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Nano Research · 2020 ·Vol. 14 ·期 7 ·2398-2409 · IF 8.183

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhang Zhicheng,Ding Yawen,Li Jinbiao,Wang Li,Xin Xiaoyan,Yan Jing,Wu Jinhui,Yuan Ahu,Hu Yiqiao

Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K 3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.

CAS / MDL: 75-05-8 7727-54-0 58-27-5 67-56-1 111-16-0

研究领域: 癌症治疗 · 纳米技术 · 材料科学 · 细胞生物学

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Acta Pharmaceutica Sinica B · 2015 · IF 0

Preliminary investigations into surface molecularly imprinted nanoparticles for Helicobacter pylori eradication

Jiaying Han,Yinjing Sun,Jiapeng Hou,Yuyan Wang,Yu Liu,Cao Xie,Weiyue Lu,Jun Pan

This paper reports investigations into the preparation and characterization of surface molecularly imprinted nanoparticles (SMINs) designed to adhere to Helicobacter pylori (H. pylori) . Imprinted nanoparticles were prepared by the inverse microemulsion polymerization method. A fraction of Lpp20, an outer membrane protein of H. pylori known as NQA, was chosen as template and modified with myristic acid to facilitate its localization on the surface of the nanoparticles. The interaction between these SMINs with the template NQA were evaluated using surface plasmon resonance (SPR), change in zeta potential and fluorescence polarization (FP). The results were highly consistent in demonstrating a preferential recognition of the template NQA for SMINs compared with the control nanoparticles. In vitro experiments also indicate that such SMINs are able to adhere to H. pylori and may be useful for H. pylori eradication.

CAS / MDL: 79-06-1 7727-54-0 110-26-9 110-18-9

研究领域: 生物医学工程 · 微生物学 · 纳米医学

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Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Preliminary investigations into surface molecularly imprinted nanoparticles for Helicobacter pylori eradication