ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Pengpeng Li,Jiahao Zhang,Yike Jin,Zifan Xu,Guohua Sun
Helical micro-nanomaterials with intelligently controllable, multi-color circularly polarized luminescence (CPL) have garnered significant interest for their promising applications in chiral chemistry, photonics, and electronics. However, the precise and convenient fabrication of multi-color and white CPL-active flexible nanofibers featuring continuous helical topological structures remains challenging, particularly in the deformable solid nanomaterials. In this study, we employed a soft (polyurethane elastomer)/ hard (conjugated helical polymer/ cellulose/fluorescent dyes) bicomponent electrospinning strategy, through which helically chiral luminescent nanofibers with predominant single-handedness were spontaneously formed due to intercomponent strain mismatch. By constructing hierarchical helices from the molecular to the mesoscopic scale, we achieved a biomimetic chiroptical flexible material that exhibits unique chirality amplifications. This work reveals a previously unreported synergistic strategy for the construction of mesoscopic chiral luminescent helical nanofibers. Furthermore, owing to the excellent flexibility and designability of electrospun nanofibers, as well as the unique physical and optical properties provided by chiral helical polymers and mesoscopic helical micro-and nanofibers, the prepared multicolor and white CPL-active nanofibrous films demonstrate promising application prospects in circularly polarized LED devices, blue-light blocking films, and even as substitutes for flexible liquid crystal cells—highlighting the innovation and potential of this research system.
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JOURNAL OF MASS SPECTROMETRY
·
2026
·Vol. 61
·期 9
·e70102
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IF 2.1
Shuyi Wang,Meiying Liu,Ling Ling,Chuan-fan Ding
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of saccharides, particularly high-molecular-weight polysaccharides, is often hampered by low ionization efficiency. To overcome this limitation, we developed a novel composite matrix comprising 4-hydrazinoquinazoline (4-HQ) and caffeic acid (CA). This matrix synergistically enhances saccharide detection: 4-HQ specifically targets the hemiacetal termini of reducing saccharides via hydrazone formation, thereby improving ionization efficiency, while CA maintains an acidic condition for derivatization and extends the detectable mass range. Using dextran 6 k as a model, we systematically optimized the 4-HQ/CA ratio, reaction temperature, and reaction time. The optimized 4-HQ/CA matrix enabled direct profiling of oligo/polysaccharides in inulin and garlic extracts, as well as N-glycans from ovalbumin and fetuin. Notably, even for non-reducing saccharides where derivatization is precluded, 4-HQ/CA outperformed conventional 2,5-dihydroxybenzoic acid (DHB) by detecting more species with higher signal-to-noise ratios. This versatile composite matrix shows potential for robust analysis of saccharides in glycobiology and food science.
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Biomaterials Research
·
2025
·
IF 9.6
Ping Dong,Shaowen Zhang,Ying Zhang,Haifeng Hu,Qing Zhou,Yanzhuo Liu,Zhangfan Mao
Photodynamic immunotherapy, which combines photodynamic therapy (PDT) with immunotherapy, has become an important and effective treatment for cancer. However, most photodynamic immunotherapy systems for cancer do not allow for the precise release of immunomodulators, leading to systemic side effects and poor patient prognosis. This study reports a dual-activatable nanoimmunomodulator (CPPM), whose photodynamic effect and agonist release are both activated in response to specific stimuli, which can be used for precise photodynamic immunotherapy of cancer. CPPM has a half-life of 119 min in circulation and accumulates in tumor tissue 4 h after injection (23.8%). In addition, CPPM is able to achieve tumor localization of nanomedicines through PD-L1-targeting peptides, blocking the specific binding of PD-L1 to PD-1, exposing tumor surface antigens, and reinvigorating the activity of T cells in combination with macitentan to promote T-cell proliferation. Meanwhile, under laser irradiation, CPPM was able to increase intracellular oxidative stress, inhibit cell proliferation through PDT, and trigger immunogenic cell death, further enhancing tumor immunogenicity through synergistic treatment. Ultimately, CPPM enhanced the immunotherapeutic efficiency against tumors by improving the tumor immunosuppressive microenvironment, synergistically inhibiting the growth of primary and distant tumors while activating systemic antitumor immunity to eliminate lung metastases without obvious side effects. This study presents an uncomplicated and multifunctional strategy for the precise modulation of tumor photodynamic immunotherapy with a dual-activatable smart nanoimmunomodulator that can improve the efficacy of PDT, enhance systemic antitumor immunity, and potentially extend it to a wide range of cancers.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Huiyao Yang,Bingxi Song,Peihong Zhang,Qijie Zhu,Fu Ding,Yao-Feng Wang,Guliang Liu,Yanyan Diao,Hongyan Wang
Perfluoro olefins, as one of the most promising fluorinated coolants, support the application of immersion liquid cooling technology. Ionic liquid catalysts exhibit significant potential in olefin oligomerization reactions. In this paper, a variety of thiocyanate ionic liquids with strong nucleophilicity were designed and synthesized for hexafluoropropylene trimerization. DABCO-based ionic liquids exhibited a selectivity 24% higher and a turnover frequency (TOF) 9 times greater than those of conventional catalysts. Under optimal reaction conditions, [C8DABCO][SCN] achieved up to 86.6% selectivity and 151.6 h-1 TOF. As demonstrated by the experimental results and density functional theory (DFT) calculations, the enhanced catalytic efficacy of [C8DABCO][SCN] can be ascribed to the nucleophilic anion, in conjunction with the cation endowed with a cyclic structure and nitrogen atom lone pair of electrons. The trimerization reaction pathway was further proposed based on the product distribution.
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Pharmaceutics
·
2026
·Vol. 18
·期 1
·135
·
IF 5.5
Kai Wang,Ayijiang Taledaohan,Liujia Chan,Yu Lu,Yijiang Jia,Yuji Wang
Background: Diabetic wound healing is hampered by persistent inflammation and excessive neutrophil extracellular traps (NET) formation. Peptidylarginine deiminase 4 (PAD4) is a key enzyme driving this pathology. This study developed a thermosensitive chitosan/β-glycerophosphate hydrogel for the local delivery of a novel PAD4 inhibitor, YJ-2, to promote diabetic wound repair.Methods: A YJ-2-loaded hydrogel (CGY) was synthesized and characterized.In vitrostudies used HaCaT cells and macrophages to assess proliferation, migration, NETs (via H3cit), and polarization. Efficacy was evaluated in diabetic C57 mouse wound models.Results: CGY exhibited temperature-sensitive gelation and sustained YJ-2 release.In vitro, YJ-2 inhibited NETs formation, reduced pro-inflammatory markers, promoted HaCaT migration, and induced M2 macrophage polarization.In vivo, CGY treatment significantly accelerated wound closure.Conclusions: Local hydrogel delivery of the PAD4 inhibitor YJ-2 effectively mitigates inflammation and NETs, promoting healing in diabetic wounds. This strategy represents a promising targeted therapy for diabetic wounds.
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高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 153
·期 10
·3092-3102
·
IF 2.936
Li Yongwei,Pan Shiguang,Han Ronghuan,Gao Jian,Liu Dan,Gui Jianzhou
Phosphotungstate organic–inorganic hybrid materials [CH 2 COOHmim]H 2 PW 12 O 40 , [(CH 2 ) 3 COOHmim]H 2 PW 12 O 40 and [Bmim]H 2 PW 12 O 40 with dual catalytic oxidation active centers, including carboxylic acid group and phosphotungstate anion, were synthesized from bisulfate acidic ionic liquid in a one-step method, and well characterized by XRD, 1 H NMR, 13 C NMR, 31 P NMR, FT-IR, and UV–vis. Then, these obtained hybrids were employed as catalysts for the selective oxidation of N-methylmorpholine (NMM) into N-methylmorpholine-N-oxide (NMMO) using H 2 O 2 as an oxidant. As expected, the –COOH functionalized hybrids showed much better activity than the conventional hybrid [Bmim]H 2 PW 12 O 40 , and even much better than the mixture of corresponding ionic liquid and H 3 PW 12 O 40 , suggesting the existence of dual active species and synergistic effect between the cation and phosphotungstate in hybrids. The best catalyst [(CH 2 ) 3 COOHmim]H 2 PW 12 O 40 gave an NMM conversion of 98.7% and selectivity to NMMO of 98.8%. The structural characterization by 31 P NMR, UV–vis, Raman and 13 C NMR analysis of the catalyst before and after oxidation demonstrated the existence of the catalytic active species PW 12 O 40 3− and peroxy carboxylic acid. Finally, a possible catalytic mechanism has been proposed. Graphical Abstract
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CHEMISTRY OF MATERIALS
·
2023
·
IF 8.6
Kai Yang,Shuo Ma,Youping Wu,Biao Zhao,Jianping Deng
Utilizing achiral fluorophores to fabricate circularly polarized luminescence (CPL) materials is of significant importance in both fundamental research and practical applications; chirality transfer has become an indispensable process in routine efforts reported so far. However, this may restrict or even become a bottleneck in further advancing CPL materials starting from achiral fluorophores. Inspired by biological light-harvesting architectural systems, we attempt to establish a new strategy, i.e., circularly polarized fluorescence energy transfer (CPF-ET) to explore multicolor CPL films in the absence of chirality transfer. CPL has been successfully realized through both radiative energy transfer and nonradiative energy transfer. The material systems consist of chiral fluorescent helical polyacetylene working as a circularly fluorescence polarized energy donor and achiral fluorophores as an energy acceptor. Achiral acceptors absorb circularly polarized fluorescence energy from the donor and hence emit the corresponding CPL; accordingly, chirality transfer is no longer an indispensable condition, and the sense of the CPL emission of the achiral fluorophores is controlled by the chiral fluorescent polymer. Moreover, multicolor CPL films can be simply prepared by employing varying achiral fluorophores. This work provides a facile and versatile platform for achieving CPL by taking advantage of achiral fluorophores.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Ren Han,Zeng Xiang-Zhong,Zhao Xiao-Xiao,Hou Da-yong,Yao Haodong,Yaseen Muhammad,Zhao Lina,Xu Wan-hai,Wang Hao,Li Li-Li
Real-time imaging of the tumour boundary is important during surgery to ensure that sufficient tumour tissue has been removed. However, the current fluorescence probes for bioimaging suffer from poor tumour specificity and narrow application of the imaging window used. Here, we report a bioactivated in vivo assembly (BIVA) nanotechnology, demonstrating a general optical probe with enhanced tumour accumulation and prolonged imaging window. The BIVA probe exhibits active targeting and assembly induced retention effect, which improves selectivity to tumours. The surface specific nanofiber assembly on the tumour surface increases the accumulation of probe at the boundary of the tumor. The blood circulation time of the BIVA probe is prolonged by 110 min compared to idocyanine green. The assembly induced metabolic stability broaden the difference between the tumor and background, obtaining a delayed imaging window between 8–96 h with better signal-to-background contrast (>9 folds). The fabricated BIVA probe permits precise imaging of small sized (<2 mm) orthotopic pancreatic tumors in vivo. The high specificity and sensitivity of the BIVA probe may further benefit the intraoperative imaging in a clinical setting.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2022
·Vol. 331
·期 4
·1759-1767
·
IF 1.754
Liu Yaoyang,Liu Zhibin,Zhao Chuang,Jiao Caishan,Zhang Meng,Zhou Yu,Gao Yang,Li Huibo,He Hui
In order to further study the structure-performance relationship of unsymmetrical diglycolamides. In this work, two types of unsymmetrical diglycolamides (Structure A : N,N’ -dimethyl- N,N’ -didecyl diglycoamide, L I , N,N’ -dimethyl- N,N’ -didodecyl diglycoamide, L III ; Structure B : N,N -dimethyl- N’,N’ -didecyl diglycoamide, L II , N,N -dimethyl- N’,N’ -didodecyl diglycoamide, L IV ), which are geometrical isomers each other, were synthesized, and their extraction performances in 40/60 (v/v)% n-octanol/kerosene were studied and compared. The related results reveal that the size of the alkyl substituents attached on the amide N atoms can influence the extractant performance of the extractant, and the difference in the geometric structure of extractants can lead to the differences in their extraction performances.
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EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Huimin Duan,Lijie Yin,Tao Chen,Dongming Qi,Dongyue Zhang
The interaction between heavy metal ions (e.g. Cu 2+ , Pb 2+ , Cr 6+ ) and bioactive biomolecules can severely cause the “poisoning behavior” due to the secondary structure transition. While in a bioinspiration strategy, functional polymers with the ability of selectively responding to metal ions can be used as effective probe candidate for metal ion detection. Herein, a series of functional substituted polyacetylenes with glycine pendants (P-Gly-NH 2 ) are deliberately designed and synthesized as a fresh member of polymeric probe arsenal for selective ions recognition. According to chemical and structural characterization including FT-IR, NMR, GPC, UV–vis and so on, the synthesized P-Gly-NH 2 polymers with glycine amide pendants possess random coil conformation on the conjugated main chains. Benefit from remarkable water-soluble ability and secondary structure, P-Gly-NH 2 can simulate the biomolecules and apply for heavy metal ions detection in aqueous solution. Because of the complexing interaction with Cu 2+ , the particular “random coil to helical” conformation transition of P-Gly-NH 2 backbone can be observed by UV–vis characterization in ion recognition experiments. Moreover, the relevant results of ions interfering and titration experiments also confirm that this selective detection towards Cu 2+ exhibits an outstanding time-efficiency and reliability with the corresponding detection limitation around 0.128 mg/L. As revealed in UV–vis, Raman, FT-IR and XPS spectra characterization, this conformation transition of P-Gly-NH 2 is owing to the complexing interaction between Cu 2+ and nitrogen atoms in polymer side groups, resulting in an ordered cis -cisoidal helical structures in polymer backbones. In a word, this study not only paves a new way for design and synthesis of water-soluble amino acid-based substituted polyacetylenes, but also implements the functional polymeric probes for selective and sensitive detection of heave ions through a bioinspiration strategy.
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Colloid and Interface Science Communications
·
2022
·
IF 5.633
Yong-Hong Gao,Kuo Zhang,Meng-Ru Ding,Xue-Feng Gong,Hui Cao,Lei Wang
Binding-induced fibrillogenesis (BIF) peptides have a promising future in biomedicine due to the processiblity in situ in vivo, which bind to a specific trigger and in situ self-assemble into nanofibrous structures (BIF process) with excellent physical/biological functions. Alkyl chains in BIF peptides as hydrophobic tails have an important effect on self-assembly behaviors of BIF peptides. Herein, BIF peptides (trigger: Ca 2+ or integrin) with different hydrophobic alkyl chains are designed to explore the influence of hydrophobicity on self-assembly behaviors of BIF peptides (Abbreviation as BIF 4 , BIF 8 , and BIF 16 for 4, 8, 16 carbons of alkyl chains). It is found that BIF peptides with weak hydrophobicity (BIF 4 ) do not form fibrous structure upon binding to Ca 2+ , but in nanoparticle formulation. While with strong hydrophobicity, BIF 16 initially self-assemble into nanoparticles, which further bind to Ca 2+ and self-assemble into nanofibers with a β-sheet conformation. As a result, when incubated with HUVECs overexpressing integrins on surfaces, BIF 4 were internalized as nanoparticles without BIF process, but BIF 16 performed BIF process and attached on cell surfaces. This study provides experimental evidences of the hydrophobicity effect on self-assembly behavior of BIF peptides and directs applications of BIF peptides with controllable self-assembly
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高影响因子
POLYMER
·
2022
·
IF 4.432
Shenghua Du,Songsong Li,Ning Xie,Yaoyao Xu,Qiang Weng,Xingming Ning,Pei Chen,Xinbing Chen,Zhongwei An
A variety of poly (ether sulfone)s based anion exchange membranes (AEMs) rPES(x/y)-Q with high-density heterocyclic quaternary ammonium groups is prepared by a polycondensation of novel difluoro monomer with biphenol and bis(4-fluorophenyl) sulfone . The AEMs rPES(x/y)-Q exhibit low IEC values in the range of 0.82–1.33 mequiv. g −1 but relatively high hydroxide conductivity of 54.1–82.3 mS cm −1 at 80 °C. Moreover, the AEMs rPES(x/y)-Q display affordable water uptake and good stability due to their rigid side-chain, high-density and stable heterocyclic quaternary ammonium cations. Noticeably, the rPES(5/20)-MPy based single fuel cell displays a large maximum power density of 141 mW cm −2 , which reveals a potential application in anion exchange membrane fuel cell.
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