JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2021
·Vol. 109
·期 12
·2227-2236
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IF 3.368
Shuxian Shen,Xuzhao He,Xiaoyi Chen,Lingqing Dong,Kui Cheng,Wenjian Weng
Electrical stimulation has been proved to be critical to regulate cell behavior. But, cell behavior is also susceptible to multiple parameters of the adverse interferences such as surface current, electrochemical reaction products, and non-uniform compositions, which often occur during direct electric stimulation. To effectively prevent the adverse interferences, a novel piezoelectric poly(vinylidene fluoride-trfluoroethylene)(P(VDF-TrFE)) layer was designed to coat onto the indium tin oxide (ITO) planar microelectrode. We found the electrical stimulation was able to regulate the osteogenic differentiation of mesenchymal stem cells (MSCs) through calcium-mediated PKC signaling pathway. Meanwhile, the surface charge of the designed P(VDF-TrFE) coating layer could be easily controlled by the pre-polarization process, which was demonstrated to trigger integrin-mediated FAK signaling pathway, finally up-regulating the osteogenic differentiation of MSCs. Strikingly, the crosstalk in the downstream of the two signaling cascades further strengthened the ERK pathway activation for osteogenic differentiation of MSCs. This P(VDF-TrFE) layer coated electrical stimulation microelectrodes therefore provide a distinct strategy to manipulate multiple-elements of biomaterial surface to regulate stem cell fate commitment.
研究领域:
生物医学工程
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细胞生物学
·
材料科学
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DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2025
·
IF 5.7
Jizhong Deng,Guoxiang Zhang,Ya Yang,Wenjun Zhu,Zhiyi Wu,Yuanyu Wang
The development of wearable technology has been driven by the increasing demand for flexible and sensitive sensors that can utilize body motion to generate electricity or acquire physiological data for health assessment and rehabilitation. In this work, piezoelectric materials K 0.5 Na 0.5 NbO 3 nanoparticles (KNN NPs), synthesized through a one-step hydrothermal method, were integrated into poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] films to enhance their electrical properties for application in wearable piezoelectric nanogenerator (PENG) sensors. The maximum content of β phase in the composite film is as high as 83.1%, which may be attributed to the enhancement of polar interface interactions. The PENG sensors exhibited an open-circuit voltage of 12 V, a short-circuit current of 0.86 μA, and a peak power of 3.18 μW under optimal load, showcasing superior performance and stability over 4700 cycles. Monitoring results from human body motion demonstrated the potential application prospects of PENG sensors in motion analysis and medical rehabilitation.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2021
·
IF 4.126
Yu Feng,Yu Zhang,Jie Sheng,Tiandong Zhang,Qingguo Chi,Qingguo Chen,Weidong Fei
Multiferroic materials have good application prospect in the field of non-volatile random access memory due to the simultaneous existence of ferroelectricity, ferromagnetism, and the coupling between them. In this work, two kinds of nanofibers (pure CoFe2O4 nanofibers and CoFe2O4 nanofibers coated with a BaTiO3 layer) were designed and fabricated. P(VDF-TrFE)-based composites with aligned nanofibers were prepared via high-speed directional electrospinning. The effect of ferromagnetic nanofibers on the ferroelectricity of composites was investigated, and the multiferroic performance and magnetic anisotropy were observed. The leakage current of the composite can be well suppressed after coating the BaTiO3 layer, and it makes the composite possess enhanced ferroelectric and ferromagnetic properties at the same time. Notably, the maximum polarization and remnant polarization of a 10 vol % P(VDF-TrFE)/CoFe2O4@BaTiO3 composite reach 8.0 and 7.0 μC/cm2, respectively, when the applied electric field is 1000 kV/cm. Meanwhile, the maximum magnetization and remnant magnetization are 5.9 and 2.0 emu/g at 20,000 Oe, respectively, and the magnetization along the nanofiber direction is larger than that perpendicular to the nanofiber direction on the surface of the composites. The maximum values of the magnetoelectric voltage coefficient reached 5111 mV/cm·Oe (Hdc = 8083 Oe) for the 5 vol % P(VDF-TrFE)/CoFe2O4@BaTiO3 composite. The excellent ferroelectric and ferromagnetic properties in a high electric field make flexible composites promising to be an ideal material for improving the multiferroic devices.
研究领域:
材料科学
·
物理学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Zhenji Zhou,Caiyin You,Zhong Li,Weimin Xia,Na Tian
Magnetic nanofiller is helpful for improving the piezoelectric properties of P(VDF-TrFE)-based composites, which shows promising potential as a flexible sensor or energy harvester. In this work, we use the interaction between the magnetic nanofiller and magnetic field to modify the structure of CoFe2O4 (CFO)@polydopamine (PDA)/P(VDF-TrFE) composite, in which CFO@PDA works as the nanofiller into the P(VDF-TrFE) matrix. It was found that the magnetic field orientation during polymer curing can significantly increase the content of the β-phase and d33 of the composite. Regarding a typical composite film with 7 wt % CFO@PDA, the composite exhibits versatile sensing originated from the ball impact, hot-water droplet, bending, and pressing. In a noncontact magnetic field-driven experiment, the magnetic field oriented film produced the highest output voltages of 17.4 mV at 4 Hz and 12 mV at a drive amplitude of 19 Vpp, in contrast to the values of 7.1 mV and 7 mV for the film without magnetic field orientation, respectively. The LED without any charging capacitor can be instantaneously lighted through vertically pressing the oriented films. Thus, this work proposes a strategy of magnetic field orientation to improve the piezoelectric performance of the CFO@PDA/P(VDF-TrFE) multifunctional composite film.
研究领域:
材料科学
·
传感器技术
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 30
·期 3
·2501-2511
·
IF 2.324
Zhang Zhao,Yang Hui,Wang Hao,Ding Xingeng,Zhang Qilong,Zhu Zhicai
In this work, KTa 0.2 Nb 0.8 O 3 –BaTiO 3 (KTN–BT) hybrid nanoparticles were synthesized via a facile one-pot hydrothermal method. Flexible nanocomposite films comprised of poly (vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) P(VDF-TrFE-CTFE) matrix and KTN–BT hybrid fillers of different molar ratio were prepared by solution-casting. It is revealed that the introduction of BT to the KTN causes decreased grain size and homogenous morphology, improving the dielectric constant, breakdown strengthen and energy density of nanocomposite films. Typically, the nanocomposite film containing 40 vol% KTN–BT possesses a dielectric constant of 322 at 100 Hz, which is 8.7 times than that of pure polymer. Also, nanocomposite film with < 10 vol% of filler could achieve high breakdown strength of over 300 MV m −1 . The energy density of the film containing 2 vol% KTN–BT filler is 61.4% higher than that of pure P(VDF-TrFE-CTFE) polymer. (7.1 J cm −3 compared to 4.4 J cm −3 .) In addition, the nanocomposites also displayed good flexibility and kept excellent dielectric properties after bending and folding. All the improved performance enables these composites to meet the requirements of many flexible electronic devices and energy storage devices.
研究领域:
材料科学
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电子工程
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产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Jizhong Deng,Qi Sun,Zhiyi Wu,Yuanyu Wang
The self-driven flexible piezoelectric sensor has wide application prospects in areas such as health monitoring, human-machine interaction, and warning detection due to its advantages of non-toxicity and high sensitivity. In this study, a composite film of poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] doped with NaNbO 3 (NN) was prepared by electrospinning. The highly oriented NN particles promote the formation of P(VDF-TrFE) β phase, reaching a maximum β phase content of 91%. Under mechanical motion at a frequency of approximately 3 Hz, the piezoelectric nanogenerator (PENG) fabricated from the nanofiber membrane achieved a maximum piezoelectric output of 17.3 V and 12 V in the transverse and longitudinal piezoelectric responses, respectively. With an external load of 100 MΩ, the PENG obtained a maximum power density of 0.67 μW/cm². Additionally, the PENG sensor exhibited sensitivity to various human activities and demonstrated high sensitivity and rapid response in monitoring the status of the proposed door lock opening/closing, highlighting its enormous potential in security monitoring applications.
研究领域:
材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Jie Peng,Xiaoyu Pan,Peng Fei Hou,Bo Li
The pyroelectric-piezoelectric dual-mode sensor simultaneously decodes temperature and strain, serving as a core component for health monitoring, human-machine interfaces, and bionic skin applications. To achieve high fidelity, self-powering, and long-term endurance, the sensing materials must balance sensitivity, stability, and multi-physics field coordination across multiple scales. This study employs a synergistic strategy combining barium titanate (BaTiO3) doping with proton irradiation to regulate polyvinylidene fluoride-trifluoroethylene copolymer (P(VDF-TrFE)). By enhancing crystallinity and β-phase content of P(VDF-TrFE) while introducing oxygen vacancies and lattice distortions within the BaTiO3 lattice, the strategy significantly strengthens interfacial polarization coupling and charge transport efficiency. As a result, doping with 2wt% BaTiO3 increases pyroelectric coefficient (p) to 66.1 μC/m2•K. Although piezoelectric coefficient (d33) slightly decreases from 22.0 pC/N to 20.1 pC/N, its variation range (standard deviation) narrows from 3.9 to 3.1. Subsequent proton irradiation at 1×1010 p/cm2 further increases p to 86.6 μC/m2•K, accompanied by a slight decrease in d33. At 5×1010 p/cm2 fluence, p maintains a 6.8% increase compare to pre-irradiation levels, and d33 recovers to 20.0 pC/N with a standard deviation reduced to 2.4, effectively balancing piezoelectric uniformity and stability with high pyroelectric sensitivity. The composite film exhibits a linear sensitivity of 1.2 V/K over a temperature range of 0.1-12.2 K, with no degradation observed after 103 thermal cycles. It conformally adheres to the human body and enables real-time analysis of respiration, pulse, and touch signals, offering a novel approach for high-sensitivity, high-reliability dual-mode sensing in wearable electronics and bionic skin applications.
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Daiyao Jiang,Tingting Wei,Kai Li,Fei Wang,Xin Sun,Jie Zhao
In this study, novel mixed matrix membranes (MMMs) composed of MoO 3 /Poly (vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) with distinctive piezo-photocatalytic properties were prepared. The membranes were made from dopes containing a high ratio of MoO 3 to P(VDF-TrFE) (2:1 wt%/wt%) through a modified solvent evaporation method. The addition of MoO 3 particles significantly impacted the crystallization and self-polarization of the P(VDF-TrFE) matrix, leading to a substantial increase in total crystallinity from 46.4% to 88.9% and a transformation from α to β phase. The flow-induced piezoelectric potential created an internal electric field, enhancing the spatial separation of photogenerated carriers through the piezoelectric effect. Controlled water flow further promoted the spatial separation of carriers. The developed MMMs demonstrated a high Rhodamine B degradation rate, reaching 83.1% within 45 minutes and over 99% within 90 minutes under natural light conditions. The MoO 3 /P(VDF-TrFE) MMMs exhibit promising piezo-photocatalytic attributes and hold potential for diverse applications due to their unique combination of piezoelectric and photocatalytic properties.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2016
·
IF 4.509
Chongyang Sun,Yiping Guo,Bijun Fang,Jiaming Yang,Ben Qin,Huanan Duan,Yujie Chen,Hua Li,Hezhou Liu
It is known that CH3NH3PbI3 perovskite films with high crystallization and controlled morphology always show enhanced power conversion efficiency. Here we incorporate a small amount of polyvinylidene fluoride–trifluoroethylene polymer P(VDF-TrFE) into PbI2 solution to control the crystallinity and morphology of perovskite layer in a two-step deposition process. Our results show that the P(VDF-TrFE) bridges the grain boundaries and also enhances the crystallinity of the perovskite layer significantly. By adjusting P(VDF-TrFE) concentration, the fabricated perovskite solar cells show improved average power conversion efficiency from 9.57 ± 0.25% to 12.54 ± 0.40% under a standard illumination of 100 milliwatts per square centimeter, which increases by nearly 31%. Thus, we demonstrate a new strategy to control the crystallinity and morphology of perovskite films by incorporating polymer into PbI2 film in a two-step deposition process. In addition, this method has been proven as an effective way to prepare high-performance perovskite solar cells.
研究领域:
材料科学
·
能源技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zaitian Wang,Xuan Li,Fei Sun,Kaining Zhang,Fei Long,Tong Zhou,Lei Liu
Flexible piezoelectric films represent a groundbreaking advancement for wearable energy harvesting and bioelectronics, where mechanical adaptability and efficient electromechanical conversion are equally crucial. However, the persistent incompatibility between high piezoelectric coefficients and structural pliability creates a critical performance ceiling that undermines device reliability in dynamic operating environments. Here, we report an in situ interface engineering strategy to fabricate high-performance flexible piezoelectric films directly on Ti foils through combining hydrothermal synthesis of BaTiO 3 films with infiltration of P(VDF-TrFE). The flexible P(VDF-TrFE)/BaTiO 3 film with spatially interlocked heterostructure exhibits an excellent piezoelectric coefficient d 33 of ~264 pC N −1 , representing an enhanced remnant polarization of 21.4 μC cm −2 and a reduced coercive field of 220 kV cm −1 . The as-prepared piezoelectric film assembled on the Ti foil substrates demonstrates long-lasting flexibility, retaining an output voltage of about 5 V after 5000 bending cycles. The exceptional performance originates from the improved polarization through the stabilized BTO nanodomain synthesized by the in situ hydrothermal process. Furthermore, the spatially interlocked architecture redistributes polarized charges, thereby mitigating polarization degradation induced by microscale defects. This study pioneers a new paradigm for developing high-performance flexible piezoelectric film, and the scalable process can be potentially applied to wearable applications.
研究领域:
材料科学
·
纳米技术
·
能源采集
·
生物电子学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Qin Luo,Kepeng Hu,Haoqing Liu,Xiyue Duan,Wen Chen,Xiaoyi Chen,Xiaojun Long,Weiming Lin,Chengwei Wu,Zhangfa Song,Chengyun Ning,Wenjian Weng,Kui Cheng
The limited self-healing capacity of critical-sized bone defects presents significant challenges in healing. An effective approach is to regulate the physicochemical properties of biomaterials to mimic the natural bone regenerative microenvironment. In this work, we have prepared Chitosan-Gelatin (CS-Gel) based hydrogel/ Poly(vinylidene fluoride- co -trifluoroethylene) (P(VDF-TrFE)) systems, which provide biomimetic and electric cues for bone regeneration. These hydrogel membranes are constructed on P(VDF-TrFE) layers, and the sustained electrical cues rely on the dipole orientation of P(VDF-TrFE). The bilayer structure decouples electrical stimulation and biocompatibility from chemical composition, allowing the generation of self-sustained electrical cues without altering the functional groups on the hydrogel surface. The results show that these hydrogel/P(VDF-TrFE) systems are more effective in polarizing macrophages toward the alternatively activated (M2) phenotype and promoting stem cell differentiation in vitro. Furthermore, the hydrogel/P(VDF-TrFE) system enhances the expression of anti-inflammatory cytokines and encourages new bone formation in vivo. This work presents a promising strategy to accelerate bone regeneration by combining electrical cues and biomimetic environments, offering a new preparation method for hydrogel/P(VDF-TrFE) systems with self-sustained electrical cues.
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
再生医学
·
高分子科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Cuicui Su,Lingling Zhang,Yuanzheng Zhang,Xiaocheng Huang,Yumin Ye,Yu Xia,Zhiyi Gong,Xiaojuan Qin,Yichao Liu,Shishang Guo
In the background of air pollution and regular COVID-19 prevention, personal protective masks are necessary for our daily life. However, protective masks with high PM0.3 filtration usually have poor air permeability and are mostly disposable, leading to a heavy burden on the environment. In this work, a reusable membrane based on piezoelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] nanofibers embedded with BaTiO3 nanoparticles (BTO NPs) was developed. The P(VDF-TrFE)/BTO composite nanofibers not only have enhanced piezoelectricity and surface polarity but also have reduced diameters that could be beneficial for electrostatic adhesion, pole–polar interactions, and mechanical sieving to increase the PM0.3 capture capacity. Moreover, the BTO NPs also improved the charge storage capacity of the composite membrane, which could further enhance the PM0.3 filtration efficiency after corona treatment. The piezoelectric mask based on P(VDF-TrFE)/BTO composite nanofibers has high filtration efficiencies of 96% for PM0.3 and 98% for bacteria, while the pressure drop was only 182 Pa, which is lower than the commercial N95 standard of 343.2 Pa. Furthermore, the piezoelectric mask has a long and stable filtration performance after 5 cycles of 75% alcohol disinfection, demonstrating that the P(VDF-TrFE)/BTO composite membrane has a potential application in personal protective masks with comfortable and reusable properties.
研究领域:
材料科学
·
环境科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）