MoS 2 has shown potential in enhancing biological scaffolds with sonodynamic therapy. However, its efficacy in generating reactive oxygen species (ROS) is constrained by electron-hole recombination, which results in insufficient ROS levels to penetrate bacterial biofilms. To address this limitation, we adopted a dual-strategy approach by utilizing MoS 2 @Cu 2 O nanozymes with Type-II heterojunctions and enzyme-like activity, thereby enabling dual-mode antibacterial effects via the integration of sonodynamic therapy (SDT) and chemodynamic therapy (CDT). Specifically, we integrated MoS 2 @Cu 2 O nanozymes into poly-L-lactic acid scaffolds via selective laser sintering. Under ultrasound excitation, the electron-hole separation in MoS 2 @Cu 2 O heterojunctions generated 1 O 2 and ● OH outside the bacteria. Both simulation and experiments revealed the carriers’ separation mechanism and transfer path. Meanwhile, the Cu ions released by the scaffolds generated ● OH and consumed glutathione through the Cu + /Cu 2+ cycle, disrupting the redox balance inside the bacteria. A reactive oxygen species storm was formed through the dual attack on the interior and exterior of bacteria, inducing bacterial apoptosis. The obtained inhibition rates of S.aureus and E.coli were 97 % and 96 %, respectively. These results indicate that the MoS 2 @Cu 2 O/PLLA scaffold is promising for dual-mode SDT/CDT efficient antibacterial treatment.
Yan Yu,Haiyu Xie,Tao Zhou,Haonan Zhang,Chenze Lu,Ran Tao,Zhaozhao Tang,Jingting Luo
Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS2@Cu2O-Au nanocomposite conjugation. The MoS2@Cu2O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors.
The extensive usage of rigid polyurethane foam (RPUF) as an energy-saving building materials in construction has raised concerns about fire risks and toxic hazards. To address these challenges, a melamine-derived polyol (MADP) was synthesized using the Mannich reaction, resulting in inherently flame-retardant RPUF materials with the introduction of flame-retardant functional groups. Furthermore, a novel MoS 2 -Cu 2 O nanohybrid was prepared and employed to enhance flame retardancy and suppress smoke toxicity in RPUF through a cooperative effect with expandable graphite (EG). The resulting M-RPUF/EG/MoS 2 -Cu 2 O nanocomposite exhibited remarkable fire safety, as evidenced by significant reductions in peak heat release rate (PHRR), total heat release (THR), total smoke production (TSP), and peak carbon monoxide (CO) release, amounting to 76.9 %, 64 %, 82 %, and 99 % respectively, compared to pristine RPUF. Furthermore, the nanocomposite effectively addressed interfacial defects and significantly enhanced the mechanical property and thermal stability. The significant improvement in fire safety is mainly ascribed to the catalytic charring effect of MADP and EG, as well as the catalytic oxidation of MoS 2 -Cu 2 O nanohybrids, resulting in the formation of a thermally stable protective layer in the condensed phase. Based on these results, the integration of the tri-phase flame retardant system holds great potential for advancing the development of fire-safe polyurethane materials.
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