CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Chen Li,Yue Jia,Xiaolong Lu,Huayan Chen
Recovery of heavy metal ions from waste water has benefits both in terms of resources reuse and environmental protection. Polymer inclusion membrane (PIM) has received increasing attention as a gentle and simple method compared to other separation techniques for the removal and recovery of heavy metal ions. The extractant and matrix are the most important components of the PIM. In this paper, a novel matrix enhanced polymer inclusion membrane (ME-PIM) system containing both octyl hydroxamic acid (OHA) and di (2-ethylhexyl) phosphoric acid (D2EHPA) as the carriers as well as poly(vinyl) chloride (PVC) and poly (vinylidene fluoride- co -chlorotrifluoroethylene) (PVDF-CTFE) as the matrix was reported. The SEM results indicate that the PVC has excellent compatibility with OHA and D2EHPA, resulting in dense ME-PIM compared to PVDF-CTFE. The effects of OHA and D2EHPA with different carrier ratios on the transport and the stability of the membrane were examined using Zn (Ⅱ) as a representative of heavy metal ions. The optimal results of this work showed that the initial mass transfer flux value of Zn (Ⅱ) was as high as 4.73 μmol/(m 2 ·s), corresponding to a permeability of 2.21 × 10 −2 m/h, using the ME-PIM composed of 61 wt.% PVC and 22 wt.% OHA + 17 wt.% D2EHPA. All these results suggest that the ME-PIM has a much higher initial mass transfer flux than those of PIMs in literatures. The addition of OHA to PIM introduced extractive functional groups into the polymer chain, forming an efficient and progressive mass transfer path with the extractant D2EHPA. Utilizing two extractants with synergistic effects, this novel ME-PIM system provides a potential advantage in promoting the mass transfer of metal ions in a PIM.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Bingxu Zhang,Xujian Li,Chuan Jiang,Chuanguang Wang,Haifeng Que,Cheng Zheng,Zhixiao Ji,Xudong Tao,Hongtao Xu,Changcan Shi
The effective prevention and treatment of anastomotic leakage after intestinal anastomosis for colorectal diseases is still a major clinical challenge. In order to assist intestinal anastomosis healing and avoid anastomotic leakage caused by high tension, low blood supply or infection, we designed a double-layer nanofiber intestinal anastomosis scaffold, which was composed of electrospun PTMC/PHA nanofibers as the main layer, and electrospun PVA/OHA-Gs nanofibers with antibacterial properties as the antibacterial surface layer. This double-layer scaffold has good toughness, its maximum tensile force value could reach 8 N, elongation could reach 400 %, and it has hydrophilic properties, and its contact angle was about 60°. On the basis of reducing anastomotic tension and isolating intestinal contents, this double-layer nanofiber anastomotic scaffold not only played an antibacterial effect in the short term after surgery to reduce inflammatory response, but also had the characteristics of multiple three-dimensional network structure like extracellular matrix which could promote tissue healing. The PVA/OHA-Gs@PTMC/PHA scaffold was implanted into a rabbit model simulating mechanical intestinal obstruction, and the results showed that the nanofibers of the scaffold could be degraded in vivo while maintaining a certain stability, that is, the overall structure of the PVA/OHA-Gs@PTMC/PHA scaffold would not shrink and deform due to degradation in a certain period of time. Therefore, the treatment with this scaffold showed better healing at the anastomotic site. Compared to the direct anastomosis group and pure PTMC scaffold group, the double-layer scaffold group promoted a faster return to normal anastomotic strength within 7 days. This PVA/OHA-Gs@PTMC/PHA double-layer nanofiber flexible scaffold appears to be a promising therapeutic strategy to prevent anastomotic leakage after intestinal anastomosis.
研究领域:
生物医学工程
·
组织工程
·
外科手术研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Yongchao Miao,Shuming Wen,Qicheng Feng,Shaojun Bai
The efficient flotation of microfine ilmenite is attracting growing interest in the field of mineral processing. In this study, the flotability of microfine ilmenite (18–37 μm) with a single collector (NaOL or OHA) or mixed collector (NaOL/OHA) was studied by micro-flotation tests, and the molar ratio of the two collectors to maximize ilmenite flotation was determined. The positive synergistic effect between the two collectors was confirmed by a surface tension calculation. Zeta potential, adsorption experiment, and X-ray photoelectron spectroscopy measurements (XPS) showed that the mixed collector could co-adsorb at the Ti and Fe sites on the surface of ilmenite and the adsorption strength of the mixed collector was stronger than that of either single collector. The adsorption morphology of flotation reagents on the mineral surface was observed by atomic force microscopy (AFM), which confirmed that the mixed collector had high coverage on the ilmenite surface, indicating the existence of co-adsorption. The results of molecular dynamics (MD) simulations indicated that the relative concentration of water in the hydration film on the ilmenite surface decreased considerably and the hydrophobicity increased after exposure to the mixed collector.
研究领域:
矿物加工工程
·
表面化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Zhuo Pu,Qiuhao Wang,Liming Tao,Hongqi Fu,Jianyong He,Zhiyong Gao
Zircon is the primary mineral for zirconium and hafnium extraction. However, removing associated gangue minerals such as feldspar from fine zircon ore is challenging due to the limitations of utilizing a single collector. This paper proposed a mixed collector n-octylphosphonic acid (n-OPA)/octyl hydroxamic acid (OHA) to promote the separation of zircon and feldspar. Accordingly, solution chemistry calculations, zeta potential, surface tension measurements and density functional theory (DFT) calculations were performed to study the detailed adsorption mechanism of mixed collector on surface of zircon. Flotation results for single minerals demonstrated that the mixed collector effectively facilitated the separation of zircon from feldspar, achieving a maximum recovery difference exceeding 88.00%. Run-of-mine ore flotation tests indicated that the use of n-OPA/OHA as a collector resulted in a zircon concentrate with a ZrSiO 4 grade of 12.57% and a recovery of 82.21%. In contrast, when sodium oleate (NaOL) was used as the collector, the ZrSiO 4 grade and recovery were 8.33% and 66.01%, respectively. Solution chemistry calculations and zeta potential measurements indicated that at pH 2.0, the mixed collector exists in the forms of n-OPA molecules, n-OPA −1 , and OHA molecules. Following interaction with the mixed collector, the surface potential of zircon significantly decreased by 14.8 mV. Surface tension measurements demonstrated a positive synergistic effect between n-OPA and OHA. DFT calculations revealed that the intermolecular interaction energies between n-OPA-OHA and n-OPA −1 -OHA were 41.5 and 32.8 kJ/mol, respectively, primarily attributed to hydrogen-bonding between them.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Kuixin Cui,Aili Zhou,Caihong Yu,Shengming Jin
The unavoidable Mn 2+ ions in pulp were considered in the flotation of rhodochrosite, and its effect and relative interaction mechanism on the floatability of calcite served as a typical gangue mineral were investigated through microflotation tests, zeta potential measurements, SEM-EDS detection, solution chemistry calculation, adsorption experiments, FTIR and XPS analyses. There exhibited a good separation performance of rhodochrosite against calcite with OHA collector, but in the presence of Mn 2+ ions, the floatability of calcite was closed to rhodochrosite within a pH of 8.0–10.0, which resulted in the separation difficulty between them. As evidenced, the surface of calcite could be modified by Mn 2+ ions, its isoelectric point shifted positively from 8.91 to 10.06, and Mn 2+ species detected on calcite surfaces were in close proximity to rhodochrosite. It indicated that MnCO 3 precipitates were generated on the surface of calcite. After modified by Mn 2+ , the calcite surface became more active and obviously increased the adsorption amount of OHA. It was verified from zeta potential and XPS analyses that Mn species on the surface of calcite were active sites for OHA adsorption, likely the hydroxamate group of OHA collector chelated with Mn species to form hydrophobic compounds. As a result, Mn 2+ ions in pulp would reduce the flotation selectivity of rhodochrosite from calcite, thus it is necessary to eliminate the disadvantage of Mn 2+ for strengthening flotation.
研究领域:
矿物加工工程
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Li Tingting,Zhao Yueming,Lin Mian,Hu Jiajun,Duan Kairui,Zhu Hu,Zi Taotao,Lee Bae Hoon
Obesity and its metabolic complications urgently require safe, effective, and minimally invasive interventions. Here, we engineered an injectable, self-healing hydrogel system (OCMU hydrogel) based on oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS) for the localized delivery of plant-based ursolic acid (UA) loaded in mesoporous polydopamine (MPDA) nanoparticles. This system synergistically induces white adipose browning through combined photothermal therapy (PTT) and pharmacological action, effectively counteracting obesity. The OCMU hydrogel exhibited excellent self-healing properties, high UA loading capacity (81.04%), efficient photothermal conversion, and favorable biocompatibility. Mechanistically, the system promotes lipolysis, mitochondrial biogenesis, and adipose browning via activation of the AMPK/SIRT1/PGC-1α pathway, with a 439% increase in UCP1 expression in vitro. In obese mice, OCMU combined with PTT reduced body weight by 10.94% and inguinal fat by 56.32%, while significantly improving metabolic profiles and alleviating inflammation. Notably, the combination of mild PTT and naturally derived UA achieved superior anti-obesity efficacy compared to monotherapies, highlighting a favorable safety and efficacy profile. This work establishes a promising platform in which UA and mild PTT act in concert to reprogram adipocyte metabolism, offering a safe and synergistic approach to combat obesity. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Yue Wang,Nan Jiang,Shuhan Wu,Guangshuai Lin,Wudang Lu,Bin Shang,Xulong Zhu,Wei Han,Yongmei Chen,Jianhui Li
In the period between surgery and systemic therapy for breast cancer, residual tumor cells may proliferate, leading to tumor recurrence. Additionally, intraoperative wound bleeding may cause surgical failure or the spread of tumor cells. This study introduces an innovative injectable hydrogel composed of oxidized hyaluronic acid (OHA) loaded 5-fluorouracil (5-FU) and N-carboxyethyl chitosan (CEC), designed for intraoperative hemostasis and tumor suppression in intraoperative breast cancer. The CEC/OHA injectable hydrogel was synthesized through a Schiff base reaction between the aldehyde group of OHA and the amino group of CEC, incorporating 5-FU during hydrogel formation. This CEC/OHA injectable hydrogel demonstrated hemostatic effects comparable to gelatin sponges in both an in vivo rat liver hemorrhage model and an in vitro rat tail amputation model. When loaded with 5-FU, the injectable hydrogel effectively inhibited the proliferation of MDA-MB-231 breast cancer cells in vitro , significantly inhibited tumor growth and recurrence in vivo , and did not induce significant damage or inflammatory response in any major organ. This CEC/OHA & 5-FU injectable hydrogel is envisioned as a complementary therapeutic regimen during the intraoperative period in breast cancer surgery to prevent hemostasis and tumor recurrence.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2022
·
IF 10.633
Jia Liu,Yongrui Huang,Weiya Yang,Xiaomin Sun,Yingni Xu,Yuehai Peng,Wenjing Song,Jin Yuan,Li Ren
The conjunctiva covers the largest area of ocular surface and is responsible for tear balance and clear vision. After trauma or surgery, the conjunctiva is prone to scarring and contracture. Transplantation with suture often implies numerous complications, such as inflammation, suture erosion, granuloma. And the suture needs to be removed, which means a secondary trauma. In this study, a bioadhesive hydrogel (GMO) for sutureless conjunctival transplantation was developed based on a semi-interpenetrating polymer network (sIPN) consisting of gelatin methacrylate (GelMA) and oxidized hyaluronic acid (OHA). The maximum adhesion strength was 157 ± 17 kPa, and the burst pressure was 357 ± 29 kPa, which was 15 times higher than the human intraocular pressure (IOP). GMO bioadhesive hydrogel significantly improved surgical efficiency and secured the collagen scaffold firmly to a rabbit conjunctival defect. The sutureless transplantation approach revealed the promoted tissue repair without scar. In conclusion, GMO bioadhesive may be an attractive alternative to suture for ocular surface reconstruction by avoiding suture-related complications and improving clinical outcome. Statement of significance Conjunctival tissue is prone to scarring and contracture after trauma, and surgery with sutures often implies numerous complications. In this study, the ocular surface reconstruction was achieved by sutureless transplantation of conjunctival scaffold using bioadhesive hydrogel. The prepared GMO bioadhesive based on the semi-interpenetrating network of gelatin methacrylate (GelMA) and oxidized hyaluronic acid (OHA) had favorable adhesion and mechanical properties . The sutureless transplantation approach significantly improved the operation efficiency, avoided suture-related complications, and promoted the regeneration of conjunctiva. This study highlights the great potential of the sutureless repair strategy for clinical application in ocular surface reconstruction.
研究领域:
生物医学工程
·
组织工程
·
眼科
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2017
·
IF 2.764
Baihao You,Qingtao Li,Hua Dong,Tao Huang,Xiaodong Cao,Hua Liao
The fabrication of osteochondral tissue engineering scaffolds comprised of different layers is a big challenge. Herein, bilayers comprised of double network hydrogels with or without nano hydroxyapatite (HAp) were developed by exploiting the radical reaction of poly(ethylene glycol) diacrylate (PEGDA) and the Schiff-base reaction of N-carboxyethyl chitosan (CEC) and oxidized hyaluronic acid sodium (OHA) for osteochondral tissue engineering. The bilayered osteochondral scaffold was successfully fabricated based on the superior self-healing property of both hydrogels and evaluated by scanning electron microscopy, macroscopic observation and mechanical measurements. In addition, the hydrogels exhibited good biocompatibility as demonstrated by the in vitro cytotoxicity and in vivo implantation tests. The results indicated that the bilayered hydrogel had great potential for application in osteochondral tissue engineering.
研究领域:
材料科学
·
生物医学工程
·
组织工程
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG TARGETING
·
2021
·
IF 5.121
Chunjing Guo,Yanguo Su,Bingjie Wang,Qiang Chen,Huimin Guo,Ming Kong,Daquan Chen
With the increasing number of oncology patients and the use of chemotherapeutic agents, tumour multidrug resistance is becoming more and more prevalent. The search for new tumour treatment strategies to overcome tumour multidrug resistance is urgent. In this study, we designed GSH and ROS dual-responsive tumour-associated macrophages (TAMs)-targeted nanoparticles (NPs) for the co-delivery of the clinical first-line anti-breast cancer chemotherapy drug paclitaxel (PTX) and baicalin (Bai), which re-educates TAMs to alter their phenotype. We synthesised oligohyaluronic acid-mannose-folic acid (oHA-Man-FA, HMF) and astragalus polysaccharide-dithiodipropionic acid-paeoniflorol (APS-S-Pae, ASP), two hybrid materials that can self-assemble in water to form hybrid nanoparticles (HP-NPs) co-loaded with paclitaxel and baicalin (HP-NPs@PTX/Bai). The experimental results show that our designed hybrid nanoparticles can be specifically released in the tumour microenvironment and deliver the antitumor drug PTX as well as Bai, which reshapes the phenotype of TAMs, to the tumour site. The hybrid nanoparticles not only effectively re-educated TAMs from M2 TAM to M1 TAM, but also ameliorated the cytotoxic side effects caused by free PTX and provided better tumour suppression than free PTX and HP.
研究领域:
肿瘤学
·
药学
·
纳米技术
·
免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Que Bai,Qian Gao,Fangfang Hu,Caiyun Zheng,Wenting Chen,Na Sun,Jinxi Liu,Yanni Zhang,Xianglong Wu,Tingli Lu
The most important function of skin is to prevent biological dehydration and protect internal structures from the environment. When a wound becomes infected, the bacteria cause a sustained inflammatory response at the infected site, further delaying the healing process. Therefore, the search for better antibacterial strategies has become a topic of great concern. Therefore, the development of multifunctional hydrogels with antibacterial properties, ROS removal, and hemostasis is urgently required for promoting wound healing process. Chitosan is the only cationic natural polysaccharide with good biocompatibility, antibacterial and hemostatic ability. It is a candidate material to prepare hydrogel wound dressing. Hyaluronic acid (HA) is a natural biological macromolecule that belongs to a group of heteropolysaccharides known as non-sulfated glycosaminoglycans. It is a major component of the skin extracellular matrix (ECM) and is involved in inflammation, angiogenesis, and tissue regeneration. Here, the hydrogel was designed with the natural macromolecular of the gallic acid-grafted quaternized chitosan (GA-QCS) and oxidized hyaluronic acid (OHA) via Schiff base and/or Michael addition reaction. It was found that the GA-QCS/OHA hydrogel exhibited multifunctional capabilities with injectable, hemostasis, degradation, and release of medicines. In addiation, GA-QCS/OHA hydrogels exhibited remarkable antioxidant and migration promoting effects in vitro. And the mupirocin-loaded GA-QCS/OHA hydrogels had inhibitory effects on E. coli (Gram-negative bacterium) and S. aureus (Gram-positive bacterium) in vitro. A full-thickness skin of S. aureus infection mouse wound model was used to test the bioactive effect of the hydrogels and the accelerated wound healing was obtained due to the inhibiting the proinflammatory factor TNF-α and upregulating the vascularization factor CD31. This study proposed an effective strategy based on antioxidant, antibacterial, self-healing multifunctional hydrogel for wound healing under various infectious complications. This natural macromolecular hydrogel could act as an effective reactive oxygen species scavenger to promote the wound healing in the future.
研究领域:
材料科学
·
生物材料
·
伤口愈合
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
·
2019
·
IF 3.785
Runlan Wan,Xi Kong,Youzhe Yang,Siwen Tao,Youyou Chen,Alexander Tobias Teichmann,Frank Heinrich Wieland
The clinical use of the steroidal aromatase inhibitor Formestane (4-hydroxandrostenedione, 4-OHA) in the treatment of advanced ER+ breast cancer has been discontinued, and therefore, interest in this remarkable drug has vanished. As a C-19 sterol, 4-OHA can undergo extensive intracellular metabolism depending on the expression of specific enzymes in the corresponding cells. We used the metabolites 4β-hydroxyandrosterone, 4β-hydroxyepiandrosterone and its 17β-reduced derivative as standards for the proof of catalytic activity present in the cell culture medium and expressed by the isolated enzymes. All of the aldo-keto reductases AKR1C1, AKR1C2, AKR1C3 and AKR1C4 catalysed the reduction of the 3-keto-group and the Δ 4,5 double bond of 4-OHA at the same time. Molecular docking experiments using microscale thermophoresis and the examination of the kinetic behaviour of the isolated enzymes with the substrate 4-OHA proved that AKR1C3 had the highest affinity for the substrate, whereas AKR1C1 was the most efficient enzyme. Both enzymes (AKR1C1and AKR1C3) are highly expressed in adipose tissue and lungs, exhibiting 3β-HSD activity. The possibility that 4-OHA generates biologically active derivatives such as the androgen 4-hydroxytestosterone or some 17β-hydroxy derivatives of the 5α-reduced metabolites may reawaken interest in Formestane, provided that a suitable method of administration can be developed, avoiding oral or intramuscular depot-injection administration.
研究领域:
药理学
·
生物化学
·
肿瘤学
·
分子生物学
·
酶学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）