Biomedical Optics Express
·
2024
·Vol. 15
·期 7
·4253-4263
·
IF 2.9
Xiaowei Zhao,Wenli Liu,Zhixiong Hu,Liangcheng Duan,Xiao Zhang,Fei Li,Baoyu Hong
Retinal vascular health holds paramount importance for healthy vision. Many technologies have been developed to examine retinal vasculature non-destructively, including fundus cameras, optical coherence tomography angiography (OCTA), fluorescein angiography (FA), and so on. However, there is a lack of a proper phantom simulating the critical features of the real human retina to calibrate and evaluate the performance of these technologies. In this work, we present a rapid, high-resolution, and economical technology based on 3D printed mold-based soft lithography and spin coating for the fabrication of a multivascular network and multilayer structural retinal phantom with the appropriate optical properties. The feasibility of the retinal phantom as a test device was demonstrated with an OCTA system and a confocal retinal ophthalmoscope. Experiment results prove that the retinal phantom could provide an objective evaluation of the OCTA and confocal retinal ophthalmoscope. Furthermore, the microfluidic phantoms enabled by this fabrication technology may support the development and evaluation of other techniques.
研究领域:
医学影像
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生物工程
·
眼科研究
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2014
·
IF 2.083
Yujing Li,Liqiang Wan,Farong Huang,Lei Du
An amphiphilic OAPS–PEO was synthesized by “click” reaction between octa(azidopropyl) POSS (OAPS) and propargyl-terminated PEO . The structure of OAPS–PEO was characterized by nuclear magnetic resonance (NMR). The amphiphilic properties and aggregation process of OAPS–PEO in aqueous solution were investigated by fluorescence, dynamic and static light scattering (DLS and SLS), and transmission electron microscopy (TEM). The critical aggregates concentration was determined at ~ 0.10 mg/mL using fluorescence measurements. At this concentration, unassociated unimolecular micelles with diameter size of 40–50 nm were found by DLS, and were also studied by means of TEM. At a lower concentration, all the OAPS–PEO self-assembled into loose balls. With the increase of the OAPS–PEO polymer concentration , OAPS centralizes to be the core of the aggregates. At the concentration of 2.0 mg/mL, aggregates present to be a core–shell structure.
研究领域:
高分子化学
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纳米材料
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软物质物理
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胶体科学
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DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 24
·12698-12708
·
IF 7.443
Sinan Feng,Guibin Wang,Haibo Zhang,Jinhui Pang
A series of octa-sulfonated poly(arylene ether)s (PAEs) was prepared via a low-temperature grafting reaction and subsequent postsulfonation. The rigid backbone with high molecular weight is conducive to higher integrity of the hydrophobic domain. And the grafting ionic clusters are expected to promote the appearance of phase separation. These membranes, with ion exchange capacity (IEC) values ranging from 1.19 to 1.90 meq. g−1, exhibited excellent dimensional stability, mechanical properties and oxidative stability. The membrane with higher IEC (>1.4 meq. g−1) exhibited adequate conductivity (>100 mS cm−1) in water at 80 °C. Furthermore, the membrane with IEC = 1.90 meq. g−1 exhibited comparable conductivity to Nafion 117 under various humidity levels. In addition, SAXS profiles confirmed the well-defined phase-separated morphology of SPAE-x. DMFC single cell performance demonstrates that SPAE-x are good candidates for proton exchange membranes in fuel cell applications.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2024
·
IF 4.5
Shuai Hong,Changxiu Lin,Junsheng Hu,Jingshu Piao,Ming Guan Piao
Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new method of nimodipine administration, namely, nasoencephalic administration. Nasal administration of nimodipine was carried out by attaching the cell-penetrating peptide octa-arginine (R8) to liposomes of nimodipine and incorporating it into a temperature-sensitive in situ gel. The prepared liposomes and gels underwent separate evaluations for in vitro characterization. In vitro release exhibited a significant slow-release effect. In vitro toad maxillary cilia model, RPMI 2650 cytotoxicity, and in vivo SD rat pathological histotoxicity experiments showed that all the dosage from the groups had no significant toxicity to toad maxillary cilia, RPMI 2650 cells, and SD rat tissues and organs, and the cilia continued to oscillate up to 694 ± 10.15 min, with the survival rate of the cells being above 85%. A transwell nasal mucosa cell model and an isolated porcine nasal mucosa model were established, and the results showed that the osmolality of the R8-modified nimodipine liposomal gel to nasal mucosal cells and isolated porcine nasal mucosa was 30.41 ± 2.14 and 65.9 ± 7.34 μg/mL, respectively, which was significantly higher than that of the NM-Solution and PEGylated nimodipine liposome gel groups. Animal fluorescence imaging studies revealed that the R8-modified nimodipine liposomal gel displayed increased brain fluorescence intensity compared to the normal liposomal gel. Pharmacokinetic results showed that after transnasal administration, the AUC(0–∞) of the R8-modified nimodipine liposomal gel was 11.662 ± 1.97 μg·mL–1, which was significantly higher than that of the plain nimodipine liposomal gel (5.499 ± 2.89 μg·mL–1). Brain-targeting experiments showed that the brain-targeting efficiencies of the PEGylated nimodipine liposome gel and R8-modified PEGylated nimodipine liposome gels were 20.44 and 33.45, respectively, suggesting that R8/PEG/Lip-NM-TSG significantly increased the brain-targeting of the drug.
研究领域:
药学
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神经学
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药物递送系统
·
药理学
·
生物技术
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Haolin Tang,Yan Zeng,Xiang Gao,Bin Yao,Dan Liu,Jiabin Wu,Deyu Qu,Kang Liu,Zhizhong Xie,Haining Zhang,Mu Pan,Liang Huang,San Ping Jiang
Development of nitrogen-doped carbon materials with well-defined nanoporous structure is critical due to their versatile applications for the electrochemical energy conversion and storage devices. In this work, we report a new and facile strategy for the synthesis of N-doped nanoporous carbon materials (NNC) with adjustable nitrogen content (3.63–5.37%), large surface area (1942 m 2 g −1 ), uniform and well-defined nanopores (∼0.85–1 nm) and high nanopore volume (0.53–0.88 cm 3 g −1 ) derived from octa(aminophenyl)silsesquioxane (OAPS). OAPS is miscible with phenolic resol, forming an uniformly distributed and self-templated and cross-linked copolymer of OAPS and resol and NNC materials after carbonization and removal of monodispersed silica domains. The symmetric supercapacitor assembled by the electrodes with OAPS to resol ratio of 95:5 in 1 M H 2 SO 4 electrolyte exhibits the high specific capacitance of 230 F g −1 at 1 A g −1 due to the pseudocapacitive contribution of the N-groups, and delivers a high energy density of 5 Wh kg −1 with a power density of 1445 W kg −1 and high stability with performance loss of less than 5% over 10,000 cycles at 50 mV s −1 .
研究领域:
材料科学
·
电化学能源
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2020
·
IF 6.092
Jin Han,Qinyue Chen,Yupeng Shen,Zhixiong Liu,Xiaoyu Hao,Mingqiang Zhong,Zhengping Zhao,Michael R. Bockstaller
An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol–ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed excellent flexibility as well as torsion resistance. Antibacterial efficacy of hydrogels (and degradation products) was evaluated using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Efficacy was found to increase with the concentration of cetyl chloroacetate (CCA) in the hydrogel network, reaching 93% and 99% for Escherichia coli and Staphylococcus aureus, respectively. Degradation of hydrogels was observed in weak alkali conditions (pH = 8) and at physiological conditions (pH = 7.4). The degradation time of the hydrogels could be finely tuned by variation of the CCA content in the hydrogel and environmental stimulus. The tunable degradation behavior under physiological conditions combined with high antibacterial efficacy could render the presented materials interesting for tissue engineering applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2017
·Vol. 75
·期 8
·3395-3406
·
IF 1.43
Li Peipei,Zhang Xin,Guo Junling,Shi Gang,Sang Xinxin,Ni Caihua,Xu Yunhui,Xu Yanhong
Taking advantage of cheap raw materials, polyaniline/octa-(aminopropylsilsesquioxane) (PANI/POSS-NH 2 ) composites with hierarchical structures were obtained by a simple and low-cost method of mechanical agitation combined with sonication. The structure, morphology and electrochemical property of PANI/POSS-NH 2 were characterized by nuclear magnetic resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammogram (CV), galvanostatic charge–discharge and electrochemical impedance spectroscopy (EIS). Compared with pure PANI, PANI/POSS-NH 2 exhibited good specific capacitance, due to the high specific surface area of POSS-NH 2 and synergetic effects of the two components. Moreover, POSS-NH 2 played an important role in improving the cycling stability of PANI/POSS-NH 2 .
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Diagnostics
·
2022
·Vol. 12
·期 2
·
IF 3.992
Guisela Fernández-Espinosa,Ana Boned-Murillo,Elvira Orduna-Hospital,María Dolores Díaz-Barreda,Ana Sánchez-Cano,Sofía Bielsa-Alonso,Javier Acha,Isabel Pinilla
Diabetic retinopathy (DR) is the most severe and frequent retinal vascular disease that causes significant visual loss on a global scale. The purpose of our study was to evaluate retinal vascularization in the superficial capillary plexus (SCP), the deep capillary plexus (DCP) and the choriocapillaris (CC) and changes in the foveal avascular zone (FAZ) by optical tomography angiography (OCTA) in patients with type 2 diabetes mellitus (DM2) with moderate DR but without diabetic macular oedema (DME). Fifty-four eyes of DM2 with moderate DR (level 43 in the ETDRS scale) and without DME and 73 age-matched healthy eyes were evaluated using OCTA with swept-source (SS)-OCT to measure microvascularization changes in SCP, DCP, CC and the FAZ. The mean ages were 64.06 ± 11.98 and 60.79 ± 8.62 years in the DM2 and control groups, respectively. Visual acuity (VA) was lower in the DM2 patients (p= 0.001), OCTA showed changes in the SCP with a significant diminution in the vascular density and the FAZ area was significantly higher compared to healthy controls, withp< 0.001 at the SCP level. The most prevalent anatomical alterations were peripheral disruption in the SCP (83.3%), microaneurysms (MA) in the SCP and in the DCP (79.6% and 79.6%, respectively) and flow changes in the DCP (81.5%). A significant positive correlation was observed between the DM2 duration and the FAZ area in the SCP (0.304 withp= 0.025). A significant negative correlation was also found between age and CC central perfusion (p< 0.001). In summary, a decrease in the vascular density in DM2 patients with moderate DR without DME was observed, especially at the retinal SPC level. Furthermore, it was found that the FAZ was increased in the DM2 group in both retinal plexuses and was greater in the SCP group.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Liping Jin,Chenpeng Ji,Shun Chen,Kun Qian,Lingxin He,Wei Wang,Wenwen Guo
Two-dimensional (2D) nanosheet materials (MXenes) have unparalleled advantages in the field of flame-retardant multifunctional composites, but their dispersibility, flame retardancy and compatibility with the matrix are poor and need to be enhanced. In this research, we employed interfacial decoration and grafting modification to firstly introduce proanthocyanidins (PCs) onto MXenes surface (forming PC-MXenes) to increase the number of available active sites. On this basis, phosphorylated A-POSS was grafted onto PC-MXene (resulting in PAP@P-MXene) via a one-pot method, organic–inorganic hybrid flame-retardant PAP@P-MXene nano-coatings were subsequently constructed on the surface of cotton fabrics via an immersion method, and their structure-property relationships were verified. Thermogravimetric analysis (TGA) results revealed that PAP@P-MXene displayed a high char residue content of 32.0 % at 800 °C, illustrating its pretty good fire-safety properties. Typically, the residual char amount of coated cotton fabric with 12 wt% PAP@P-MXene (C-PAP@P-MXene-3) under a N 2 atmosphere was as high as 37.1 %. Additionally, the limiting oxygen index (LOI) increased to 31 %, while the peak heat release decreased by 79.83 %. C-PAP@P-MXene-3 also displayed a UL-94 V-0 rating and self-extinguishing ability, all of which demonstrated excellent fire safety performance. The unique 2D nanosheet structure of MXenes, along with their innovative structural design and synergistic flame-retardant strategy, endows the nanomaterials with good dispersibility and flame-retardant effects, which has led to the development of new flame-retardant strategies and expanded the potential applications of MXene materials.
研究领域:
材料科学
·
纺织工程
·
化学工程
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产品关联
DOI
PubMed
高影响因子
E-POLYMERS
·
2022
·Vol. 22
·期 1
·357-369
·
IF 3.074
Xing Huang,Guomin Song,Jianjun Shi,Jiafei Ren,Ruilu Guo,Chunyuan Li,Guangxin Chen,Qifang Li,Zheng Zhou
Octa(dimethylethoxysiloxy) POSS (ODES) was synthesized successfully and used as the novel curing agent to prepare RTV silicone rubber (SROD) with outstanding mechanical properties and thermal stability. Compared with the silicone rubber cross-linked by tetraethoxysilane (SRTE), the novel RTV silicone rubber using octa(dimethylethoxysiloxy) POSS as a cross-linker had better mechanical, thermal, and optical properties. The highest tensile strength of SROD reached 1.26 MPa, which is three times that of SRTE. Besides, the decomposition temperature of 10% weight loss reached 507.7°C, exceeding that of SRTE by nearly 150°C. In addition, it was remarkable that due to the good compatibility of ODES with the silicone rubber matrix, the series of SROD showed good transmittance, greater than 87%. The thermal decomposition process of SROD was investigated by TGA coupled with real-time FTIR, and the results revealed the rigid structure and large steric hindrance of ODES that efficiently blocked the “backbiting” of the polysiloxy chains and delayed the end-induced ring decomposition, and consequently, improved the thermal stability of SROD significantly.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Lingfeng Cui,Jing Qiao,Guanyue Zeng,Yuzhu Xiong,Gege Huang,Daiqiang Li
Developing biobased rubber composites that simultaneously boost tensile strength and elongation at break while integrating self-healing capacity and reprocessability remains a critical challenge in the rubber industry. Inspired by the unique multiple hydrogen bonding structure of spider silk and the dynamic β-hydroxy ester exchange reaction, this study constructed an epoxy polyurethane rubber containing octuple hydrogen bonds and incorporated it into epoxidized natural rubber. Carboxylated silica was utilized as a bridging agent to form β-hydroxy ester reversible covalent bonds at the interface between the filler and the rubber, thereby designing a high-strength, self-repairing, and reprocessable’vitrimer’ biobased elastomer. This design approach endows the material with outstanding mechanical properties (tensile strength of 8.92 MPa, Young’s modulus of 2.71 MPa, toughness of 17.45 MJ/m3), excellent self-healing performance (healing efficiency of 92.1%), and superior processability (tensile strength recovery of 97.6%). These properties are primarily attributed to the presence of reversible noncovalent octet hydrogen bonds and dynamic covalent β-hydroxy ester bonds. Furthermore, this design can be readily implemented across different biobased epoxy polymers and carboxyl-rich nanofillers. The design concepts presented herein can be applied to the development of self-healing and reprocessable’vitrimer’ biobased elastomers, providing valuable insights for the future design of green and sustainable polymers.
研究领域:
材料科学
·
高分子化学
·
绿色化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Ping Guan,Shuaixin Wu,Haoyan Meng,Zhenya Li,Mengru Liu,Yuping An,Yingliang Liu,Shengang Xu,Shaokui Cao
Resistive random access memory (RRAM) has emerged as a promising candidate for next-generation storage technologies due to its simple structure, high running speed, excellent durability, high integration density, and low power consumption. This paper focuses on the application of organic–inorganic hybrid perovskite (OIHP) materials in RRAM by introducing an innovative three-dimensional POPA modification strategy, which is realized by binding octa-amine-polyhedral oligomeric silsesquioxanes (8NH2–POSS) onto the side chains of poly(acrylic acid) (PAA), thereby enhancing the material’s resilience under elevated temperatures and humidity conditions. POPA cross-links with perovskite grains at crystalline boundaries through multiple –NH3+ and –C═O chemical anchoring sites on its branch chain, enhancing the grain adhesion, optimizing the film quality, and improving the cage structure distribution at the perovskite grain boundaries. The experimental results demonstrate that the POPA-modified OIHP RRAM exhibits an excellent resistance switching performance, with an optimal ON/OFF ratio of 5.0 × 105 and a data retention time of 104 s. After 150 days of environmental exposure, the ON/OFF ratio remains at 1.0 × 105, indicating good stability. Furthermore, the POPA modification endows the perovskite film with considerable flexibility, maintaining stable resistance switching performance under various bending radii. This study provides a vital reference for flexible, high-performance, and long-lifespan perovskite memory devices.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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