BIOMATERIALS
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2015
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IF 8.557
Leyong Zeng,Yuanwei Pan,Ying Tian,Xin Wang,Wenzhi Ren,Shouju Wang,Guangming Lu,Aiguo Wu
The combination therapy has exhibited important potential for the treatment of cancers, especially for drug-resistant cancers. In this report, bi-functional nanoprobes based on doxorubicin (DOX)-loaded NaYF 4 :Yb/Tm–TiO 2 inorganic photosensitizers (FA-NPs-DOX) were synthesized for in vivo near infrared (NIR)-triggered inorganic photodynamic therapy (PDT) and enhanced chemotherapy to overcome the multidrug resistance (MDR) in breast cancers. Using the up-conversion luminescence (UCL) performance of NaYF 4 :Yb/Tm converting near-infrared (NIR) into ultraviolent (UV) lights, reactive oxygen species (ROS) were triggered from TiO 2 inorganic photosensitizers for PDT under the irradiation of a 980 nm laser, by which the deep-penetration and low photo-damage could be reached. Moreover, nanocarrier delivery and folic acid (FA) targeting promoted the cellular uptake, and accelerated the release of DOX in drug-sensitive MCF-7 and resistant MCF-7/ADR cells. The toxicity assessment in vitro and in vivo revealed the good biocompatibility of the as-prepared FA-NPs-DOX nanocomposites . By the combination of enhanced chemotherapy and NIR-triggered inorganic PDT, the viability of MCF-7/ADR cells could decrease by 53.5%, and the inhibition rate of MCF-7/ADR tumors could increase up to 90.33%, compared with free DOX. Therefore, the MDR of breast cancers could be obviously overcome by enhanced chemotherapy and NIR-triggered inorganic PDT of FA-NPs-DOX nanocomposites under the excitation of a 980 nm laser.
研究领域:
肿瘤学
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纳米医学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
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2017
·Vol. 47
·期 5
·1666-1673
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IF 4.029
Yan Lv,Lin Yue,Qian Li,Baoyi Shao,Sen Zhao,Haitao Wang,Shijia Wu,Zhouping Wang
Herein, the design and synthesis of a multifunctional (Fe3O4-NaYF4:Yb,Tm)@TiO2 photocatalyst through a facile sol–gel process combined with electrostatic self-assembly has been reported. Particularly, as an upconversion sensor, NaYF4:Yb,Tm nanoparticles have the ability to convert near-infrared (NIR) light into ultraviolet (UV) emissions, so that the catalytic body TiO2 can indirectly utilize the NIR part of sunlight but not UV light. The excellent photocatalytic activity of the hybrid samples is evaluated using a model of the degradation of methylene blue (MB). Most importantly, the obtained materials exhibit remarkable magnetic properties because of the addition of a magnetic component (Fe3O4), therefore, the photocatalysts possess desired recyclability and reusability, which is significant for actual applications. Finally, the possible photocatalysis mechanism of the nanohybrids is discussed and hydroxyl radicals (OH˙) are confirmed as the main reactive species.
研究领域:
材料科学
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环境科学
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纳米技术
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
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2015
·Vol. 3
·期 28
·14642-14650
·
IF 7.443
Yongmei Ma,Honglin Liu,Zhenzhen Han,Liangbao Yang,Jinhuai Liu
An effective near-infrared (NIR) active photocatalyst, NaYF4:Yb,Tm@TiO2/Ag (UC@TiO2/Ag) core@comby shell composite, was synthesized by a simple three-step hydrothermal process. Under the full-spectrum light of a Xe lamp in UV-Vis absorbance experiments, about 96% of R6G dyes in solution were degraded by UC@TiO2/Ag in 120 minutes, while only about 64% of the dyes were degraded by pure TiO2 under the same conditions. Under a UV-filtered Xe lamp, about 35% of the dyes were degraded by UC@TiO2/Ag in 120 minutes; interestingly, only about 8% of the dyes were degraded by pure TiO2. Under irradiation by a 785 nm laser in surface enhanced Raman scattering (SERS) experiments, the photodegradation rate constants were 0.02612 s−1 for UC@TiO2/Ag and 0.00046 s−1 for TiO2/Ag, indicating a nearly 58 fold improvement. After deducting the photobleaching effect, the photodegradation rate constants for UC@TiO2/Ag under 633 and 532 nm lasers were 0.00715 s−1 and 0.00565 s−1, respectively, revealing a sharp decrease under irradiation at shorter wavelengths. Electron spin resonance (ESR) analysis revealed that the presence of UC in this photocatalytic system certainly induced the increase of ˙OH free radicals with NIR irradiation, i.e. the UC core converts NIR light into ultraviolet (UV) light and initiates excellent photocatalytic activity of the TiO2/Ag comby shell. Furthermore, the decorating of Ag nanoparticles not only enhances the photocatalytic ability, but also provides a structural basis for monitoring the photocatalytic kinetics by the SERS technique. By virtue of monochrome laser lines, SERS analysis provides direct evidence to prove the capability of UC-initiated non-UV photocatalysis and the improvement of the utilization of non-UV lights on TiO2. The results revealed that this new photocatalytic platform can efficiently utilize different bands of the solar spectrum and also find new applications in SERS fields.
研究领域:
材料科学
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光催化
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纳米技术
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光谱学
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环境化学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Nguyen Thi Ngoc Yen,Vuong Thanh Tuyen,Cao Thi My Dung,Le Thuy Thanh Giang,Tran T.T. Van
The degradation of persistent organic dyes, such as methylene blue (MB), is crucial for protecting aquatic environments, as these compounds are chemically stable and resistant to conventional treatment methods. The TiO 2 -based photocatalysts have been widely explored for pollutant degradation owing to their chemical robustness, eco-friendliness, and strong oxidative capability under light irradiation. However, its wide bandgap (∼3.0–3.2 eV) restricts optical absorption to the ultraviolet region, which comprises only a small portion, less than 5 % of solar energy. In this work, a UCNRs@TiO 2 core–shell nanostructured photocatalyst composed of NaYF 4 :30 Yb 3+ ,0.5 Tm 3+ upconversion nanorods (UCNRs) and TiO 2 nanoparticles was successfully fabricated to enhance both ultraviolet (UV) and near infrared (NIR)-responsive photocatalytic activity. The UCNRs serve as efficient optical converters, absorbing near-infrared light at 980 nm and emitting UV photons to activate TiO 2 , thereby extending its operational spectral range. Photocatalytic activity was evaluated under solar simulated irradiation by monitoring the degradation of MB at a concentration of 15 mg/L. The UCNRs@TiO 2 photocatalyst achieved a remarkable degradation efficiency of 100 % MB within 90 min with an apparent rate constant of 0.063 min −1 , in contrast to 195 min required by bare TiO 2 . In addition, the photocatalytic enhancement mechanism of UCNRs@TiO 2 materials was also proposed based on the results of Photoluminescence, UV–Vis spectra and LC-MS. The excellent stability of the composites after three cycles of reuse demonstrates their promise for the rational design of NIR-driven photocatalysts for sustainable wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Zhenli Qiu,Jian Shu,Dianping Tang
Titanium dioxide (TiO2; as a potential photosensitizer) has good photocurrent performance and chemical stability but often exhibits low utilization efficiency under ultraviolet (UV) region excitation. Herein, we devised a near-infrared light-to-UV light-mediated photoelectrochemical (PEC) aptasensing platform for the sensitive detection of carcinoembryonic antigen (CEA) based on core–shell NaYF4:Yb,Tm@TiO2 upconversion microrods by coupling with target-triggered rolling circle amplification (RCA). The upconversion microrods synthesized through the hydrothermal reaction could act as a photosensing platform to convert the near-infrared (near-IR) excitation into UV emission for generation of photoinduced electrons. The target analyte was determined on a functional magnetic bead by using the corresponding aptamers with a sandwich-type assay format. Upon target CEA introduction, a complex was first formed between capture aptamer-1-conjugated magnetic bead (Apt1-MB) and aptamer-2-primer DNA (Apt2-pDNA). Thereafter, the carried primer DNA by the aptamer-2 paired with linear padlock DNA to trigger the RCA reaction. The guanine (G)-rich product by RCA reaction was cleaved by exonuclease I and exonuclease III (Exos I/III), thereby resulting in the formation of numerous individual guanine bases to enhance the photocurrent of core–shell NaYF4:Yb,Tm@TiO2 upconversion microrods under near-IR illumination (980 nm). Under optimal conditions, the near-IR light-mediated PEC aptasensing system could exhibit good photoelectrochemical response toward target CEA and allowed for the detection of target CEA as low as 3.6 pg mL–1. High reproducibility and good accuracy were achieved for analysis of human serum specimens. Importantly, the near-IR-activated PEC aptasensing scheme provides a promising platform for ultrasensitive detection of other biomolecules.
研究领域:
生物医学工程
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分析化学
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癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）