JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Wei Chen,Yiran Liang,Zhili Chen,Yunxiang Zhang,Jian Wang,Xin Chen,Chenliang Zhou,Keshun Nie,Zhongjie Wang,Qinfang Zhang
Designing of an efficient heterojunction for the practical application of photocatalysis has been considered as the promising topic for the settle of the energy crisis and environmental pollution. Herein, a dual Bi 2 O 3 /BiOCl/Bi 24 O 31 Cl 10 ternary heterojunction has been constructed by the in-situ photoreduction technique for the photocatalytic degradation of rhodamine B (RhB) and tetracycline hydrochloride (TCH). The significant difference in the work function ( W f ) among Bi 2 O 3 , BiOCl, and Bi 24 O 31 Cl 10 leads to the formation of the space charge region (built-in electric field) around the heterojunction interface along with band bending, which facilitates the directional migration and spatial separation of photogenerated carriers and offers the strong redox capacity of photogenerated electrons and holes. This process is beneficial for the generation of active species of superoxide free radical ( ∙ O 2 − ) and the photo-generated hole (h + ). The optimized removal efficiencies of RhB and TCH for the ternary heterojunction were nearly 7.19 and 1.28 times higher than these for the pure Bi 24 O 31 Cl 10 , respectively. Furthermore, the involved vital reactive radicals, potential degradation pathway, and the eco-toxicity of intermediates over Bi 2 O 3 /BiOCl/Bi 24 O 31 Cl 10 are evaluated through the trapping experiment, LC-MS calculation, and toxicity analysis. This work demonstrates a new heterojunction photocatalyst for the elucidation of pollutant degradation mechanism.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Xinyu Yao,Jinying Gao,Lanqiao Wang,Xiaoning Hou,Litao Ge,Xinxin Qin,Jiazhang Qiu,Xuming Deng,Wei Li,Jianfeng Wang
Ethnopharmacology relevance Cananga oil (CO) is derived from the flowers of the traditional medicinal plant, the ylang-ylang tree. As a traditional antidepressant, CO is commonly utilized in the treatment of various mental disorders including depression, anxiety, and autism. It is also recognized as an efficient antibacterial insecticide, and has been traditionally utilized to combat malaria and acute inflammatory responses resulting from bacterial infections both in vitro and in vivo . Aim of the study The objective of this study is to comprehensively investigate the anti- Salmonella activity and mechanism of CO both in vitro and in vivo , with the expectation of providing feasible strategies for exploring new antimicrobial strategies and developing novel drugs. Methods The in vitro antibacterial activity of CO was comprehensively analyzed by measuring MIC, MBC, growth curve, time-killing curve, surface motility, biofilm, and Live/dead bacterial staining. The analysis of the chemistry and active ingredients of CO was conducted using GC-MS. To examine the influence of CO on the membrane homeostasis of Salmonella , we conducted utilizing diverse techniques, including ANS, PI, NPN, ONPG, BCECF-AM, DiSC3(5), and scanning electron microscopy (SEM) analysis. In addition, the antibacterial mechanism of CO was analyzed and validated through metabolomics analysis. Finally, a mouse infection model of Salmonella typhimurium was established to evaluate the toxic side effects and therapeutic effects of CO. Results The antibacterial effect of CO is the result of the combined action of the main chemical components within its six (palmitic acid, α-linolenic acid, stearic acid, benzyl benzoate, benzyl acetate, and myristic acid). Furthermore, CO disrupts the balance of purine metabolism and the tricarboxylic acid cycle (TCA cycle) in Salmonella , interfering with redox processes. This leads to energy metabolic disorders and oxidative stress damage within the bacteria, resulting in bacterial shock, enhanced membrane damage, and ultimately bacterial death. It is worth emphasizing that CO exerts an effective protective influence on Salmonella infection in vivo within a non-toxic concentration range. Conclusion The outcomes indicate that CO displays remarkable anti- Salmonella activity both in vitro and in vivo . It triggers bacterial death by disrupting the balance of purine metabolism and the TCA cycle, interfering with the redox process, making it a promising anti- Salmonella medication.
研究领域:
药理学
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微生物学
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代谢组学
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传染病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）