CHINESE JOURNAL OF POLYMER SCIENCE
·
2018
·Vol. 36
·期 12
·1328-1341
·
IF 2.016
Mumtaz Fatima,Chen Chao-Shi,Zhu Hai-Kun,Atif Muhammad,Wang Yan-Mei
In this study we report design of stimuli-responsive coating based on poly(2-methyl-2-oxazoline-random-glycidyl methacrylate) (PMOXA- r -GMA) comb copolymer and poly(acrylic acid)-block-poly(glycidyl methacrylate) (PAA- b -PGMA) block copolymers and scrutinize its ability to control protein adsorption. Firstly, PMOXA/PAA based coatings were prepared by simply spin coating the mixture of PMOXA- r -GMA and PAA- b -PGMA copolymer solutions onto silicon substrates followed by annealing at 110 °C. Then coatings were rigorously characterized by X-ray photoelectron spectroscopy (XPS), the static water contact angle (WCA) test, ellipsometry and atomic force microscopy (AFM). After that, the relationship of switchable behavior of PMOXA/PAA based coatings with PAA content and chain length was investigated through the change of thickness and WCA upon pH and ionic strength ( I ) trigger, which indicated that the change in thickness and WCA was triggered when PAA contents were increased as well as by increasing chain length of PAA in PMOXA/PAA based coatings. Finally, real-time adsorption/desorption of lysozyme (Lyso) on PMOXA/PAA based coatings was monitored using quartz crystal microbalance with dissipation monitoring (QCM-D). The results showed that the Lyso adsorption amount was increased upon increasing chain length and contents of PAA in PMOXA/PAA based coatings. The adsorbed Lyso was then efficiently desorbed by changing pH and I of medium with the maximum desorption (> 90% desorption percentage) observed for the suitable ratio of PMOXA and PAA while chain length of PAA was kept longer than that of PMOXA. Furthermore, the prepared coatings were found to repeatedly adsorb and desorb Lyso for four successive cycles of adsorption/desorption, which confirmed the stability of prepared coatings.
研究领域:
生物材料学
·
表面化学
·
高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 12
·8070-8077
·
IF 1.354
Zhao Hongli,Sun Shanshan,Wang Zhaodong,Hong Yayun,Shi Lulu,Lan Minbo
In this work, a novel combination of drug therapy and cryotherapy for tumor treatment was developed. Pluronic F127 modified with poly(acrylic acid) at two terminals (denoted as PAA-PF127-PAA) was used as carriers for doxorubicin (DOX) delivery. Due to the pH-sensitive property endowed
by PAA, the DOX-loaded PAA-PF127-PAA micelles released DOX faster in the slightly acidic physiological environment of the tumor site than that in the neutral physiological environment. Three-group rats bearing Walker 256 carcinosarcoma were respectively treated with cryotherapy, combination
of DOX-loaded micelles and cryotherapy, and saline injection to investigate the effect of the combined therapy. The apoptosis rate of TdT-mediated dUTP nick-end labeling (TUNEL) slices indicated that compared with cryotherapy alone, the DOX-loaded PAA-PF127-PAA micelles combining with cryotherapy
showed increased apoptosis. Thus, the combination of drug therapy and cryotherapy can be used as an effective technique for tumor treatment.
研究领域:
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Yajun Ren,ZhuanZhuan Zhang,Wenlong Xia,Qifeng Zhou,Xiaofeng Song
Poly(L-lactide) (PLLA) was one of the most well-known biodegradable polyesters. Although its thermo-responsive shape memory (SM) function has been studied by proper program, high transformation temperature is not suitable in some biomedical applications. Water-responsive SM polymer is an alternative choice and exhibits great potential because it is harmless to the cells and tissues of organisms. In the work, a novel PCL-(PMVS- s -PAA)-PCL-PTMG-PCL-(PMVS- s -PAA)-PCL copolymer was devised as an additive to endow PLLA with water-responsive SM capability. The incorporated PLLA was characterized by cross-section, water contact angle, differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). Inserted PTMG segment and assisted ambient temperature were contributed to its SM behaviors. The shape fixation ratio and shape recovery ratio were 92.0% and 94.2%, respectively. The schematic diagram between internal microstructures and macroscopic properties was proposed. At the same time, the incorporated PLLA showed excellent toughness. So the obtained SM material would be promising for medical and biomimetic fields.
研究领域:
材料科学
·
生物医学工程
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2023
·
IF 12.8
Tao Yang,Linqian An,Ge Zeng,Maoju Jiang,Juan Li,Changyu Liu,Jianbo Jia,Jun Ma
The widespread occurrence of p -arsanilic acid ( p -ASA) in natural environments poses big threats to the biosphere due to the generation of toxic inorganic arsenic (i.e., As(III) and As(V), especially As(III) with higher toxicity and mobility). Oxidation of p -ASA or As(III) to As(V) followed by precipitation of total arsenic using Fe-based advanced oxidation processes demonstrated to be a promising approach for the treatment of arsenic contamination. This study for the first time investigated the efficiency and inherent mechanism of p -ASA and As(III) oxidation by Fe(II)/peracetic acid (Fe(II)/PAA) and PAA processes. p -ASA was rapidly degraded by the Fe(II)/PAA process within 20 s at neutral to acidic pHs under different conditions, while it was insignificantly degraded by PAA oxidation alone. Lines of evidence suggested that hydroxyl radicals and organic radicals generated from the homolytic O O bond cleavage of PAA contributed to the degradation of p -ASA in the Fe(II)/PAA process. p -ASA was mainly oxidized to As (V), NH 4 + , and p -aminophenol by the Fe(II)/PAA process, wherein the aniline group and its para position were the most vulnerable sites. As(III) of concern was likely generated as an intermediate during p -ASA oxidation and it could be readily oxidized to As(V) by the Fe(II)/PAA process as well as PAA alone. The in-depth investigation demonstrated that PAA alone was effective in the oxidation of As(III) under varied conditions with a stoichiometric molar ratio of 1:1. Efficient removal (> 80%) of total arsenic during p -ASA oxidation by Fe(II)/PAA process or during As(III) oxidation by PAA process with additional Fe(III) in synthetic or real waters were observed, mainly due to the adsorptive interactions of amorphous ferric (oxy)hydroxide precipitates. This study systematically investigates the oxidation of p -ASA and As(III) by the Fe(II)/PAA and PAA processes, which is instructive for the future development of arsenic remediation technology.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Fatima Mumtaz,Chaoshi Chen,Haikun Zhu,Chao Pan,Yanmei Wang
In this work, poly(2-methyl-2-oxazoline-random-glycidyl methacrylate) (PMOXA-r-GMA) and poly(acrylic acid)-block-poly(glycidyl methacrylate) (PAA-b-PGMA) copolymers were synthesized via cationic ring-opening polymerization (CROP) of 2-methyl-2-oxazoline (MOXA) and reversible addition-fragmentation chain transfer (RAFT) polymerization of acrylic acid (AA) followed by their random and block copolymerization with glycidyl methacrylate (GMA), respectively, and then characterized carefully. PMOXA/PAA based coatings were then prepared by simply spin coating the mixture of PMOXA-r-GMA and PAA-b-PGMA copolymer solutions onto silicon/glass substrates followed by annealing at 110 °C. The coatings were rigorously characterized by using X-ray photoelectron spectroscopy (XPS), the static water contact angle (WCA) test, ellipsometry and atomic force microscopy (AFM). The results demonstrated that the coating based mixed PMOXA/PAA brushes with desired surface composition could be attained by simply maintaining their percentage in the mixture of PMOXA-r-GMA and PAA-b-PGMA copolymer solutions. Finally, the switchable behavior of PMOXA/PAA based coatings toward bovine serum albumin (BSA) adsorption was investigated by fluorescein isothiocyanate-labelled BSA (FITC-BSA) assay and quartz crystal microbalance with dissipation monitoring (QCM-D), which indicated that the coating based mixed PMOXA/PAA brushes could control BSA adsorption/desorption from very low to high amount (>90% desorption) through adjusting the composition of PMOXA-r-GMA and PAA-b-PGMA solution used in preparing PMOXA/PAA based coatings upon pH and ionic strength change. Furthermore, PMOXA/PAA based coatings displayed efficient repeatability of reversible BSA adsorption/desorption cycles.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2017
·
IF 2.084
Qian Wang,Xiao Qi Jin,Ji Hong Sun,Shi Yang Bai,Xia Wu
The polymer/SiO 2 hybrid material (P/SiO 2 -MPS) with core-shell structure were synthesized using the dense nanosilica spheres (DNSS) as core and pH responsive poly(acrylic acid) (PAA) as a shell. Meanwhile, using ibuprofen (IBU) as a model drug, the structure and properties of obtained P/SiO 2 -MPS were characterized by SEM, TEM , FT-IR, TGA , EDS, NMR, XRD , DLS and SAXS . The results elucidated that PAA was successfully incorporated onto the surface of DNSS, and thereafter the thickness of PAA shell could be controlled by adjusting the additive amount of AA. Particularly, SAXS patterns evidently exhibited that P/SiO 2 -MPS before IBU-loading and after releasing possessed the surface fractal feature, which increased from 2.19 for SiO 2 -MPS, to 2.41 for P/SiO 2 -MPS, to 2.54 for IBU-loaded P/SiO 2 -MPS, and to 2.65 for IBU-released P/SiO 2 -MPS. Moreover, the IBU-releasing percentage of three samples (P/SiO 2 -MPS-1, P/SiO 2 -MPS-3 and P/SiO 2 -MPS-5) increased gradually at both pH 3.0 and 7.4 with the enlarged thickness of PAA shells, while for P/SiO 2 -MPS-7 with the thickest PAA layer, its release rate was not more than that of P/SiO 2 -MPS-5. Therefore, IBU molecules were hindered from passing through PAA layer. Furthermore, the IBU loading of P/SiO 2 -MPS was fitted into the pseudo-second-order model, while its drug-release kinetic profile was favorable to Korsmeyer-Peppas model. These observations evidently demonstrated that the surface effects of P/SiO 2 -MPS on its surface fractal feature and the diffusion of IBU delivery were very important, and therefore its mechanism was essentially proposed.
研究领域:
材料科学
·
药物递送
·
生物医学工程
✓ 已验证
DOI
高影响因子
POLYMER
·
2019
·
IF 3.771
Chao Lv,Ruiyang Wang,Jia Gao,Ning Ding,Shunni Dong,Jingjing Nie,Junting Xu,Binyang Du
Enhanced phase separation and inverse order-to-order phase transition with increasing temperature was observed for a series of poly (acrylic acid)- b -poly (propylene oxide)- b -poly (acrylic acid) triblock copolymers with various block lengths by temperature-variable synchrotron small-angle X-ray scattering (SAXS). This abnormal phase behavior was attributed to the change of hydrogen (H)-bonding interaction in block copolymers upon increasing temperature and theoretically explained from thermodynamic viewpoint. The temperature-dependent FTIR analysis revealed that increasing temperature led to the weakening of overall H-bonding interactions and the increase of free C O and C–O–C groups. The Flory-Huggins interaction parameter χ of PAA and PPO blocks was positive and increased with increasing temperature as determined from the SAXS profiles of disordered block copolymer. The thermodynamic calculation indicated that the increase of Δ H was larger than the decrease of – T Δ S with increasing temperature because of the relatively large value of χ , leading to the increase of overall Δ G mix and hence the enhanced phase separation at higher temperature.
研究领域:
高分子科学
·
材料科学
·
热力学
·
物理化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Chong Shen,Shi Tang,Qin Meng
Heavy metal ions can accumulate in the area’s crop harvest, such as rice, via a tight binding with protein. Such binding paves great difficulties to remove heavy metal ions. This study aims to remove cadmium from contaminated rice protein using rhamnolipid biosurfactant together with Pluronic F127/poly (acrylic acid) (i.e., F127/PAA) hydrogels. The two-step consequential washing removed 92% of cadmium in rice protein, making the residual cadmium content below the safety level (<0.2 mg/kg) without impairing the main components and structure of rice protein. Interestingly, the washing by either rhamnolipids or hydrogels failed to effectively remove cadmium, indicating the synergistic effect of the two materials. Mechanistically, rhamnolipids with higher Cd 2+ binding constant compete with protein on binding with cadmium and then deliver it to F127/PAA hydrogels that present highest Cd 2+ adsorptive capability for immobilization. In considering that the F127/PAA hydrogels are reusable, this treatment is low-cost, safe and effective for removal of cadmium from polluted rice products.
研究领域:
环境科学
·
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 27
·9355-9365
·
IF 6.4
Qiang Gao,Chao Li,Mingxu Wang,Jiadeng Zhu,Chunxia Gao
Biomedical hydrogels always suffer from curvilinearity, deformability, and wetness associated with bio-tissues, which are therefore limited by low stability and longevity in practical applications. To overcome these issues, we have proposed a robust PAA/PEDOT conductive hydrogel and investigated its performance by using a low-crosslink-density polyacrylic acid (PAA) hydrogel with 82 wt% water. Meanwhile, poly(3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) has been used as both a major junction point and a conducting network contractor. Benefiting from the introduction of PEDOT:PSS, the resultant composite hydrogel exhibits strong adhesion (37.2 kPa), well-matched modulus with skin tissue (∼10 kPa), low swelling (2.88), and negligible hysteresis (η = 2.7% of 200% stretching, energy loss coefficient). As a scalable application platform, we have further demonstrated the potential application of this novel hydrogel as body-conformable electronics in a series of conceptual displays, including a full range of human motion responses, ECG signal detection, TENG device assembly, and energy harvesting application.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Micro & Nano Letters
·
2018
·Vol. 13
·期 5
·661-665
·
IF 0.841
Bin Zhang,Jian Han
The preparation of silicon dioxide (SiO 2 )@poly(acrylic acid) (PAA) microsphere was reported. The modified microspheres can be well dispersed in polyvinyl chloride (PVC) matrix. The structure of SiO 2 @PAA microspheres can be well-controlled and its mixtures with chlorinated polyethylene (CPE) for controlling diisooctyl terephthalate (DOTP) migration from PVC matrix. The results showed that the migration of DOTP was decreased with increasing content of SiO 2 @PAA microspheres, and the use of CPE together with SiO 2 @PAA microspheres has a synergistic effect on the reduction of DOTP migration. Moreover, CPE can enhance the interface combination between SiO 2 @PAA microsphere and PVC, and good dispersibility was observed in PVC/CPE/SiO 2 @PAA composites.
研究领域:
材料科学
·
高分子化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 22
·11899-11907
·
IF 6.895
Fei-Fei Liu,Ye-Chang Guo,Wei Wang,Yu-Ming Chen,Chen Wang
In recent decades, the ionic current rectification (ICR) property of asymmetric nanochannels has been widely explored in applications of energy conversion, gas separation, water purification and bioanalysis/sensors. How to fabricate nanofluidic devices with a high ICR characteristic remains of critical importance to the development of nanofluidics. Herein, we fabricated an asymmetric MOFs/PAA hybrid via in situ synthesis of a zeolitic imidazole framework (ZIF-90) on porous anodic alumina (PAA) nanochannels. The introduction of asymmetric geometry and charge distribution provides the hybrid with ultrahigh ionic rectification, which can be easily measured using an electrochemical detector. This rectification mechanism is elucidated via finite element simulation, which proves that asymmetric geometry as well as the protonation and deprotonation under varied pH values dominates the ICR property. With the advantages of low cost and facile fabrication while supporting high ionic current rectification, the prepared MOFs/PAA hybrid can be considered as a significant paradigm in nanofluidic systems and has potential applications in the fields of new ionic devices and energy conversion systems.
研究领域:
纳米流体学
·
材料科学
·
能源转换
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 79
·41902-41909
·
IF 3.708
Tian Jin,Qiang Yang,Chun Meng,Jian Xu,Honglai Liu,Jun Hu,Hao Ling
The world is becoming more stringent on lowering the sulfur concentrations in fuels. To fulfill this expectation, a new type of magnetic desulfurization adsorbent, Fe3O4@PAA@MOF-199, was designed and fabricated using a facile two-step assembly approach, in which PAA inventively acted like a bridge to incorporate different amounts of magnetite Fe3O4 into a MOF-199 crystal matrix. Fe3O4@PAA@MOF-199s were demonstrated to be efficient adsorbents for the removal of S-compounds, such as thiophene, benzothiophene (BT) and dibenzothiophene (DBT), from a model fuel, and the sulfur saturated adsorption capacity followed the order of DBT > BT > thiophene. The magnetization of Fe3O4@PAA@MOF-199s ensured that the adsorbents had good performance in magnetic separation. The relative high adsorption capacity, the separation efficiency, as well as the stable recyclability indicated that magnetic Fe3O4@PAA@MOF-199 would be a promising adsorbent in adsorptive desulfurization.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）