ACS Applied Energy Materials
·
2024
·
IF 5.4
Yi-Fu Huang,Mao-Jin Ran,Zhi-Rong Li,Man-Man Yuan,Ting-Ting Shen,Kai Liu,Ze-Yu Jiang,Shokir Khojiev,Zhi-Yi Hu,Jing Liu,Li-Hua Chen,Yu Li,Bao-Lian Su
The conversion of solar energy into hydrogen (H2) through photocatalysis technology has been considered to be one of the most promising ways to alleviate the energy crisis. However, achieving efficient H2 production is still a big challenge due to the rapid recombination of photogenerated carriers. In this work, we direct Mn0.2Cd0.8S/Co3O4 np junctions via in situ growing p-type Co3O4 nanoparticles on the surface of n-type Mn0.2Cd0.8S nanorods for photocatalytic hydrogen production. Compared to ex-situ-grown samples, the in-situ-grown samples construct many more channels for photogenerated charge carrier transfer via the np junctions and built-in electric field to promote their separation and migration, leading to enhanced photocatalytic hydrogen production. The results show that Mn0.2Cd0.8S/Co3O4-20 exhibits a H2 production rate of 26.98 mmol h–1 g–1 under visible light, which is about 2.71 times higher than that of pure Mn0.2Cd0.8S. In addition, the apparent quantum efficiency at 450 nm of Mn0.2Cd0.8S/Co3O4-20 reaches 14.0%. Our work here provides insights into constructing heterojunctions to facilitate photogenerated charge separation and transfer for photocatalysis and photovoltaic applications.
研究领域:
材料科学
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能源科学
·
光化学
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DOI
高影响因子
RSC Advances
·
2022
·Vol. 13
·期 1
·499-505
·
IF 4.036
Rong Wang,Jiamin Luo
Rapid and accurate identification of bacteria is essential to ensure food safety and prevent pathogenic bacterial infection. In this study, a highly efficient method was established for accurately identifying bacterial species by applying Ag NP-filter paper based Surface enhanced Raman spectroscopy (SERS) analysis and Partial Least Squares-Discriminant Analysis (PLS-DA) statistical methods. The flexible Ag NP filter paper substrate with high sensitivity and uniformity was prepared by a facile and low-cost silver mirror reaction at room temperature, which exhibited desirable SERS activity in bacteria detection. Furthermore, PLS-DA was successfully employed to distinguish SERS spectra from S. aureus CMCC 26003, E. faecalis ATCC29212 and L. monocytogenes ATCC 19115 with a sensitivity of 93.3–100%, specificity of 96.7–97%, and overall predicting accuracy of 95.8%. This exploratory study demonstrates that a Ag NP-filter paper based SERS sensor coupled with PLS-DA has great potential for rapid and effective detection and identification of bacteria.
研究领域:
分析化学
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微生物学
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食品安全
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DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2016
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IF 4.839
Naling Bai,Rexiding Abuduaini,Sheng Wang,Meinan Zhang,Xufen Zhu,Yuhua Zhao
Nonylphenol (NP), ubiquitously detected as the degradation product of nonionic surfactants nonylphenol polyethoxylates, has been reported as an endocrine disrupter . However, most pure microorganisms can degrade only limited species of NP with low degradation efficiencies. To establish a microbial consortium that can effectively degrade different forms of NP, in this study, we isolated a facultative microbial consortium NP-M2 and characterized the biodegradation of NP by it. NP-M2 could degrade 75.61% and 89.75% of 1000 mg/L NP within 48 h and 8 days, respectively; an efficiency higher than that of any other consortium or pure microorganism reported so far. The addition of yeast extract promoted the biodegradation more significantly than that of glucose. Moreover, surface-active compounds secreted into the extracellular environment were hypothesized to promote high-efficiency metabolism of NP. The detoxification of NP by this consortium was determined. The degradation pathway was hypothesized to be initiated by oxidization of the benzene ring, followed by step-wise side-chain biodegradation. The bacterial composition of NP-M2 was determined using 16S rDNA library, and the consortium was found to mainly comprise members of the Sphingomonas , Pseudomonas , Alicycliphilus , and Acidovorax genera, with the former two accounting for 86.86% of the consortium. The high degradation efficiency of NP-M2 indicated that it could be a promising candidate for NP bioremediation in situ .
研究领域:
环境微生物学
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生物修复
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微生物生态学
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2023
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IF 5.8
Jun Ma,Cuixia Wen,Meng Chen,Wei Zhang,Lifeng Wang,Haitao Yin
This study fabricates a nanoparticle delivery system of gold nanoparticles–dextran nanoparticles loaded with hypoxia-activated paclitaxel dimeric prodrug nanoparticles (PTX2-NP) and photosensitizer chlorin e6/paclitaxel-nanoparticle/gold@N-(2-hydroxypropyl) (Ce6/PTX2-NP/G@NHs) and analyzed the possible molecular mechanism for enhancing the radiosensitivity of non-small cell lung cancer (NSCLC). Ce6/PTX2-NP/G@NHs were prepared by a coupling reaction and dextran inclusion, followed by characterization using spectroscopy techniques. The cellular uptake and cytotoxicity of Ce6/PTX2-NP/G@NHs were analyzed. Radiosensitizing effects of the nanoparticles were evaluated by determining the malignant phenotypes and reactive oxygen species production of A549 cells and PI3K/AKT pathway-related proteins under 685 nm laser irradiation. A549 tumor-bearing nude mice were modeled to further confirm the radiosensitizing effect. Ce6/PTX2-NP/G@NHs were effectively internalized by A549 cells, producing cytotoxicity under laser irradiation. Ce6/PTX2-NP/G@NHs reduced cell viability, clonogenic potential, migration, and invasion along with reactive oxygen species (ROS) production while promoting apoptosis in A549 cells under laser irradiation. By inhibiting the PI3K/AKT pathway, Ce6/PTX2-NP/G@NHs increased the sensitivity of A549 cells to radiotherapy where apoptotic body (ApoBD)-mediated neighboring effects also played a key role. Ce6/PTX2-NP/G@NHs accumulated in tumor sites of nude mice and enhanced the radiosensitivity of NSCLC. Ce6/PTX2-NP/G@NHs showed no obvious toxicity or side effects in vivo. Collectively, the new Ce6/PTX2-NP/G@NHs nanoparticle delivery system can enhance the radiosensitivity of NSCLC via the promotion of ApoBD-mediated neighboring effects and inactivation of the PI3K/AKT pathway.
研究领域:
肿瘤学
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药学
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纳米技术
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分子生物学
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放射生物学
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DOI
PubMed
高影响因子
NEURAL PLASTICITY
·
2026
·Vol. 2026
·期 1
·9997801
·
IF 3.4
Xiuli Zeng,Xiaomei Xie,Junrun Zhang,Jinyu Jia,Li’an Huang
Background Nurr1, an orphan nuclear receptor that lacks an endogenous ligand, plays a key role in hippocampal function, synaptic plasticity, and cognitive processes. It is linked to various central nervous system diseases; however, its association with chronic cerebral hypoperfusion (CCH)-induced cognitive impairment remains unclear. This study investigated whether the Nurr1 agonist, amodiaquine (AQ), can enhance synaptic plasticity and alleviate cognitive deficits caused by CCH. Methods A CCH rat model was created using the bilateral common carotid arterial occlusion method, followed by a 2-week AQ treatment (20 mg/kg, every 12 h, through intraperitoneal injection). Learning and spatial memory were assessed using the Morris water maze (MWM), Y-maze, and object recognition tests. Cerebral blood flow (CBF) in the cortex and hippocampus was measured using arterial spin labeling (ASL) with 3.0T magnetic resonance imaging (MRI), and white matter fiber density was assessed using diffusion tensor imaging (DTI). Hippocampal neuron morphology and count were examined using Nissl and NeuN staining, while dendritic spine morphology and density in CA1 and CA3 hippocampal regions were analyzed using Golgi staining. Results Experiments with the water maze, Y-maze, and object recognition tests demonstrated that CCH rats treated with AQ exhibited improved long-term and short-term memory and spatial recognition compared to the control group, with benefits persisting after two and 6 weeks. MRI DTI sequences revealed that AQ reversed the decline in white matter fiber density observed in CCH model rats compared to the sham group. Golgi staining confirmed that AQ protected the dendritic spines of the neurons damaged in the CCH model. Conclusion Administrating Nurr1 agonist AQ demonstrated a sustained ameliorative effect on cognitive deficits in CCH rats. This effect is potentially mediated through the mitigation of hippocampal neuronal loss and improvement of dendritic spine integrity.
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DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 19
·5329-5345
·
IF 6.183
Wei Dong,Anqi Huang,Jixiu Huang,Pengying Wu,Shifang Guo,Huasheng Liu,Mengfan Qin,Xinxing Yang,Bo Zhang,Mingxi Wan,Yujin Zong
Using ultrasound activating contrast agents to induce sonoporation is a potential strategy for effective lesion-targeted gene delivery. Previous reports have proven that submicron nanodroplets have a better advantage than microbubbles in that they can pass through tumor vasculature endothelial gaps by passive targeting; however, they cannot achieve an adequate dose in tumors to facilitate ultrasound-enhanced gene delivery. Additionally, a few studies focused on delivering macromolecular genetic materials (i.e. overexpression plasmid and CRISPR plasmid) have presented more unique advantages than small-molecular genetic materials (i.e. miRNA mimics, siRNA and shRNA etc.), such as enhancing the expression of target genes with long-term effectiveness. Thereby, we constructed novel plasmid-loadable magnetic/ultrasound-responsive nanodroplets, where superparamagnetic iron oxide nanoparticle dispersed perfluoropentane was encapsulated with lipids to which plasmids could be adhered, and branched polyethylenimine was used to protect the plasmids from enzymolysis. Furthermore, in vitro and in vivo studies were performed to verify the magnetic tumor-targeting ability of the plasmid-loadable magnetic/ultrasound-responsive nanodroplets and focused ultrasound enhanced intracellular plasmid delivery. The plasmid-loadable magnetic/ultrasound-responsive nanodroplets, carrying 16–19 plasmids per droplet, had desirable diameters less than 300 nm, and integrated the merits of excellent magnetic targeting capabilities and phase transition sensitivity to focused ultrasound. Under programmable focused ultrasound exposure, the plasmid-loadable magnetic/ultrasound-responsive nanodroplets underwent a phase-transition into echogenic microbubbles and the subsequent inertial cavitation of the microbubbles achieved an ∼40% in vitro plasmid delivery efficiency. Following intravenous administration, T2-weighted magnet resonance imaging, scanning electron microscopy and inductively coupled plasma optical emission spectrometry of the tumors showed significantly enhanced intratumoral accumulation of the plasmid-loadable magnetic/ultrasound-responsive nanodroplets under an external magnetic field. And a GFP ELISA assay and immunofluorescence staining indicated that focused ultrasound-induced inertial cavitation of the plasmid-loadable magnetic/ultrasound-responsive nanodroplets significantly enhanced the intracellular delivery of plasmids within the tumor after magnet-assisted accumulation, while only lower GFP levels were observed in the tumors on applying focused ultrasound or an external magnet alone. Taken together, utilizing the excellent plasmid-loadable magnetic/ultrasound-responsive nanodroplets combined with magnetism and ultrasound could efficiently deliver plasmids to cancer cells, which could be a potential strategy for macromolecular genetic material delivery in the clinic to treat cancer.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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基因递送
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超声成像
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磁性靶向
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2024
·
IF 2.6
Xiaoting Li,Xin Li,Jiayi Chen,Zuomin Tan,Chuan Wang
Bacteremia , as a serious infectious disease, has an increasing incidence and a high mortality rate . Early diagnosis and early treatment are crucial for improving the cure rate. In this work, we proposed an inductively coupled plasma mass spectrometry (ICP-MS)-based detection method combined with gold nanoparticle (Au NP) and silver nanoparticle (Ag NP) labeling for the simultaneous detection of Salmonella and Escherichia coli ( E. coli O157:H7) in human blood samples. Salmonella and E. coli O157:H7 were captured by magnetic beads coupled with anti-8G3 and anti-7C2, and then specifically labeled by Au NP-anti-5H12 and Ag NP-anti-8B1 respectively, which were used as signal probes for ICP-MS detection. Under the optimal experimental conditions, the limits of detection of 164 CFU mL −1 for Salmonella , 220 CFU mL −1 for E. coli O157:H7 and the linear ranges of 400–80,000 CFU mL −1 Salmonella , 400–60,000 CFU mL −1 E . coli O157:H7 were obtained. The proposed method can realize the simultaneous detection of two types of pathogenic bacteria in human whole blood in 3.5 h, showing great potential for the rapid diagnosis of bacteremia in clinic.
研究领域:
医学诊断
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纳米技术
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微生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2024
·Vol. 46
·期 9
·1-11
·
IF 3.2
Yang Yu,Li Jing,Xu Jie
The levels of three phenolic endocrine-disrupting compounds (EDCs), NP, BPA and 4-t-OP were determined in water and sediment collected from sites along the Xiangjiang River, Zunyi, China. The NP, BPA and 4-t-OP concentrations ranged from 18.02 to 311.79 ng/L in the surface water, 16.04–408.12 ng/L in the submerged water, and 21.13–892.37 μg/kg dw in the sediment. NP contamination was most severe in both the river water and sediment. The ranges of the three phenolic EDCs were slightly greater in the submerged water than in the surface water ( p > 0.05). The concentrations in the middle reaches were greater than those in the upstream and downstream reaches in both the water and sediment, and significant differences in content were detected in some reaches. The levels of three phenolic EDCs in the water and sediment had a positive correlation. In addition, the distribution coefficient (K d ) indicated that NP was more likely to adsorb to the sediment, and BPA and 4-t-OP were more likely to adsorb to river water. Moreover, the risk quotient (RQ) and hazard quotients (HQ) were used to reveal the environmental and health risks caused by coexposure to the three phenolic pollutants. The results showed that the current pollution is a threat to the environment of the study area and not a threat to the health of the local population.
研究领域:
环境科学
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毒理学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 142
·期 2
·e56359
·
IF 2.7
Guixin Zhang,Shuxian Weng,Jie Wang,Zhimin Kou,Meiting Liu,Guoqiang Zhu,Lihong Hu,Yonghong Zhou
Polylactic acid (PLA) is a new type of biodegradable material that has been applied in many fields such as extrusion, injection molding, film drawing, and spinning. In contrary, it does not have flame retardancy. In this paper, N-PCDL was synthesized by amidation reaction between COOH of PCDL and NH 2 of tetraethylenepentamine (TEPA), followed by an Atherton-Todd reaction of unreacted NH 2 at the other end of TEPA with P H of DOPO to prepare a novel lignin-based flame retardant containing nitrogen and phosphorus (NP-PCDL). The Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic hydrogen spectroscopy ( 1 H NMR) analysis results showed that proton peaks of CO NH , P N , and NH appeared in the NP-PCDL spectrum, while the characteristic absorption peak of P H bond disappeared in DOPO, the X-ray photoelectron spectroscopy (XPS) results showed that the degraded lignin consisted of elements C and O, while NP-PCDL consisted of elements C, O, N and P. The above results indicated that NP-PCDL was successfully prepared. NP-PCDL accounted for 3% (mass percentage, the same below), 5% and 10% of PLA, then lignin based flame-retardant PLA composites were prepared by internal mixing and injection molding. Thermogravimetric analysis (TGA) showed that the residual carbon of PLA/3% NP-PCDL, PLA/5% NP-PCDL and PLA/10% NP-PCDL at 800°C were higher than that of pure PLA, with the increase of 56.56%, 97.54%, and 301.64%, respectively; The analysis of SEM, XPS, and Raman showed that PLA/NP-PCDL formed dense, regular and highly graphitized residual carbon with phosphorus nitrogen structure during the combustion process. At the same time, NH 3 , H 2 O and PO˙ free radicals were released, which could dilute combustible gases, destroy free radical chain reaction, isolate combustible gases and heat, so as to play a flame-retardant role.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 20
·6951
·
IF 4.927
Yujie Tao,Fang Zhou,Kaixin Wang,Dequan Yang,Edward Sacher
Although a facile route to prepare AgCu nanoalloys (NAs) with enhanced antibacterial efficacy using Ag NP catalysis of Cu ions at elevated temperatures was previously developed, its detailed reaction process is still unclear due to the fast reaction process at higher temperatures. This work found that AgCu NAs can also be synthesized by the same process but at room temperature. AgCu NAs formation kinetics have been studied using UV–Visible spectra and Transmission Electron Microscopy (TEM), where formation includes Cu2+deposition onto the Ag NP surface and Ag+release, reduction, and agglomeration to form new Ag NPs; this is followed by a redistribution of the NA components and coalescence to form larger AgCu NPs. It is found that SPR absorption is linear with time early in the reaction, as expected for both pseudo-first-order (PFO) and pseudo-second-order (PSO) kinetics; neither model is followed subsequently due to contributions from newly formed Ag NPs and AgCu NAs. The antibacterial efficacy of the AgCu NAs thus formed was estimated, with a continuous increase over the whole alloying process, demonstrating the correlation of antibacterial efficacy with the extent of AgCu NA formation and Ag+release.Keywords:Ag nanoparticles;AgCu nanoalloys;antibacterial efficacies;reaction kinetics
研究领域:
材料科学
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微生物学
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DOI
PubMed
高影响因子
Applied Materials Today
·
2021
·
IF 10.041
Huizhu Yu,Ming Ma,Kaicheng Liang,Jie Shen,Zhengyi Lan,Hangrong Chen
Engineering nanotherapeutics with simple ingredients but multiple functions at large-scale via easy methods is still a formidable challenge for cancer treatment. Herein, a novel multifunctional nanotherapeutic agent (named as FeEP-NP) was fabricated by a one-pot self-assembly method based on the coordination between Fe II and (-)-epigallocatechin gallate (EGCG) with poly(vinylpyrrolidone) serving as a stabilizer. The designed FeEP-NPs could produce the toxic hydroxyl radical (•OH) effectively via Fenton reaction for chemodynamic therapy (CDT). Intriguingly, the unique binding between EGCG and Fe II ions endows nanoparticles with strong absorption and photothermal conversion capabilities in the near-infrared (NIR) region, which could achieve mild hyperthermia-enhanced CDT under NIR laser irradiation. More impressively, the partially released EGCG could accelerate the Fe III /Fe II conversion to augment the generation of •OH to further promote CDT, and simultaneously down regulate the intracellular expression of heat shock protein 90 (HSP 90) to enhance mild photothermal therapy (PTT). Both in vitro and in vivo results demonstrate that the low-temperature PTT-potentiated CDT based on FeEP-NPs could suppress tumors more efficiently. Overall, this work presents a novel multifunctional nanoplatform with succinct design, highlighting significant prospects for future clinical application.
研究领域:
纳米医学
·
肿瘤学
·
生物材料学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Liu Yuan,Liu Junhui,Xiong Hanting,Chen Jingwen,Chen Shixia,Zeng Zheling,Deng Shuguang,Wang Jun
Efficient adsorptive separation of acetylene (C 2 H 2 ) from carbon dioxide (CO 2 ) or ethylene (C 2 H 4 ) is industrially important but challenging due to the identical dynamic diameter or the trace amount. Here we show an electrostatic potential compatible strategy in a nitroprusside-based Hofmann-type metal-organic framework, Cu(bpy)NP (NP = nitroprusside, bpy = 4,4’-bipyridine), for efficient C 2 H 2 separation. The intruding cyanide and nitrosyl groups in undulating one-dimensional channels induce negative electrostatic potentials for preferential C 2 H 2 recognition instead of open metal sites in traditional Hofmann-type MOFs. As a result, Cu(bpy)NP exhibits a 50/50 C 2 H 2 /CO 2 selectivity of 47.2, outperforming most rigid MOFs. The dynamic breakthrough experiment demonstrates a 99.9% purity C 2 H 4 productivity of 20.57 mmol g −1 from C 2 H 2 /C 2 H 4 (1/99, v / v ) gas-mixture. Meanwhile, C 2 H 2 can also be captured and recognized from ternary C 2 H 2 /CO 2 /C 2 H 4 (25/25/50, v/v/v ) gas-mixture. Furthermore, computational studies and in-situ infrared spectroscopy reveal that the selective C 2 H 2 binding arises from the compatible pore electro-environment generated by the electron-rich N and O atoms from nitroprusside anions.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
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