Food Bioscience
·
2024
·
IF 4.8
Linhui Feng,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The Amadori rearrangement product (GR-ARP) derived from glutathione/ribose mixture (GSH/Rib) was prepared through spray drying characterized by short-term high temperature dehydration. The water activity of spray-dried samples containing GR-ARP decreased continuously with an intensified degree of dehydration. Lower water activity (from 0.23 to 0.13) and higher GR-ARP yield (from 46.56% to 64.02%) in the spray-dried products were found with the increase of inlet temperature, the slowdown of feed speed, and the alkalization of stock solution. Moreover, during the spray drying and formation of powders, the intensified dissipation of bound water to free water promoted intermolecular condensation that compensated bound water, favoring the directed conversion of GSH/Rib into GR-ARP. Compared to rotary evaporation at 80 °C, spray drying enabled a stronger restraint of amide cleavage and sulfhydryl oxidation in GSH, which reduced the yield of GSH-derived byproducts by 16.39%. Thus, GR-ARP was achieved a peak yield of 64.02% at an initial pH of 7.00 based on more efficient intermolecular condensation and controlled side reactions of GSH when the inlet temperature was set at 170 °C. The spray-dried sample containing richer GR-ARP and other flavor precursors showed a more similar flavor profile to the heated GSH/Rib mixture (complete Maillard reaction products) than other GR-ARP-related thermal processing samples, such as vacuum-dehydrated, GR-ARP, GR-ARP + GSH, and GR-ARP + Rib samples, revealing a great potential of the ARP mixture prepared by spray drying for flavor enhancement.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Li-Hui Liu,Jia-Yan Zhang,Guang-Xuan Tang,Yu-Hong Huang,Xiang-Qing Xie,Jun Geng,Hui-Xiong Lü,Hui Li,Yan-Wen Li,Ce-Hui Mo,Hai-Ming Zhao,Quan-Ying Cai
Endophytic bacteria can degrade toxic phthalate (PAEs). Nevertheless, the colonization and function of endophytic PAE-degrader in soil-crop system and their association mechanism with indigenous bacteria in PAE removal remain unknown. Here, endophytic PAE-degrader Bacillus subtilis N-1 was marked with green fluorescent protein gene. Inoculated strain N-1- gfp could well colonize in soil and rice plant exposed to di-n-butyl phthalate (DBP) as directly confirmed by confocal laser scanning microscopy and realtime PCR. Illumina high-throughput sequencing demonstrated that inoculated N-1- gfp shifted indigenous bacterial community in rhizosphere and endosphere of rice plants with significant increasing relative abundance of its affiliating genus Bacillus than non-inoculation. Strain N-1- gfp exhibited efficient DBP degradation with 99.7% removal in culture solutions, and significantly promoted DBP removal in soil-plant system. Strain N-1- gfp colonization help plant enrich specific functional bacteria (e.g., pollutant-degrading bacteria) with significant higher relative abundances and stimulated bacterial activities (e.g., pollutant degradation) compared with non-inoculation. Furthermore, strain N-1- gfp displayed strong interaction with indigenous bacteria for accelerating DBP degradation in soil, decreasing DBP accumulation in plants and promoting plant growth. This is the first report on well colonization of endophytic DBP-degrader Bacillus subtilis in soil-plant system and its bioaugmentation with indigenous bacteria for promoting DBP removal.
研究领域:
环境微生物学
·
土壤学
·
植物-微生物互作
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产品关联
DOI
PubMed
高影响因子
ANALYST
·
2011
·Vol. 136
·期 22
·4770-4773
·
IF 3.913
Ling Chen,Tingting Lou,Chunwei Yu,Qi Kang,Lingxin Chen
An approach for mercury ions (Hg2+) sensing based on the Hg2+-induced aggregation of thymine (T)–SH-functionalized gold nanoparticles (AuNPs) has been reported. The T–SH ligands that we synthesized can easily be coupled to the surface of AuNPs through the Au–S bond and can recognize Hg2+ with high selectivity by forming a T–Hg–T complex with strong affinity. For the T–SH-functionalized AuNPs (T–S-AuNPs) sensor, upon addition of Hg2+, the formation of the T–Hg–T complex induces aggregation of T–S-AuNPs and results in a significant change of color and UV-Vis absorption spectra. Thus, our method can be used for the rapid, easy and reliable screening of Hg2+ in aqueous solution, with high sensitivity (2.8 nM) and selectivity over competing analytes. The developed method is successfully applied to the sensing of Hg2+ in real environmental samples.
研究领域:
分析化学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2022
·
IF 5.318
Caixing Pan,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
This research elucidated the reason of flavor deficiency during the thermal degradation of glutamic acid (Glu)-galactose (Gal) Amadori rearrangement product (GG-ARP) and the solution. The flavor formation from GG-ARP during the thermal degradation was investigated. Compared to the volatile compounds in Glu-Gal Maillard reaction products (GG-MRP), pyrazines in the volatile compounds derived from GG-ARP were restrained. The disadvantage in evolution asynchrony and content sufficiency of α -dicarbonyl compounds and Glu in the GG-ARP model limited the pyrazines formation. With the addition of Gal, the asynchronous effect was further exacerbated, and the furans in the GG-ARP-Gal model (956.81 μg/L, 120 °C, 60 min) were more significantly dominant among the volatile flavor compounds than in the GG-ARP model (454.98 μg/L, 120 °C, 60 min), while the pyrazines were still missing. Whereas, the extra-added Glu in the GG-ARP model could offset the deficiency of amino acids growth after α -dicarbonyl formation and promote the formation of pyrazines (74.47 μg/L, 120 °C, 60 min). Meanwhile, the formation of diketones (92.96 μg/L, 120 °C, 60 min) was promoted. The addition of Glu enhanced both milk-like and baking flavor of the GG-ARP system simultaneously. Formulated GG-ARP-Glu mixture was proposed to promisingly achieve the controlled formation of process flavors for baked foods with both desirable milk-like and baking scent.
研究领域:
食品科学
·
风味化学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-23
·
IF 10.6
Chen Rong,Wang Pinkai,Xie Jiajun,Tang Zinan,Fu Jinlang,Ning Yanhong,Zhong Qiang,Wang Ding,Lei Mingyuan,Mai Huaming,Li Hao,Shi Zhanjun,Wang Jian,Cheng Hao
The proficient handling of diabetic wounds, a rising issue coinciding with the global escalation of diabetes cases, poses significant clinical difficulties. A range of biofunctional dressings have been engineered and produced to expedite the healing process of diabetic wounds. This study proposes a multifunctional hydrogel dressing for diabetic wound healing, which is composed of Polyvinyl Alcohol (PVA) and N 1 -(4-boronobenzyl)-N 3 -(4-boronophenyl)-N 1 , N 1 , N 3 , N 3 -teramethylpropane-1, 3-diaminium (TSPBA), and a dual-drug loaded Gelatin methacryloyl (GM) microgel. The GM microgel is loaded with sodium fusidate (SF) and nanoliposomes (LP) that contain metformin hydrochloride (MH). Notably, adhesive and self-healing properties the hydrogel enhance their therapeutic potential and ease of application. In vitro assessments indicate that SF-infused hydrogel can eliminate more than 98% of bacteria within 24 h and maintain a sustained release over 15 days. Additionally, MH incorporated within the hydrogel has demonstrated effective glucose level regulation for a duration exceeding 15 days. The hydrogel demonstrates a sustained ability to neutralize ROS throughout the entire healing process, predominantly by electron donation and sequestration. This multifunctional hydrogel dressing, which integrated biological functions of efficient bactericidal activity against both MSSA and MRSA strains, blood glucose modulation, and control of active oxygen levels, has successfully promoted the healing of diabetic wounds in rats in 14 days. The hydrogel dressing exhibited significant effectiveness in facilitating the healing process of diabetic wounds, highlighting its considerable promise for clinical translation. Graphical Abstract
研究领域:
生物材料
·
伤口愈合
·
糖尿病
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2012
·
IF 0.633
Shuguang Zhou,Mingxia Xu,Siyu Ye,Dashuai Li,Jing Xu,Pei Mao,Jing Xiong
24 Aza-Michael adducts were synthesised in moderate to excellent yields by the addition of 5-substituted uracils to acrylates with ethylamine as a catalyst. Many of the adducts were obtained in almost quantitive yield without column chromatography. The procedure provideded an efficient approach to the synthesis of N-1 uracil adducts using acrylates as acceptors. The structures of the compounds were determined by 1H NMR, 13C NMR, mass spectra and X-ray crystallography analyses. The uracil unit is present in DNA and related natural products and has a broad spectrum of biological activity.
研究领域:
有机化学
·
药物化学
·
生物化学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Yuehua Li,Shaoxian Li,Weiwei Meng,Lei Dai,Ling Wang
A series of impedancemetric sensors for ammonia detection were fabricated using yttrium stabilized zirconia (YSZ) electrolyte and La n+1 Ni n O 3n+1 (n = 1, 2, and 3) sensing electrodes. The sensing materials with layered perovskite structure were prepared using in-situ impregnation method and well-dispersed in YSZ porous skeleton after calcination at 900 °C. The sensing performances of the sensors with La n+1 Ni n O 3n+1 sensing electrodes were investigated using the impedancemetric modulus |Z| and phase angle Θ as response signals, respectively. The results show that the sensor with La 2 NiO 4+ δ sensing electrode exhibits the higher response values and sensitivity compared to the sensor using La 3 Ni 2 O 7- δ or La 4 Ni 3 O 10- δ sensing electrodes, which is attributed to the largest NH 3 adsorption capacity of La 2 NiO 4+ δ . The response signals |Z| or Θ of the La 2 NiO 4+ δ based sensor linearly depend on NH 3 concentrations. The sensor hardly is insensitive to co-existing gases such as CO 2 , CH 4 , H 2 and relative humidity, but NO or NO 2 causes a positive error.
研究领域:
材料科学
·
化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Fengjiao Lai,Feng Yan,Pengju Wang,Shubin Wang,Shun Li,Zuotai Zhang
The design of stable heteropolyacid (HPA) catalysts with strong Brønsted acidity and mild Lewis acidity is crucial for the efficient conversion of renewable biomass to value-added chemicals. Firstly, a novel strategy was proposed to synthesize the Ce-based HPA of H 5 CeW 12 O 40 . Secondly, the H 5 CeW 12 O 40 was combined with ChCl to form a series of temperature-responsive HPA catalysts (Ch n H 5-n CeW 12 O 40 , n = 1–5), which allowed the catalysts to be applied as soluble catalysts at a temperature >80 °C and be easily separated as an insoluble catalyst at a temperature <80 °C. In the H 2 O/DMSO/MIBK biphasic system, one-pot production of 5-hydroxymethylfurfural (5-HMF) from cellulose was achieved with an excellent yield of 67.5% over ChH 4 CeW 12 O 40 catalysis at 140 °C for 6 h, and other carbohydrates were converted, including fructose (83.1%), glucose (74.2%), sucrose (75.8%), cellobiose (70.2%) and starch (68.7%). Such high efficiency was attributed to the homogeneous catalysis at high temperature, the strong Brønsted acidity of [H 5-n CeW 12 O 40 ] n− , and the appropriate Lewis acidity from Ce(III). Moreover, the temperature-responsive property and the high stability were beneficial for recycling without significant structural change and activity loss.
研究领域:
化学工程
·
生物质能
·
催化化学
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产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Hongmei Chen,Xiaoqin Sun,Xiaoxiang Xu
Here we report two Ruddlesden-Popper type ferrite perovskites (SrO)(LaFeO 3 ) n (n = 1 and 2) which demonstrate p-type semiconductivity. Their crystal structure, optical absorption and other physicochemical properties have been systematically explored. Our results show that both ferrites crystallize in tetragonal symmetry with structural lamination along c axis. Efficient photocatalytic hydrogen production has been achieved for both samples under full range and visible light illumination. Better performance is noticed for LaSrFeO 4 with apparent quantum efficiency approaches 0.31% and 0.19% under full range and visible light illumination, respectively. The p-type semiconductivity is verified by their cathodic photocurrent as well as negative Mott-Schottky slop during Photoelectrochemical measurement. The relative lower activity for La 2 SrFe 2 O 7 compared to LaSrFeO 4 is likely due to its higher defect concentration which facilitates charge recombination. Both compounds exhibit anisotropic phenomenon for charge migrations according to theoretical calculations. Their p-type semiconductivity, strong visible light absorption, chemical inertness and high abundance of constituent elements signify promising applications in the field of solar energy conversion and optoelectronics.
研究领域:
材料科学
·
能源转换技术
·
光电化学
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产品关联
DOI
高影响因子
Crystals
·
2023
·Vol. 13
·期 6
·955
·
IF 2.7
Qi Su,Jingjing Qu,Fei Liu,Changlai Yuan,Xiao Liu,Mingwei Su,Liufang Meng,Guohua Chen
Ti4+-ion-doped (n+ 1)SrO −nCeO2(n= 2) ceramic systems were prepared with the conventional solid-state reaction method, and the effects of the phase structures and compositions, sintering behaviors, microstructures and microwave dielectric properties of these ceramic systems were investigated in detail as a function of TiO2content. The analytical results of the XRD patterns show that the pure (n+ 1)SrO −nCeO2(n= 2) system is a composite-phase ceramic system with coexisting SrCeO3and Sr2CeO4phases (represented as a SrCeO3+ Sr2CeO4system), which belong to the orthogonal structures of the Pmcn (62) and Pbam (55) space groups, respectively. For thexTiO2-(1 − x) (SrCeO3+ Sr2CeO4) (x= 0.1–0.4) ceramic samples, the secondary phase Sr2TiO4can also be detected within the range of the investigated components. Meanwhile, the Raman spectroscopy, SEM-EDS, and HRTEM (SAED) analysis results also verified the correctness and consistency of the phase structures and compositions for all the given specimens. In addition, complex impedance spectroscopy was used to detect the conductive behavior of these compound ceramic systems, and the calculation results show that the appropriate addition of Ti4+-ions can make the SrCeO3+ Sr2CeO4system have better thermal stability. The composition ofx= 0.2 multiphase structural ceramic sample sintered at 1330 °C for 4 h has a near zero τfvalue of ~−4.6 ppm/°C, a moderateεrof ~40.3 and a higherQ×f~44,020 GHz (at 6.56 GHz). The relatively superior-performing ceramics developed in this work are expected to provide a promising microwave dielectric material for communication components.Keywords:phase structures and compositions;SrCeO3+ Sr2CeO4system;TiO2addition;microwave dielectric properties
研究领域:
材料科学
·
陶瓷学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2024
·
IF 3.1
Fangqi Cao,Shuchen Yu,Xiujuan Chen,Lu Xiao,Tingting Qiu,Xiru Wang,Daiwen Zhang,Xiaoliang Yuan,Ping Shi
Synthetic cannabinoids (SCs) are an evolving class of new psychoactive substances (NPS) with structurally various compounds that are increasing over the past few years. Therefore, they are initially hard to identify because of the lack of analytical information. Moreover, there is little to no information regarding the pharmacology of these compounds despite human abuse. In the present study, gas chromatography-mass spectrometry (GC-MS), ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS), and nuclear magnetic resonance (NMR) spectroscopy were used to identify the structure of three compounds obtained from seized materials. The pharmacological properties of these compounds were evaluated by subsequent behavioral testing, including von Frey and cold allodynia tests. The results indicated that these compounds were determined to be 2-(1 H -indazole-3-carboxamido)-3,3-dimethylbutanoate (MDMB-INACA), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1 H -indazole-3-carboxamide (ADB-INACA), and N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1 H -indazole-3-carboxamide (ADB-HINACA) via GC-MS, UPLC-Q-TOF MS and NMR analysis, and they can attenuate mechanical and cold allodynia induced by paclitaxel in rats with peripheral neuropathy. Compared with MDMB-INACA and ADB-HINACA, ADB-INACA showed better analgesic effects on paclitaxel-induced peripheral neuropathy (PIPN) in rats, and its effect was similar to that of the positive drug N′-(1-hexyl-2-oxoindolin-3-ylidene) benzohydrazide (MDA-19).
研究领域:
药理学
·
毒理学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2017
·
IF 1.795
Shan-Shan Zhao,Peng Wang,Li-Na Wang,Lin Fu,Xiao-Meng Han,Jie Qin,Shao-Song Qian
The multidentate Schiff-base ligand N′-(1-(pyrazin-2-yl)ethylidene)isonicotinohydrazide (HL) has been prepared. Reaction with zinc, copper, and silver nitrate afford three complexes, [Zn(HL′)2](NO3)2·3H2O (1), {[Cu2(L)2(NO3)(H2O)2]·NO3}n (2) and {[Ag2(L)2]·3H2O}n (3). These complexes have been characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction. In 1, HL is a neutral tridentate ligand, whereas in 2 and 3, HL is a deprotonated tetradentate ligand. The hydrogen bonding interactions between NO3− and the host framework result in various supramolecular polymeric structures: a 2-D layer for 1 and 3-D network for 2 and 3. The antibacterial activities of these complexes have been investigated and the results indicate that 3 showed good antibacterial activities.
研究领域:
无机化学
·
材料科学
·
药物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）