The Cu(I)- and HNO3-catalyzed oxidation of substituted toluenes to the benzoic acid based on NO x recycling
Based on the recycling of NO x , the Cu(I)- and HNO 3 -catalyzed oxidation of 2-chloro-4-(methylsulfonyl)toluene to 2-chloro-4-(methylsulfonyl)benzoic acid has been developed with an excellent yield of 84.2% and a purity of 99.7%. The optimized reaction conditions (160 °C, oxygen pressure 1.5 MPa, HNO 3 concentration 25 wt%, HNO 3 : substrate 0.5:1) use 1.0 mol% CuI as catalyst. The dosage of HNO 3 in the new process is only 25% of the stoichiometric amount and 12.5% of the amount of the traditional process. The NO x emission is 5% amount of the traditional process. The oxidation of several additional toluene derivatives with comparable yields demonstrates the generality to these reaction conditions.
危险品化学品经营许可证（带存储）