ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Xinying Gong,Linyan Xu,Siming Huang,Xiaoxue Kou,Shu Lin,Guosheng Chen,Gangfeng Ouyang
Herein, a novel solid-phase microextraction (SPME) fiber based on the NU-1000 sorbent was developed for direct immersion extraction of organochlorine pesticides (OCPs) in water samples. As a kind of metal-organic framework, the NU-1000 possessed the mesoporous channels which were beneficial for the mass transfer of target analytes. Extraction equilibrium was achieved rapidly with the optimal extraction time of 30 min. The NU-1000 coated fiber with a high specific surface area showed better extraction efficiencies than commercial fibers (65 μm PDMS/DVB or 85 μm PA) towards OCPs, with the enrichment factors of the NU-1000 coated fiber 2–20 times higher than the latter. NU-1000 coated fiber showed higher extraction efficiencies toward polycyclic aromatic hydrocarbons (PAHs) than OCPs and nitrobenzenes . This indicated that π-π interaction and CH-π interaction between pollutants and aromatic groups of the NU-1000 contributed to the high extraction efficiencies. Under the optimal conditions (extraction at 40 °C for 30 min and desorption at 260 °C for 6 min), the NU-1000 coated fiber coupled with gas chromatography-mass spectrometry (GC-MS) exhibited satisfied analytical performance on analysis of OCPs, with a wide linear range (0.1–2000 ng L −1 ), low limits of detections (LODs, 0.011–0.058 ng L −1 ), and good reproducibility and repeatability. The established method has been successfully applied to the determination of OCPs in surface water with good sensitivity and recoveries, which proved the great promise of the NU-1000 on the extraction of organic pollutants with conjugated groups.
研究领域:
分析化学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2023
·
IF 5.2
Wenhui Hao,Gengli Huang,Guoyong Jiang,Sa-adu Abiola Dauda,Fuwei Pi
To control and on-site evaluate the contamination of organophosphorus pesticides, one direct sensing approach based on spontaneous fluorescence resonance energy transfer (FRET) was developed in this study. The luminescent metal-organic frameworks (LMOFs), a novel achievement of MOFs, could provide adjustable adsorption capacity and fluorescence index to scientific analysis was first employed to evaluate phoxim molecules in vegetables and fruits. Through the π-π recognition and FRET sensing between phoxim molecules and skeleton of Nu-1000 LMOFs probes, an ultra-low detection limit of 1.65 pg/L in the range of 5×10 −7 to 5×10 −3 mg/mL ( R 2 =0.998) was achieved in the presence of phoxim. Such simple and accurate LMOFs- FRET-based sensing strategy could offer valuable reference for developing sensitive FRET sensors and/or on-site evaluation approaches in the areas of food quality control and food safety.
研究领域:
分析化学
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食品科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
En-Ze Deng,Qijie Mo,Yuying Li,Zongwen Mo,Li Zhang,Jiewei Liu
Although Z-scheme heterojunction composites have been widely studied in photocatalysis, in-depth investigation of oxygen vacancies (Ov) in the Z-scheme photocatalysts is still rare. Herein, an oxygen vacancies modified NU-1000/BiOCl-Ov composite with Z-scheme heterojunction was rationally designed and fabricated. The combination of X-ray photoelectron spectroscopy (XPS) and electron paramagnetic resonance (EPR) experiment verified the presence of oxygen vacancies, meanwhile the Z-scheme charge transfer across the heterojunction interface was confirmed in detail by the in situ -XPS, Kelvin probe force microscope (KPFM) studies, ultraviolet photoelectron spectroscopy (UPS), EPR radical capture experiment, as well as density functional theory (DFT) calculation. Importantly, compared to pristine NU-1000 and BiOCl, the optimized NU-1000/BiOCl-Ov composite displayed enhanced photocatalytic performance in the degradation of tetracycline hydrochloride (TCH) under visible light (λ ≥ 400 nm). Theoretical calculations reveal that the oxygen vacancies could induce electron redistribution, facilitating the activation of O 2 and TCH molecules, thereby promoting the photodegradation efficiency. Moreover, mechanism studies suggested that the synergistic effect of oxygen vacancies and Z-scheme heterojunction could facilitate the effective separation of photogenerated carriers. At last, the degradation routes of TCH were proposed and the toxicity of degradation intermediates was assessed. This work underlines the cooperative functions of oxygen vacancies and Z-scheme heterojunction towards improved photocatalytic performance, which offers new perspectives on the design of metal–organic frameworks (MOFs) composites for efficient photocatalysis.
研究领域:
材料科学
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环境科学
·
化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Jing Xia,Yanxin Gao,Gang Yu
The adsorptive removal of tetracycline (TC) was studied with three types of zirconium-based metal–organic frameworks (Zr-MOFs), UiO-66, NU-1000 and MOF-525. The adsorption kinetics best fitted with the pseudo-second-order kinetic model and the adsorption equilibrium was rapidly reached within 40 min on UiO-66 and NU-1000, and 120 min on MOF-525. The adsorption isotherms best fitted with Sips model, and the maximum Sips adsorption capacities of TC on UiO-66, NU-1000 and MOF-525 were 145 mg·g −1 , 356 mg·g −1 and 807 mg·g −1 respectively, which were much higher than common adsorbents. The X-ray photoelectron spectra measurements and the influence of pH suggested that the π-π interaction played a crucial role during the adsorption. Pore characteristics and topology of MOFs showed great effect on adsorption performance. The cages whose size match well with TC helped MOF-525 to get highest adsorption amount per surface area among MOFs we studied. The proper topology of NU-1000 contributed to its high adsorption rate. River water was also used to confirm the excellent adsorptive performance of these three Zr-MOFs in practical application. These results might aid us to comprehend the adsorption of TC on Zr-MOFs and expand the application of Zr-MOFs in water treatment for removal of emerging contaminants.
研究领域:
环境科学
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材料科学
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水处理技术
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产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Yingyue Hu,Bing Zeng,Siyu Zhang,Keke Zhang,Hong Yuan,Xianjun Lang
Metal–organic frameworks (MOFs) are crystalline porous materials constituted of metal–oxo nodes and multitopic organic linkers, which have emerged as promising visible light photocatalysts. Herein, NU-1000, a MOF constructed from Zr 6 O 8 cluster node and 4,4′,4′′,4′′′-(pyrene-1,3,6,8-tetrayl)tetrabenzoic acid organic linker, serves as a photocatalyst for the selective oxidation of organic sulfides with atmospheric oxygen (O 2 ). Notably, the TEMPO (2,2,6,6-tetramethylpiperidine- N -oxyl)-mediated hole transfer significantly enhances the oxidation reaction. TEMPO not only suppresses electron–hole recombination but also facilitates charge transfer to organic sulfides. Remarkably, the incorporation of TEMPO (3 mol%) approximately doubles the conversions of thioanisoles compared to NU-1000 alone under blue light irradiation. Furthermore, electron paramagnetic resonance (EPR) spectroscopy tracks the transmutations of TEMPO into an EPR-inactive species and O 2 into superoxide resulting from hole and electron transfers over the NU-1000 photocatalyst under blue light irradiation. NU-1000 and TEMPO enable the selective generation of organic sulfoxides from diverse thioanisoles with O 2 . This work lays the groundwork for the future development of MOFs as effective photocatalysts via mediated electron transfer.
研究领域:
光催化
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材料化学
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有机合成
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金属有机框架（MOFs）
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氧化反应
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产品关联
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Caiwen Pan,Qinghong Shi,Xiaoyan Dong,Linling Yu,Yan Sun
Effective degradation and detoxification of the highly toxic organophosphate pesticide methyl parathion (MP) are important for pollution treatment and sustainable development. Enzymatic hydrolysis of MP by organophosphate hydrolase (OPH) is an effective way. However, hydrolytic product 4-nitrophenol (4-NP) remains environmentally hazardous. A promising strategy is to reduce 4-NP to 4-aminophenol (4-AP), which not only is weakly toxic but also has high application value. To realize the cascade conversion of MP to 4-AP with the dual objectives of detoxification and recycling, we designed a chemoenzymatic catalyst by immobilizing the OPH within a reduction-catalytic nanocomposite (NCu) constructed by generating copper nanoparticles (Cu NPs) in a zirconium-based metal–organic framework, NU-1000. Optimized OPH@NCu exhibited a 239% enhancement in catalytic activity compared to free OPH, attributed to substrate enrichment by NCu and activation of OPH by Cu2+. Moreover, OPH@NCu exhibited an average cascade conversion rate of 11.1 μmol min–1 gcatalyst–1, achieving a complete conversion of 50 μM MP to 4-AP within 9 min by using a low reductant concentration (15 mM NaBH4). Notably, OPH@NCu demonstrated robust stability, retaining >86% of its activity after being stored for 10 days and nearly 80% of its activity over six reuse cycles. These results validate OPH@NCu as an efficient and sustainable platform for the cascaded detoxification and recycling of MP.
研究领域:
环境毒理学
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生物催化
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纳米生物技术
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环境污染治理
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酶工程
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可持续化学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Junjie Qi,Wenhui Hao,Jingkun Li,Yuqi Wan,Guoyong Jiang,Yukihiro Ozaki,Fuwei Pi
Phoxim is a broad-spectrum organophosphorus pesticide widely used in the world; however, its neurotoxicity and potential risk pose a significant threat to human health and ecosystems. To address this issue, based on the same metal clusters and similar topologies, a MOF-on-MOF composite strategy, i.e., PCN222(Fe)@NU-1000, was developed for rapid evaluation of phoxim via ratiometric fluorescence and colorimetric dual-signal output. Herein, the inner core, PCN222(Fe), imparts peroxidase-like catalytic activity enabling colorimetric detection based on the 3,3′,5,5′-tetramethylbenzidine (TMB) and the solution decolourisation caused by acetylcholinesterase (AChE) products, while the outer shell, NU-1000, provides a strong fluorescence emission at 461 nm. This core-shell structure also facilitates fluorescence resonance energy transfer (FRET), whereby phoxim selectively quenches the fluorescence of NU-1000 without affecting PCN222(Fe), enabling ratiometric fluorescence sensing. This integrated dual-signal system-comprising ratiometric fluorescence and enzyme-mimetic colorimetry-ensures signal cross-verification and improved detection accuracy. The fluorescence mode exhibits a quantification range of 5.0 ng/mL to 4.0 μg/mL with a detection limit of 4.0 ng/mL, while the colorimetric mode shows a linear range from 2.5 ng/mL to 25.0 ng/mL and a detection limit of 1.76 ng/mL. Furthermore, the method accurately evaluates phoxim levels in fruits and vegetables such as apples and celery, achieving recoveries ranging from 95 % to 115 % and a relative standard deviation (RSD) of less than 9 %. This MOF-on-MOF dual-signal sensing strategy is designed to be simple, user-friendly, and highly reliable, providing significant value for the development of rapid and sensitive approaches in food and environmental science.
研究领域:
分析化学
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材料科学
·
环境科学
·
食品科学
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纳米技术
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传感器技术
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Siting Zhou,Shuyi Qin,Qin Zhang,Baizhen Yuan,Yan Pang,Jiali Liang,Jinqiu Yang,Hai-Bo Liu,Jing Wang
The increasing environmental contamination by tetracycline antibiotics (TCs) necessitates efficient detection and removal strategies. This study presents the development of a bifunctional material, Eu-NU-1000, which integrates ratiometric fluorescence detection and high-capacity adsorption of TCs. The material is constructed by doping europium ions (Eu 3+ ) into the zirconium-based metal-organic framework (MOF) NU-1000, offering a dual-channel fluorescence response for selective TCs detection and enhanced adsorption performance. Eu-NU-1000 enables highly sensitive and selective detection of TCs through ratiometric fluorescence at 617 and 472 nm, the detection mechanism was based on antenna effect and photoinduced electron transfer, with a low limit of detection (LOD): 22.14 nM for tetracycline and 11.83 nM for oxytetracycline. Furthermore, the material exhibits a high adsorption capacity of 440.6 mg·g −1 for tetracycline, surpassing several existing MOF-based adsorbents. The study also investigates the adsorption mechanisms, including electrostatic interactions, coordination chelation, and π-π stacking, which collectively contribute to the exceptional tetracyclin removal efficiency of Eu-NU-1000. The material maintains over 80% adsorption efficiency after five regeneration cycles, highlighting its reusability and practical applicability in environmental remediation.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Mengxuan Zhang,Xuxiang Zheng,Lanyue Kou,Lizhu Xiao,Huan Cai,Tao Hu,Yujiao Ma,Anyi Chen,Min Zhao
In situ -engineered NU-1000@Gra gives 2.20-fold ECL enhancement via dual paths, surmounting single-component trade-off. • First Zr-MOF/graphene synergistically boosts ECL, lifting quantum yield from 11.89% to 15.69% via excited-state optimization. • TDN strategy enhances stability and anti-interference, enabling PD-L1 + tEV detection with LOD 899.35 particles/mL. • NGTA platform detects NSCLC with 100% sensitivity, 90.91% accuracy, 32.09-fold lower LOD than ELISA for tEV biopsy. Tumor-derived PD-L1 + extracellular vesicles (PD-L1 + tEVs) represent valuable liquid-biopsy biomarkers for non-small-cell lung cancer, whereas their reliable quantification is largely restricted by low abundance and complex matrix interference. Herein, we fabricated an in-situ engineered NU-1000@Graphene (Gra) nanohybrid as a kinetics-efficiency dual-boosted electrochemiluminescence (ECL) emitter to build the N U-1000@ G ra t etrahedral a ptasensor (NGTA). Benefiting from intimate interfacial coupling, Gra acted as a bifunctional accelerator in the NU-1000/S 2 O 8 2− system, accelerating interfacial electron transfer and sulfate radical production to realize a 1.58-fold improvement in ECL kinetics and a 1.39-fold enhancement in luminescence efficiency. Assisted by the tetrahedral DNA nanostructure scaffold that suppressed non-specific adsorption, the NGTA achieved an ultralow detection limit of 899.35 particles/mL for PD-L1 + tEVs. Preliminary clinical results demonstrated its diagnostic potential. This work underscores the significance of metal-organic framework (MOF)-Gra interfacial engineering for synergistic ECL amplification, providing a rational material design paradigm for high-performance liquid-biopsy biosensors.
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Gege Zhu,Li Qi,Bing Niu,Qi Zhang,Qin Chen,Dan Zhong,Xiaodong Sun
Metal-organic frameworks (MOFs) are promising chiral separation materials owing to their well-defined pore structures and tunable functionality. In this work, mesoporous/microporous NU-1000 was functionalized with L-Cysteine (L-Cys) via solvent-assisted ligand exchange to produce L-Cys-NU-1000, which was applied as a stationary phase in capillary electrochromatography (CEC). The resulting L-Cys-NU-1000@capillary system achieved baseline separation of five chiral amino acid enantiomers with excellent intra-day, inter-day, and batch reproducibility (RSDs < 5%). Notably, the system retained high enantioselectivity even after 100 consecutive injections. This study represents the first application of NU-1000 in chiral separation, opening new avenues for its use and laying a foundation for broader future applications. The system demonstrates distinct advantages for quality control of amino acids, offering high efficiency, robustness, and reproducible enantiomeric separation crucial for food and pharmaceutical analysis.
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产品关联
DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 4
·707
·
IF 5.2
Linzhi Li,Xiaofeng Wang,Jian Chen,Tianzeng Huang,Hongmei Cao,Xing Liu
In this study, an electrochemiluminescence (ECL) immunosensor based on nanobody heptamer and resonance energy transfer (RET) between g-C3N4(g-CN) and NU-1000(Zr) was proposed for ultrasensitive ochratoxin A (OTA) detection. First, OTA heptamer fusion protein was prepared by fusing OTA-specific nanometric (Nb28) with a c-terminal fragment of C4 binding protein (C4bpα) (Nb28-C4bpα). Then, Nb28-C4bpα heptamer with the high affinity used as a molecular recognition probe, of which plenty of binding sites were provided for OTA-Apt-NU-1000(Zr) nanocomposites, thereby improving the immunosensors’ sensitivity. In addition, the quantitative analysis of OTA can be achieved by using the signal quenching effect of NU-1000(Zr) on g-CN. As the concentration of OTA increases, the amount of OTA-Apt-NU-1000(Zr) fixed on the electrode surface decreases. RET between g-CN and NU-1000(Zr) is weakened leading to the increase of ECL signal. Thus, OTA content is indirectly proportional to ECL intensity. Based on the above principle, an ultra-sensitive and specific ECL immunosensor for OTA detection was constructed by using heptamer technology and RET between two nanomaterials, with a range from 0.1 pg/mL to 500 ng/mL, and the detection limit of only 33 fg/mL. The prepared ECL-RET immunosensor showed good performance and can be successfully used for the determination of OTA content in real coffee samples, suggesting that the nanobody polymerization strategy and the RET effect between NU-1000(Zr) and g-CN can provide an alternative for improving the sensitivity of important mycotoxin detection.Keywords:Nb28-C4bpα heptamer;electrochemiluminescence immunosensor;resonance energy transfer;ochratoxin A
研究领域:
分析化学
·
毒理学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Weiwei Li,Chunhua Zhang,Ziman Zheng,Xiaoyu Zhang,Lin Zhang,Alexander Kuhn
Electrochemical regeneration of the reduced form of the nicotinamide adenine dinucleotide (NADH) cofactor catalyzed by immobilized [Rh(Cp*)(bpy)Cl]+ is a promising approach for the enzymatic synthesis of many valuable chemicals with NAD-dependent dehydrogenases. However, rational control of the efficiency is often limited by the irregular structure of the electrode/electrolyte interface and the accessibility of the molecular catalyst. Here, we propose an electrochemical system for NADH cofactor regeneration, based on highly ordered three- dimensional (3D) metal–organic framework (NU-1000) films. [Rh(Cp*)(bpy)Cl]+ is incorporated at the zirconium nodes of NU-1000 via solvent-assisted ligand incorporation (SALI), leading to a diffusion-controlled behavior, associated with an electron hopping mechanism. Varying the ratio of redox-active [Rh(Cp*)(bpy)Cl]+ and inactive postgrafting agents enables the elaboration of functional electrodes with tunable electrocatalytic activity for NADH regeneration. The exceptionally high faradic efficiency of 97%, associated with a very high turnover frequency (TOF) of ∼1400 h–1 for NADH regeneration, and the total turnover number (TTN) of over 20000 for the enzymatic conversion from pyruvate to l-lactate, when coupled with l-lactate dehydrogenases (LDH) as a model reaction, open up promising perspectives for employing these electrodes in various alternative bioelectrosynthesis approaches.
研究领域:
电化学
·
催化
·
生物电化学
·
材料科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）