APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Ying Meng,Lin An,Xin Han,Yaogang Li,Chengyi Hou,Qinghong Zhang,Hongzhi Wang
(Ga 1−x Zn x )(N 1−x O x ) has attracted extensive attention in photoelectrochemical (PEC) water splitting for its narrow and controllable band gap recently. For optimizing PEC performance of (Ga 1−x Zn x )(N 1−x O x ) photoanodes, the key points are to tailor its band gap and improve the light harvesting. In this work, black silicon prepared by metal-assisted chemical etching (MACE) is selected as the substrate of photoanodes, owing to its excellent features such as porous structure and much lower reflective index compared to smooth Si wafer. Moreover, a rapid and effective synthesis method is developed to prepare (Ga 1−x Zn x )(N 1−x O x ) nanorods with ZnO content from 16 to 94% on black silicon. As prepared black silicon/(Ga 1−x Zn x )(N 1−x O x ) nanorods were characterized by XRD, FESEM, EDS, XPS, TEM and UV–Vis et al. The (Ga 1−x Zn x )(N 1−x O x ) nanorods with a diameter of 200 nm and an aspect ratio of 15 are directly grown on black silicon as photoanodes, which lead to much better light harvesting and better interface adherence. As a consequence, the photocurrent density of black silicon/(Ga 1−x Zn x )(N 1−x O x ) nanorods photoanode is 55 μA/cm 2 , almost 5.5 times higher than (Ga 1−x Zn x )(N 1−x O x ) nanorods on single-crystal silicon under the same conditions. The result indicates that the (Ga 1−x Zn x )(N 1−x O x ) nanorods grown on black silicon as photoanodes have great potential application in the PEC water splitting.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Jingjing Dong,Yanli Wang,Ying Chen,Qin Wang,Bo Zhang,Xiaoxiao Li,Zhengyu Jin,Yuxiang Bai
The recently characterized Limosilactobacillus reuteri N1 GtfB (LrN1 GtfB) from glycoside hydrolase family 70 is a novel 4,6-α-glucanotransferase acting on starch/maltooligosaccharides with high enzyme activity and soluble protein yield (in heterogenous system). In this study, the influence of the treatment by LrN1 GtfB on the fine structure and functional characteristics of three maize starches were furtherly investigated and elucidated. Due to the treatment of LrN1 GtfB, the starch molecules were transformed into reuterans containing linear and branched (α1 → 6) linkages with notably smaller molecular weight and shorter chain length. Moreover, the (α1 → 6) linkage ratios in the GtfB-modified high-amylose maize starch (GHMS)/normal maize starch (GNMS)/waxy maize starch (GWMS) increased by 18.3 %/12.6 %/9.0 % as compared to their corresponding controls. In vitro digestibility experiment revealed that the resistant starch content of GHMS, GNMS and GWMS increased by 16 %, 18 % and 25 % as compared to the starch substrates. Furthermore, the butyric acid yielded from GHMS, GNMS and GWMS in the in vitro fermentation experiments were 1.4, 1.5 and 1.4 times higher than those of commercial galactose oligosaccharides . These results indicated that the highly-branched short-clustered reuteran synthesized by LrN1 GtfB might serve as novel potential prebiotics , and provide insights for the synthesis of promising prebiotic dietary fiber from starch.
研究领域:
食品科学
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微生物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Chen Cheng,Jingjie Wu,Zhiqiang Huang
In this study, a novel collector, N 1 ,N 10 -dihydroxydecanediamide (DHH) was synthesized in our lab and introduced in flotation of malachite ore. The separation performance and action mechanism of DHH were explored and compared with octyl hydroxamic acid (OHA). The results of single mineral flotation tests indicated that DHH exhibited a stronger collecting ability to malachite and better selectivity against quartz and calcite than OHA, and floated out 94 % malachite, 8.5 % quartz and 17 % calcite at pH = 10 with a collector concentration of 60 mg/L. The FTIR spectra, zeta-potential tests and XPS tests proved that DHH could absorb onto malachite surface though a chemical mode. DFT calculation results showed that DHH anion owned a stronger affinity to malachite than DHH molecular and OHA anion/molecular, and its bis-minerophilic groups could form C(=O)NHO-Cu bond with surface Cu atom. It exhibited that DHH was an excellent candidate and capable for high efficiency flotation of malachite ore.
研究领域:
矿物加工工程
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
IMMUNITY
·
2025
·
IF 26.3
Zheng-Yu Liu,Cai-Yuan Wu,Rui-Qi Wu,Jun-Cheng Wang,Chun-Xiang Huang,Xu-Yan Wang,Yaojun Zhang,Limin Zheng,Yun Chen,Xiang-Ming Lao,Dong-Ping Chen,Dong-Ming Kuang
Metabolic reprogramming is a hallmark of tumor progression. Here, we examined the metabolic profile of hepatocellular carcinoma (HCC), a disease that responds poorly to immune checkpoint blockade (ICB). Polyamine metabolism increased in HCC samples. Of the polyamine spectrum analyzed, N1-acetylspermidine (N1-Ac-Spd) accumulated in HCC tissue as compared with nontumoral liver tissue and was elevated in paired plasma. Injection of N1-Ac-Spd promoted tumor progression in preclinical models and compromised the efficacy of ICB. Inflammatory macrophages increased expression of the spermidine/spermine N1-acetyltransferase 1, SAT1, in hepatoma cells, leading to increased N1-Ac-Spd efflux via the polyamine transporter protein SLC3A2. Mechanistically, N1-Ac-Spd efflux activated SRC signaling in a charge-dependent manner, which in turn induced CCL1 + macrophage polarization, the recruitment of CCR8 + regulatory T cells, and an immunosuppressive tumor microenvironment (TME). In vivo interventions targeting SLC3A2, SAT1, or CCL1 enhanced the antitumor effects of ICB therapy. Our findings provide insight into the mechanisms whereby metabolic reprogramming fosters an immunosuppressive TME, with implications for the treatment of HCC.
研究领域:
肿瘤学
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免疫学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 16
·7862-7872
·
IF 3.3
Zhuhui Chen,Yue Xiong,Ranran Ma,Pei Chen,Le Duan,Shuying Yang,Ineza Urujeni Gisèle,Linjun You,Deli Xiao
To overcome the low concentration and matrix complexity of N1-methylnicotinamide (MeNam) in biological samples, this work developed a method for the detection of MeNam in urine samples using a Fe3O4@hydroxypropylmethylcellulose@2,3-dimercaptosuccinic acid (Fe3O4@HPMC@DMSA) magnetic fluid as a pre-treatment material in combination with high performance liquid chromatography. The novel adsorbent material exhibited ultra-fast adsorption kinetics and a large adsorption capacity because Fe3O4@HPMC@DMSA NPs acted as a homogeneous magnetic fluid with more varieties and quantities of interaction sites (hydrogen-bonding interaction and electrostatic interaction). The limit of determination for MeNam was 0.05 μg mL−1 with Fe3O4@HPMC@DMSA NPs. Recoveries of spiked urine samples ranged between 95.49% and 106.4%, indicating that the developed method was promising for the accurate quantification of trace amounts of MeNam in urine samples. It provides research value for the rapid assessment of the nutritional effects of NMN dietary supplements and offers a sensitive assay for metabolism studies of related functional foods.
研究领域:
分析化学
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生物医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2023
·
IF 5.7
Guandong Liang,Jianqiang Bi,Linjing Qiao,Shaoyin Wang,Yao Yang,Zhuangzhuang Yin
In view of the lack of a conformal, load-bearing, lightweight, and high-temperature resistant integrated microwave-absorbing composites for applications under extremely complex conditions, this study successfully applies gel casting craft to porous Si 3 N 4 microwave-absorbing composites. The high-temperature decomposition reaction of Ti 3 SiC 2 powder was utilized to generate uniform Ti-C x -N 1−x grains in situ and to enhance the mechanical and microwave-absorption properties of porous Ti-C x -N 1−x /Si 3 N 4 composites. The bending strength , fracture toughness, density, maximum reflection loss value, absorption bandwidth and matched thickness in P-band of the composite with 30 wt% Ti 3 SiC 2 addition were 164.87 ± 7.56 MPa, 2.61 ± 0.13 MPa·m 1/2 , 2.077 g/cm 3 , 32.42 dB, 1.74 GHz and 4.2 mm, respectively. The fracture toughness and bending strength of the composite were increased by 71.71% and 58.13%, respectively, compared with monolithic porous Si 3 N 4 . The electromagnetic wave loss mechanisms of the composites are proposed as a combination of conductivity loss, multiple reflections and scattering, interfacial polarization and defect polarization.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2021
·
IF 3.365
Yan-Ying Xu,Fei Qin,Yi-Xin Dai,Xue-Feng Zhong,Juan Yan,Su-Mei Xu,Ping-Sheng Xu
This study aimed to develop an LC-MS/MS method for determining sildenafil and its metabolites N -desmethylsildenafil and N1,N4 -desmethylsildenafil in human plasma and applying it to a pharmacokinetic study of sildenafil in healthy volunteers. Sildenafil-d8 was used as the internal standard. Plasma samples were pretreated via protein precipitation with acetonitrile . The extractives were then separated on an ACQUITY UPLC BEH C18 (50-mm × 2.1-mm, 1.7-μm) column using gradient elution . The aqueous and organic mobile phases were ammonium formate 2 mM supplemented with 0.1% formic acid in water and acetonitrile, respectively, and the flow rate was 0.3 mL/min. An electrospray ionization source was applied, and multiple reaction monitoring was operated in the positive mode with selective channels at m / z 475.30 → 100.10, 461.20 → 283.30, 483.30 → 108.10, and 449.00 → 283.00 for sildenafil, sildenafil-d8, N - desmethylsildenafil, and N1,N4 -desmethylsildenafil, respectively. The linear calibration curves of sildenafil and its metabolites spanned 1.0–1000 ng/mL. The lower limit of quantification was 1.0 ng/mL. The extractive recovery of analytes from the biological matrix was more than 90% and the matrix effect complied with relevant provisions. The intra- and inter-day precisions of sildenafil and its metabolite were <10%. The intra- and inter-day accuracy of sildenafil, N - desmethylsildenafil, and N1,N4 -desmethylsildenafil was more than 99%. The method is highly sensitive and selective, and it was successfully applied to the bioequivalence studies of 100-mg sildenafil citrate tablets in 40 healthy Chinese volunteers.
研究领域:
药物分析
·
临床药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Yunlei Zhou,Yue Wang,Shurong Li,Xi Fang,Huanshun Yin,Po Wang,Shiyun Ai
Photoelectrochemical (PEC) immunosensor was designed to detect N 1 -methyladenosine (m 1 A), where BiVO 4 /g-C 3 N 4 heterojunction was employed as photoactive material, polyamidoamine (PAMAM) and 4-carboxyphenylboronic acid (CPBA) were used as m 1 A antibody immobilization matrix, and Ti-based metal-organic framework encapsulated heterostructure of TiO 2 @NH 2 -MIL-125(Ti) was adopted as signal amplification. Due to the interaction between TiO 2 and phosphate, TiO 2 @NH 2 -MIL-125(Ti) was captured after immunoreaction between m 1 A and its antibody, which can further improve the detection sensitivity with increased PEC response. Under optimal experimental conditions, this method presented wide dynamic range (0.05–35 nM) with the low determination limit (16.7 pM, S/N = 3). This detection strategy showed good detection reproducibility, stability and selectivity. This method was applied to assess the effect of antibiotics on m 1 A content in the leaves, stems and roots of rice seedlings.
研究领域:
分析化学
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环境科学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Yu-Fang Ma,Fang Yuan,Yue Yu,Ying-Lin Zhou,Xin-Xiang Zhang
A facile and rapid postsynthetic modification strategy for functionalization of covalent organic framework (COF) was developed to synthesize a tailor-made pH-responsive COF called TpPa-1@Au@GSH for highly efficient extraction of N1-methyladenosine (m1A). Glutathione (GSH) was judiciously designed as the functional group for extracting and releasing m1A by pH variations. With the aid of gold nanoparticles (Au NPs) as linkers, GSH was successfully introduced to the robust substrate TpPa-1 in only one step spending only 1 h. Owing to the several-to-one immobilization of GSH on Au NPs and the large surface area of TpPa-1, this functional COF was constructed with abundant m1A binding sites. TpPa-1@Au@GSH showed excellent selectivity for m1A extraction by capturing m1A from a mixture of 14 nucleoside analogues followed by mass spectrometry analysis. It was proved to have ultrafast adsorption ability (only 1 min incubation time), high binding capacity (5 mg g–1, m1A/TpPa-1@Au@GSH), good reusability (at least 5 times), and good storage stability (at least 8 months at room temperature). Great performance was also achieved in extracting m1A from both animal and plant biological samples. The adsorption mechanism was demonstrated to be based on the electrostatic interaction. This work proposed a new approach for m1A extraction, demonstrated the high potential of COFs in biological sample pretreatment, and offered an effective and versatile route for functionalization of COFs.
研究领域:
材料科学
·
分析化学
·
生物技术
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADSORPTION SCIENCE & TECHNOLOGY
·
2017
·
IF 0.754
Weichao Du,Xiaolin Pu,Jinsheng Sun,Xiao Luo,Yanna Zhang,Lu Li
A novel monomeric amine sodium montmorillonite swelling inhibitor: N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide was obtained from diethanolamine, 1-bromotetradecane, and 1, 2-dibromoethane. N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide was characterized by means of Fourier transform infrared, 1H NMR spectroscopy, elemental analysis, linear swelling tests, particle size distribution tests, X-ray diffraction, and thermogravimetric. Linear swelling tests showed that the swelling height of sodium montmorillonite in 1.0 wt% N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide solution was only 2.0 mm after 16 h (fresh water was 5.0 mm). Particle size distribution tests exhibited that the median diameter and mean particle size of sodium montmorillonite in 1.0 wt% N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide solution obviously increased to 16.1 and 85.4 µm, respectively (fresh water was 8.1 and 21.8 µm). In thermogravimetric tests, in comparison with pure sodium montmorillonite, the decrease of water content in sodium montmorillonite/N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide indicated N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide expelled the water molecules out of the interlayer, which was beneficial to wellbore stability. Fourier transform infrared spectra of certain concentration N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide/sodium montmorillonite indicated the successful physical adsorption and interaction between N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide with sodium montmorillonite. In addition, the results of X-ray diffraction tests showed the obtained 1.0 wt% N1,N2-ditetradecy-N1, N1, N2, N2-tetrakis (2-hydroxyethyl) ethane-1,2-diaminium bromide solution could remarkably reduce the interlayer distance of wet sodium montmorillonite (from 1.94 to 1.37 nm).
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2020
·
IF 2.213
Lihua Liu,Zhengchi Yang,Lu Zhao,Jinyan Liu,Xiong Liu,Jianrong Xue,Anping Tang
The adsorption characteristic and mechanism of poly(N1,N1,N3,N3-tetraallylpropane-1,3-diaminium chloride) (PTAPDAC) toward Cr(VI) ions were systematically investigated. Results showed that the removal efficiency of PTAPDAC toward Cr(VI) could reach above 98% at pH = 3–6. The equilibrium data of Cr(VI) adsorbed by PTAPDAC fitted the Langmuir model well, and the maximum sorption capacity deduced from the Langmuir model at 293 K was 273.17 mg g−1. The adsorption of PTAPDAC toward Cr(VI) was rapid and reached equilibrium within 60 min, and the adsorption kinetic process was relevant to the pseudo-second-order kinetic model. Moreover, the activation energy Ea was calculated as −22.505 kJ mol−1. The adsorption processes were spontaneous and exothermic driven by an increase in entropy, which involved electrostatic attraction, ion exchange, and redox reactions. The X-ray photoelectron spectroscopy analysis revealed that approximately 64.5% of Cr(VI) reduced to be Cr(III), and 24.29% of –C–NH+ deprotonated. The combination of reduced Cr(III) with tertiary amine groups resulted in a positively charged tertiary amine group, which further promoted Cr(VI) adsorption, thereby increasing the adsorption capacity of PTAPDAC toward Cr(VI). Therefore, PTAPDAC has a broad application prospect in removing Cr(VI) ions in wastewater.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Lihua Liu,Zhengchi Yang,Lu Zhao,Gang Su,Zuoxiao Wei,Anping Tang,Jianrong Xue
A novel poly(N 1 ,N 1 ,N 6 ,N 6 -tetraallylhexane-1,6-diammonium dichloride) (PTAHDADC) microparticle was prepared via inverse emulsion polymerization . The adsorption characteristics and mechanism for Mo(VI) in an aqueous solution were investigated systemically. Results showed that PTAHDADC had a high positively charge density with a positive charge at every six CH 2 (or CH ) units and presented a coral-like morphology, with macropores distributed in 30–130 μm, and a porosity of up to 46.52%. The Mo(VI) removal efficiency was >99% at pH = 3.0–4.0. The adsorption data could be effectively described using the Langmuir and pseudo-second-order kinetic models . The maximum adsorption capacity was up to 394.11 mg·g −1 at 293 K. The adsorption process was rapid, and reached equilibrium within 120 min with an adsorption activation energy E a of 41.15 kJ·mol −1 . The adsorption process of Mo(VI) by PTAHDADC was accompanied by the partial ion exchange of counterion Cl − , the partial deprotonation of functional groups ( CH 2 ) 3 N + H on PTAHDADC, and the new interaction and bond formation between Mo(VI) and PTAHDADC. Mo(VI) removal by PTAHDADC was a process of spontaneously endothermic entropy increment, which involves physisorption , electrostatic attraction, ion exchange, and chemisorption . PTAHDADC offers a simple synthesis and excellent adsorption performance and recyclability. Therefore, PTAHDADC is a highly potential adsorbent for removing Mo(VI) ions from wastewater and has a broad application prospect.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）