DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Yu-Jiao Xie,Qi-Long Wang,Michael Adu-Frimpong,Jian Liu,Kang-Yi Zhang,Xi-Ming Xu,Jiang-Nan Yu
Isoliquiritigenin (ISL) possesses a variety of pharmacological activities amid poor solubility in water which has restricted its clinical application. In this study, isoliquiritigenin-loaded F127/P123 polymeric micelles (ISL-FPM) were successfully prepared and evaluated in vitro and in vivo. The particle size, polydispersity index, and zeta potential of the selected formulation were 20.12 ± 0.72 nm, 0.183 ± 0.046, and −38.31 ± 0.33 mV, respectively, coupled with high encapsulation efficiency of 93.76 ± 0.31%. Drug-loading test showed the solubility of ISL after formulating into micelles was 232 times higher than its intrinsic solubility. Moreover, critical micelle concentration (CMC) was tested with fluorescence probe method and turned out to be quite low, which implied high stability of ISL-FPM. Release profile in HCl (pH 1.2), double distilled water, and PBS (pH 7.4) of ISL-FPM reached over 80%, while free ISL was around 40%. Pharmacokinetic research revealed that formulated ISL-FPM significantly increased bioavailability by nearly 2.23-fold compared to free ISL. According to the results of in vitro antioxidant activity, scavenging DPPH activity of ISL was significantly strengthened when it was loaded into polymeric micelles. Altogether, ISL-FPM can act as a promising approach to improve solubility as well as enhance bioavailability and antioxidant activity of ISL.
研究领域:
药剂学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Chong Shen,Bin Peng,Ying Wang,Qin Meng
Milk is often polluted by heavy metal ions due to the growing environment pollution, but few methods have been developed to remove the heavy metal ions. Here a non-toxic sorbent, namely di-acrylated Pluronic P123 (P123-DA) hydrogel, was fabricated for removal of Hg 2+ and Pb 2+ from milk without impairing their nutritive contents. This hydrogel possessed high mechanical stress and maximum adsorption capacity of 35.2 and 53.9 mg/g for Pb 2+ and Hg 2+ . The removal ratio of Pb 2+ and Hg 2+ by P123-DA hydrogel respectively reached 85.3% and 81.9% for the polluted whole milk while was individually 86.3% and 83.8% for the skim milk. Interestingly, the treatment by P123-DA hydrogel didn’t significantly reduce the main nutritive contents in milk. Such hydrogel will be a recyclable, safe and effective tool for reuse of milk that polluted by heavy metal ions.
研究领域:
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 5
·1-16
·
IF 2.6
Cao Xiaoyan,Xu Xiao,Wu Gongming,Gu Zhenggui
The ring-opening polymerization lays the foundation for synthesizing polypropylene glycol. Nevertheless, homogeneous alkali catalysts usually require complex post-treatments, hindering green synthesis and environmental sustainability. Here, we studied a heterogeneous epoxide polymerization method based on a P123-modified nanocomposite layered double oxide (CoMgAl-LDO(P123)). Thereafter, the composition, crystal structure, morphology, and thermal stability of the catalyst were characterized through SEM, XRD, FTIR, XPS, BET, and TG-DTG techniques. The results indicated that due to the designable and self-assembled P123 micelles, CoMgAl-LDO(P123) generated consistent mesoporous channels and a larger specific surface area. The introduction of cobalt enriched the alkaline sites on the CoMgAl-LDO(P123) surface. In the synthesis of small molecular weight poly(propylene glycol) (i.e., number average molecular weight less than 500), the catalytic performance of CoMgAl-LDO(P123) for the conversion of propylene oxide reached 96.3% under the optimal reaction conditions, which was superior to that of other catalysts. Our strategy addresses the trade-off issue that alkali catalysts faced in terms of sustainability and operational complexity, holding great promise in green chemistry.
研究领域:
材料科学
·
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ONCOLOGY RESEARCH
·
2024
·
IF 2
HUAN GAO,JIE ZHANG,TONY G. KLEIJN,ZHAOYONG WU,BING LIU,YUJIN MA,BAOYUE DING,DONGFENG YIN
Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The DOX-loaded polymeric micelles were spherical, 123 nm in diameter on average, and exhibited a narrow size distribution. The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release. The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells. Rapid binding of the micelles to hydroxyapatite (HA) microparticles indicated their high affinity for bone. P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model. In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity. In conclusion, our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.
研究领域:
肿瘤学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2018
·
IF 4.521
Guojun Lv,Senlin Deng,Yi Zhai,Yongqiang Zhu,Haichao Li,Fumin Wang,Xubin Zhang
Hierarchical TS-1 stacked nanoplates with constrained mesopores were hydrothermally synthesized via a self-assembly process with the aid of P123 lamellar micelles. P123 lamellar micelles serve concomitantly as mesotemplate for hierarchical TS-1 zeolite and nanostructure regulator for TS-1 nanoplates. The successful preparation of TS-1 stacked nanoplates were verified by Scanning and Transmission electron microscope, X-ray diffraction patterns, FTIR spectra and UV–vis spectra. Moreover, their formation processes with crystallization time were investigated, and accordingly the possible mechanism was proposed. Hierarchical TS-1 stacked nanoplates displayed a chemical composition similar to that of hierarchical TS-1 zeolite with P123 spherical micelles as mesotemplate and showed remarkably enhanced catalytic activity in oxidative desulfurization of dibenzothiophene (DBT), 4,6-dimethyldibenzothiophene (4,6-DMDBT) and benzothiophene (BT) with tert-butyl hydroperoxide (TBHP) or hydrogen peroxide (H 2 O 2 ) as oxidant.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 48
·30250-30261
·
IF 3.108
Xin Liu,Yuebin Li,Jian He,Tingting Zhao,Changmei Chen,Haoshuang Gu,Xingguo Wang
A novel anticancer drug PFPSNT, paclitaxel (PTX)-loaded polymeric F127/P123 silica nanocapsules conjugated with TRAIL (tumor necrosis factor (TNF)-related apoptosis-inducing ligand), was designed and synthesized. Transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis absorption and particle size analysis revealed that the synthesized PFPSNT was a spherical particle with a size of 24 nm and excellent colloidal stability. Drug loading efficiency (DL%) and encapsulation ratio (ER%) were 0.39% and 26.5%, and its cumulative release profile was linear. In vitro study showed that PFPSNT had marked cytotoxic and apoptotic activities towards HepG2 (liver cancer cell line) and CaSki (cervical cell line) cells with the IC50 values of 921.07 ng mL−1 and 236.24 ng mL−1, respectively. The antitumor efficacy of PFPSNT was evaluated by using a HepG2-xenografted BALB/c nu/nu mice model. In vivo study showed PFPSNT markedly inhibited HepG2 hepatocellular carcinoma, and its antitumor efficacy was more superior than those of TRAIL, PTX or PTX/F127/P123 silica nanocapsules. Our studies provided a novel strategy to synthesize anticancer nanodrugs with mutiple functions, and demonstrated that PFPSNT was a very effective anticancer drug. This novel nanodrug should be a promising drug for targeted cancer therapy to treat complex cancers.
研究领域:
药学
·
纳米技术
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Jing Yuan,Wenhao Su,Jingyang Gao,Xiaoqing Ma,Ronghuan Yin,Tong Jia
Purpose Praziquantel (PZQ) is currently the preferred medication for treating various parasites. However, its use is hindered by several issues, such as poor solubility, first-pass effect, and individual variability. A novel immediate release system was developed by loading PZQ onto Pluronic P123/L64 mixed micelles (PMMs). This approach aims to improve its bioavailability following oral administration.Methods PZQ-PMMs were prepared by thin film dispersion method. The encapsulation efficiency (EE), particle size, and polydispersity index (PDI) were utilized to identify the optimal formulation. Characterization techniques, including electron microscopy, infrared spectroscopy, thermal analysis, and X-ray diffraction were utilized to get an understanding of the molecular interactions between PZQ and micelles. This system was compared with commercially available preparations both in vitro and in vivo.Results The particle size of the prepared PZQ-PMMs (P123:L64 1:1, w/w) was 19.33 ± 0.22 nm, with a PDI value of 0.106 ± 0.044, an EE of 86.88 ± 4.60%, and a drug loading of 4.16 ± 0.21%. Structural characterization results indicated that the spherical micelles were uniformly dispersed, with the drug existing in an amorphous form within PMMs. In vitro, PZQ-PMMs exhibited a faster immediate release in both pH 1.2 and pH 6.8 buffers. In vivo, at the same dosage, the micelles rapidly produced higher blood drug concentrations. The relative bioavailability of PZQ-PMMs was comparable to that of the PZQ 30% ethanol solution and was 1.7 times greater than that of commercially available preparations, with the increase in bioavailability being highly significant (P < 0.01).Conclusion The findings of this study confirm that Pluronic P123/L64 PMMs represent a novel and promising approach for enhancing solubility and bioavailability of PZQ, both in vitro and in vivo. The development of immediate release formulations is anticipated to be an effective option for drugs exhibiting a notable first-pass effect.
研究领域:
药剂学
·
药物递送系统
·
药代动力学
·
纳米医学
·
生物药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2017
·Vol. 13
·期 12
·1631-1646
·
IF 4.521
Wang Jiao,Liu Qiang,Yang Linnan,Xia Xiaofei,Zhu Rongrong,Chen Shengguang,Wang Mei,Cheng Liming,Wu Xianzheng,Wang Shilong
Cervical cancer is the fourth most common cancer in women worldwide, and existing treatments cause severe side effects and great burdens. Thus, the development of safe, inexpensive therapeutic agents is necessary. Curcumin (Cur), a well-known natural product, exerts promising anti-cancer
activities against various cancer types. However, its therapeutic efficacy is severely restrained due to rapid degradation, poor aqueous solubility, and low bioavailability. The objective of this study was to investigate the therapeutic potential of novel curcumin-loaded TPGS/F127/P123 mixed
polymeric micelles (Cur@NPT100) for cervical cancer treatment. The Cur@NPT100 exhibited an average size of approximately 19 nm, a zeta potential of around –4 mV, a drug loading of 8.18 ± 0.36%, and an encapsulation efficiency of 79.38 ± 4.65%. Unlike free Cur, Cur@NPT100
are readily dispersed in aqueous medium, showing enhanced stability and a sustained release profile over a 6-day period. In vitro cell culture experiments revealed that TPGS/F127/P123 mixed polymeric micelles (NPT100) based nanocarriers substantially promoted the selective cellular
uptake of Cur into HeLa cells rather than by non-cancerous NIH3T3 cells, inducing higher cytotoxicity and greater apoptosis and significantly increasing the percentage of cells arrested at the G2/M phase of the cell cycle. Additionally, the Cur@NPT100 facilitated more Cur accumulation in the
mitochondria and decreased the mitochondrial membrane potential. In addition, western blot assays demonstrated that Cur@NPT100 were more potent than free Cur at activating the mitochondria-mediated apoptosis pathway. In vivo results further confirmed that Cur@NPT100 exhibited a much higher
antitumor efficacy than free Cur and had excellent biocompatibility. In conclusion, Cur@NPT100 might be an effective therapeutic agent for cervical cancer.
研究领域:
药学
·
肿瘤学
·
纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 38
·8994-9000
·
IF 3.858
Tiantian Xing,Yongbing Lou,Qilong Bao,Jinxi Chen
Nanocrystals of ZIF-8 have been successfully prepared in the presence of non-ionic triblock copolymers P123 and F127 under microwave irradiation. Noticeably, the reaction time could be significantly reduced down to 1 min. The obtained ZIF-8 nanocrystals had sizes of sub-104 nm and exhibited a high BET surface area of 1599 m2 g−1. This approach is expected to be an efficient and environmentally friendly method for the preparation of ZIF-8.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2018
·
IF 0
Chenlu Ye,Kang Hu,Zhijuan Niu,Yiran Lu,Lin Zhang,Kai Yan
One-step controllable synthesis of rhombohedral α-Fe 2 O 3 photocatalyst has been successfully developed by P123 soft template assisted method. A combination analysis of XRD, BET, SEM and HRTEM has documented that P123 surfactant plays a crucial role in the controllable synthesis of rhombohedral α-Fe 2 O 3 with the exposure of (110) and (012). The as-obtained α-Fe 2 O 3 material is efficient for the photocatalytic degradation of Bisphenol A (BPA). About 91% of BPA (30 mg/L) was degraded by using 1 g/L α-Fe 2 O 3 within 6 h under the simulated sunlight irradiation, which was almost twice higher than that of commercial Fe 2 O 3 . More importantly, reaction intermediates (e.g., 4, 4′-methylenediphenol, phenol and lactic acid) were confirmed by LC–MS/MS analysis, and the rational pathway of BPA degradation was finally proposed.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
ENERGY & FUELS
·
2023
·
IF 5.3
Peng Guo,Songling Zhang,Xiuwu Liu,Shijie Zhu,Huimin Li,Jilin Cao
Compared with the synthesis process of the CMK-3 material, the ordered mesoporous carbon (OMC) materials were successfully synthesized by simplifying the synthesis steps. The silica/P123 composite material that had formed nanostructures was not filtered, washed, and calcined to form SBA-15 material, but it was directly used as a hard template to synthesize OMC materials. The self-assembly of block polymers (P123) in the pore space was not removed but directly carbonized as partial carbon source. The template agent (surfactant P123) was not removed but used as part of the carbon source. The synthetic materials exhibited large pore volume, high specific surface area, regular hexagonal pore structures, and good long-range order, which was confirmed by the 77 K N2 adsorption–desorption isotherms, transmission electron microscopy (TEM), and small-angle X-ray diffraction (XRD). The synthetic materials were applied to capture carbon dioxide, and the results of carbon dioxide capture were better than those of the CMK-3 material reported previously. Under the conditions of 3.4 MPa pressure and 275 K temperature, the CO2 capture capacity of the dry synthetic MC-1.5–0.8 material without water was 25 mmol/g at 275 K, which was 1.4 times that of the dry CMK-3 material. In addition, the CO2 capture capacity of the same pre-adsorbed water MC-1.5–0.8 sample with Rw = 3.8 at 3.3 MPa was 47.6 mmol/g, which was 1.9 times that of the dry MC-1.5–0.8 sample.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 14
·8375-8383
·
IF 3.361
Kaijun Wang,Qifan Mao,Weimin Fei,Lingxin Kong,Xiaoyan Cao,Zhenggui Gu
Layered double hydroxides are a promising platform material which can be combined with a variety of active species based on their characteristic features. Silicon@P123-templated Ce-doped layered double hydroxide (SiO2@CeMgAl-LDH(P123)) composites were synthesized via a facile in situ co-precipitation method, and characterized by TEM, X-ray diffraction, FTIR, XPS, CO2-, etc. in detail. Meanwhile, the calcined powder (SiO2@CeMgAl-LDO(P123)) possessed an excellent core–shell structure and a high surface area inherited from the LDH structure, which led to an outstanding catalytic activity (99.7% conversion of propylene oxide, 92.4% selectivity of propylene glycol methyl ether) under mild reaction conditions (120 °C). Cerium oxide provides a large number of oxygen vacancies and significantly improves the medium basic strength of the material, which facilitates the selective ring-opening of PO. Furthermore, the introduction and removal of P123 make the cerium oxide uniformly dispersed on the LDH layers, providing more reaction sites for the reaction of methanol and propylene oxide. The core–shell structure prepared by the in situ co-precipitation method could solve the shortcomings of agglomeration of layered double hydroxides and prolong the catalytic life evidently.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）