaluation indicated that the toxicity of Mn3O4@PEG-GMBP1 NPs in mice was negligible. Therefore, the GMBP1 conjugated Mn3O4 nanoplates can be clinically used for accurate imaging and monitoring of MDR gastric cancer.
Transition-metal oxides are a primary focus in the development of oxygen evolution reaction electrocatalysts due to their demonstrated efficacy. However, the structural characteristics of these materials often necessitate the use of hazardous, multi-step synthesis methods. In this study, we present a straightforward impregnation technique utilizing plant petal templates for the synthesis of catalytic Mn 3 O 4 nanosheets. The resulting lamellar Mn 3 O 4 nanosheets exhibit a 320 mV overpotential at 10 mA cm −2 , a reduced Tafel slope of 131 mV dec −1 , and enhanced durability in alkaline environments. The successful fabrication of these manganese oxide nanosheets may offer a novel approach for the rational design of high-performance OER catalysts.
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