Chunlei Li,Yanxiao Xiang,Tao Jiang,Jiyuan Zhang,Xuekui Xia,Anchang Liu
Inflammation is a natural host defense response to injury or infection, and seafood-derived polypeptides exhibit prominent anti-inflammatory potential with promising therapeutic applications. Here, we report the screening, characterization and anti-inflammatory evaluation of a novel cupin-like polypeptide OGP1-1 from Ostrea gigas . OGP1-1 exerted significant anti-inflammatory effects in RAW264.7 macrophages in vitro and in a transgenic zebrafish model in vivo. Chemical proteomics identified transforming growth factor-β-activated kinase 1 (TAK1) as the direct molecular target, and molecular docking and dynamics simulations confirmed stable binding within TAK1's activation loop. Mechanistic studies demonstrated that OGP1-1 exerts its anti-inflammatory effects by suppressing the TAK1-mediated NF-κB signaling pathway. Collectively, these findings position OGP1-1 as a novel cupin-like polypeptide with potent anti-inflammatory activity and high potential for development as a functional food ingredient in inflammation management.
In order to assess the radioactive impact of Fukushima Incident on the coastal environment of Dapeng Peninsula, Shenzhen, China, combining accelerator mass spectrometry with epithermal neutron activation analysis, we measured the 129 I/ 127 I ratios and 129 I levels in surface seawater, oyster ( Ostrea gigas ) and kelp ( Sargassum henslouianum ). The results showed that the influence of Daya Bay Nuclear Power Base was ignorable to local environment, but the Fukushima Incident had caused significant increase of 129 I levels in oyster ( P < 0.001) and kelp ( P < 0.05) from Dapeng Peninsula between Jun-2011 and Apr-2012. However, the 129 I levels in oyster and kelp were far below the guideline given by Codex Alimentarius Commission and would not cause immediate harm to the health of local residents.
危险品化学品经营许可证（带存储）