Pharmaceutics
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2022
·Vol. 14
·期 7
·1337
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IF 6.525
Lijun Song,Jiabo Chen,Yuxuan Feng,Yujing Zhou,Feng Li,Guiqin Dai,Yue Yuan,Haosen Yi,Yupei Qian,Siyan Yang,Yang Chen,Wenchang Zhao
Genistein (Gen), a kind of natural isoflavone drug monomer with poor water solubility and low oral absorption, was incorporated into oral nanoparticles with a new mesoporous carrier material, NH2-MCM-41, which was synthesized by copolycondensation. When the ratio of Gen to NH2-MCM-41 was 1:0.5, the maximum adsorption capacity of Gen was 13.15%, the maximum drug loading was 12.65%, and the particle size of the whole core–shell structure was in the range of 370 nm–390 nm. The particles were characterized by a Malvern particle size scanning machine, XRD, Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption and desorption. Finally, Gen-NH2-MCM-41 was encapsulated by sodium alginate (SA), and the chimerism of this material, denoted as GEN-NH2[email protected], was investigated. In vitro release experiments showed that, after 5 h in artificial colon fluid (pH = 8.0), the cumulative release reached 99.56%. In addition, its anti-rotavirus (RV) effect showed that the maximum inhibition rate was 62.24% at a concentration of 30 μM in RV-infected Caco-2 cells, and it significantly reduced the diarrhea rate and diarrhea index in an RV-infected-neonatal mice model at a dose of 0.3 mg/g, which was better than the results of Gen. Ultimately, Gen-NH2[email protected]was successfully prepared, which solves the problems of low solubility and poor absorption and provides an experimental basis for the application of Gen in the clinical treatment of RV infection.Keywords:genistein;mesoporous silica;Caco-2 cells;sodium alginate;targeted release
研究领域:
药学
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纳米技术
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病毒学
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药物递送系统
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaosong Zhou,Xukai Li,Weirui Chen,Laisheng Li
Perfluorinated compounds (PFCs), which were difficult to biodegrade and posed significant ecological and health risks, had made their removal an urgent global challenge. Herein, NH 2 -MCM-41 was designed by modifying MCM-41 with 3-aminopropyltriethoxysilane (APTS) to remove PFOA, PFOS and OBS. X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) results indicated that though the implanting of NH 2 – on MCM-41 decreased S BET and pore size, but it dramatically increased the PFOA, PFOS and OBS adsorption capacity. The maximum uptake capacity of NH 2 -MCM-41 increased from 14.41 to 350.61, 19.53 to 445.11, and 28.6 to 452.98 mg/g for PFOA, PFOS and OBS, respectively. Three PFCs adsorptions were more favorable under acidic condition. Both the pseudo-second-order and intra-particle diffusion models provided a good fit for the kinetic data, and the adsorption isotherms were well described by the Langmuir and Freundlich models. The primary adsorption mechanisms involved hydrophobic interactions, electrostatic forces, H bond interaction and micellar or sub-micellar effects. This study demonstrated valuable insights into the applicability of NH 2 -MCM-41 for environmental remediation.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Peng Liao,Binrui Li,Lin Xie,Xiaoao Bai,Han Qiao,Qianqian Li,Biwei Yang,Chongxuan Liu
Engineered nanoparticles-mediated contaminant transport has been recognized as a significant process governing the mobility of metals and radionuclides in groundwater. Engineered silicate nanoparticles (ESNPs) are attractive materials for the sequestration or extraction of Cr(VI) and other metals and radionuclides from groundwater. While great efforts have been devoted toward the application of these materials for Cr(VI) sequestration, the underlying interface adsorption mechanism is not thoroughly elucidated. This study investigates the immobilization mechanisms of Cr(VI) on a representative ESNPs, NH 2 -MCM-41, over a range of water chemistry conditions. By combining batch adsorption experiments with an array of complementary characterizations, we provided spectroscopic and microscopic evidence that the electrostatic interactions between the positively charged NH 2 -MCM-41 surface derived from amino functionality and the negatively charged Cr(VI) species was the dominant mechanism responsible for Cr(VI) immobilization. In addition, the weak hydrogen bonding interactions may also contribute to adsorption to a degree. Furthermore, thermodynamic studies suggested a favorable, spontaneous, and exothermic adsorption process. Site energy analysis illustrated that the distribution of energy binding sites on NH 2 -MCM-41 is Cr(VI) loading dependent. The new insights provided here can advance understanding of the transport of Cr(VI) associated NH 2 -MCM-41 that benefits the application of ESNPs-based technologies for metals immobilization in groundwater.
研究领域:
环境科学
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纳米技术
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污染治理
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）