The advancement of novel MXene materials characterized by heightened stability and remarkable antibacterial attributes has garnered substantial attention in recent research endeavours. In this article, it is first time to prepare boron dipyrromethene (BODIPY) modified Mo 2 C nanosheets (BODIPY-Mo 2 C) via electrostatic interactions to achieve the desirable antibacterial property, enriching by both photothermal and photodynamic effects. The photothermal conversion efficiency of the produced Mo 2 C nanosheets reached to 42.6 %. Furthermore, in the photothermal antibacterial tests against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), both Mo 2 C and BODIPY-Mo 2 C demonstrated 100 % antibacterial efficiency at a concentration of 100 μg·mL −1 . Remarkably, at a lower concentration gradient of 75 μg·mL −1 , BODIPY-Mo 2 C nanosheets showed clearly enhanced antibacterial capabilities compared to pure Mo 2 C, underscoring the efficacy of BODIPY in boosting the antibacterial performance of Mo 2 C.
Yunfei Chen,Biao Gao,Mingyong Wang,Xiang Xiao,Aijing Lv,Shuqiang Jiao,Paul K. Chu
Dual-phase structures usually have better electrocatalytic activity in the hydrogen evolution reaction (HER) due to synergistic effects . Herein, a novel strategy is proposed to prepare dual-phase MoC-Mo 2 C nanosheets by electro-reduction of CO 2 on the Mo cathode in CaCl 2 -CaO molten salts through an in situ reaction between molybdenum and carbon. The composition of the molybdenum carbide samples can be adjusted by the cell voltage and temperature. As the Mo 2 C contents go up, the HER activity of molybdenum carbide increases initially and then decreases slightly. The dual-phase MoC-Mo 2 C nanosheets prepared at 850 °C and 2.5 V show the best activity due to the hydrogen adsorption-desorption balance. The results reveal an innovative and sustainable strategy to prepare highly efficient HER electrocatalysts and also a green route to recycle and utilize CO 2 .
Diabetic wounds are prevalent complications of diabetes and are difficult to heal because of the complicated pathophysiology. Considering the multifactorial pathogenesis and clinical needs, the combined multifunctional therapy represents the efficient solution for diabetic wound healing, and the key is to find suitable agents possessing multiple responses.Here, we present a two-dimensional (2D) ultrathin molybdenum carbide (Mo 2 C) MXene nanosheets (NSs) to accelerate diabetic wound healing by exerting antioxidant, anti-inflammation, anti-apoptosis and pro-angiogenesis functions. The Mo 2 C NSs are characterized by mixed Mo valence, Mo vacancy and abundant unpaired electrons, and abundant surface groups. The unique structures make Mo 2 C NSs can scavenge reactive oxygen species (ROS) through electron transfer, H atom transfer and enzyme-like catalysis, thus exhibit broad-spectrum and high-efficiency antioxidant capacity, and catalyze oxygen production. The therapeutic efficacy of biologically safe Mo 2 C NSs modified with tannic acid in diabetic wounds has been systematically investigated in cellular and animal models. They can remarkably promote diabetic wound healing by reducing oxidative stress, activating macrophages to polarize toward M2 phenotype, suppressing the inflammatory response, inhibiting apoptosis and accelerating epidermal formation and collagen deposition. This study will facilitate the exploration of multifunctional materials and treatment strategies for diabetic wound healing and ROS/inflammation related multifactorial diseases.
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