ACS Applied Nano Materials
·
2022
·
IF 6.14
Sheng Zhang,Zhenyang Liu,Linlin Mao,Jian Wu,Di Zhang,Ruiyuan Liu,Li Qi
High quality visualization of live mammalian embryo is an important requirement for studying fetal development. Photoacoustic tomography (PAT) and optical coherence tomography (OCT) are two advanced imaging modalities that have been utilized for embryonic imaging separately. However, high contrast, multiscale, and deep tissue imaging of embryos in vivo remains challenging. Here, we demonstrate multimodal contrast-enhanced imaging of live embryos by gold nanostar-meditated near-infrared I (NIR-I) PAT and near-infrared II (NIR-II) OCT. We investigate intravenous and intravaginal administration of gold nanostars, and significant enhancement of signal, image contrast, and imaging depth are achieved for both PAT and OCT. Our findings may facilitate detailed studies of the morphological and functional changes during embryonic development.
研究领域:
生物医学工程
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成像科学
·
发育生物学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 29
·1-12
·
IF 2.8
Zhang Zeqing,Liu Wei,Li Lin,Li Huan,Zhang Zhijun,Cheng Shuai,Rao Guanghui,Zhao Jingtai
In recent years, materials exhibiting multimodal luminescence properties from deep red to near-infrared (NIR) wavelengths have been a focal point of research, particularly in the exploration of applications within the realms of stress sensing and dynamic signature anti-counterfeiting. A pyroxene-type layered crystal structure compound, CaMgGe 2 O 6 : Mn 2+ , has been reported as a mechanoluminescent (ML) material. Upon incorporation into the host, Mn 2+ ions preferentially substitute for Mg 2+ ions, emitting deep red to near-infrared light (600–800 nm) within this six-coordinated [MgO 6 ] octahedral environment. The congruence of photoluminescence and ML spectra indicates that both types of luminescence originate from the same emissive center. The doping of Mn 2+ ions introduces impurity band, effectively reducing the optical band gap, as evidenced by ultraviolet diffuse reflectance measurements. Thermoluminescence results reveal three defect centers within the phosphor, whose concentrations decrease with Mn 2+ doping, correlating with a reduction in ML intensity. The ML mechanism of the phosphor is elucidated through the analysis of local piezoelectric properties within the crystal. Overall, this study may pave new pathways for the development of efficient near-infrared mechanoluminescent materials, showcasing potential applications within the biological domain.
研究领域:
材料科学
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光学
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生物医学工程
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DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2023
·
IF 8.6
Zong Chang,Liangjian Liu,Jingying Zhai,Chenchen Liu,Xiao Wang,Chengbo Liu,Xiaojiang Xie,Qinchao Sun
Molecular electronic coupling has been found to play a crucial role in the light-induced processes of natural and artificial systems. The light-induced acoustic process (photoacoustic) is also considered to be one of the most essential characters of the light-absorbing molecules. Herein, we report an interesting observation of the molecular electronic coupling-induced photoacoustic effect (MECPA) in which the PA intensity is dominated by the molecular electronic coupling, rather than the absorption intensity as usually concerned. The molecular electronic coupling effect results in a significant exciton absorption suppression from the monomer to pentamer. However, the corresponding PA efficiency was found to be approximately 2 orders of magnitude greater for the latter. A well-behaved linear correlation between the molecular exciton absorbance and PA efficiency was observed. The surprisingly significant MECPA effect was realized via novel NIR-II squaraine-benzothiopyrylium dyes. Excellent photophysical properties of the novel NIR-II dyes were achieved, such as a large absorption extinction coefficient and high photostability. In vivo duplex PA imaging was demonstrated for tumor tissue and macrophage cells and blood and lymphoid vessels. The MECPA effect would open a new window for the design of PA contrast agent systems for in vivo imaging.
研究领域:
生物医学工程
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光学成像
·
分子生物学
·
材料科学
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DOI
高影响因子
Laser & Photonics Reviews
·
2025
·
IF 10
Ziyi Niu,Pengfei Zhang,Wenbo Chen,Junyang Xia,Zhili Zhang,Jinwei Liu,Yanyan Li,Bitao Liu,Lei Zhao
Near-infrared (NIR) mechanoluminescence (ML) holds significant promise for in vivo biomechanical detection and imaging due to its self-powered excitation and self-recovery capabilities. However, its broader application remains constrained by the limited availability of suitable ML materials and the narrow spectral range of NIR emission. In this study, we report the Y 3 Ga 5 O 12 (YGO): Cr 3+ , Nd 3+ , Yb 3+ /polydimethylsiloxane (PDMS) NIR-ML composite with broadband NIR emission tunable from 600 to 1100 nm, covering both the NIR-I and NIR-II windows. The ML of composite device is driven by an interfacial triboelectric effect arising from the mechanical interaction between the inorganic particles and the polymer matrix. Comparative studies on photon penetration through biological tissues reveal that co-doping with Nd 3+ and Yb 3+ markedly enhances tissue penetration depth. Specifically, the luminescence decay rate in biological tissues is reduced by 20.8% relative to Cr 3+ single doping, indicating improved optical persistence and signal transmission. These findings demonstrate the potential of full-spectrum NIR-ML devices for high-resolution, deep-tissue biomechanical sensing and imaging. This work provides a generalizable design strategy for the development of broadband NIR-ML materials tailored for in vivo mechanical diagnostics.
研究领域:
材料科学
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生物医学工程
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光学成像
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机械发光
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体内传感
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiajia Wang,Li Li,Ruyi Wei,Renfeng Dong
Here, we report the first PbS quantum dot (QD)-based micromotors with NIR-I light-driven photocatalytic propulsion and NIR-II fluorescence. Under the irradiation of NIR-I light (808 nm), PbS QD-doped cuprous oxide (Cu2O@PbS) micromotors can display efficient propulsion in a variety of biocompatible fuels such as malic acid, glucose, and urea. Among them, the Cu2O@PbS micromotors exhibit the best propulsion performance in a very low concentration of malic acid, with an average speed as high as 11.86 μm/s. The enhanced NIR-I photocatalytic activity of Cu2O@PbS micromotors benefits from the doping of NIR-I PbS QDs that can be excited by NIR-I light and exhibit high electron transport efficiency. The doped PbS QDs can effectively increase the absorption efficiency of the micromotors in the NIR-I region while also inhibiting the recombination of photogenerated electron–hole pairs. Interestingly, due to the presence of NIR PbS QDs, the Cu2O@PbS micromotors demonstrate prominent and stable NIR-II fluorescence (emission wavelength: 1100 nm), which offer promising potential for visualization of their position in vivo. In comparison to other photocatalytic micromotors, the simple fabrication strategy, excellent NIR-II fluorescence, together with the NIR-I light-dependent propulsion behavior of the current Cu2O@PbS micromotors, thus pave the way for further development of advanced smart “robots” for intelligent biomedical applications.
研究领域:
纳米技术
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生物医学工程
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材料科学
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DOI
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 18
·6074-6083
·
IF 4.174
Rongyun Jiang,Jian Yang,Yangqi Meng,Duanting Yan,Chunguang Liu,Changshan Xu,Yuxue Liu
Zn2Ga3−x−yCrxNdyGe0.75O8 (ZGGO:Crx,Ndy) persistent luminescent nanoparticles (PLNPs) (x = 0, 0.02; and y = 0, 0.01, 0.02, 0.03, 0.04) were synthesized via a hydrothermal method in combination with a following heat treatment under vacuum. The effects of Nd3+ concentration on chemical composition, size distribution, luminescence property, the persistent energy transfer from Cr3+ to Nd3+ and afterglow imaging were studied in detail. When the Nd3+ concentration was increased from 0 to 0.04, the particle size increased from 45.4 to 86.2 nm. The afterglow emissions in the NIR-I (696 nm) and NIR-II (1067 nm) regions, which are ascribed to the 2E, 4T2 → 4A2 transitions of Cr3+ and the 4F3/2 → 4I11/2 transition of Nd3+, respectively, were simultaneously acquired after stopping the 635 nm excitation. Among the nanoparticles with different concentrations, ZGGO:Cr0.02,Nd0.02 exhibits the strongest NIR-II afterglow intensity and the corresponding energy transfer efficiency from Cr3+ to Nd3+ is found to be 25.9%. In addition, enhanced X-ray excited afterglow imaging can be observed in Nd3+/Cr3+ codoped nanoparticles dispersed in water, human serum albumin solution and simulated lysosomal environment compared to the Cr3+ singly doped nanoparticles. Renewable NIR afterglow imaging was realized through an X-ray reexcitation strategy. In particular, both the X-ray excitation strategy accompanied by NIR-I afterglow emission and the red light (635 nm) excitation strategy accompanied by NIR-II afterglow emission exhibit high tissue penetration capability. This study provides a further understanding of how to develop a suitable strategy for realizing deep tissue autofluorescence-free bioimaging.
研究领域:
生物医学工程
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材料科学
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光学成像
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Jundong Shao,Jing Zhang,Chao Jiang,Jing Lin,Peng Huang
As a prominent member of two dimensional (2D) materials, MXenes have shown encouraging photophysical properties and so there is highly desirability to explore their phototherapeutic potential in cancer. Herein, we demonstrate a facile top-down strategy for the synthesis of nitride-based MXene, titanium nitride quantum dots (Ti 2 N QDs) in solution. With a size of around 5 nm, the obtained Ti 2 N QDs exhibit extraordinarily high photothermal conversion efficiency under laser irradiation in both first and second near-infrared (NIR) biowindows (NIR-I, 808 nm, 48.62%; and NIR-II, 1064 nm, 45.51%). In vitro and in vivo assessments demonstrate that the Ti 2 N QDs possess excellent biocompatibility, photoacoustic (PA) effect, and photothermal therapy (PTT) efficiency. Moreover, the Ti 2 N QDs showing obvious aggregation in tumors after 4 h post-injection, which enables facilitate PA imaging-guided PTT in both NIR-I/II biowindows without noticeable toxicity. Encouragingly, the Ti 2 N QDs with appropriate degradation property also show an applicable excretion rate from the body in vivo , which ensures sufficient stability in circulation to accomplish therapeutics roles and then can be smoothly discharged from the body after that. These results indicate the high potential of biodegradable Ti 2 N QDs in PA imaging-guided PTT in both NIR-I/II biowindows for precision cancer treatment.
研究领域:
材料科学与工程
·
肿瘤学
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生物医学工程
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产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 18
·4602-4607
·
IF 7.779
Meng Zhao,Shengqiang Liu,Hao Cai,Fangyi Zhao,Zhen Song,Quanlin Liu
Near-infrared (NIR) light devices have great potential in non-destructive testing and biomedicine fields. However, the lack of stable and efficient long wavelength NIR phosphors hinders their development. In this work, utilizing the compositional flexibility of antimonate double perovskites, we realized efficient and tunable broadband NIR emissions based on A2MSbO6:Cr3+ materials (A = Ca, Sr, and Ba; M = Ga, In, Sc, and Y). The NIR emission peaks ranged from 825 to 1010 nm by a composition modulation. In particular, Ca2ScSbO6:Cr3+ exhibits an 850 nm-centering broadband NIR emission with an internal quantum efficiency of 84.5% and a high thermal quenching temperature, retaining ∼71% at 410 K of the initial intensity at 80 K. Comparatively, Sr2InSbO6:Cr3+ with a 920 nm-centering broadband emission has 63.2% internal quantum efficiency. This work could help in discovering novel NIR phosphors with long-wavelength emissions and high efficiency.
研究领域:
生物医学工程
·
材料科学
·
光学成像
·
无损检测
·
分子探针开发
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DOI
高影响因子
Laser & Photonics Reviews
·
2026
·
IF 9.7
Yuanheng Mu,Yun Ling,Tangkun Wang,Bin Sun,Nan Yang,Meng Zhang,Pengpeng Dai
Near-infrared (NIR) luminescence capable of covering NIR-I and NIR-II is highly promising for biomedical imaging and non-invasive inspection. However, achieving both broadband and long-wavelength emission remains challenging due to the activator ion site-occupation constraints. In this work, we report La 3 TiGa 5 O 14 :Cr 3+ (LTG:Cr 3+ ) phosphor that exhibits an ultrawideband NIR emission spanning the spectral range of 650–1400 nm. The underlying mechanism involves Ti and Ga site exchange, which triggers local polyhedral reorganization. This structural transformation creates a weak crystal field, large Stokes shift, lower energy barrier of activator ion site occupancy, and more sites favorable for Cr 3+ incorporation ─ collectively relaxing Cr 3+ site-occupation constraints. The optimized LTG:0.03Cr 3+ phosphor exhibits NIR emission at 1017 nm with an exceptionally broad full width at half maximum (FWHM) of 476 nm. Moreover, introducing Ta 5+ as a charge-compensating dopant boosts NIR emission intensity by nearly 3.9-fold. A prototype NIR LED device fabricated with this phosphor demonstrates effective multi-channel signal detection. This work advances site-occupancy engineering from extrinsic doping to intrinsic polyhedral reorganization, providing a molecular design framework for high-performance NIR phosphor.
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产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 16
·5469-5477
·
IF 7.393
Hao Cai,Shengqiang Liu,Zhen Song,Quanlin Liu
The practical application of near-infrared (NIR) phosphors is hindered due to their limited light emitting region and narrow bandwidth. Here, we report a series of Cr3+-doped olivine phosphors, (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+, with tunable luminescence from NIR-I to NIR II based on crystallographic site engineering. By using a [Li+–Sc3+] unit substituting for a [Mg2+–Mg2+] unit, the NIR luminescence can be largely tuned from 940 nm to 1110 nm, and the corresponding FWHM can be modified from 236 to ∼300 nm. The internal quantum efficiency (IQE) and external quantum efficiency (EQE) of Mg2GeO4:1% Cr3+ were measured to be 48.19% and 16.38%, respectively. The photoluminescence of the phosphors matches well with the absorption of several functional groups. By measuring the NIR absorption of different liquids illuminated by NIR light from our phosphors, qualitative and quantitative analysis can be realized. These results suggest that the super-broad NIR luminescence of (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+ has potential applications as light sources for nondestructive food analysis.
研究领域:
材料科学
·
光学
·
分析化学
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DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 47
·10854-10866
·
IF 5.344
Cuifu Fang,Zhiwei Zhong,Teng Zhang,Shuang Jia,Xingwei Ding,Weimin Zhou,Xiaolei Wang
Problems such as massive hemorrhage caused by uncontrolled drug dosage are the main significant obstacles in clinical thrombolytic therapy, which are prominently due to the lack of targeting and controlled release ability of efficient thrombolytic drug systems. In recent years, our team demonstrated that the photothermal effect can facilitate the thrombolytic effect of urokinase plasminogen activator (uPA). However, conventional photothermal agents are relatively expensive or contain heavy metals. If drug delivery systems with low toxicity, minimized heavy metal elements and easy accessibility (preferably provided by human self) can be developed, they will be of value in the future related applications. Herein, uPA-loaded human black hair derived nanoparticles with gelatin capsules (uPA@HBHNP@GNCs) were applied for the first time as a thrombolytic system. Upon irradiation by near-infrared I window (NIR-I) laser or II window (NIR-II) laser, the photothermal effect of HBHNP was triggered to promote the melting of the gelatin encapsulated around the outer layer, thereby realizing the targeted release of uPA. The in vitro and in vivo experiments demonstrated that the deep response to NIR (especially II window) of this system exhibited a satisfactory thrombolytic effect with ideal biosafety. Briefly, the proposed hair derived drug delivery system has the characteristics of human source, low cost, minimum heavy metal components, deep response to NIR (II window) laser, and good biocompatibility, which is expected to be expanded to the treatment for some diseases, even in deep tissue areas.
研究领域:
药学
·
生物医学工程
·
治疗学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Rui Jiang,Jie Zhao,Yifei Qiao,Bo Tan,Jialin Yin,Zhenyu Dai,Shiliang Mei,Wanlu Zhang,Ruiqian Guo
Near-infrared (NIR) emission has garnered significant attention owing to its broad application potential in next-generation optoelectronics. Among various candidates, indium phosphide (InP) quantum dots (QDs) have emerged as particularly promising candidate due to their environmentally benign composition and relatively facile synthesis. However, the synthesis of NIR-emitting InP-based QDs exhibiting high luminescence efficiency remains a critical challenge. The inherent difficulties primarily stem from insufficient core nucleation and the complex shell growth processes essential for achieving high-performance QDs. Herein, we report an expeditious synthetic strategy for achieving NIR-I emissive core-only InP QDs with tunable emission ranging from 683 to 742 nm, mediated by the synergistic effect of ZnCl 2 and NH 4 PF 6 . Under the competitive adsorption between ZnCl 2 and NH 4 PF 6 , high-covalent InP QDs with sizes of approximately 6 to 10 nm can be obtained within 5 min. During the later stages in this dual-salt system, PF 6 − effectively eliminates surface oxides while zinc ion enrichment establishes a negatively charged surface. This Zn-related configuration promotes subsequent adsorption and defect passivation by NH 4 + . The final core-only QDs exhibit bright NIR-I emission with a photoluminescence quantum yield of up to 74 % in solution. Furthermore, the application potential of these core-only QDs is demonstrated through simple patterning. This work establishes a straightforward, post-treatment-free synthesis of high-performance NIR-I core-only InP QDs, highlighting their substantial promise for next-generation optoelectronic devices.
研究领域:
纳米材料
·
量子点
·
光电子学
·
合成化学
·
半导体纳米晶体
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）