Xiaofang Qi,Jing Peng,Dongyan Tang,Ning Wang,Hongyun Zou
Molybdenum oxide nanomaterials have received increasing attention in recent years for their strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region and pH-dependent degradability. However, the rapid degradation of MoOx at physiological pH values would decrease the NIR photothermal effect. Here, we designed and prepared PEGMa–MoOx/p(NIPAM-co-MAA) microgels (NCs) exhibiting adjustable degradation. For that purpose, PEGMa (Mn = 400) modified MoOx was synthesized through a simple hydrothermal process. Then, PEGMa–MoOx with existing CC groups was continually polymerized with NIPAM and MAA through emulsion polymerization. MAA was introduced to provide an acidic microenvironment (pH at 3–5) to control the degradation rate of PEGMa–MoOx. The photothermal efficiency of the NCs could be maintained at 54% even after 14 days. Meanwhile, the NCs also displayed a pH-dependent thermal response. Moreover, PEGMa was added again in the emulsion polymerization process to elevate the photothermal efficiency, and the irradiation result indicated that the NCs could increase the temperature by 27 °C. The complex microgel integrates pH/temperature/photothermal triple response characteristics and exhibits huge potential for chemo-photothermal combination cancer therapy.
Yuanpeng Cai,Danyang Li,Yufei Ling,Huihui Jiang,Hui Liu
A novel triple-responsive composite hydrogel, p(NIPAM-co-MAA-co-SPMA), was designed and synthesized via free radical polymerization, incorporating N-isopropylacrylamide (NIPAM) for temperature responsiveness, methacrylic acid (MAA) for pH sensitivity, and spiropyran methacrylate (SPMA) for light responsiveness. This study aimed to develop a novel stimuli-responsive sustained release drug delivery system. The composition and structure of the hydrogel were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Doxorubicin (DOX) was used as a model drug to evaluate loading and release behavior. The hydrogel achieved a drug loading content (DLC) of 25.7% and a drug loading efficiency (DLE) of 74.3% and enabled controlled release with approximately 89% cumulative DOX release within 6 h under combined thermal, acidic, and ultra-violet light stimuli. Cytotoxicity assays and cellular uptake studies confirmed the excellent biocompatibility of the hydrogel and its efficacy in suppressing cancer cell growth. These results highlight the potential of p(NIPAM-co-MAA-co-SPMA) as an intelligent platform for on-demand targeted anticancer therapy.
Fan Yang,Jincheng Wang,Shiqiang Song,Pinhua Rao,Runkai Wang,Shihui Liu,Liqi Xu,Feng Zhang
A novel type of temperature and pH dual-stimuli-responsive microspheric soil conditioner was prepared for the controlled release of urea. First, poly(N-isopropylacrylamide-co-methacrylic acid) [P(NIPAM-co-MAA)] was synthesized, and the microspheric soil conditioner was prepared on the basis of chitosan-coated P(NIPAM-co-MAA) via the emulsion cross-linking method. The structure and morphology of the microsphere were characterized by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance, polarization optical microscopy, and scanning electron microscopy. The microsphere showed controlled release behavior in different temperature and pH conditions, indicating good stimuli responsiveness. The plant experiment revealed that the microsphere can effectively promote plant growth in acidified soil and high-temperature conditions, and the pH value of acidified soil could be improved. In addition, the microsphere possessed good biodegradation property in the soil. Therefore, the multi-responsive microspheric soil conditioner owns a great potential value to amend soil conditions and promote plant growth in agriculture applications.
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