查找使用阿拉丁产品的科研文献

Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives

Yue-E Tian,Di Sun,Xiao-Xiao Han,Jin-Ming Yang,Song Zhang,Nan-Nan Feng,Li-Na Zhu,Zhong-Yuan Xu,Zhi-Ping Che,Sheng-Ming Liu,Xiao-Min Lin,Jia Jiang,Gen-Qiang Chen

Three series of sulfonate derivatives of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, respectively. Among all the compounds, 4m displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 26.87 mg/L, respectively. The results show that acetyl and 4-OCH3 are two necessary groups. The existence of these two sites is closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group is well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased.