JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 96
·期 1
·69-79
·
IF 1.429
Duan Nannan,Ye Lin,Zhang Ai-ying,Feng Zeng-guo
Abstract A series of PPR-based multiblock copolymers were prepared by using a PPR self-assembled from a distal 2-bromoisobutyryl end-capped ferrocenyl containing derivative Br-TEG-Fc-TEG-Br with 4 β-CDs as initiator to initiate the in situ ATRP of NIPAAm in aqueous solution at room temperature. After the ATRP, about 2 β-CDs were resided on the polymeric backbone through a 7 day dialysing purification, but those β-CDs were all slipped off the polymeric chain through a further 7 day dialysing treatment. It suggested that the resulting multiblock copolymers are really the PPR-based instead of the PR-based ones showing an impeded dethreading behavior of β-CDs and the PNIPAAm blocks attached are not bulky enough as polymeric stoppers to end-cap the β-CD-TEG-Fc-TEG PPRs into the PR-based multiblock copolymers. Graphic abstract A series of PPR-based multiblock copolymers were prepared by using a PPR self-assembled from Br-TEG-Fc-TEG-Br with 4 β-CDs as initiator to initiate the aqueous ATRP of NIPAAm. After the polymerization there are about 2 β-CDs still entrapped on the polymeric chain through a 7 day dialyzing purification. Those threaded β-CDs are all slipped off the polymeric backbone through a further 7 day dialyzing treatment.
研究领域:
高分子化学
·
材料科学
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DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2016
·
IF 1.817
Hui Zhao,Jun Gao,Ruina Liu,Sanping Zhao
To fabricate thermo- and pH-sensitive hydrogels functionalized with β -cyclodextrin ( β -CD) moieties, β -CD polymer bearing methacrylate (CDP- g -GMA) used as a reactive and functional crosslinker was synthesized, and then copolymerized with N -isopropylacrylamide (NIPAAm) and acrylic acid (AA) in aqueous solution via UV-initiated free radical polymerization. The stimulus-responsiveness of the resultant hydrogels has been carried out by measuring the swelling ratio at different temperatures and pH values. The results showed that the thermo- and pH-sensitivities of the produced hydrogels were significantly dependent on the compositions of the hydrogels, and the dual sensitivities exhibited good reversible process. The interior morphology observed by SEM exhibited that the pore size of the hydrogels could be tailored by pH of the local medium. Using a water-soluble cationic dye methyl violet (MV) as a model drug, MV loading and release profiles of the hydrogels as potential drug controlled release carriers were evaluated. The MV release rate from CD-functionalized hydrogels was much slower than that from the hydrogel without β -CDs at both pH 2.0 and pH 7.4. The release of MV from CD-functionalized hydrogels at pH 2.0 was faster than that at pH 7.4, the release kinetics of MV from the CD-functionalized hydrogels displayed a sustained release profile, and the release mechanism followed Fickian diffusion.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 1
·323-331
·
IF 3.119
Juan Li,Jingxin Zhu,Lan Jia,Yanlong Ma,Haijuan Wu
This paper presents a green method for fabricating dual temperature- and pH-responsive electrospun fibrous mats from an aqueous-based blend poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAAm-co-AAc)) and regenerated silk fibroin (RSF) by employing electrospinning technique. P(NIPAAm-co-AAc) was synthesized by free radical solution polymerization and its low critical solution temperature (LCST) was in the physiological range (38.8 °C). The P(NIPAAm-co-AAc)/RSF fibers were prepared by electrospinning technology in the presence of the crosslinking agents (EDC·HCl and NHS) with water as solvent. After in situ crosslinking and water-annealing process, the water-stable composite fibrous mats were obtained. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to analyze the crosslinking process. Temperature and pH dual stimuli-responsive swelling-shrinking behavior of the fibrous mats were observed when the temperature was below and above the LCST of the copolymer at different pHs. In addition, rhodamine B-loaded the fibrous mats also showed dual temperature and pH controlled release behavior, demonstrating the potential use of the fibrous mats for “smart” controlled drug delivery applications.
研究领域:
材料科学
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生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Yuansong Ye,Jian Huang,Xiaolin Wang
Surface hydrophilicity and the inherent washing force are two crucial factors for constructing an underwater self-cleaning surface. Following this self-cleaning mechanism, we fabricated thermosensitive copolymer brushes of N-isopropylacrylamide (NIPAAm) and poly(ethylene glycol) methacrylate (PEGMA) on the polypropylene (PP) surface. Benefiting from the hydrophilic poly(ethylene glycol) (PEG) side chains, the copolymer brushes with the PEGMA content exceeding 5 mol % exhibited good surface hydrophilicity, whenever at temperatures below or above the lower critical solution temperatures (LCST). Hence their underwater oleophobicity was greatly improved with oil contact angles higher than 141° and oil adhesive forces lower than 20 μN. In addition, the sharp volume-phase transition feature was reserved in their copolymer backbones, as proved by the AFM result. Self-cleaning evaluation of the modified surfaces was performed by a simple temperature-change water cleaning method, after which only 0.2 wt % of oil residues remained on the brush surface of P(NIPAAm-5PEGMA) (with 5 mol % of PEGMA contents). The excellent self-cleaning capability is believed to be ascribed to its balanced surface features in hydrophilicity and the sharper volume-phase transition, when a hydrophilic surface can facilitate oil desorption and an intense conformation change of chain stretching and shrinking can offer the strong washing force to assist oil detachment. This study contributes to development of the underwater self-cleaning surface based on a hydrophilic surface with the chain motion.
研究领域:
材料科学
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表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Lei Miao,Jiwen Hu,Mangeng Lu,Yuanyuan Tu,Xin Chen,Yinwen Li,Shudong Lin,Fei Li,Shengyu Hu
A ternary system thermoresponsive hydrogel, poly( N -isopropylacrylamide- co -hydroxyethyl methylacrylate polycaprolactone)/hydroxypropyl cellulose (or P(NIPAAm- co -HEMAPCL)/HPC), was prepared via “alkynyl/azide” click chemistry between the azide modified graft copolymer P(NIPAAm- co -HEMAPCL-N 3 ) and the alkynyl modified HPC (or alkynyl-HPC). The structures of P(NIPAAm- co -HEMAPCL-N 3 ) and alkynyl-HPC were characterized by 1 H NMR, SEC and FT-IR, and the results demonstrated that the mole ratio of the alkynyl and azide functional groups, and the feed ratios of HPC, PCL, and PNIPAAm could be easily adjusted. The incorporation of PCL and HPC dramatically enhanced the compression modulus of the P(NIPAAm- co -HEMAPCL)/HPC hydrogel, which ranged from 500 to 1000 g/cm 2 . Due to the immiscibility of HPC and PCL, a heterogeneous and semicontinuous structure was observed via SEM. The incorporation of HPC accelerated the water absorption rate and enhanced the hydrogel's ability to shed water. The swelling–deswelling and compressive properties could also be adjusted by changing the feeding ratio. The hydrogel exhibited reversible swelling–deswelling behavior after three “swelling–deswelling” cycles.
研究领域:
材料科学
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高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2017
·
IF 3.386
Yue Wang,Ning Yang,Dandan Wang,Yang He,Li Chen,Yiping Zhao
The lack of identified binding sites for drugs and the undegradability limited the development of the thermo-sensitive hydrogels based on N-isopropylacrylamide (NIPAAm) in the intelligent drug delivery system (DDS). Therefore, the poly (Maleic anhydride-β-cyclodextrin- co -NIPAAm) (poly (MAH-β-CD- co -NIPAAm)) hydrogels were obtained to overcome these disadvantages. β-cyclodextrin (β-CD) with the drug inclusion properties and degradation capacity was modified by maleic anhydride (MAH) and the resultant monomer was fixed in the gel network by a series of polymerization reactions . The physical and chemical properties of the monomer and the poly (MAH-β-CD- co -NIPAAm) hydrogels were systemically investigated. The swelling/deswelling kinetics at different temperature and pH indicated that the gels exhibit dual responsiveness. The model drug naproxen sodium was identified by MAH-β-CD, so it was efficiently loaded on the hydrogels. The drug released in a controlled manner from the copolymerization hydrogels, especially displayed slower release efficiency in simulates stomach conditions. And these hydrogels also showed biodegradability in the presence of α-amylase. The above facts demonstrated that the poly (MAH-β-CD- co -NIPAAm) hydrogels was an effective oral drug system.
研究领域:
材料科学
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药学
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 28
·4402-4412
·
IF 5.047
Mengwei Zou,Rongrong Jin,Yanfei Hu,Ying Zhang,Haibo Wang,Gongyan Liu,Yu Nie,Yunbing Wang
Indomethacin (IND) is a nonsteroidal anti-inflammatory drug (NSAID), which is widely used to relieve inflammation. However, general eye drops cannot reach lesions efficiently due to the presence of complicated and special biological barriers in the eye. Repeated administration of this drug for chronic ophthalmic diseases also showed poor patient compliance. Herein, an in situ injectable thermo-sensitive hydrogel of indomethacin-conjugated polymer was fabricated to overcome these crucial problems. The poly(NIPAAm-co-MAA-co-HTI) (PNMHTI) hydrogel, composed of N-isopropylacrylamide (NIPAAm), methacrylic acid (MAA), and 2-hydroxylethyl methacrylate-g-poly(trimethylene carbonate)-indomethacin (HEMA-g-PTMC-IND) (HTI), was synthesized by radical polymerization of NIPAAm, MAA and HTI. According to the rheology investigation, the sol–gel conversion temperature of the hydrogels was around 33 °C, and the sol–gel transition occurred at physiological temperature (37 °C). The release of indomethacin from the injectable hydrogels was sustained for over 2 weeks in phosphate buffer saline with esterase due to the sustained biodegradable behavior by the hydrolytic cleavage of the residual PTMC chains. In addition, these hydrogels displayed excellent biocompatibility against mouse fibroblasts, reduced cytotoxicity for indomethacin and a significant anti-inflammatory effect against macrophages. Uveitis was successfully established in New Zealand rabbits, and the PNMHTI hydrogels were injected into the vitreous body. Histopathological examination of retinas confirmed the good biocompatablity and anti-inflammatory effects of PNMHTI hydrogels in vivo. Overall, the PNMHTI hydrogels reported herein offer an attractive biomaterial-centered treatment option for uveitis.
研究领域:
药学
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材料科学
·
眼科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Shaoping Ma,Fenfang Li,Zhijian Tan
Aqueous two-phase systems (ATPSs) have been used in the chiral resolution of various enantiomers in recent years. However, it is difficult to recycle and reuse the phase-forming components and chiral selectors in these applications. Therefore, a completely recyclable ATPS that is based on two temperature-responsive polymers, viz. , poly(MAH-β-CD-co-NIPAAm-DMAEMA-BMA) (P NDB-CD ) and poly(NVCL-AM) (P VAm ), was employed for the chiral separation of mandelic acid (MA) enantiomers. The two polymers can be recovered by simply adjusting the temperature; meanwhile, the polymer P NDB-CD can be used as a chiral selector. The factors that affect the chiral resolution process were also investigated. A maximum separation factor ( α ) of 1.49 was achieved via a one-step extraction under the following conditions: P VAm concentration of 14.0 wt%, P NDB-CD concentration of 9.0 wt%, MA concentration of 5.0 mg/g, and system pH of 4.0. Moreover, the two polymers can be easily recycled after the chiral separation process. The recyclable ATPS used for enantioseparation in the current study can provide new ideas for other applications by using enantioselective liquid–liquid extraction (ELLE).
研究领域:
化学
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材料科学
·
分离科学
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产品关联
DOI
高影响因子
POLYMER
·
2022
·
IF 4.432
Congcong Cui,Guojie Liu,He Gao,Min Wang,Jun Gao
A photo and thermal-responsive smart polymer, enabling controllable wettability according to different temperature and light conditions, was developed in this paper. The 3-(3′,3′-dimethyl-6-nitrospiro-[chromene-2,2′-indolin]-1′-yl) propyl methacrylate (SPMA) and N -isopropylacrylamide (NIPAAm) by 2,2′-azobis(isobutyronitrile) (AIBN) were grafted on the surface of polydimethylsiloxane (PDMS) to induce free radical polymerization . The SPMA isomerizes from a colorless, hydrophobic spiropyran (SP) form to a deep purple, hydrophilic merocyanine form (MCMA) upon UV-light. The wettability of poly( N -isopropylacrylamide) (PNIPAAm) is sensitive to temperature, showing hydrophobicity above the low critical solution temperature (LCST) and hydrophilicity below LCST. Furthermore, the addition of SPMA has realized the significant reversible wettability synergistic with PNIPAAm. The reversible wettability can be controlled by selectively applying single or both factors of light and temperature. Thus, practical application of the above controllable wettability can be greatly expanded. When the polymer is transferred from 40 °C (>LCST)-visible light to 10 °C (
研究领域:
材料科学
·
聚合物化学
·
表面科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yanzhen Sun,Xiaodong Jing,Yang Liu,Bing Yu,Hao Hu,Hailin Cong,Youqing Shen
Nucleic acid-based agents have advantages in therapeutic efficacy and biological safety. However, due to its facile degradability, it lacks an effective route of administration in wound treatment. Designing smart hydrogels for the spatiotemporally controllable delivery of nucleic acids is of great significance for clinical applications. Here, a near-infrared (NIR)-responsive nanocomposite hydrogel was prepared using methyl methacrylate (GMA)-modified chitosan as the macromolecular cross-linker, N-isopropylacrylamide (NIPAAm) as the backbone, and molybdenum disulfide nanosheets (MoS 2 NSs) as the nanocomponents. The polydeoxyribonucleotide (PDRN), a nucleic acid-based agent that promotes tissue regeneration , was loaded and delivered. The photothermal conversion capability of MoS 2 NSs enables customized care of PDRNs and antibacterial enhancement. In a full-thickness skin defect model, high-quality wound healing effects were demonstrated under the action of nanocomposite hydrogels. The proposed nanocomposite hydrogel provides a new reference for local delivery of nucleic acid-based agents.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Yukun Wu,Quanyong Lai,Shuqi Lai,Jing Wu,Wei Wang,Zhi Yuan
Polymeric micelles formed in aqueous solution by assembly of amphiphilic block copolymers have been extensively investigated due to their great potential as drug carriers. However, the stability of polymeric assembly is still one of the major challenges in delivering drugs to tissues and cells. Here, we report a facile route to fabricate core cross-linked (CCL) micelles using an enzymatic polymerization as the cross-linking method. We present synthesis of poly(ethylene glycol)-block-poly(N-isopropyl acrylamide-co-N-(4-hydroxyphenethyl) acrylamide) diblock copolymer PEG-b-P(NIPAAm-co-NHPAAm) via reversible addition-fragmentation chain transfer (RAFT) polymerization. The diblock copolymer was then self-assembled into non-cross-linked (NCL) micelles upon heating above the lower critical solution temperature (LCST), and subsequently cross-linked using horseradish peroxidase (HRP) and hydrogen peroxide (H 2 O 2 ) as enzyme and oxidant. The characterization of the diblock copolymer and micelles were studied by NMR, DLS, UV–vis, and fluorescence spectroscopy. The fluorescence study reveals that the cross-linking process endows the micelles with much lower critical micelle concentration (CMC). In addition, the drug release study shows that the CCL micelles have lower release amount of doxorubicin (DOX) than the NCL micelles due to the enhanced stability of the CCL micelles by core cross-linking process.
研究领域:
材料科学
·
药学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2011
·
IF 3.829
Zhuan Yi,Liping Zhu,Liang Cheng,Baoku Zhu,Youyi Xu
An amino-substituted polyethersulfone (PES) was synthesized by the polycondensation of a functional monomer bis(3-amino-4-hydroxyphenyl) sulfone with bis(4-fluorophenyl) sulfone. The amine groups incorporated into PES were employed as anchors to immobilize the chain transfer agents of reversible addition-fragmentation polymerization (RAFT). The resultant macro chain transfer agent was used to initiate the polymerization of the hydrophilic monomers N -isopropyl acrylamino (NIPAAm) and N, N -dimethylamino-2-ethyl methacrylate (DMAEMA), respectively. The gel permeation chromatography (GPC) results confirmed the successful synthesis of the amphiphilic copolymers PES- g -PNIPAAm and PES- g -PDMAEMA, and these two copolymers were perhaps the few examples of amphiphilic copolymer synthesized via a radical polymerization from PES main chains. The amino-substituted PES seemed a versatile precursor that showed a potential of functionalization via various strategies including click chemistry, atom transfer radical polymerization and RAFT polymerization. The synthesized amphiphilic copolymers were finally used as additives to improve the hydrophilicity and the filtration performances of PES membranes.
研究领域:
高分子化学
·
材料科学
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）