APPLIED SURFACE SCIENCE
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2024
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IF 6.3
Songhao Yu,Guifen Tian,Liduan Li,Fei Wang,Kefeng Wang,Junyu Lei,Haijun Hao,Qinghong Xu
TpFO-PA, a novel spherical hollow mesoporous polyamide, was firstly synthesized by the reaction among 1,3,5-tris(4-aminophenyl)benzene (TAPB), furylamine and oxalyl chloride in using silica-gel nanoparticle as hard template, and the composite Cu(I)@TpFO-PA with high catalytic activities in C-N coupling reactions between (hetero)aryl bromide and (hetero)aryl amines under mild conditions was prepared basing on presence of N in the framework. A maximum activity of the catalyst with yield of C-N coupling product were about 311.9 g (product) /mol Cu(I) ·h and 95 % respectively, and the activity could be maintained at least 5 times after the catalyst was reused. The composite Cu(I)@TpFO-PA is a few heterogeneous catalysts reported in catalyzing coupling reaction between aromatic amines and brominated aromatic compounds.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
Science China-Chemistry
·
2020
·Vol. 63
·期 12
·1777-1784
·
IF 6.356
Ma Xiaoshuang,Ma Guanyu,Qin Lubing,Chen Guangxu,Chen Shaowei,Tang Zhenghua
Despite the recent progress on controllable synthesis of alkynyl-protected Au nanoclusters, the effective synthetic means are very limited and the cluster formation process still remains puzzling. Here, we develop a novel synchronous nucleation and passivation strategy to fabricate Au 36 (PA) 24 (PA=phenylacetylenyl) nanoclusters with high yield. In Au 36 (PA) 24 formation process, Au 22 (PA) 18 as key intermediate was identified. Meanwhile, Au 22 (PA) 18 can be synthesized under a low amount of reductant, and by employing more reductants, Au 22 (PA) 18 can turn into Au 36 (PA) 24 eventually. Moreover, the structure evolution from Au 22 (PA) 18 to Au 36 (PA) 24 is proposed, where four Au 13 cuboctahedra can yield one Au 28 kernel. Finally, the ratiocination is verified by the good accordance between the predicted intermediate/product ratio and the experimental value. This study not only offers a novel synthetic strategy, but also sheds light on understanding the structural evolution process of alkynyl-protected Au nanoclusters at atomic level.
研究领域:
材料科学
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纳米技术
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化学
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DOI
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2025
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IF 4.2
Zhuohui Liang,Bin Zhang,Wanying Yue,Siqi Zhang,Yuanchen Xia,Boqiao Wang,Wenbin Zhu,Jinnan Zhang
To achieve effective suppression of hydrogen-air deflagration, a new deflagration-suppressing material PA@SH-SiC is formed by grafting a phosphorus-containing compound, phytic acid (PA), onto the surface of porous silicon carbide (SiC) using a self-assembly technique. Scanning Electron Microscope (SEM) and Fourier Transform Infrared (FTIR) results show that PA is successfully and uniformly grafted onto the SiC substrate. In a semi-open duct with dimensions of 130∗130∗820 mm, the effects of two deflagration-suppressing materials, SiC and PA@SH-SiC, are being investigated under three pore sizes (30, 40, 50 PPI) and two thicknesses (20, 40 mm), in response to hydrogen-air deflagration at different equivalence ratios (0.3, 0.4, 0.5). Experimental results show that PA@SH-SiC exhibits superior performance in hydrogen-air deflagration compared to using porous SiC alone, reducing explosion overpressure and flame propagation velocity while minimizing flame distortion. PA coating enhances the chemical suppression effect of SiC by generating HOPO and other groups through endothermic decomposition, which absorb critical radicals like H, O, and OH, thereby weakening chain reactions. Under equivalence ratios of 0.3 and 0.4, porous SiC with 50 PPI effectively blocks most of the flame, reducing explosion overpressure and flame propagation velocity. However, 30 and 40 PPI porous SiC exacerbate deflagration. With a pore size smaller than hydrogen's MESG, 50 PPI porous SiC predominantly exhibits quenching effects, thus suppressing deflagration under equivalence ratios of 0.3 and 0.4. At 30 and 40 PPI, the pore size of porous SiC is too large, resulting in insufficient quenching capability. Instead, the disturbance caused by this leads to elongation and wrinkling of the flame, thereby intensifying the downstream gas deflagration. Taking the 0.4 equivalence ratio conditions as an example, increasing the thickness of 50 PPI porous SiC enhances deflagration suppression. Conversely, increasing the thickness of 30 PPI SiC from 20 mm to 40 mm increases Flame propagation velocity peak (V max ) by 6.3 m/s and overpressure peak (P max ) by 2.82 kPa. This is due to under the conditions of 30 and 40 PPI, increasing the thickness is equivalent to increasing the volume blocking ratio of obstacles, thereby exacerbating the deflagration effect. In addition, under different equivalence ratios, there are differences in the energy release and reaction rates of combustion, which directly affect the deflagration suppression performance of the porous materials.
研究领域:
材料科学
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燃烧与爆炸学
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DOI
高影响因子
MOLECULES
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2021
·Vol. 26
·期 23
·7326
·
IF 4.412
Xin Meng,Ye Wang
Drug repurposing can quickly and effectively identify novel drug repurposing opportunities. The PA endonuclease catalytic site has recently become regarded as an attractive target for the screening of anti-influenza drugs. PA N-terminal (PAN) inhibitor can inhibit the entire PA endonuclease activity. In this study, we screened the effectivity of PANinhibitors from the FDA database through in silico methods and in vitro experiments. PANand mutant PAN-I38T were chosen as virtual screening targets for overcoming drug resistance. Gel-based PA endonuclease analysis determined that the drug lifitegrast can effectively inhibit PANand PAN-I38T, when the IC50is 32.82 ± 1.34 μM and 26.81 ± 1.2 μM, respectively. Molecular docking calculation showed that lifitegrast interacted with the residues around PA or PA-I38 T’s active site, occupying the catalytic site pocket. Both PAN/PAN-I38T and lifitegrast can acquire good equilibrium in 100 ns molecular dynamic simulation. Because of these properties, lifitegrast, which can effectively inhibit PA endonuclease activity, was screened through in silico and in vitro research. This new research will be of significance in developing more effective and selective drugs for anti-influenza therapy.Keywords:lifitegrast;virtual screening;drug repurposing
研究领域:
药理学
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病毒学
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计算生物学
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产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
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2019
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IF 2.781
Hongtao Wu,Furong Tao,Yuezhi Cui,Li Guo
Two tiphenylamine-based materials SM-1 and SM-2 were synthesized via simple one-step synthetic progress, which exhibits aggregation induced emission (AIE) in DMSO/H 2 O (1/9, v/v) solution due to intermolecular interactions and the restriction of intramolecular rotation in the aggregated state. The relationships between their structures and photophysical properties were studied via spectroscopic methods and density functional theory (DFT) calculations. The single crystal data of SM-1 and SM-2 revealed that multiple intermolecular interactions between molecules. Due to the excellent AIE nature of the two compounds. SM-1 and SM-2 were highly sensitive toward PA in the aggregated state. The quenching constant ( K SV ) of SM-2 was 5.33 × 10 4 M −1 , and SM-1 was 1.1 × 10 5 M −1 , with limit of detection (LOD) were 1.9 μM and 93 ppb for SM-1 and SM-2, respectively. For this reason, it shows that AIE materials are promising candidate in detection of explosives.
研究领域:
化学
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材料科学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2017
·Vol. 27
·期 45
·1703934
·
IF 12.124
Cong Li,Hui Du,Aizhen Yang,Shuaibing Jiang,Zhenhua Li,Dan Li,John L. Brash,Hong Chen
Surface modification with bioactive agents capable of combating thrombosis is a widely used strategy for developing antithrombotic biomaterials. However, exposure of the blood to the antithrombotic agent on the material surface may cause hemostatic disorders under normal conditions. Ideally an implanted biomaterial should respond appropriately on demand to a specific change in the physiologic environment, as happens in the body itself. In the present study, a thrombosis-responsive surface coating with the ability to lyse fibrin as it forms is reported. The coating consists of nanocapsules (NCs) in which the fibrinolysis activator t-PA is encapsulated in a thrombin-degradable hydrogel shell. The t-PA NCs are attached to several materials covalently through a polydopamine adhesive layer. The resulting surfaces are treated with the antifouling agent glutathione (GSH) to prevent further interactions with blood/plasma components. The t-PA NCs/GSH-coated surface is stable and remain inert in normal plasma environment while releasing t-PA and promoting fibrinolysis when thrombin is present. The fibrinolytic activity increases with increasing thrombin concentration, and therefore presumably with the extent of thrombosis. This work constitutes the first report of an antithrombotic coating whose function is triggered and regulated, respectively, by the appearance of thrombin and the extent of coagulation.
研究领域:
生物材料
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医学工程
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血液学
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产品关联
DOI
高影响因子
WASTE MANAGEMENT
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2025
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IF 7.1
Tianxiang Deng,Yi Chen,Delong Hou
The recycling of discarded THHN cables generates a substantial amount of mixed PVC/PA waste plastics, presenting a significant challenge to achieving sustainable development. In this study, we present a simple, catalyst-free, and scalable approach for upcycling all components of mixed PVC/PA waste. This method leverages HCl released from PVC during hydrothermal treatment to catalyse the cleavage of amide bonds in PA, converting mixed PVC/PA waste into valuable platform chemicals (over 80 % product yield) and carbon black within 30 min. Our work demonstrates a high-value recycling process for mixed PVC/PA waste in discarded THHN cables, reducing the generation of harmful Cl-containing waste, mitigating environmental pollution caused by mixed plastics, and offering valuable insights for the recycling of other PVC-containing mixed plastic wastes.
研究领域:
环境科学
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材料工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Yan Cheng,Cheng Yang,Tianxue Zhu,Che Wu,Jianying Huang,Yuekun Lai
Due to its widespread availability and spontaneity, moisture electricity generation (MEG) holds unique advantages in self-powered systems. However, it faces challenges, including the limitations of relying on a single kind of power generation and insufficient output performance. Inspired by the mechanisms of water absorption of plants, this paper explores a light-moisture coordinated electricity generating hydrogel (L-MEGH) device with flexible, scalable, and highly efficient energy conversion performance, which is obtained through the UV polymerization of hydrophilic acrylamide (AAM) and phytic acid (PA) in the presence of photosensitizers. The obtained hydrogel demonstrates superior moisture absorption and remarkable electricity generation stability across a range of humidity conditions. Notably, the open-circuit voltage ( V oc ) of the L-MEGH increased from 0.675 to 0.838 V after the addition of photosensitizers (Erythrosin B, E) (the significant enhancement, up to 24%), and the short-circuit current ( I sc ) reaching 635.543 µA. This L-MEGH can realize stable electrical output even under extreme temperatures, producing 0.5 V at −20 °C for 45 h. The scalable L-MEGHs (connected on-demand in series/parallel) can power various commercial electronics, including nighttime illumination, mobile phones, and health monitoring sensors. This work pioneers a sustainable power generation pathway capable of enhancing performance through the hybrid collection of multiple natural energy sources.
研究领域:
材料科学
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能源技术
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产品关联
DOI
高影响因子
Nature Communications
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2024
·Vol. 15
·期 1
·1-15
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IF 14.7
Chen Zhengfang,He Mudan,Wang Houpeng,Li Xuehui,Qin Ruirui,Ye Ding,Zhai Xue,Zhu Junwen,Zhang Quanqing,Hu Peng,Shui Guanghou,Sun Yonghua
Although the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is pivotal for embryonic development, the underlying mechanism remains elusive. Here we find that the zebrafish hydroxysteroid (17-β) dehydrogenase 12a ( hsd17b12a ), which encodes an intestinal epithelial-specific enzyme, is essential for the biosynthesis of long-chain polyunsaturated fatty acids in primitive intestine of larval fish. The deficiency of hsd17b12a leads to severe developmental defects in the primitive intestine and exocrine pancreas. Mechanistically, hsd17b12a deficiency interrupts DHA synthesis from essential fatty acids derived from yolk-deposited triglycerides, and consequently disrupts the intestinal DHA-phosphatidic acid (PA)-phosphatidylglycerol (PG) axis. This ultimately results in developmental defects of digestive organs, primarily driven by ferroptosis. Our findings indicate that the DHA-PA-PG axis in the primitive intestine facilitates the uptake of yolk lipids and promotes the expansion of digestive organs, thereby uncovering a mechanism through which DHA regulates embryonic development.
研究领域:
发育生物学
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脂质代谢
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分子生物学
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2023
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IF 6.1
Baisen Chen,Rongxia Tan,Yanhui Zhong,Yufei Hu,Gongke Li
Ce-PA-Tb polymer with Ce and Tb as metal ion centers was prepared and applied in chemiluminescence (CL) reaction. The structure and property of Ce-PA-Tb were explored. Ce-PA-Tb combines both the oxidant ion (Ce(IV)) and luminescence ion (Tb(III)). Difloxacin can enhance the CL signal of Ce-PA-Tb-SO 3 2- reaction in acidic medium. Under the optimized affecting factors, a CL method for the selective difloxacin determination was established. The CL intensity showed a good linear relationship from 10.0 to 300.0 μg/L (r = 0.9996) with the limit of detection was 1.1 μg/L. The method with the signal response at 0.5 s and completed the CL process within 10 s. The method was used to determine difloxacin in aquatic products, and the recovery rate was in the range of 88.1%–104.0%. The CL method designed Ce-PA-Tb based is demonstrated to be an excellent tool for difloxacin determination in aquatic products.
研究领域:
分析化学
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食品科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1915-1925
·
IF 1.282
Gao Y.,Hou D.,He D. X.,Jiang M.,Yang X. C.,Liao S.,Zhang W.,Yan X. M.,Tan N.
The grafted mangrove endophytic fungus Fusarium sp. #ZZF51 by phytic acid with polyphosphate groups (PA-ZZF51) was successfully synthesized by esterification reaction, and its uranium(VI) biosorption conditions, models, mechanism and regeneration property were also obtainted. The uranium(VI) removal from aqueous solution by PA-ZZF51 was optimized at pH (5.0), S/L ratio (0.2 g L −1 ), time (45 min), and the initial uranyl ions concentration (100 mg L −1 ) with 453.70 mg g −1 of biosorption capacity and 90.74% of removal percentage, respectively. Kinetic and equilibrium biosorption studies showed pseudo-second-order equation and Langmuir isotherm model could better fit with the experiment data. FTIR and SEM of the prepared material indicated the various functionalities on the mycelium surface including hydroxyl, carboxyl, phosphate groups and so on were responsible for the binding of uranyl ions.
研究领域:
环境生物学
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生物化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xia Zhan,Rui Ge,Teng Huo,Juan Lu,Jiding Li
Graphene oxide (GO) membranes exhibit ultrafast water permeation properties, which have been employed in various membrane-based separations including nanofiltration for dye removal from textile wastewater. However, it’s still a great challenge to achieve precise control over the microstructure of GO membranes and obtain ultrathin GO membranes with exceptional separation efficiency and robust membrane structure. Herein, in-situ confined interfacial polymerization (IP) is proposed for fabricating loose polyamide (PA)@GO hybrid membranes with high permeance and dye rejection as well as robust membrane stability. A new diamine of sulfadiazine (SA) with intrinsic hydrophilic and conjugated sulfonamide groups is employed as cross-linker of GO membranes and monomer of PA in IP process, simultaneously. PA is in-situ synthesized in confined GO interlayer via IP process and intercalated into GO interlayer, which enlarges the interlayer spacing of GO membranes gradiently. The combination of hydrophilic PA nanofiltration layer on GO membrane surface and the PA intercalated GO membrane with varying interlayer spacing creates hierarchical transport channels for water molecules, which contributes to the high water permeance. Moreover, the less reactive SA monomer endows PA@GO selective layer with appropriate negative charge and loose transport channels, which contributes to both of high permeance and dye rejection due to Donnon effect and size exclusion effect. The PA@GO hybrid membrane exhibits high permeance of 75.5 L/(m 2 ·h·bar) with TB dye rejection of 99.8 %, and exhibits low NaCl rejection of 11.6 %. Moreover, PA@GO hybrid membrane shows good fouling resistance and long-term stability as well as stable separation performance under harsh conditions. Both of high permeance and dye rejection of PA@GO hybrid membrane suggests that the integration of PA nanofiltration layer and GO membrane via in-situ confined interfacial polymerization can achieve the delicate control over the interlayer channel structure and the physicochemical properties of the membrane surface of GO membranes, which offers a promising method to break through the trade-off effect between permeability and selectivity of GO membranes.
研究领域:
材料科学
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环境工程
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膜技术
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水处理
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）