Nanoscale Research Letters
·
2018
·Vol. 13
·期 1
·1-12
·
IF 3.125
Wang Qi,Ma Chunlei,Tang Jianke,Zhang Cuihong,Ma Lihua
Taking advantages of reticular proteins and reductive groups on the surface, eggshell membrane (ESM) was selected to synthesize MnO 2 nanoparticles from potassium permanganate through a super simple way in which ESM acted as both template and reductant. This process avoided harsh reaction conditions or complicated aftertreatments and thus owned the merits of green synthesis, handy operation, low cost, and easy purification. The ESM-templated MnO 2 nanoparticles (MnO 2 NPs/ESM) were characterized, and the content of nanomaterials on the template was tested. MnO 2 NPs/ESM showed a good capacity for decontamination of tetracycline hydrochloride (TCH). The macroscopical materials can be separated easily by taking the membrane out to stop the degradation instead of centrifugation or filtration. It was studied that 72.27% of TCH (50 mg/L) was decontaminated in 20 min by 0.1920 g/L MnO 2 nanoparticles, and removal efficiency could reach 83.10% after 60 min under buffered condition. The kinetics was studied with or without buffer, and it was concluded that the degradation process followed a pseudo-second-order model. The facile synthesis of materials and effective degradation would facilitate the nano-MnO 2 -based decontamination applications.
研究领域:
材料科学
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环境科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Jing Zhang,Min Zha,Shanghua Xiao,Nina Filipczak,Satya Siva Kishan Yalamarty,Xiangping Wu,Chenkai Gong,Xiang Li
Objective Nanoparticles constructed with silver/manganese dioxide (Ag@MnO2) as the core, in conjunction with survivin siRNA (sis) and cyclo(RGD-DPhe-K) (Ag@MnO2-sis-c-L), were prepared for integrated tumor diagnosis and therapy.Methods Ag@MnO2-sis-c-L particles were prepared and characterized. The silver and manganese content were determined by inductively coupled plasma optical emission spectroscopy (ICP-OES). The stability of sis in the system was evaluated by incubation with 50% FBS before the agarose gel electrophoresis experiment. The in vitro photothermal conversion ability, cytotoxicity to 4T1 cells, and cellular uptake of preparations were evaluated. The dialysis technique was employed to determine the in vitro release profile of Ag and Mn from Ag@MnO2-sis-c-L under various pH conditions. The pharmacokinetic behavior and tissue distribution of silver in vivo were detected by ICP-OES. Animal model experiments were conducted to further evaluate the anti-tumor efficacy of Ag@MnO2-sis-c-L against breast cancer in combination with infrared irradiation.Results Our newly synthesized Ag@MnO2-sis-c-L nanoparticles displayed superior physicochemical properties. The combined application of these nanoparticles with photothermal therapy (PTT) exerted the strongest synergistic inhibitory effects on tumor growth. Survivin protein expression in tumor tissues were markedly suppressed following delivery of nanoparticles loaded with sis. Additionally, magnetic resonance imaging revealed the high imaging capability of hybrid nanoparticles.Conclusion This study supports the potential utility of Ag@MnO2-sis-c-L coupled with PTT in therapeutic and diagnostic imaging applications.
研究领域:
纳米医学
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肿瘤学
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生物材料
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分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Energy & Environmental Materials
·
2022
·Vol. 6
·期 3
·e12376
·
IF 13.443
Jiaxin Ren,Yang Ding,Jiang Gong,Jinping Qu,Ran Niu
Harvesting solar energy in an effective manner for steam and electricity generation is a promising technique to simultaneously cope with the energy and water crises. However, the construction of efficient and easy scale-up photothermal materials for steam and electricity cogeneration remains challenging. Herein, we report a facile and cost-effective strategy to prepare MnO 2 -decorated cotton cloth (MC x ). The wide adsorption spectrum and excellent photothermal conversion ability of the in situ-formed MnO 2 nanoparticles make the MC x to be advanced photothermal materials. Consequently, the hybrid device integrated with MC x as the photothermal layer and the thermoelectric (TE) module for electricity power conversion exhibits an extremely high evaporation rate of 2.24 kg m −2 h −1 under 1 kW m −2 irradiation, which is ranked among the most powerful solar evaporators. More importantly, during solar evaporation, the hybrid device produces an open-circuit voltage of 0.3 V and a power output of 1.6 W m −2 under 3 Sun irradiation, and outperforms most of the previously reported solar-driven electricity generation devices. Therefore, the integrated device with synergistic solar-thermal utilization opens up a green way toward simultaneous solar vapor and electric power generation in remote and resource-constrained areas.
研究领域:
材料科学
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能源技术
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Shanyi Wang,Weihao Jin,Yujia Wu,Wanzhen Li,Yugui Tao,Jun Wang,Kai Yang,Weiwei Zhang,Lin Gui,Fei Ge
Drug-resistant bacterial infections pose a significant threat to global public health. Furthermore, the formation of biofilms makes traditional antibiotic treatments significantly less effective in killing multidrug-resistant (MDR) bacteria. In this work, we prepared a molybdenum disulfide (MoS2) nanosphere-based nanocomposite that utilized both photothermal therapy (PTT) and chemodynamic therapy (CDT) for effectively eradicating biofilms. A layer of manganese dioxide (MnO2) was adsorbed onto the surface of the MoS2 nanospheres by redox and electrostatic adsorption methods, and the resulting MoS2/MnO2 were loaded with 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH) to form the MoS2/MnO2-AIPH nanocomposite (MMA). The microenvironment of biofilms is slightly acidic, lacks oxygen, and has a high concentration of glutathione (GSH). The MnO2 was capable of reacting with GSH to deplete it while also generating •OH radicals for CDT. In the presence of NIR light (808 nm), the temperature increase brought about by PTT further enhanced the CDT efficacy synergistically. The results showed that the photothermal conversion efficiency of the MMA was 40.5% at a concentration of 100 μg/mL, and the biofilm eradication rate of both MDR Escherichia coli and MDR Staphylococcus aureus was above 90%. The high bacterial inhibition rate (above 96%), as well as the excellent biosafety and biocompatibility of the MMA nanocomposite enabled it to effectively promote wound healing, which has significant implications in treating bacterial infections and promoting wound healing in clinical settings.
研究领域:
生物医学工程
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材料科学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 25
·20542-20550
·
IF 3.289
Renjie Li,Lifen Liu,Yuehua Zhang,Fenglin Yang
In this paper, nanoscale MnO2 particles were attached onto the surface of a PVDF flat sheet membrane, step by step, first through dispersion of graphene oxide (GO) in the PVDF membrane, then reduction of immobilized GO by hydroiodic acid and further micro-wave assisted oxidation of RGO (reduced graphene oxide) by KMnO4 and formation of MnO2 on GO. The SEM observation revealed an asymmetric structure with a finger-like transition layer dominating the membrane of PVDF/MnO2. The uniform distribution of MnO2 on the membrane is revealed by EDX and XPS analysis. The attached MnO2 endowed the membrane with high adsorption capacity for aqueous Ni(II). The adsorption was spontaneous and endothermic, fitting a pseudo-first-order kinetic model and Freundlich isotherm model well. The pure water flux and stable permeation flux of the PVDF/MnO2 membrane reached 31.2 L m−2 h−1 and 9.0 L m−2 h−1 under 0.1 MPa, which were 2.3 and 2.6 times those of the PVDF membrane. The analysis of the fouling resistance and flux recovery ratio indicated that the PVDF/MnO2 membrane had better antifouling properties than the PVDF membrane, attributed to the changes of membrane morphologies and surface hydrophilicity. The PVDF/MnO2 membrane had a high removal ratio (≥87.4%) of Ni2+ in dynamic adsorption. Meanwhile the Ni(II) adsorbed membrane could be easily regenerated by a 0.1 M HNO3 solution.
研究领域:
材料科学
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环境工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yongping Lu,Wenjin Ye,Weiqi Kang,Shuaibing Wang,Zhongqiang Zhu,Xingyu Chen,Jianshu Li
Wound healing, a global medical issue, poses a substantial financial burden. Therefore, developing low-cost and highly efficacious wound-healing materials is essential. In this study, we prepared keratin–hyperbranched polymer hydrogel-M (KHBP-M), a multifunctional composite gel, by mixing reduced keratin containing free sulfhydryl groups extracted from human hair waste, hyperbranched polymer (HBP) with double bonds at the end, and MnO2 nanoparticles prepared using the biological template method. Keratin has intrinsic wound-healing properties, and MnO2 is a wound-healing material with both photothermal antibacterial and reactive oxygen species (ROS)–scavenging abilities. KHBP-M showed antibacterial effects against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. When exposed to irradiation (808 nm), the killing ratio for S. aureus reached 99.99%, which is especially suitable for wound environments. A similar trend was noted for E. coli. The composite hydrogel also showed excellent ROS-scavenging ability and could resist oxidative stress in L929 cells. Furthermore, in an animal model of infected wounds, the KHBP-M hydrogel treated with near-infrared light had the fastest wound-healing rate, reaching 82.98% on day 15. Our study provides a promising wound-healing material, with simple preparation methods, easy access to sources, and low cost involved.
研究领域:
生物材料学
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医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Xiaochan Liu,Xibin Yi,Jing Zhang,Xinfu Zhao,Sijia Liu,Tingwei Wang,Sheng Cui
Constructing heterostructure in nanomaterials is a scientific and efficient method to optimize the electrochemical properties of supercapacitors. Carbon aerogels (CAs) can enhance electrical conductivity and ion diffusion because of their three-dimensional porous structure, which is useful for fabricating electrodes. The moderate nanoheterostructures in aerogel nanomaterials have made great contributions to the optimization of application performance. Herein, a simple method for constructing the MnO2 nanoparticle/CA (MnO2/CA) heterostructure is proposed. The MnO2/CA heterostructure exhibits outstanding electrochemical capability in a three-electrode system, with a specific capacitance of 384 F/g, higher than 201 F/g of the CA, at a current density of 0.5 A/g. When MnO2/CA is used as a symmetric supercapacitor, it also exhibits a high energy density and power density, with the highest energy density of 33.78 Wh/kg. The prepared MnO2/CA shows improved performance for synergies in providing a high specific capacity and long cycle life.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-11
·
IF 5.3
Tian Siyu,Wang Jiahui,Jie Yu,Ding Zhu,Wang Xiao,Wang Jijiang,Hou Xiangyang
A novel nanobiosensor was constructed by in situ locating nanometer MnO 2 particles with controllable size and morphology in a Zr-MOF substrate to serve as an electrochemical probe. The synergistic effect of the two components, Zr-MOFs with high specific surface area and compatibility as a carrier for MnO 2 , resulted in improved electrochemical activity and excellent electrochemical identification performance for the MnO 2 @Zr-MOF/GCE biosensor. Under optimized experimental conditions and using CV and DPV technology, the biosensor showed a wide linear detection range (2–200 μM), a low detection limit (2.577 × 10 −8 M), a recovery range (106.26–115.01%), and maximum relative standard deviation (5.155) for tetracycline (TC) identification. The recognition mechanism of the sensor was investigated adopting Laviron adsorption theory. The applicability of the sensor was verified through practical measurements. Overall, the MnO 2 @Zr-MOF/GCE sensor possesses the advantages of fast analysis speed, high sensitivity, high selectivity, and simple operation, making it suitable for detecting trace amounts of TC in food. Graphical abstract
研究领域:
分析化学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Mingcong Rong,Yi Huang,Xiaoting Zhuang,Yingming Ma,Haijiao Xie,Yanfang Wu,Li Niu
Tetracyclines (TCs) are the most common antibiotic drugs in the world. However, due to the overuse and difficulty of degradation, TCs pollution is becoming a global threat to aquatic and terrestrial biodiversity. Current methods for detecting TCs mainly rely on fluorescent probes or nanomaterials with enzyme-mimicking catalytic activities , which only provide a single signaling mode and are vulnerable to experimental factors. Herein, this study reports the development of an AND logic-gate-based sensing platform for TCs with fluorescent and colorimetric dual-signal readouts using Au@MnO 2 nanoparticles that could be mutually verified for the selective sensing of TCs. It was found that Au@MnO 2 nanoparticles could oxidize TC into its oxidation state (oxTC), resulting in significant green fluorescence emission . Meanwhile, the MnO 2 shell was etched away, and the released Au core nanoparticles gradually aggregated, with a color change from brown to light blue. As such, we established the fluorescence “turn-on” and colorimetric quantitative relationships towards TC with detection limits of 21.9 and 83.3 nM, respectively. Furthermore, Au@MnO 2 -based analytical paper devices were prepared and demonstrated successfully for the fluorescent and colorimetric dual-signal readout detection of TC in real samples. This paper sheds light on the on-site detection of tetracycline using paper-based analytical devices and smartphones.
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 16
·A3972
·
IF 3.12
Yayun Zheng,Xiaodong Zhang,Yunrui Tian,Huaiping Zhang,Qingping Guo,Yaodong Zhang,Jujie Luo,Ziyan Li
MnO2 nanoparticles were rapidly grown on a carbon fiber cloth (CFC) substrate via microwave solid-state synthesis and used as an electrode material to improve the cycling stability of NiO battery-type supercapacitors. The morphology and electrochemical properties of NiO@CFC and NiO/MnO2@CFC composites were characterised, and the electrochemical properties of the electrode materials prepared under different feeding qualities and microwave conditions were compared. NiO/MnO2@CFC showed a high specific capacitance of 188.3 mAh/g at a current density of 1 A/g and excellent cycling stability (capacity retention of 88.4% after 2000 cycles); these results indicate that the MnO2 nanoparticles improve the cycling stability of CFC-supported NiO supercapacitors (37.8% capacitance loss after 1000 cycles). An asymmetric NiO/MnO2@CFC supercapacitor revealed a competitive energy density of 20.87 Wh/kg at a power density of 850 W/kg. The successful design and synthesis of these composites via the microwave-assisted solid-state method provides a novel strategy for preparing electrode materials for high-performance energy storage devices.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Jingfang Guo,Feng Zhao,Zhenhui Yue,Zhen Lei
Rapid and accurate detection of carbosulfan residues in vegetables is important for ensuring food safety. Herein, based on the unique hydrolysis behavior of carbosulfan, a nanozyme-based colorimetric sensing platform was proposed for detection of carbosulfan. Hollow polydopamine/MnO 2 nanoparticles (H-PDA/MnO 2 NPs) with excellent oxidase-like activity were synthesized, which can promote the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) into blue oxidative product (oxTMB). Under acidic conditions, carbosulfan can be decomposed and produce reductive sulfide species (-SH), which are capable to disintegrate MnO 2 NPs, resulting in decreased oxidase-like activity of H-PDA/MnO 2 NPs. Based on the inhibitory effect on oxidase activity of H-PDA/MnO 2 NPs, an acetylcholinesterase-free colorimetric assay was proposed for detection of carbosulfan with low limit of detection of 0.63 ng mL −1 . Integrating test swabs with smartphone, a portable colorimetric sensor was constructed, showing great potential for on-site detection. To demonstrate the feasibility of this method, carbosulfan in real vegetable samples were determined.
研究领域:
食品安全
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Yujia Luo,Fang Zheng,Yuanyuan Gao,Wenyu Chen,Xinrui Xue,Chujie Xiao,Kun Wei
Chemodynamic therapy (CDT) generating hydroxyl radicals (•OH) by utilizing metal ions reacting with hydrogen peroxide (H2O2) is a highly encouraging strategy for cancer treatment. However, highly expressed GSH in tumor cells severely limits the efficacy of CDT, and CDT alone is also not sufficient to produce excellent antitumor efficiency. Herein, a dual GSH depletion nanosystem (MnO2@PDA@PEG@DOX) was designed and synthesized to achieve synergistic cancer treatment under ultrasound (US) irritation. To achieve an acidic response, dopamine (DA) was loaded onto manganese dioxide, and the water solubility and stability were greatly improved after PEG modification; finally, the loading of doxorubicin (DOX) achieved the combinational therapy. When the nanoparticles arrived at the tumor site, the acidic and high expression of GSH in the tumor microenvironment prompted the degrading of the nanosystem, followed by the release of MnO2 and DOX. The released MnO2 can react with intracellular GSH to produce Mn2+, which realizes chemodynamic therapy by catalyzing H2O2 to generate highly toxic hydroxyl radicals (•OH) at the tumor site; also, the depletion of GSH will significantly promote the level of •OH, improving the efficiency of CDT simultaneously. Moreover, the release of DOX could be boosted by US irradiation, thus enhancing the effect of chemotherapy on DOX and achieving sonodynamic therapy (SDT). Therefore, strategies to enhance CDT efficiency by dual GSH depletion and combining chemotherapy and sonodynamic therapy modalities can provide more ideas and approaches for combination therapy in cancer treatment.
研究领域:
纳米医学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）