JOURNAL OF LUMINESCENCE
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2019
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IF 2.961
Han Xia,Lei Lei,Jienan Xia,Youjie Hua,Degang Deng,Shiqing Xu
Non-contact optical thermometry based on fluorescence intensity ratio (FIR) technique has been widely researched over the past few decades. However, the reported systems exhibit two important shortcomings including the existence of a few interferential signals in addition to the required spectral bands for FIR and the absence of internal standard for reference signal. Herein, only two emission bands of Er 3+ : 4 F 9/2 → 4 I 15/2 (~673 nm) and Tm 3+ : 3 H 4 → 3 H 6 (~800 nm) are achieved in Yb/Er/Tm tri-doped Na 3 ZrF 7 nano-system. Moreover, the upconversion (UC) emission intensity of Er 3+ keeps unchanged with the rising of temperature, which is applied as reference signal; while that of Tm 3+ enhances evidently, which is applied as temperature signal. The calculated maximum absolute temperature sensitivity (S a ) and relative temperature sensitivity (S r ) are 0.17 K −1 at 393 K and 1.76% K −1 at 313 K, respectively.
研究领域:
材料科学
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纳米技术
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光学
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温度传感
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产品关联
DOI
高影响因子
Journal of Materials Chemistry C
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2019
·Vol. 7
·期 5
·1321-1329
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IF 6.641
Daqin Chen,Yue Liu,Jiangkun Chen,Hai Huang,Jiasong Zhong,Yiwen Zhu
Efficient dual-modal luminescence is highly desired for applications in high security anti-counterfeiting. In the present work, Yb3+/Ln3+/Mn4+ (Ln = Er, Ho, and Tm) tri-doped Na3ZrF7 phosphors were fabricated via oil–water interface cation exchange using Yb3+/Ln3+:Na3ZrF7 as the exchanging hosts. The as-prepared products exhibited typical Mn4+ red down-shifting luminescence under UV light excitation and Er3+ red, Ho3+ yellow and Tm3+ near-infrared multi-color upconversion emissions under 980 nm laser excitation. The Mn4+ dopants in the Na3ZrF7 host experienced strong crystal-field strength Dq of 3.63 and showed superior thermal stability with up to 90% of the initial emission intensity retained at 448 K. Steady-state and time-resolved emission spectra verified that there was no detrimental energy transfer interaction between Mn4+ and Ln3+, enabling bright and eye-visible bi-functional emissions for the present products. As a consequence, the as-prepared phosphors were demonstrated to be applicable in anti-counterfeiting by a proof of concept experiment of fluorescent labeling for specially designed patterns.
研究领域:
材料科学
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光学
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纳米技术
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化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
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2022
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IF 6.14
Wubin Lv,Jin Ye,Qiang Wang,Chunsheng Li,Jun Wang,Zhiyong Zhang,Na Niu,Zhiguo Liu,Jiating Xu,Yujie Fu
Rare earth (RE)-based inorganic upconversion nanoparticles (UCNPs) have huge potency for applications varying from bioimaging to theranostics of tumors. For these applications, it is of great importance that UCNPs be expelled innocuously from a living body during a rational period of time after executing their diagnostic and/or therapeutic tasks. Despite great efforts to modulate biodegradability, a reasonable biodegradation rate for currently available UCNPs in weakly alkaline physiochemical buffers has not yet been realized. Herein, to achieve a tunable biodegradation rate for UCNPs, a class of core–shell-structured nanoparticles is invented by heteroepitaxially growing a CaF2:Yb shell with varying Zr4+ doping content on a biodegradable Na3ZrF7:Yb,Er core. The CaF2:Yb,Zr shell can not only enhance the emission intensity but also ensure the overall biodegradation of the nanocrystals. The degradation rate of core–shell UCNPs can be easily modulated by changing the Zr4+ doping content in the shell, and the degradation rate is pH-responsive; thus, tumor acidity-triggered degradation can be realized. When sodium alginate (SA)-modified UCNPs are used for the bioimaging of tumors, the intracellularly degraded metal ions and the released SA molecules can self-assemble through a coordination cross-linking effect, thereby improving the tumor retention of the nanosystems. These discoveries will unequivocally promote the future clinical applications of RE-based UCNPs.
研究领域:
纳米技术
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生物医学工程
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材料科学
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癌症研究
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光学成像
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产品关联
DOI
高影响因子
BIOMATERIALS
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2025
·
IF 12.9
Lin Liu,Kaiyan Huang,Xia Sun,Junpeng Shi,Xianggui Yin,Wenpeng Zhao,Peng Lin,Yutong Han,Fangrong Zhang,Weibing Miao,Yun Zhang
Pyroptosis is an effective strategy for inducing inflammatory responses in 'cold' tumors, boosting the efficacy of immunotherapy. Although biodegradable inorganic nanoparticles (BINPs) show great potential in pyroptosis by releasing ions to break intracellular homeostasis, the limited intracellular ion release efficiency restricts pyroptosis level and subsequent immune activation. Herein, by heterovalent substitution strategy, a series of Na 3 ZrF 7 :x%Yb 3+ (NZF:x%Yb, x = 0, 9, and 18) BINPs with tunable intracellular ion release efficiency are synthesized for enhanced pyroptosis and tumor immunotherapy. Specifically, the size of NZF:x%Yb 3+ gradually decrease with increasing Yb 3+ -doped and smaller NZF:x%Yb presents a higher degradation rate and cellular uptake ability, enabling improved intracellular ion release efficiency. This leads to drastic intracellular homeostasis stress and abundant ROS generation, thereby provoking enhanced caspase-1-related pyroptosis. Antitumor experiments in triple-negative breast cancer model confirm that the ultra-small NZF:x%Yb (NZF:18%Yb) with the highest intracellular ion release efficiency shown the most effective antitumor ability, and significant inhibition of distal tumor. This study reveals precise control over the size of NZF:x%Yb is especially vital to achieving pyroptosis-induced immunotherapy, which offers a new perspective for the design of BINPs.
研究领域:
纳米医学
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癌症免疫治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）