Advanced Healthcare Materials
·
2025
·
IF 9.6
Lu Liu,Daiyong Chao,Qing Dong,Xianli Zhang,Kai Zhang,Zhenyu Ju
Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but is associated with significant adverse effects, particularly DOX-induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses and ferroptosis inhibition are essential for mitigating DIC. An innovative bimetallic metal-organic framework (MOF), NiCu-MOF (NCM), is developed, exhibiting multifaceted antioxidant enzyme-mimicking activities that effectively scavenge a broad spectrum of ROS. Additionally, the bimetallic NCM exhibits excellent iron-chelating ability. In vitro experiments demonstrate that NCM significantly reduces cardiomyocyte death by attenuating ROS levels and inhibiting ferroptosis. Furthermore, in a mouse model of DIC, NCM treatment results in substantial myocardial protection, evidenced by improved cardiac function and structural integrity. This protective effect is attributed to suppression of ferroptosis, preservation of mitochondrial function, and attenuation of inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as a novel cardioprotective agent and offer a promising therapeutic strategy for managing DIC.
研究领域:
药理学
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心血管病学
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纳米医学
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DOI
PubMed
高影响因子
ELECTROANALYSIS
·
2025
·Vol. 37
·期 8
·e70036
·
IF 2.3
Yujing Zhong,Nan Zhang,Qiulin Lyu,Muhammad Waqas,Chengzhou Liu,Liujie Lu,Shiyin Xu,Youjun Fan,Guang Liu,Wei Chen
Metal-organic frameworks (MOFs) and layered double hydroxides (LDHs) have emerged as highly efficient platforms for electrochemical sensors due to their simplicity, rapid response, low cost, and elevated sensitivity. However, the underlying mechanism of their interaction in electrochemical sensors is still unclear. Herein, the porous composite of MOF-supported LDHs (NiCu MOF@LDHs) is successfully fabricated using a simple hydrothermal method. Interestingly, the integration of LDHs and MOFs synergistically enhanced the hierarchical structure of the composite, leading to an increased specific surface area and improved electrical conductivity. Thus, the NiCu MOF@LDHs/GCE presents excellent glucose sensing features, including a good linear range (4.9504–1.1701 mM and 1.1701–2.8248 mM), a low detection limit (1.4249 μM, S/N = 3). Specifically, the sensor exhibited enhanced sensitivities (1071.1 and 545.2 µA mM –1 cm –2 ) and high selectivity in the presence of common interfering species including dopamine, hydrogen peroxide, ascorbic acid, L-arginine, and sodium chloride. Furthermore, the NiCu MOF@LDHs/GCE sensor demonstrated excellent performance in the practical detection of glucose levels in human serum, appreciating its potential for real-time applications. This work not only highlights the unique structural and functional properties of the NiCu MOF@LDHs composite but also paves the way for its future applications in glucose sensing and electrochemical biosensing.
研究领域:
电化学传感
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纳米材料
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生物传感器
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分析化学
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材料科学
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DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124306
·
IF 7.5
Raza Ullah,Nasim Ullah,Abdul Qadir,Muzamil Ahmad,Alamgir,Muhammad Fayaz,Muhammad Rafiq,Adeel Ahmed,Muhammad Adnan,Fangqing Wang,Bing Yu,Hailin Cong
Photocatalysts based on metal–organic frameworks (MOFs) have garnered significant interest for enhanced advanced oxidation processes; yet, inadequate charge separation and limited availability of redox-active sites continue to impede their catalytic performance. A hierarchical Co-MOF/NiCu-MOF heterostructure was synthesised using an in-situ MOF-on-MOF growth strategy and employed for visible-light-assisted activation of peroxymonosulfate (PMS) to effectively degrade pharmaceutical contaminants. The integration of Co-MOF with bimetallic NiCu-MOF resulted in an interfacially linked framework exhibiting improved visible-light absorption, hierarchical structure, plentiful Co/Ni/Cu redox centers, and expedited interfacial charge transfer. The Co-MOF/NiCu-MOF demonstrated significantly enhanced catalytic activity relative to individual Co-MOF, Ni-MOF, Cu-MOF, and NiCu-MOF. Under optimized conditions, the Co-MOF/NiCu-MOF/PMS/visible-light system attained 98.2% ciprofloxacin (CIP) degradation with a pseudo-first-order rate constant of 0.1312 min −1 . The catalytic activity was significantly influenced by PMS dosage, catalyst loading, pH, CIP concentration, interfering species, and water matrix. The system exhibited superior performance in both tap water and simulated wastewater, indicating strong practical application. Radical quenching experiments and EPR analysis established that OH • was the predominant oxidative species, along with the minor contribution of SO 4 • ‾ and 1 O 2 to the degradation process. Mass Spectrometry analysis indicated that the CIP underwent degradation via sequential hydroxylation, oxidation, side-chain cleavage, ring-opening, and mineralisation processes. The catalyst maintained 96.3% degradation efficiency after five cycles with minimal metal leaching, indicating exceptional stability and reusability. This study emphasises MOF-on-MOF interfacial engineering as a proficient approach for developing effective PMS activators for the remediation of pharmaceutical wastewater.
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DOI
高影响因子
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